Basic Information:

  VIRBase ID:  

HHID00053442

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-188-5p:  MIMAT0000457          TMTC3:  NM_001366583     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-188-5p	TMTC3
miRBase Accession/Entrez ID	MIMAT0000457	160418
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	LIS8//SMILE

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-188-5p	rs1406924167 chrX:50003525    G/A rs1557180919 chrX:50003530    G/T rs186369276 chrX:50003535    G/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TMTC3	chr12:88557908(+) A-I      intronic chr12:88557899(+) A-I      intronic chr12:88556882(+) A-I      intronic chr12:88556709(+) A-I      intronic chr12:88556895(+) A-I      intronic chr12:88557711(+) A-I      intronic chr12:88556711(+) A-I      intronic chr12:88557812(+) A-I      intronic chr12:88557916(+) A-I      intronic chr12:88556779(+) A-I      intronic chr12:88556757(+) A-I      intronic chr12:88556749(+) A-I      intronic chr12:88557734(+) A-I      intronic chr12:88585561(+) A-I      intronic chr12:88557814(+) A-I      intronic chr12:88552842(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	TMTC3	chr12:88557814(+) A-G intron -    22484847 chr12:88556749(+) A-G intron -    22484847 chr12:88556757(+) A-G intron -    22484847 chr12:88556779(+) A-G intron -    22484847 chr12:88557734(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TMTC3	chr12:88536086-88536087(+) m6A 5'UTR       25456834//24981863 chr12:88536116-88536117(+) m6A 5'UTR       25456834//24981863 chr12:88536155-88536156(+) m6A 5'UTR       25456834//24981863 chr12:88536177-88536178(+) m6A 5'UTR//intron       25456834//24981863 chr12:88586407-88586408(+) m6A CDS       24981863//26404942 chr12:88586451-88586452(+) m6A CDS       24284625//24981863//26404942//22608085 chr12:88586500-88586501(+) m6A CDS       24284625//24981863//26404942//22608085 chr12:88586509-88586510(+) m6A CDS       24284625//24981863//26404942//22608085 chr12:88586529-88586530(+) m6A CDS       24284625//24981863//26404942//22608085 chr12:88586548-88586549(+) m6A CDS       24284625//24981863//26404942//22608085 chr12:88586566-88586567(+) m6A CDS       24284625//24981863//26404942//22608085 chr12:88588624-88588625(+) m6A CDS       24284625//24981863//26404942//22608085 chr12:88588630-88588631(+) m6A CDS       24284625//24981863//26404942//22608085 chr12:88588731-88588732(+) m6A CDS       24284625//24209618//24981863//26404942//22575960//22608085 chr12:88588823-88588824(+) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085 chr12:88588911-88588912(+) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085 chr12:88589002-88589003(+) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085 chr12:88589037-88589038(+) m6A CDS       24284625//24981863//27773535//22575960//22608085 chr12:88589069-88589070(+) m6A CDS       24284625//24981863//27773535//22575960//22608085 chr12:88589242-88589243(+) m6A CDS       24284625//24981863//27773535//22575960//22608085 chr12:88589261-88589262(+) m6A CDS       24284625//24981863//27773535//22575960//22608085 chr12:88589296-88589297(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr12:88589324-88589325(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr12:88589336-88589337(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr12:88589346-88589347(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr12:88589389-88589390(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr12:88589459-88589460(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr12:88589577-88589578(+) m6A 3'UTR       24284625//24209618//24981863//26404942//22575960//22608085 chr12:88589765-88589766(+) m6A 3'UTR       22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-188-5p	Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome Pulmonary epithelial cell line (BEAS-2B)     31520698 Exosome Jurkat-derived T cell line (J77cl20)     21505438 Exosome Ovarian follicular fluid     22116803 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     - Mitochondrion Skeletal muscle myoblasts     21637849 Nucleolus Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
	TMTC3	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleolus K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-188-5p	Iodine Green 9956454 Drug sensitive Actinomycin X4357G methoxime 9573583 Drug sensitive [[4-(3-Aminophenyl)-2-pyridyl]methyleneamino]thiourea 9556427 Drug sensitive Tiotixene 941651 Drug sensitive Dichlorodipropylstannane 93562 Drug sensitive Terreic acid 91437 Drug sensitive [(1R,2Z,4R,8R,9R,11R,12S)-1,12-Dihydroxy-2-(hydroxymethyl)-11-methyl-7-methylidene-6-oxo-5,14-dioxatricyclo[9.2.1.04,8]tetradec-2-en-9-yl] (Z)-2-methylbut-2-enoate 90475906 Drug sensitive 2,5-Dimethyl-1,4-benzoquinone 8718 Drug sensitive Acid Green 27 80837 Drug sensitive Vancide 26 79411 Drug sensitive Clothixamide maleate 76972759 Drug sensitive Secalonic acid D 73431 Drug sensitive Redoxal 72571 Drug sensitive Piperidinium pentamethylenedithiocarbamate 72508 Drug sensitive Sulbentine 67686 Drug sensitive Reactive Blue 2 656725 Drug sensitive Verrucarin A 6326658 Drug sensitive Tributyrin 6050 Drug sensitive Piriqualone 6015423 Drug sensitive Pharmakon1600-01503602 60148415 Drug sensitive 8B-Hydroxy-9B,10B-epoxyverrucarin A 5477536 Drug sensitive Caracemide 54747 Drug sensitive 7Z-Plakortide H 5472712 Drug sensitive Tetrocarcin A, sodium salt 54724658 Drug sensitive Artelasticin 5471311 Drug sensitive (Z)-4-Bromo-4-iodo-3-phenylbut-3-en-2-one 5467656 Drug sensitive 3,19-(4-Acetamido)benzylidineandrographolide 54612901 Drug sensitive 9-alpha-Acetoxyparthenolide 54611286 Drug sensitive p-Chloranilinum[bis(p-chloraniline)dioxalatoruthenate(III)] 54608061 Drug sensitive Antineoplastic-651590 54604785 Drug sensitive Herveline O 5459269 Drug sensitive Cuspidatin C 5459164 Drug sensitive Methyl (1R,4R,7E,9S,10R,11S)-9-acetyloxy-10-(2,3-dimethyloxirane-2-carbonyl)oxy-4-methyl-12-methylidene-13-oxo-3,14-dioxatricyclo[9.3.0.02,4]tetradec-7-ene-8-carboxylate 5458601 Drug sensitive Thiram 5455 Drug sensitive (E)-1-(2,5-Dihydroxyphenyl)ethene-2-isonitrile 5388136 Drug sensitive (1E,4E)-1,5-Dipyridin-3-ylpenta-1,4-dien-3-one 5382674 Drug sensitive Crassin, acetate 5355441 Drug sensitive Dihydro-5-azacytidine 5351280 Drug sensitive Erioflorin acetate 5281443 Drug sensitive 8-Hydroxymanzamine A 5270765 Drug sensitive Kekule 499328 Drug sensitive Lychnopholide 49767028 Drug sensitive Pipamperone 4830 Drug sensitive N-Methyl-1,5-bis(4-cyanophenoxy)-3-aza-pentane 45028719 Drug sensitive 1-(4-(Benzyloxy)phenyl)-3-(3-(1-ethyl-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-3-yl)phenyl)urea 44587530 Drug sensitive Isopinnatal 44558939 Drug sensitive Elephantopin 442206 Drug sensitive Isobrucein A 441802 Drug sensitive Oridonin (thiol adduct OF) 432952 Drug sensitive S-(Dimethylarsino)-3-mercapto-1,2-propyl dibenzoate 406481 Drug sensitive S-(Dimethylarsino)-3-mercapto-1,2-propyl diacetate 406479 Drug sensitive S-(Diisopropylarsino)-3-mercapto-1,2-propanediol 406478 Drug sensitive 2-[(Phenylamino)methyl]benzene-1,4-diol 403336 Drug sensitive Triacetyl crambescidin 800 hydrochloride 400721 Drug sensitive 7-Epi-3,4-bis-nor-dolastatin 11 396354 Drug sensitive Loratadine 3957 Drug sensitive Sjg-136 393111 Drug sensitive 2-Amino-4-(2-hydroxy-4-methylphenyl)-5-phenylpyrimidine 392744 Drug sensitive 3-(4-Fluorophenyl)-3-(4-hydroxy-2-methylphenyl)-2-benzofuran-1(3H)-one 387973 Drug resistant 1,3-Diphenyl-6-((triphenylphosphoranylidene)amino)-2,4(1H,3H)-pyrimidinedione 387460 Drug sensitive Acetic acid,4,7,10-tetraazacyclododecane-1,7-diyl]bis 387352 Drug sensitive (-)7,8-Dihydrocalanolide A 383107 Drug sensitive N8-Actinomycin D 383040 Drug sensitive 1-Azido-2-phenyl-3-phenalenone 381891 Drug sensitive 2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant 3,8-Dimethyl-1,2-naphthoquinone 373912 Drug sensitive 4-(1-Benzofuran-2-yl)-7-methoxychromen-2-one 364364 Drug resistant 4-Nitro-6-(trifluoromethyl)-2,1,3-benzoselenadiazole 362897 Drug sensitive Aplidazole C . TFA 362402 Drug sensitive Bis(helenalinyl)glutarate 336831 Drug sensitive Dmask 32465 Drug sensitive 2,3-Dimethoxy-5-naphthalen-2-ylsulfanylcyclohexa-2,5-diene-1,4-dione 314728 Drug sensitive 2-Chloro-3-(dodecylsulfanyl)-5,6-dimethoxycyclohexa-2,5-diene-1,4-dione 312122 Drug sensitive 2,3-Bis(iodomethyl)-6-methoxyquinoxaline 286257 Drug sensitive Dichloroallyl lawsone 277767 Drug sensitive 1H-Benzo[a]carbazole-1,4(11H)-dione, 11-methyl- 261066 Drug sensitive Hydrazine sulfate 24842 Drug sensitive Antimycin A3 245869 Drug sensitive (2-Methoxy-9,10-dihydrophenanthren-3-yl)methyl-dimethyl-(phenylsulfanylmethyl)azanium;bromide 24200489 Drug sensitive Prumycin HCl 24197905 Drug resistant 9H-Purine, 2-amino-6-(o-chlorobenzylthio)-9-propyl- 239486 Drug sensitive Cytembena 23665583 Drug sensitive (1S,2R,5Z,10R,11S,12R,16S)-2-Hydroxy-2,6,10-trimethyl-15-methylidene-13,18-dioxatricyclo[9.6.1.012,16]octadec-5-en-14-one 23425613 Drug sensitive Helenalin 23205 Drug sensitive Drostanolone propionate 224004 Drug sensitive (1S,3R,7Z,9R,12S,13R,15R)-13-Hydroxy-3,7,12-trimethyl-13-prop-1-en-2-yl-10,14,16-trioxatetracyclo[7.5.1.13,6.012,15]hexadeca-5,7-diene-4,11-dione 20835084 Drug sensitive Methyl 1,6,8,14a-tetrahydroxy-11-[(4-hydroxy-3,5-dimethoxy-6-methyloxan-2-yl)amino]-6a-methoxy-3-methyl-7,9,12,14-tetraoxo-5,6-dihydrobenzo[a]tetracene-2-carboxylate 197261 Drug sensitive 4-Chloro-5-(pyridin-2-ylthio)-3H-1,2-dithiole-3-thione 16766538 Drug sensitive 4-Chloro-5-phenoxy-3H-1,2-dithiole-3-thione 16766044 Drug sensitive Phenethyl isothiocyanate 16741 Drug sensitive 2,2-Diethyl-6-(hydroxymethyl)-4,6,7,7a-tetrahydro-3aH-[1,3,2]dioxastannolo[4,5-c]pyran-4,7-diol 16683462 Drug sensitive Trihexyltetradecylphosphonium hexafluorophosphate 16212610 Drug sensitive (3As,3bR)-3b-hydroxy-3a,5,5-trimethyl-3-methylidene-4H-cyclopenta[a]pentalene-2,6-dione 15699597 Drug sensitive N-[3-[(3-Amino-3-oxoprop-1-en-2-yl)amino]-3-oxoprop-1-en-2-yl]-2-[(1S)-18-[(2S)-2,3-dihydroxybutan-2-yl]-11-ethylidene-59-hydroxy-8,31-bis(1-hydroxyethyl)-26,46-dimethyl-40,43-dimethylidene-6,9,16,23,28,38,41,44,47-nonaoxo-37-propan-2-yl-27-oxa-3,13,20,56-tetrathia-7,10,17,24,36,39,42,45,48,52,58,61,62,63,64-pentadecazanonacyclo[23.23.9.329,35.12,5.112,15.119,22.154,57.01,53.032,60]tetrahexaconta-2(64),4,12(63),19(62),21,29(61),30,32(60),33,51,54,57-dodecaen-51-yl]-1,3-thiazole-4-carboxamide 146156820 Drug sensitive 1H-2,10a-Ethanophenanthrene, kaur-16-en-15-one deriv. 146156727 Drug sensitive Diphenyltin dichloride 14342 Drug sensitive Methyl 3-bromo-2-(bromomethyl)propionate 140895 Drug sensitive Astrazon Orange R 135747272 Drug sensitive C8, Carbonyl prodigiosine 135540857 Drug sensitive Inosine dialdehyde 135400916 Drug sensitive DTIC-Dome 135398738 Drug sensitive (1R,2S,5S,8S,9S,17R,18R,21S,24R,26S,27S)-14-Chloro-5,15-dihydroxy-2,9,26-trimethyl-3,19,23,28-tetraoxaoctacyclo[16.9.1.118,27.01,5.02,24.08,17.09,14.021,26]nonacos-11-ene-4,10,22,29-tetrone 134715214 Drug sensitive Dibutyltin dichloride 12688 Drug sensitive 15-Deacetylsergeolide 125729 Drug sensitive (2S,4S,5R)-20-De(1-hydroxypropyl)-6-demethyl-2,6-diethyl-5-hydroxy-20-(1-hydroxybutyl)lysocellin 124081057 Drug sensitive Melampodinin 11953936 Drug sensitive Unii-C616DV5Y11 117587576 Drug sensitive Gentian violet 11057 Drug sensitive (1S,2R,4R,6S,11R,12S,15R,18S,19R,20R,21S,23R,26R)-15-Hydroxy-11,18,21-trimethyl-5,17,24,28,29-pentaoxanonacyclo[17.9.1.11,20.02,12.04,6.06,11.015,19.018,23.021,26]triacont-8-ene-10,16,25,30-tetrone 101528280 Drug sensitive Erigerol 101318126 Drug sensitive (1S,3R,6R,12S,14R,15S,18R,19E,21Z,25R,26S,27R)-6,15-Dihydroxy-18-[(1R)-1-hydroxyethyl]-5,14,26-trimethylspiro[2,10,13,17,24-pentaoxapentacyclo[23.2.1.03,8.08,26.012,14]octacosa-4,19,21-triene-27,2'-oxirane]-11,23-dione 101307863 Drug sensitive Chimaphilin 101211 Drug sensitive [(1S,2S,4Z,8Z,12R,13S)-12-Hydroxy-4,8,12-trimethyl-16-methylidene-15-oxo-14-oxabicyclo[11.3.1]heptadeca-4,8-dien-2-yl] acetate 100921072 Drug sensitive 6-phenyl-6h-indeno[1,2-c]isoquinoline-5,11-dione - Drug resistant antineoplastic-d655481 - Drug resistant tp4ek - Drug resistant (1s,2e,4r,7e,11e)-4-hydroxy-2,7,11-cembratrien-6-one - Drug sensitive (E)-2-(2-(benzo[d][1,3]dioxol-5-yl)vinyl)-5-(3-methyl-1H-pyrazol-5-yl)-1,3,4-oxadiazole - Drug sensitive (Z)-5-methoxy-3-((1-(3,4,5-trimethoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methylene)indolin-2-one - Drug sensitive 1,6,7,8-tetra-o-phenylcarbamoylcastnospermine - Drug sensitive 1,8-naphthyridin-4(1h)-one, 2-(3-chlorophenyl)-5-methyl- - Drug sensitive 1h-benzimidazole, 5,5'-dithiobis[2-(trifluoromethyl)- (9ci) - Drug sensitive 2,2',5,5'-tetrahydroxy-4,4'-dimethylbiphenyl - Drug sensitive 2,3,4-tri-o-acetyl-1-s-dimethylarsino-1-thio- a -d-xylose - Drug sensitive 2-[(3,4-dicloro)anilino]-3-phenyl-5,7-diamino quinoxaline - Drug sensitive 4-[3-(3,4-dihydro-1H-isoquinolin-2-yl)prop-1-en-2-yl]-N-pyrazin-2-ylbenzamide - Drug sensitive 4-[4-(3-Methoxy-phenyl)-piperazin-1 -yl]-5H-pyrrolo[3,2-d]pyrimidine - Drug sensitive 4'-deoxy-13',17-dinitro-3',4'-epoxy-vincaleukoblastine - Drug sensitive 4-morpholinecarbodithioic acid, antimony complex - Drug sensitive 4-piperidinone, 3,5-bis[(4-fluorophenyl)methylene]-, (e,e)- - Drug sensitive 4-thiomorpholinecarbodithioic acid, antimony complex - Drug sensitive 7h-5,6-dithioleno[4,3-d]uracil - Drug sensitive 7-n,n-dimethylamino brefeldin a hydrochloride - Drug sensitive 9h-purine, 2-amino-6-(2,4-dichlorobenzylthio)-9-isobutyl- - Drug sensitive benzamide, 5-bromo-2-hydroxy-n-[3-(trifluoromethyl)phenyl]- - Drug sensitive benzene, 1,1'-[(1,3-butadiene-1,4-diyl)sulfonyl]bis - Drug sensitive benzofurazan, 4-nitro-7-(2-pyridinylthio)-, n-oxide - Drug sensitive cis-difluorobis(1-phenylhexane-1,3-dionato)titanium(iv) - Drug sensitive furan-2(3h)-one, 5-(4-methylphenyl)-3,3-diphenyl- - Drug sensitive geldanamycin, n,n'-dimethyl - Drug sensitive indoline, 5-chloro-1,3,3-trimethyl-2-methylene- (8ci) - Drug sensitive isoflavone, 5,7-dihydroxy-4'-nitro- - Drug sensitive n,n'-bis(oxydiethylene)thiocarbamoylsulfenamide - Drug sensitive phosphonium, (3-bromopropyl)triphenyl- bromide - Drug sensitive propan-1-one, 2,3-dichloro-1,3-bis(4-methylphenyl)- - Drug sensitive propanedinitrile, [(3,5-dibromo-2-ethoxyphenyl)methylene]- - Drug sensitive roridin a, 8-hydroxy-9b,10b-epoxy- - Drug sensitive (Z)-3-((2-(4-(trifluoromethyl)phenyl)-3H-benzo[d]imidazol-5-yl)methylene)indolin-2-one - Drug sensitive (Z)-6-chloro-3-((2-(4-methoxyphenyl)-3H-benzo[d]imidazol-5-yl)methylene)indolin-2-one - Drug sensitive [bis(aminomethyl)diethylsilane]dichloroplatinum (ii) - Drug sensitive 4-carbo-1-thiazolidine-3-o-gluconyl-.gamma.-lactone - Drug sensitive 5-methoxy camptothecin - Drug sensitive 9-(3-fluorobenzyl)-7-(3-fluorobenzyloxy)-2-(4-fluorobenzyl)-1-methyl-9H-beta-carbolinium bromide - Drug sensitive antineoplastic-d665837 - Drug sensitive aromoline - Drug sensitive arylmethylene-f - Drug sensitive dichlorobisoxinatotitanium(iv) - Drug sensitive isatin dr - Drug sensitive n-myristoyl-(s)-phenylalaninal diethylcetal - Drug sensitive thiadiazines - Drug sensitive trans-4-{4-[3-(4-chloro-3-trifluoromethyl-phenyl)-ureido]-cyclohexyloxy}-pyridine-2-carboxylic acid methylamide - Drug sensitive Uniroyal Compound-38 - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-188-5p	Gemcitabine 60750 Drug interaction    RC00003241 Imatinib 5291 Drug interaction    RC00003236 Naringin 442428 Drug interaction    RC00003243 Etoposide 36462 Drug interaction    RC00003240 Paclitaxel 36314 Drug interaction    RC00003239 5-Fluorouracil 3385 Drug interaction    RC00003235 Doxorubicin 31703 Drug interaction    RC00003238 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00003234 Ginsenoside Rh2 119307 Drug interaction    RC00003242 Hesperidin 10621 Drug interaction    RC00003237 Bio-Oss - Drug interaction    RC00003244

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-188-5p	Imatinib 5291       25349971 Etoposide 36462       25973145 Doxorubicin 31703       25973145

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-188-5p
Interactor2: TMTC3

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.