Detail Information

Basic Information:


  VIRBase ID:  

HHID00053250

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-185-5p:           GBA2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-185-5p GBA2
miRBase
Accession/Entrez ID		 MIMAT0000455 57704
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - AD035//NLGase//SPG46

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-185-5p
rs1249170072 chr22:20033164    G/A
rs770235403 chr22:20033168    T/C
rs775856637 chr22:20033173    G/A
rs1398989482 chr22:20033154    G/A
rs761385932 chr22:20033159    GAA/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR GBA2
chr9:35738810(-) A-I      NonSyn:Tyr->Cys
chr9:35738866(-) A-I      Syn:Leu->Leu
chr9:35745229(-) A-I      intronic
chr9:35738828(-) A-I      NonSyn:Lys->Arg
chr9:35738843(-) A-I      NonSyn:Lys->Arg
chr9:35738856(-) A-I      NonSyn:Thr->Ala
chr9:35738870(-) A-I      NonSyn:Tyr->Cys
chr9:35745134(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED GBA2
chr9:35745134(-) A-G intron -    22484847
chr9:35745154(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase GBA2
chr9:35736874-35736875(-) m6A 3'UTR       27773535
chr9:35736895-35736896(-) m6A 3'UTR       27773535
chr9:35737067-35737068(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr9:35737093-35737094(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr9:35737155-35737156(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr9:35737181-35737182(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr9:35737201-35737202(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr9:35737218-35737219(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr9:35737225-35737226(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr9:35737237-35737238(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr9:35737365-35737366(-) m6A 3'UTR//CDS       24284625//24209618//27773535//22608085
chr9:35737419-35737420(-) m6A 3'UTR//CDS       24284625
chr9:35737527-35737528(-) m6A 3'UTR//CDS//intron       22608085
chr9:35737692-35737693(-) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22608085
chr9:35737899-35737900(-) m6A CDS       24209618
chr9:35738040-35738041(-) m6A CDS//exon       24209618
chr9:35738078-35738079(-) m6A CDS//exon       24209618
chr9:35738225-35738226(-) Gm CDS//exon//intron       -
chr9:35738241-35738242(-) m6A CDS//exon       24209618
chr9:35738296-35738297(-) m6A 5'UTR//CDS//exon       24284625//24209618//24981863
chr9:35738388-35738389(-) m6A 5'UTR//exon//intron       24284625//24209618//24981863
chr9:35739650-35739651(-) m6A CDS//exon       24284625
chr9:35739680-35739681(-) m6A CDS//exon       24284625
chr9:35739707-35739708(-) m6A CDS//exon       24284625
chr9:35740855-35740856(-) m6A CDS//exon       24284625//27773535
chr9:35740895-35740896(-) m6A CDS//exon       24284625//27773535
chr9:35740965-35740966(-) m6A CDS//exon       24284625//27773535
chr9:35741745-35741746(-) m6A CDS//exon       24284625//27773535
chr9:35741801-35741802(-) m6A CDS//exon       24284625//27773535
chr9:35741856-35741857(-) m6A CDS//exon       24284625//27773535
chr9:35741941-35741942(-) m6A exon//intron       24284625
chr9:35744621-35744622(-) m6A CDS//exon       27773535
chr9:35744659-35744660(-) m6A CDS//exon       27773535
chr9:35744677-35744678(-) m6A CDS//exon       27773535
chr9:35748404-35748405(-) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr9:35748510-35748511(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr9:35748528-35748529(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr9:35748552-35748553(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr9:35748570-35748571(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr9:35748601-35748602(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr9:35748670-35748671(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr9:35748678-35748679(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr9:35748694-35748695(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr9:35748719-35748720(-) m6A 5'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr9:35748834-35748835(-) m6A 5'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr9:35748912-35748913(-) m6A 5'UTR//exon       24284625//24981863//27773535//27371828//22608085
chr9:35748922-35748923(-) m6A 5'UTR//exon       24284625//24981863//27773535//27371828//22608085
chr9:35748968-35748969(-) Y 5'UTR//exon//intron       26075521
chr9:35749107-35749108(-) m6A 5'UTR       24981863//27773536
chr9:35749129-35749130(-) m6A 5'UTR       24981863//27371828//27773536
chr9:35749222-35749223(-) m6A 5'UTR       24981863//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-185-5p
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Plasma     29130611
Exosome Primary dendritic cells|T cell line (J77)     21505438
Exosome Breast milk     22211110
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Serum     25135963
Exosome Blood|Tongue tissue     -
Extracellular vesicle HEK-293T cells     22849433
Microvesicle Plasma     23077538
Microvesicle Seminal plasma     23539611
Microvesicle Follicular fluid     23666971
Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
GBA2
Chromatin K562 cells     -
Cytosol HCC cell line (HepG2)     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|K562 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-185-5p
7-Epi-10-deacetylbaccatin III 9872117 Drug sensitive
Midostaurin 9829523 Drug resistant
Tiotixene 941651 Drug sensitive
Acridine Yellow G 8672 Drug resistant
1,9-Pyrazoloanthrone 8515 Drug resistant
Pingyangmycin 84046 Drug resistant
Tanakan 83818 Drug sensitive
2,4,6-Tris(2-pyridyl)-s-triazine 77258 Drug sensitive
Secalonic acid D 73431 Drug sensitive
Coptisine chloride 72321 Drug sensitive
7-Hydroxystaurosporine 72271 Drug resistant
Anaxirone 71218 Drug resistant
Dihydroxydiphenyl-pyridyl methane 69046 Drug resistant
Mevastatin 64715 Drug resistant
Everolimus 6442177 Drug resistant
Primaquine phosphate 6135 Drug sensitive
1,1'-Diethyl-2,2'-cyanine chloride 5717105 Drug sensitive
8B-Hydroxy-9B,10B-epoxyverrucarin A 5477536 Drug sensitive
Thiopyrimidine-CH3 5473238 Drug sensitive
Iejimalide A. 5473233 Drug sensitive
11-Cyanomethylen-11H-indolo[1,2-a]indazole 5472501 Drug resistant
6-(4-Ethylphenyl)-2-benzenesulfonamidepyridazine-3(2H)-one 54612980 Drug sensitive
Bleomycin 5460769 Drug resistant
Herveline O 5459269 Drug sensitive
[2-[2-[(1R,2S)-2-[[6-Amino-2-[1-[(2S)-2,3-diamino-3-oxopropyl]-4-oxoazetidin-2-yl]-5-methylpyrimidine-4-carbonyl]amino]-3-[[(2R,3S,4S)-3-hydroxy-5-[[(2S,3R)-3-hydroxy-1-[2-[4-[4-[2-(2-hydroxypropylamino)ethylcarbamoyl]-1,3-thiazol-2-yl]-1,3-thiazol-2-yl]ethylamino]-1-oxobutan-2-yl]amino]-4-methyl-5-oxopentan-2-yl]amino]-1-(1H-imidazol-5-yl)-3-oxopropoxy]-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl] carbamate 5458321 Drug resistant
Melampodin B acetate 5359212 Drug sensitive
5-Methyl-2-{[(2)-3-phenylprop-2-enoyl]amino}benzamide 53329052 Drug sensitive
Lovastatin 53232 Drug resistant
Cytochalasin B 5311281 Drug resistant
Herbimycin 5311102 Drug sensitive
5-Fluoro-2'-deoxycytidine 515328 Drug resistant
Dichloroplatinum; 2-(4-methoxyphenyl)ethanamine 498558 Drug sensitive
Staurosporine, 98% 49831000 Drug resistant
2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 4713 Drug sensitive
Methyl (13S,15S,16R,18S)-13-[(10S,11R,12R,19R)-11-acetyloxy-12-ethyl-10-hydroxy-5-methoxy-10-methoxycarbonyl-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraen-4-yl]-18-ethyl-1-oxido-17-oxa-11-aza-1-azoniapentacyclo[13.4.1.04,12.05,10.016,18]icosa-4(12),5,7,9-tetraene-13-carboxylate 462173 Drug sensitive
3-3'-(1H-Pyrazole-3,5-diyl)bis(1-methyl-1H-indole) 44433919 Drug resistant
4-[1-(4-Aminomethyl-phenyl)-1H-imidazo[4,5-c]pyridin-2-yl]-furazan-3-ylamine 44397453 Drug resistant
1-Benzyl-3-hexadecyl-2-methylimidazolium chloride 44219704 Drug sensitive
Bleomycin-BAPP 431594 Drug resistant
Bleomycin A5, sulfate 422920 Drug resistant
Aminopyrimidine-CH3 406278 Drug sensitive
1H-Naphth[2,3-d]imidazole, 2-[(4-chlorophenyl)methyl]- 405626 Drug resistant
Purpureagitosid 401298 Drug resistant
Trapoxin B 395803 Drug sensitive
3-(4-Fluorophenyl)-3-(4-hydroxy-2-methylphenyl)-2-benzofuran-1(3H)-one 387973 Drug resistant
2,7-Bis(methoxycarbonylmethyl)-10-methylphenothiazine 384444 Drug sensitive
2-(3-Chloropropyloxy)naphthazarin 378771 Drug sensitive
5,8-Dihydroxy-2-(4-(2-pyridinyl)-1-piperazinyl)naphthoquinone 376947 Drug sensitive
2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant
2,3-Bis(dodecanoyloxy)propylarsonic acid 375754 Drug sensitive
Naphtho[2,3-f]quinoxaline-7,12-dione, 3-hydroxy-2-methyl- 371563 Drug resistant
1-(4-Methoxy-2-methylphenyl)naphtho[1,2-c]furan-3(1H)-one 369148 Drug sensitive
3,8,13,18,23-Pentaazapentacosane 368998 Drug sensitive
2,7-Dicyanoxanthone 363841 Drug sensitive
Girolline 362388 Drug resistant
1,2,4,5-Tetrazine, 3,6-bis(1-azetidinyl)- 362170 Drug sensitive
7alpha-Acetoxyroylenane 362048 Drug sensitive
Thiosangivamycin 3580213 Drug sensitive
Imidazole, 1-(4-chlorophenyl)-4-(4-nitrophenyl)- 355940 Drug resistant
2,3-Dimethylbenzo[g]quinoxaline-5,10-dione 353644 Drug sensitive
1,4-Diaminoanthraquinone 31420 Drug resistant
Clomifene citrate 3033832 Drug sensitive
SMA-491 (free base of NSC D742838) 302576 Drug resistant
Gardenin A 261859 Drug resistant
Hookerianamide J 25016666 Drug sensitive
Hookerianamide K 25016412 Drug sensitive
(2-Methoxy-9,10-dihydrophenanthren-3-yl)methyl-dimethyl-(phenylsulfanylmethyl)azanium;bromide 24200489 Drug sensitive
CID 24197685 24197685 Drug sensitive
Antibiotic U 29135 24196291 Drug sensitive
4,5-Bis(4-methoxyphenyl)-1,5-dihydroimidazol-2-one 231112 Drug sensitive
Kinetin riboside 20345 Drug resistant
Chonemorphine 165208 Drug sensitive
(6R)-1,6,11-Trihydroxy-8-[(2S,4R,5R,6R)-4-hydroxy-5-[(2S,4R,5R,6R)-5-hydroxy-4-[(2S,5S,6S)-5-[(2S,4R,5R,6R)-4-hydroxy-5-[(2S,4R,5R,6R)-5-hydroxy-4-[(2S,5S,6S)-5-hydroxy-6-methyloxan-2-yl]oxy-6-methyloxan-2-yl]oxy-6-methyloxan-2-yl]oxy-6-methyloxan-2-yl]oxy-6-methyloxan-2-yl]oxy-6-methyloxan-2-yl]oxy-3-methyl-5,6-dihydrobenzo[a]anthracene-7,12-dione 15507920 Drug sensitive
Ellipticine analog 148569 Drug resistant
(2R)-2-Hydroxy-3-[(6R)-11-hydroxy-2-[4-[(6R)-4-hydroxy-2-[1-hydroxy-3-[(6S)-3-methyl-1,7-dioxaspiro[5.5]undecan-2-yl]butyl]-3-methylidenespiro[4a,7,8,8a-tetrahydro-4H-pyrano[3,2-b]pyran-6,5'-oxolane]-2'-yl]but-3-en-2-yl]-4-methyl-1,7-dioxaspiro[5.5]undec-4-en-8-yl]-2-methylpropanoic acid 146158002 Drug sensitive
Astrazon Orange R 135747272 Drug sensitive
[(8Ar)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2-methylbutanoate 134694047 Drug resistant
Methyl (1S,10R,11S,12S)-11-acetyloxy-12-ethyl-4-[(13R,15R,17R)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 133126830 Drug sensitive
(2R,4R,6S,7S,12S)-6,7,16-Trihydroxy-18-methoxy-12-methyl-3,13-dioxatricyclo[13.4.0.02,4]nonadeca-1(15),9,16,18-tetraene-8,14-dione 131676399 Drug sensitive
1,4-Bis((2-aminoethyl)amino)-5,8-dihydroxy-9,10-anthraquinone 125982 Drug resistant
Pepleo 122804 Drug resistant
Cyanoaminopyranopyridine derivatives 11494577 Drug resistant
1-Phenyl-5-(4-(trifluoromethyl)phenyl)-1H-imidazole 11162021 Drug resistant
Uridine, 2'-deoxy-2'-methylene- 11075548 Drug resistant
Acetylenedicarboxamide 10971 Drug sensitive
Cladospirone bisepoxide 10316810 Drug sensitive
Binimetinib 10288191 Drug sensitive
(1S,3R,6R,12S,14R,15S,18R,19E,21Z,25R,26S,27R)-6,15-Dihydroxy-18-[(1R)-1-hydroxyethyl]-5,14,26-trimethylspiro[2,10,13,17,24-pentaoxapentacyclo[23.2.1.03,8.08,26.012,14]octacosa-4,19,21-triene-27,2'-oxirane]-11,23-dione 101307863 Drug sensitive
Selumetinib 10127622 Drug sensitive
1,3,6-triphenyl-oxazolo(5,4-d)pyrimidin-2',4(1h,3h)-dion - Drug resistant
1,3-diphenyl-4-(3-phenyl-4,5-dihydro-1H-pyrazol-5-yl)-1H-pyrazole - Drug resistant
1-naphthalenecarboxamide, n,n'-1,8-(octanediyl)bis- - Drug resistant
6-phenyl-6h-indeno[1,2-c]isoquinoline-5,11-dione - Drug resistant
3-peg fudr (peg floxuridine) - Drug resistant
6-aryl alkyl fluoro quinolone derivative - Drug resistant
Annamycin Liposomal - Drug resistant
antineoplastic-d655481 - Drug resistant
Camptothecin Derivative - Drug resistant
geldanamycin dimethylglycinate - Drug resistant
organosulfur compound - Drug resistant
tartrolon a1 - Drug resistant
toxin .delta.53l - Drug resistant
tp4ek - Drug resistant
viridomycin - Drug resistant
(z) 3,3',4,5-tetramethoxystilbene - Drug sensitive
1,2-benzo-8-(d,l-alanyl)-3-phenoxazone nitrate salt - Drug sensitive
1-piperidinecarbodithioic acid, antimony complex - Drug sensitive
2-azabicyclo[16.3.1]docosane, geldanamycin deriv. - Drug sensitive
4-morpholinecarbodithioic acid, antimony complex - Drug sensitive
5,6-dimethyl-9-oxo-9h-xanthene-4-acetic acid, sodium salt - Drug sensitive
benzo[1,2-b:4,5-b']dithiophene-4,8-diol, dipropionate - Drug sensitive
E)-1-(4-(quinazolin-4-ylamino)phenyl)-3-(2,4,6-trimethoxyphenyl)prop-2-en-1-one - Drug sensitive
iodonium, (4-methoxyphenyl)(3-methylphenyl)-, bromide - Drug sensitive
(Z)-6-chloro-3-((2-(4-methoxyphenyl)-3H-benzo[d]imidazol-5-yl)methylene)indolin-2-one - Drug sensitive
1-[(2-phenylethoxy)methyl]-5-ethyl-6-(phenylseleno)uracil - Drug sensitive
5-hydroxyamino camptothecin - Drug sensitive
antineoplastic-615538 - Drug sensitive
dichlorobisoxinatotitanium(iv) - Drug sensitive
geldanamycin deriv - Drug sensitive
tetra(isobutenyl)antimony bromide - Drug sensitive
xenorhabdin 1 - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-185-5p
Formaldehyde 712 Drug interaction    RC00003208
Oxaliplatine 6857599 Drug interaction    RC00003218
Gemcitabine 60750 Drug interaction    RC00003213
Cholesterol 5997 Drug interaction    RC00003211
Eloxatine 5310940 Drug interaction    RC00003217
Decitabine 451668 Drug interaction    RC00003215
5-Fluorouracil 3385 Drug interaction    RC00003210
Doxorubicin 31703 Drug interaction    RC00003212
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00003209
Tamoxifen 2733526 Drug interaction    RC00003216
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00003219
Benzene 241 Drug interaction    RC00003207
Leucovorin 135403648 Drug interaction    RC00003220
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-185-5p
Cisplatin 5702198       27906433
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-185-5p
Interactor2: GBA2

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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