Basic Information:

  VIRBase ID:  

HHID00053211

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-185-5p:  MIMAT0000455          EIF4G1:  NM_001194947     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-185-5p	EIF4G1
miRBase Accession/Entrez ID	MIMAT0000455	1981
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	EIF-4G1//EIF4F//EIF4G//EIF4GI//P220//PARK18

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-185-5p	rs1249170072 chr22:20033164    G/A rs770235403 chr22:20033168    T/C rs775856637 chr22:20033173    G/A rs1398989482 chr22:20033154    G/A rs761385932 chr22:20033159    GAA/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	EIF4G1	chr3:184036782(+) A-I      intronic chr3:184048645(+) A-I      intronic chr3:184047243(+) A-I      intronic chr3:184047381(+) A-I      intronic chr3:184036812(+) A-I      intronic chr3:184048052(+) A-I      intronic chr3:184048154(+) A-I      intronic chr3:184048669(+) A-I      intronic chr3:184048673(+) A-I      intronic chr3:184048702(+) A-I      intronic chr3:184036615(+) A-I      intronic chr3:184036456(+) A-I      intronic chr3:184036747(+) A-I      intronic chr3:184036751(+) A-I      intronic chr3:184047965(+) A-I      intronic chr3:184042515(+) A-I      intronic chr3:184036764(+) A-I      intronic chr3:184047286(+) A-I      intronic chr3:184036492(+) A-I      intronic chr3:184048046(+) A-I      intronic chr3:184036290(+) A-I      intronic chr3:184036493(+) A-I      intronic chr3:184047915(+) A-I      intronic chr3:184036189(+) A-I      intronic chr3:184036156(+) A-I      intronic chr3:184036573(+) A-I      intronic chr3:184036807(+) A-I      intronic chr3:184047989(+) A-I      intronic chr3:184047166(+) A-I      intronic chr3:184048111(+) A-I      intronic chr3:184036412(+) A-I      intronic chr3:184048796(+) A-I      intronic chr3:184048667(+) A-I      intronic chr3:184036284(+) A-I      intronic chr3:184036798(+) A-I      intronic chr3:184036510(+) A-I      intronic chr3:184036783(+) A-I      intronic chr3:184036654(+) A-I      intronic chr3:184036742(+) A-I      intronic chr3:184048003(+) A-I      intronic chr3:184036223(+) A-I      intronic chr3:184036741(+) A-I      intronic chr3:184036715(+) A-I      intronic chr3:184036808(+) A-I      intronic chr3:184048112(+) A-I      intronic chr3:184047258(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	EIF4G1	chr3:184036189(+) A-G intron -    22484847 chr3:184036306(+) A-G intron -    22484847 chr3:184036412(+) A-G intron -    22484847 chr3:184036472(+) A-G intron -    22484847 chr3:184036493(+) A-G intron -    22484847 chr3:184036510(+) A-G intron -    22484847 chr3:184036719(+) A-G intron -    22484847 chr3:184036741(+) A-G intron -    22484847 chr3:184036764(+) A-G intron -    22484847 chr3:184036807(+) A-G intron -    22484847 chr3:184036808(+) A-G intron -    22484847 chr3:184042515(+) A-G intron -    22484847 chr3:184042519(+) A-C intron -    22484847 chr3:184047931(+) G-T intron -    22484847 chr3:184047965(+) A-G intron -    22484847 chr3:184048667(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	EIF4G1	chr3:184032407-184032408(+) m6A 5'UTR//exon       24284625//25456834//24981863//22575960 chr3:184032445-184032446(+) m6A 5'UTR//exon       24284625//25456834//24981863//22575960 chr3:184032455-184032456(+) m6A 5'UTR//exon       24284625//25456834//24981863//22575960 chr3:184032964-184032965(+) m6A 5'UTR//intron       24284625//25456834//24981863//22575960 chr3:184033119-184033120(+) m6A 5'UTR//intron       24284625 chr3:184033204-184033205(+) m6A 5'UTR//intron       24284625 chr3:184033293-184033294(+) m6A 5'UTR//exon//intron       24284625//22575960 chr3:184033313-184033314(+) m6A 5'UTR//exon//intron       24284625 chr3:184033561-184033562(+) m6A 5'UTR//exon//intron       24284625//24981863 chr3:184033588-184033589(+) m6A 5'UTR//CDS//exon//intron       24284625//24981863 chr3:184033634-184033635(+) m6A 5'UTR//CDS//exon//intron       24284625//24981863 chr3:184033683-184033684(+) m6A exon//intron       24284625//24981863 chr3:184033898-184033899(+) m6A 5'UTR//exon//intron       24284625 chr3:184033940-184033941(+) m6A 5'UTR//CDS//intron       24284625//22575960 chr3:184033983-184033984(+) m6A 5'UTR//CDS//intron       24284625//22575960 chr3:184035281-184035282(+) m6A CDS//intron       24284625//22575960 chr3:184035597-184035598(+) m6A 5'UTR//CDS//intron       24284625//22575960 chr3:184036999-184037000(+) m6A 5'UTR//intron       24284625//22575960 chr3:184037005-184037006(+) m6A 5'UTR//intron       24284625//22575960 chr3:184037010-184037011(+) m6A 5'UTR//intron       24284625//22575960 chr3:184037026-184037027(+) m6A 5'UTR//intron       24284625//22575960 chr3:184037548-184037549(+) m6A 3'UTR//CDS//exon//intron       24284625 chr3:184038148-184038149(+) m6A 5'UTR//intron       24284625 chr3:184038436-184038437(+) m6A 3'UTR//5'UTR//CDS//exon       24284625 chr3:184038674-184038675(+) m6A 3'UTR//intron       24284625//22575960 chr3:184038688-184038689(+) m6A 3'UTR//intron       24284625//22575960 chr3:184039190-184039191(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960 chr3:184039234-184039235(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr3:184039290-184039291(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr3:184039319-184039320(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr3:184039337-184039338(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr3:184039370-184039371(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr3:184039484-184039485(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr3:184039577-184039578(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr3:184039612-184039613(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr3:184039817-184039818(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//27773536//22575960//22608085 chr3:184040215-184040216(+) m6A 3'UTR//CDS       24209618//24981863//26404942//27773535//22575960 chr3:184040335-184040336(+) m6A 3'UTR//CDS       24981863//26404942//27773535//22575960 chr3:184040439-184040440(+) m6A 3'UTR//CDS       24981863//26404942//27773535//22575960 chr3:184040446-184040447(+) m6A 3'UTR//CDS       24981863//26404942//27773535//22575960 chr3:184040458-184040459(+) m6A 3'UTR//CDS       24981863//26404942//27773535//22575960 chr3:184040479-184040480(+) m6A 3'UTR//CDS       24981863//26404942//22575960 chr3:184040495-184040496(+) m6A 3'UTR//CDS       24981863//26404942//22575960 chr3:184040515-184040516(+) Cm 3'UTR//CDS       - chr3:184040626-184040627(+) m6A 3'UTR//CDS       26404942 chr3:184040737-184040738(+) m6A 3'UTR//CDS       26404942 chr3:184040879-184040880(+) m6A 3'UTR//CDS       26404942 chr3:184040908-184040909(+) m6A 3'UTR//CDS       26404942 chr3:184040934-184040935(+) m6A 3'UTR//CDS       22575960 chr3:184040966-184040967(+) m6A 3'UTR//CDS       22575960 chr3:184041206-184041207(+) m6A 3'UTR//CDS       22575960 chr3:184041227-184041228(+) m6A 3'UTR//CDS       22575960 chr3:184041239-184041240(+) m6A 3'UTR//CDS       22575960 chr3:184041246-184041247(+) Am 3'UTR//CDS       - chr3:184041284-184041285(+) m6A 3'UTR//CDS       22575960 chr3:184041289-184041290(+) m6A 3'UTR//CDS       22575960 chr3:184041311-184041312(+) m6A 3'UTR//CDS       22575960 chr3:184041355-184041356(+) m1A 3'UTR//CDS       26863410 chr3:184041375-184041376(+) m6A 3'UTR//CDS       22575960 chr3:184041602-184041603(+) m6A 3'UTR//CDS       26404942//22575960 chr3:184042028-184042029(+) m6A 3'UTR//CDS       27773535 chr3:184042034-184042035(+) Gm 3'UTR//CDS       - chr3:184042076-184042077(+) m6A 3'UTR//CDS       24981863//26404942//27773535 chr3:184042711-184042712(+) m6A 3'UTR//CDS       24981863//26404942//27773535 chr3:184042766-184042767(+) m6A 3'UTR//CDS       24981863//26404942//27773535 chr3:184042811-184042812(+) m6A 3'UTR//CDS       24981863//26404942//27773535 chr3:184042822-184042823(+) m6A 3'UTR//CDS       24981863//26404942//27773535 chr3:184042879-184042880(+) m6A 3'UTR//CDS       24981863//26404942//27773535 chr3:184042885-184042886(+) m6A 3'UTR//CDS       24981863//26404942//27773535 chr3:184043306-184043307(+) m6A 3'UTR//CDS//exon       24284625//26404942//22575960 chr3:184043344-184043345(+) m6A 3'UTR//CDS//exon       24284625//26404942//22575960 chr3:184043552-184043553(+) Tm intron       - chr3:184043645-184043646(+) m6A 3'UTR//CDS//exon       24284625//26404942//22575960 chr3:184043674-184043675(+) m6A 3'UTR//CDS//exon       24284625//26404942//22575960 chr3:184045038-184045039(+) Gm 3'UTR//CDS       - chr3:184045041-184045042(+) m6A 3'UTR//CDS       24284625//24209618//24981863//26404942//27773535//22575960 chr3:184045050-184045051(+) m6A 3'UTR//CDS       24284625//24209618//24981863//26404942//27773535//22575960 chr3:184045080-184045081(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960 chr3:184045089-184045090(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960 chr3:184045109-184045110(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//26404942//22575960 chr3:184045218-184045219(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//22575960 chr3:184046447-184046448(+) m6A 3'UTR//CDS//exon       22575960 chr3:184046490-184046491(+) m6A 3'UTR//CDS//exon       24284625//22575960 chr3:184046580-184046581(+) m6A exon//intron       24284625//22575960 chr3:184046655-184046656(+) m6A exon//intron       24284625//22575960 chr3:184046717-184046718(+) m6A 3'UTR//CDS//exon       24284625//22575960 chr3:184049126-184049127(+) m6A 3'UTR//CDS//exon       24284625//22575960 chr3:184049148-184049149(+) m6A 3'UTR//CDS//exon       24284625//22575960 chr3:184049329-184049330(+) m6A 3'UTR//CDS//exon       24284625//22575960 chr3:184049606-184049607(+) m6A exon//intron       24284625//22575960 chr3:184049642-184049643(+) m6A exon//intron       24284625//22575960 chr3:184049687-184049688(+) m6A exon//intron       24284625//22575960 chr3:184049738-184049739(+) m6A 3'UTR//CDS//exon       24284625//22575960 chr3:184049863-184049864(+) m6A 3'UTR//CDS//exon       24284625//22575960 chr3:184052578-184052579(+) Cm 3'UTR//CDS//exon       - chr3:184052598-184052599(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr3:184052714-184052715(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//27773536//22575960//22608085 chr3:184052730-184052731(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//27773536//22575960//22608085 chr3:184052759-184052760(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27371828//22575960//22608085 chr3:184052819-184052820(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr3:184053024-184053025(+) m6A 3'UTR//exon       24284625

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-185-5p	Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome Plasma     29130611 Exosome Primary dendritic cells|T cell line (J77)     21505438 Exosome Breast milk     22211110 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Human mast cell line (HMC-1)     24009880 Exosome Serum     25135963 Exosome Blood|Tongue tissue     - Extracellular vesicle HEK-293T cells     22849433 Microvesicle Plasma     23077538 Microvesicle Seminal plasma     23539611 Microvesicle Follicular fluid     23666971 Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
	EIF4G1	Chromatin K562 cells     - Cytosol HeLa-S3 cells     - Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-185-5p	7-Epi-10-deacetylbaccatin III 9872117 Drug sensitive Midostaurin 9829523 Drug resistant Tiotixene 941651 Drug sensitive Acridine Yellow G 8672 Drug resistant 1,9-Pyrazoloanthrone 8515 Drug resistant Pingyangmycin 84046 Drug resistant Tanakan 83818 Drug sensitive 2,4,6-Tris(2-pyridyl)-s-triazine 77258 Drug sensitive Secalonic acid D 73431 Drug sensitive Coptisine chloride 72321 Drug sensitive 7-Hydroxystaurosporine 72271 Drug resistant Anaxirone 71218 Drug resistant Dihydroxydiphenyl-pyridyl methane 69046 Drug resistant Mevastatin 64715 Drug resistant Everolimus 6442177 Drug resistant Primaquine phosphate 6135 Drug sensitive 1,1'-Diethyl-2,2'-cyanine chloride 5717105 Drug sensitive 8B-Hydroxy-9B,10B-epoxyverrucarin A 5477536 Drug sensitive Thiopyrimidine-CH3 5473238 Drug sensitive Iejimalide A. 5473233 Drug sensitive 11-Cyanomethylen-11H-indolo[1,2-a]indazole 5472501 Drug resistant 6-(4-Ethylphenyl)-2-benzenesulfonamidepyridazine-3(2H)-one 54612980 Drug sensitive Bleomycin 5460769 Drug resistant Herveline O 5459269 Drug sensitive [2-[2-[(1R,2S)-2-[[6-Amino-2-[1-[(2S)-2,3-diamino-3-oxopropyl]-4-oxoazetidin-2-yl]-5-methylpyrimidine-4-carbonyl]amino]-3-[[(2R,3S,4S)-3-hydroxy-5-[[(2S,3R)-3-hydroxy-1-[2-[4-[4-[2-(2-hydroxypropylamino)ethylcarbamoyl]-1,3-thiazol-2-yl]-1,3-thiazol-2-yl]ethylamino]-1-oxobutan-2-yl]amino]-4-methyl-5-oxopentan-2-yl]amino]-1-(1H-imidazol-5-yl)-3-oxopropoxy]-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl] carbamate 5458321 Drug resistant Melampodin B acetate 5359212 Drug sensitive 5-Methyl-2-{[(2)-3-phenylprop-2-enoyl]amino}benzamide 53329052 Drug sensitive Lovastatin 53232 Drug resistant Cytochalasin B 5311281 Drug resistant Herbimycin 5311102 Drug sensitive 5-Fluoro-2'-deoxycytidine 515328 Drug resistant Dichloroplatinum; 2-(4-methoxyphenyl)ethanamine 498558 Drug sensitive Staurosporine, 98% 49831000 Drug resistant 2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 4713 Drug sensitive Methyl (13S,15S,16R,18S)-13-[(10S,11R,12R,19R)-11-acetyloxy-12-ethyl-10-hydroxy-5-methoxy-10-methoxycarbonyl-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraen-4-yl]-18-ethyl-1-oxido-17-oxa-11-aza-1-azoniapentacyclo[13.4.1.04,12.05,10.016,18]icosa-4(12),5,7,9-tetraene-13-carboxylate 462173 Drug sensitive 3-3'-(1H-Pyrazole-3,5-diyl)bis(1-methyl-1H-indole) 44433919 Drug resistant 4-[1-(4-Aminomethyl-phenyl)-1H-imidazo[4,5-c]pyridin-2-yl]-furazan-3-ylamine 44397453 Drug resistant 1-Benzyl-3-hexadecyl-2-methylimidazolium chloride 44219704 Drug sensitive Bleomycin-BAPP 431594 Drug resistant Bleomycin A5, sulfate 422920 Drug resistant Aminopyrimidine-CH3 406278 Drug sensitive 1H-Naphth[2,3-d]imidazole, 2-[(4-chlorophenyl)methyl]- 405626 Drug resistant Purpureagitosid 401298 Drug resistant Trapoxin B 395803 Drug sensitive 3-(4-Fluorophenyl)-3-(4-hydroxy-2-methylphenyl)-2-benzofuran-1(3H)-one 387973 Drug resistant 2,7-Bis(methoxycarbonylmethyl)-10-methylphenothiazine 384444 Drug sensitive 2-(3-Chloropropyloxy)naphthazarin 378771 Drug sensitive 5,8-Dihydroxy-2-(4-(2-pyridinyl)-1-piperazinyl)naphthoquinone 376947 Drug sensitive 2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant 2,3-Bis(dodecanoyloxy)propylarsonic acid 375754 Drug sensitive Naphtho[2,3-f]quinoxaline-7,12-dione, 3-hydroxy-2-methyl- 371563 Drug resistant 1-(4-Methoxy-2-methylphenyl)naphtho[1,2-c]furan-3(1H)-one 369148 Drug sensitive 3,8,13,18,23-Pentaazapentacosane 368998 Drug sensitive 2,7-Dicyanoxanthone 363841 Drug sensitive Girolline 362388 Drug resistant 1,2,4,5-Tetrazine, 3,6-bis(1-azetidinyl)- 362170 Drug sensitive 7alpha-Acetoxyroylenane 362048 Drug sensitive Thiosangivamycin 3580213 Drug sensitive Imidazole, 1-(4-chlorophenyl)-4-(4-nitrophenyl)- 355940 Drug resistant 2,3-Dimethylbenzo[g]quinoxaline-5,10-dione 353644 Drug sensitive 1,4-Diaminoanthraquinone 31420 Drug resistant Clomifene citrate 3033832 Drug sensitive SMA-491 (free base of NSC D742838) 302576 Drug resistant Gardenin A 261859 Drug resistant Hookerianamide J 25016666 Drug sensitive Hookerianamide K 25016412 Drug sensitive (2-Methoxy-9,10-dihydrophenanthren-3-yl)methyl-dimethyl-(phenylsulfanylmethyl)azanium;bromide 24200489 Drug sensitive CID 24197685 24197685 Drug sensitive Antibiotic U 29135 24196291 Drug sensitive 4,5-Bis(4-methoxyphenyl)-1,5-dihydroimidazol-2-one 231112 Drug sensitive Kinetin riboside 20345 Drug resistant Chonemorphine 165208 Drug sensitive (6R)-1,6,11-Trihydroxy-8-[(2S,4R,5R,6R)-4-hydroxy-5-[(2S,4R,5R,6R)-5-hydroxy-4-[(2S,5S,6S)-5-[(2S,4R,5R,6R)-4-hydroxy-5-[(2S,4R,5R,6R)-5-hydroxy-4-[(2S,5S,6S)-5-hydroxy-6-methyloxan-2-yl]oxy-6-methyloxan-2-yl]oxy-6-methyloxan-2-yl]oxy-6-methyloxan-2-yl]oxy-6-methyloxan-2-yl]oxy-6-methyloxan-2-yl]oxy-3-methyl-5,6-dihydrobenzo[a]anthracene-7,12-dione 15507920 Drug sensitive Ellipticine analog 148569 Drug resistant (2R)-2-Hydroxy-3-[(6R)-11-hydroxy-2-[4-[(6R)-4-hydroxy-2-[1-hydroxy-3-[(6S)-3-methyl-1,7-dioxaspiro[5.5]undecan-2-yl]butyl]-3-methylidenespiro[4a,7,8,8a-tetrahydro-4H-pyrano[3,2-b]pyran-6,5'-oxolane]-2'-yl]but-3-en-2-yl]-4-methyl-1,7-dioxaspiro[5.5]undec-4-en-8-yl]-2-methylpropanoic acid 146158002 Drug sensitive Astrazon Orange R 135747272 Drug sensitive [(8Ar)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2-methylbutanoate 134694047 Drug resistant Methyl (1S,10R,11S,12S)-11-acetyloxy-12-ethyl-4-[(13R,15R,17R)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 133126830 Drug sensitive (2R,4R,6S,7S,12S)-6,7,16-Trihydroxy-18-methoxy-12-methyl-3,13-dioxatricyclo[13.4.0.02,4]nonadeca-1(15),9,16,18-tetraene-8,14-dione 131676399 Drug sensitive 1,4-Bis((2-aminoethyl)amino)-5,8-dihydroxy-9,10-anthraquinone 125982 Drug resistant Pepleo 122804 Drug resistant Cyanoaminopyranopyridine derivatives 11494577 Drug resistant 1-Phenyl-5-(4-(trifluoromethyl)phenyl)-1H-imidazole 11162021 Drug resistant Uridine, 2'-deoxy-2'-methylene- 11075548 Drug resistant Acetylenedicarboxamide 10971 Drug sensitive Cladospirone bisepoxide 10316810 Drug sensitive Binimetinib 10288191 Drug sensitive (1S,3R,6R,12S,14R,15S,18R,19E,21Z,25R,26S,27R)-6,15-Dihydroxy-18-[(1R)-1-hydroxyethyl]-5,14,26-trimethylspiro[2,10,13,17,24-pentaoxapentacyclo[23.2.1.03,8.08,26.012,14]octacosa-4,19,21-triene-27,2'-oxirane]-11,23-dione 101307863 Drug sensitive Selumetinib 10127622 Drug sensitive 1,3,6-triphenyl-oxazolo(5,4-d)pyrimidin-2',4(1h,3h)-dion - Drug resistant 1,3-diphenyl-4-(3-phenyl-4,5-dihydro-1H-pyrazol-5-yl)-1H-pyrazole - Drug resistant 1-naphthalenecarboxamide, n,n'-1,8-(octanediyl)bis- - Drug resistant 6-phenyl-6h-indeno[1,2-c]isoquinoline-5,11-dione - Drug resistant 3-peg fudr (peg floxuridine) - Drug resistant 6-aryl alkyl fluoro quinolone derivative - Drug resistant Annamycin Liposomal - Drug resistant antineoplastic-d655481 - Drug resistant Camptothecin Derivative - Drug resistant geldanamycin dimethylglycinate - Drug resistant organosulfur compound - Drug resistant tartrolon a1 - Drug resistant toxin .delta.53l - Drug resistant tp4ek - Drug resistant viridomycin - Drug resistant (z) 3,3',4,5-tetramethoxystilbene - Drug sensitive 1,2-benzo-8-(d,l-alanyl)-3-phenoxazone nitrate salt - Drug sensitive 1-piperidinecarbodithioic acid, antimony complex - Drug sensitive 2-azabicyclo[16.3.1]docosane, geldanamycin deriv. - Drug sensitive 4-morpholinecarbodithioic acid, antimony complex - Drug sensitive 5,6-dimethyl-9-oxo-9h-xanthene-4-acetic acid, sodium salt - Drug sensitive benzo[1,2-b:4,5-b']dithiophene-4,8-diol, dipropionate - Drug sensitive E)-1-(4-(quinazolin-4-ylamino)phenyl)-3-(2,4,6-trimethoxyphenyl)prop-2-en-1-one - Drug sensitive iodonium, (4-methoxyphenyl)(3-methylphenyl)-, bromide - Drug sensitive (Z)-6-chloro-3-((2-(4-methoxyphenyl)-3H-benzo[d]imidazol-5-yl)methylene)indolin-2-one - Drug sensitive 1-[(2-phenylethoxy)methyl]-5-ethyl-6-(phenylseleno)uracil - Drug sensitive 5-hydroxyamino camptothecin - Drug sensitive antineoplastic-615538 - Drug sensitive dichlorobisoxinatotitanium(iv) - Drug sensitive geldanamycin deriv - Drug sensitive tetra(isobutenyl)antimony bromide - Drug sensitive xenorhabdin 1 - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-185-5p	Formaldehyde 712 Drug interaction    RC00003208 Oxaliplatine 6857599 Drug interaction    RC00003218 Gemcitabine 60750 Drug interaction    RC00003213 Cholesterol 5997 Drug interaction    RC00003211 Eloxatine 5310940 Drug interaction    RC00003217 Decitabine 451668 Drug interaction    RC00003215 5-Fluorouracil 3385 Drug interaction    RC00003210 Doxorubicin 31703 Drug interaction    RC00003212 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00003209 Tamoxifen 2733526 Drug interaction    RC00003216 N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00003219 Benzene 241 Drug interaction    RC00003207 Leucovorin 135403648 Drug interaction    RC00003220

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-185-5p	Cisplatin 5702198       27906433 N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-185-5p
Interactor2: EIF4G1

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.