Detail Information

Basic Information:


  VIRBase ID:  

HHID00053062

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-126-5p:           CDCA7:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-126-5p CDCA7
miRBase
Accession/Entrez ID		 MIMAT0000444 83879
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - ICF3//JPO1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-126-5p
rs1424556578 chr9:136670632    A/T
rs746772073 chr9:136670629    G/C
rs757031753 chr9:136670633    C/T
rs781001989 chr9:136670634    G/A
rs993093735 chr9:136670628    T/C
rs1487240924 chr9:136670616    CATT/C
rs777307469 chr9:136670618    T/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR CDCA7
chr2:174221358(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED CDCA7
chr2:174227320(+) C-T intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase CDCA7
chr2:174229696-174229697(+) m6A CDS//exon       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-126-5p
Exosome Breast milk     22211110
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Blood|B lymphoblastoid cells|Chronic lymphocytic leukemia cells|Endothelial cells|Lymphoma tissue|Mast cells     -
Extracellular vesicle Plasma     32498409
Microvesicle Plasma     19002258
Microvesicle Plasma     23077538
Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
CDCA7
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Membrane HCC cell line (HepG2)     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-126-5p
Estradiol 5757 Drug interaction    RC00003040
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-126-5p
Cytarabine 6253       25759982
Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885
Cetuximab -       26107137

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-126-5p
Interactor2: CDCA7

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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