Basic Information:

  VIRBase ID:  

HHID00053058

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-126-5p:  MIMAT0000444          COQ10B:  NM_001320819     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-126-5p	COQ10B
miRBase Accession/Entrez ID	MIMAT0000444	80219
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-126-5p	rs1424556578 chr9:136670632    A/T rs746772073 chr9:136670629    G/C rs757031753 chr9:136670633    C/T rs781001989 chr9:136670634    G/A rs993093735 chr9:136670628    T/C rs1487240924 chr9:136670616    CATT/C rs777307469 chr9:136670618    T/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	COQ10B	chr2:198339351(+) A-I      3'UTR chr2:198339214(+) A-I      3'UTR chr2:198339190(+) A-I      3'UTR chr2:198339211(+) A-I      3'UTR chr2:198331788(+) A-I      intronic chr2:198332195(+) A-I      intronic chr2:198333040(+) A-I      intronic chr2:198333108(+) A-I      intronic chr2:198336127(+) A-I      intronic chr2:198336128(+) A-I      intronic chr2:198336470(+) A-I      intronic chr2:198323913(+) A-I      intronic chr2:198329883(+) A-I      intronic chr2:198324090(+) A-I      intronic chr2:198325158(+) A-I      intronic chr2:198336489(+) A-I      intronic chr2:198326465(+) A-I      intronic chr2:198326617(+) A-I      intronic chr2:198332925(+) A-I      intronic chr2:198329711(+) A-I      intronic chr2:198323909(+) A-I      intronic chr2:198329800(+) A-I      intronic chr2:198329817(+) A-I      intronic chr2:198325082(+) A-I      intronic chr2:198325151(+) A-I      intronic chr2:198326810(+) A-I      intronic chr2:198329845(+) A-I      intronic chr2:198329861(+) A-I      intronic chr2:198330405(+) A-I      intronic chr2:198330467(+) A-I      intronic chr2:198330632(+) A-I      intronic chr2:198330737(+) A-I      intronic chr2:198326832(+) A-I      intronic chr2:198339319(+) A-I      3'UTR chr2:198339330(+) A-I      3'UTR chr2:198339233(+) A-I      3'UTR chr2:198339289(+) A-I      3'UTR chr2:198339232(+) A-I      3'UTR chr2:198339331(+) A-I      3'UTR chr2:198339359(+) A-I      3'UTR chr2:198339252(+) A-I      3'UTR chr2:198339172(+) A-I      3'UTR chr2:198339154(+) A-I      3'UTR chr2:198339148(+) A-I      3'UTR chr2:198339389(+) A-I      3'UTR chr2:198339263(+) A-I      3'UTR chr2:198339254(+) A-I      3'UTR chr2:198339426(+) A-I      3'UTR chr2:198339411(+) A-I      3'UTR chr2:198339390(+) A-I      3'UTR chr2:198339239(+) A-I      3'UTR chr2:198339209(+) A-I      3'UTR chr2:198339299(+) A-I      3'UTR chr2:198339200(+) A-I      3'UTR chr2:198339234(+) A-I      3'UTR chr2:198339185(+) A-I      3'UTR chr2:198334041(+) A-I      intronic chr2:198326842(+) A-I      intronic chr2:198333073(+) A-I      intronic chr2:198328547(+) A-I      intronic chr2:198330514(+) A-I      intronic chr2:198332243(+) A-I      intronic chr2:198330736(+) A-I      intronic chr2:198330353(+) A-I      intronic chr2:198328295(+) A-I      intronic chr2:198330658(+) A-I      intronic chr2:198335941(+) A-I      intronic chr2:198336075(+) A-I      intronic chr2:198336049(+) A-I      intronic chr2:198330114(+) A-I      intronic chr2:198330615(+) A-I      intronic chr2:198328424(+) A-I      intronic chr2:198330463(+) A-I      intronic chr2:198336012(+) A-I      intronic chr2:198339290(+) A-I      3'UTR chr2:198339245(+) A-I      3'UTR chr2:198330693(+) A-I      intronic chr2:198330630(+) A-I      intronic chr2:198329629(+) A-I      intronic chr2:198336516(+) A-I      intronic chr2:198333056(+) A-I      intronic chr2:198332171(+) A-I      intronic chr2:198333046(+) A-I      intronic chr2:198330554(+) A-I      intronic chr2:198325026(+) A-I      intronic chr2:198332375(+) A-I      intronic chr2:198331800(+) A-I      intronic chr2:198328089(+) A-I      intronic chr2:198335228(+) A-I      intronic chr2:198326846(+) A-I      intronic chr2:198332903(+) A-I      intronic chr2:198333020(+) A-I      intronic chr2:198327965(+) A-I      intronic chr2:198330037(+) A-I      intronic chr2:198326565(+) A-I      intronic chr2:198325028(+) A-I      intronic chr2:198328012(+) A-I      intronic chr2:198326507(+) A-I      intronic chr2:198324125(+) A-I      intronic chr2:198333943(+) A-I      intronic chr2:198328271(+) A-I      intronic chr2:198336510(+) A-I      intronic chr2:198330555(+) A-I      intronic chr2:198328287(+) A-I      intronic chr2:198332119(+) A-I      intronic chr2:198330506(+) A-I      intronic chr2:198335769(+) A-I      intronic chr2:198332165(+) A-I      intronic chr2:198333567(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	COQ10B	chr2:198337928(+) A-I intron -    21960545 chr2:198323900(+) C-T intron -    22484847 chr2:198325026(+) A-G intron -    22484847 chr2:198325028(+) A-G intron -    22484847 chr2:198326507(+) A-G intron -    22484847 chr2:198328012(+) A-G intron -    22484847 chr2:198329783(+) A-G intron -    22484847 chr2:198329816(+) A-G intron -    22484847 chr2:198330037(+) A-G intron -    22484847 chr2:198330114(+) A-G intron -    22484847 chr2:198330362(+) A-G intron -    22484847 chr2:198330421(+) A-G intron -    22484847 chr2:198330463(+) A-G intron -    22484847 chr2:198330630(+) A-G intron -    22484847 chr2:198330658(+) A-G intron -    22484847 chr2:198330693(+) A-G intron -    22484847 chr2:198330695(+) A-G intron -    22484847 chr2:198330696(+) A-G intron -    22484847 chr2:198330736(+) A-G intron -    22484847 chr2:198330741(+) A-G intron -    22484847 chr2:198330748(+) A-G intron -    22484847 chr2:198332165(+) A-G intron -    22484847 chr2:198332171(+) A-G intron -    22484847 chr2:198332243(+) A-G intron -    22484847 chr2:198333020(+) A-G intron -    22484847 chr2:198333046(+) A-G intron -    22484847 chr2:198334041(+) A-G intron -    22484847 chr2:198335215(+) A-G intron -    22484847 chr2:198335281(+) T-C intron -    22484847 chr2:198335941(+) A-G intron -    22484847 chr2:198336506(+) A-G intron -    22484847 chr2:198339245(+) A-G intron -    22484847 chr2:198339290(+) A-G intron -    22484847 chr2:198339334(+) C-T intron -    22484847 chr2:198339360(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	COQ10B	chr2:198318197-198318198(+) m6A 5'UTR       24981863 chr2:198318296-198318297(+) m6A CDS       - chr2:198338600-198338601(+) m6A CDS       24981863 chr2:198338660-198338661(+) m6A 3'UTR       24981863//26404942 chr2:198338767-198338768(+) m6A 3'UTR       24981863//26404942 chr2:198338802-198338803(+) m6A 3'UTR       24981863//26404942 chr2:198338853-198338854(+) m6A 3'UTR       24981863//26404942

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-126-5p	Exosome Breast milk     22211110 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Blood|B lymphoblastoid cells|Chronic lymphocytic leukemia cells|Endothelial cells|Lymphoma tissue|Mast cells     - Extracellular vesicle Plasma     32498409 Microvesicle Plasma     19002258 Microvesicle Plasma     23077538 Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
	COQ10B	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)     - Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-126-5p	Estradiol 5757 Drug interaction    RC00003040

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-126-5p	Cytarabine 6253       25759982 Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885 Cetuximab -       26107137

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-126-5p
Interactor2: COQ10B

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.