Basic Information:

  VIRBase ID:  

HHID00053037

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-126-5p:  MIMAT0000444          MAP3K20:  NM_016653     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-126-5p	MAP3K20
miRBase Accession/Entrez ID	MIMAT0000444	51776
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	AZK//CNM6//MLK7//mlklak//MLT//MLTK//MLTKalpha//MLTKbeta//MRK//pk//SFMMP//ZAK

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-126-5p	rs1424556578 chr9:136670632    A/T rs746772073 chr9:136670629    G/C rs757031753 chr9:136670633    C/T rs781001989 chr9:136670634    G/A rs993093735 chr9:136670628    T/C rs1487240924 chr9:136670616    CATT/C rs777307469 chr9:136670618    T/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	MAP3K20	chr2:174090211(+) A-I      3'UTR chr2:173967738(+) A-I      intronic chr2:174090202(+) A-I      3'UTR chr2:174090214(+) A-I      3'UTR chr2:174090201(+) A-I      3'UTR chr2:173967741(+) A-I      intronic chr2:174090166(+) A-I      3'UTR chr2:174095613(+) A-I      intronic chr2:174090170(+) A-I      3'UTR chr2:173967746(+) A-I      intronic chr2:174090164(+) A-I      3'UTR chr2:174090243(+) A-I      3'UTR chr2:174090237(+) A-I      3'UTR chr2:174090224(+) A-I      3'UTR chr2:174090191(+) A-I      3'UTR chr2:173967731(+) A-I      intronic chr2:173967747(+) A-I      intronic chr2:174009014(+) A-I      intronic chr2:174090163(+) A-I      3'UTR chr2:174090198(+) A-I      3'UTR chr2:174009032(+) A-I      intronic chr2:174009034(+) A-I      intronic chr2:174090162(+) A-I      3'UTR chr2:174009040(+) A-I      intronic chr2:174100938(+) A-I      intronic chr2:174100941(+) A-I      intronic chr2:174100961(+) A-I      intronic chr2:174100964(+) A-I      intronic chr2:174095604(+) A-I      intronic chr2:174110509(+) A-I      intronic chr2:174009008(+) A-I      intronic chr2:174009064(+) A-I      intronic chr2:174009070(+) A-I      intronic chr2:174009080(+) A-I      intronic chr2:174110498(+) A-I      intronic chr2:174110450(+) A-I      intronic chr2:174110440(+) A-I      intronic chr2:174110435(+) A-I      intronic chr2:174110426(+) A-I      intronic chr2:173946764(+) A-I      intronic chr2:174009146(+) A-I      intronic chr2:174009365(+) A-I      intronic chr2:174030025(+) A-I      intronic chr2:174030423(+) A-I      intronic chr2:174030474(+) A-I      intronic chr2:174042192(+) A-I      intronic chr2:174042275(+) A-I      intronic chr2:174042367(+) A-I      intronic chr2:174042401(+) A-I      intronic chr2:174042410(+) A-I      intronic chr2:174042420(+) A-I      intronic chr2:174043100(+) A-I      intronic chr2:174094659(+) A-I      intronic chr2:174094693(+) A-I      intronic chr2:174100716(+) A-I      intronic chr2:174100833(+) A-I      intronic chr2:174100842(+) A-I      intronic chr2:174100953(+) A-I      intronic chr2:174102661(+) A-I      intronic chr2:174102681(+) A-I      intronic chr2:174102714(+) A-I      intronic chr2:174102717(+) A-I      intronic chr2:174102718(+) A-I      intronic chr2:174106204(+) A-I      intronic chr2:174009019(+) A-I      intronic chr2:174108550(+) A-I      intronic chr2:174007656(+) A-I      intronic chr2:174008781(+) A-I      intronic chr2:174008967(+) A-I      intronic chr2:174008988(+) A-I      intronic chr2:173946887(+) A-I      intronic chr2:174008989(+) A-I      intronic chr2:174008991(+) A-I      intronic chr2:174110500(+) A-I      intronic chr2:174009076(+) A-I      intronic chr2:174110608(+) A-I      intronic chr2:174110604(+) A-I      intronic chr2:174110513(+) A-I      intronic chr2:174005261(+) A-I      intronic chr2:174005252(+) A-I      intronic chr2:174005251(+) A-I      intronic chr2:174005097(+) A-I      intronic chr2:174005095(+) A-I      intronic chr2:174004844(+) A-I      intronic chr2:174004809(+) A-I      intronic chr2:173998938(+) A-I      intronic chr2:173989673(+) A-I      intronic chr2:173989595(+) A-I      intronic chr2:173964160(+) A-I      intronic chr2:173962049(+) A-I      intronic chr2:173962029(+) A-I      intronic chr2:173962005(+) A-I      intronic chr2:173961990(+) A-I      intronic chr2:173961933(+) A-I      intronic chr2:173961931(+) A-I      intronic chr2:173961928(+) A-I      intronic chr2:173961924(+) A-I      intronic chr2:173961897(+) A-I      intronic chr2:173961313(+) A-I      intronic chr2:173961309(+) A-I      intronic chr2:173961197(+) A-I      intronic chr2:174005156(+) A-I      intronic chr2:174009272(+) A-I      intronic chr2:173967661(+) A-I      intronic chr2:173962004(+) A-I      intronic chr2:173961168(+) A-I      intronic chr2:174009031(+) A-I      intronic chr2:174007696(+) A-I      intronic chr2:174007013(+) A-I      intronic chr2:174044100(+) A-I      intronic chr2:174005338(+) A-I      intronic chr2:173967771(+) A-I      intronic chr2:173989661(+) A-I      intronic chr2:173967772(+) A-I      intronic chr2:173961167(+) A-I      intronic chr2:174030451(+) A-I      intronic chr2:173961243(+) A-I      intronic chr2:174042276(+) A-I      intronic chr2:174007052(+) A-I      intronic chr2:173989665(+) A-I      intronic chr2:174005196(+) A-I      intronic chr2:174042269(+) A-I      intronic chr2:173961919(+) A-I      intronic chr2:173961234(+) A-I      intronic chr2:173967647(+) A-I      intronic chr2:174009299(+) A-I      intronic chr2:173989641(+) A-I      intronic chr2:174009268(+) A-I      intronic chr2:174009025(+) A-I      intronic chr2:173999020(+) A-I      intronic chr2:173961297(+) A-I      intronic

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-126-5p	Exosome Breast milk     22211110 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Blood|B lymphoblastoid cells|Chronic lymphocytic leukemia cells|Endothelial cells|Lymphoma tissue|Mast cells     - Extracellular vesicle Plasma     32498409 Microvesicle Plasma     19002258 Microvesicle Plasma     23077538 Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
	MAP3K20	Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-126-5p	Estradiol 5757 Drug interaction    RC00003040

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-126-5p	Cytarabine 6253       25759982 Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885 Cetuximab -       26107137

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-126-5p
Interactor2: MAP3K20

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.