Detail Information

Basic Information:


  VIRBase ID:  

HHID00053036

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-126-5p:           GSKIP:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-126-5p GSKIP
miRBase
Accession/Entrez ID		 MIMAT0000444 51527
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - C14orf129//HSPC210

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-126-5p
rs1424556578 chr9:136670632    A/T
rs746772073 chr9:136670629    G/C
rs757031753 chr9:136670633    C/T
rs781001989 chr9:136670634    G/A
rs993093735 chr9:136670628    T/C
rs1487240924 chr9:136670616    CATT/C
rs777307469 chr9:136670618    T/G

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase GSKIP
chr14:96829823-96829824(+) m1A 5'UTR       26863410
chr14:96829884-96829885(+) m1A 5'UTR//exon       26863196//26863410
chr14:96830369-96830370(+) m6A 5'UTR//intron       25456834
chr14:96830443-96830444(+) m6A 5'UTR//intron       24209618
chr14:96830456-96830457(+) m6A 5'UTR//intron       24209618
chr14:96830759-96830760(+) m6A 5'UTR//intron       24209618//25456834//24981863//22608085
chr14:96830765-96830766(+) m6A 5'UTR//intron       24209618//25456834//24981863//22608085
chr14:96830778-96830779(+) m6A 5'UTR//intron       24209618//25456834//24981863//22608085
chr14:96830899-96830900(+) m6A 5'UTR//intron       24284625//22608085
chr14:96830940-96830941(+) m6A 5'UTR//intron       -
chr14:96830996-96830997(+) m6A 5'UTR//intron       24981863
chr14:96831097-96831098(+) m6A 5'UTR//intron       25456834//24981863//22608085
chr14:96831119-96831120(+) m6A 5'UTR//intron       25456834//24981863//22608085
chr14:96831204-96831205(+) m6A 5'UTR//intron       24284625//25456834//24981863//22608085
chr14:96831311-96831312(+) m6A 5'UTR//intron       22608085
chr14:96831324-96831325(+) m6A 5'UTR//intron       22608085
chr14:96845319-96845320(+) m6A 5'UTR//intron       24981863
chr14:96845346-96845347(+) m6A 5'UTR//intron       24981863
chr14:96848590-96848591(+) m6A CDS       25456834//24981863//22608085
chr14:96848665-96848666(+) m6A CDS       24284625//25456834//24981863//22575960//22608085
chr14:96848678-96848679(+) m6A CDS       24284625//25456834//24981863//22575960//22608085
chr14:96848791-96848792(+) m6A CDS       24284625//24209618//25456834//24981863//22608085
chr14:96848804-96848805(+) m6A CDS       24284625//24209618//25456834//24981863//22608085
chr14:96848820-96848821(+) m6A CDS       24284625//24209618//24981863//22608085
chr14:96851050-96851051(+) Y intron       25219674
chr14:96851901-96851902(+) m6A CDS       24284625//24209618//24981863//22608085
chr14:96851916-96851917(+) m6A CDS       24284625//24209618//24981863//22608085
chr14:96851987-96851988(+) m6A CDS       24284625//25456834//24981863//26404942//22608085
chr14:96852011-96852012(+) m6A CDS       24284625//25456834//24981863//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-126-5p
Exosome Breast milk     22211110
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Blood|B lymphoblastoid cells|Chronic lymphocytic leukemia cells|Endothelial cells|Lymphoma tissue|Mast cells     -
Extracellular vesicle Plasma     32498409
Microvesicle Plasma     19002258
Microvesicle Plasma     23077538
Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
GSKIP
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleus HeLa-S3 cells|K562 cells     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-126-5p
Estradiol 5757 Drug interaction    RC00003040
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-126-5p
Cytarabine 6253       25759982
Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885
Cetuximab -       26107137

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-126-5p
Interactor2: GSKIP

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

Starting a new search, please wait ...