Detail Information

Basic Information:


  VIRBase ID:  

HHID00053034

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-126-5p:           ERGIC2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-126-5p ERGIC2
miRBase
Accession/Entrez ID		 MIMAT0000444 51290
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - cd002//CDA14//Erv41//PTX1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-126-5p
rs1424556578 chr9:136670632    A/T
rs746772073 chr9:136670629    G/C
rs757031753 chr9:136670633    C/T
rs781001989 chr9:136670634    G/A
rs993093735 chr9:136670628    T/C
rs1487240924 chr9:136670616    CATT/C
rs777307469 chr9:136670618    T/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR ERGIC2
chr12:29499291(-) A-I      intronic
chr12:29495219(-) A-I      intronic
chr12:29499290(-) A-I      intronic
chr12:29498626(-) A-I      intronic
chr12:29495173(-) A-I      intronic
chr12:29525869(-) A-I      intronic
chr12:29525789(-) A-I      intronic
chr12:29525600(-) A-I      intronic
chr12:29509138(-) A-I      intronic
chr12:29509135(-) A-I      intronic
chr12:29509131(-) A-I      intronic
chr12:29509092(-) A-I      intronic
chr12:29505616(-) A-I      intronic
chr12:29505514(-) A-I      intronic
chr12:29505461(-) A-I      intronic
chr12:29505439(-) A-I      intronic
chr12:29505430(-) A-I      intronic
chr12:29505370(-) A-I      intronic
chr12:29499396(-) A-I      intronic
chr12:29499194(-) A-I      intronic
chr12:29525200(-) A-I      intronic
chr12:29499260(-) A-I      intronic
chr12:29509052(-) A-I      intronic
chr12:29499250(-) A-I      intronic
chr12:29499285(-) A-I      intronic
chr12:29498629(-) A-I      intronic
chr12:29505448(-) A-I      intronic
chr12:29495006(-) A-I      intronic
chr12:29505564(-) A-I      intronic
chr12:29499187(-) A-I      intronic
chr12:29499398(-) A-I      intronic
chr12:29498713(-) A-I      intronic
chr12:29499289(-) A-I      intronic
chr12:29499350(-) A-I      intronic
chr12:29505555(-) A-I      intronic
chr12:29505561(-) A-I      intronic
chr12:29498709(-) A-I      intronic
chr12:29505458(-) A-I      intronic
chr12:29499246(-) A-I      intronic
chr12:29498707(-) A-I      intronic
chr12:29505521(-) A-I      intronic
chr12:29498602(-) A-I      intronic
chr12:29494533(-) A-I      intronic
chr12:29505433(-) A-I      intronic
chr12:29509134(-) A-I      intronic
chr12:29498590(-) A-I      intronic
chr12:29525729(-) A-I      intronic
chr12:29498731(-) A-I      intronic
chr12:29525848(-) A-I      intronic
chr12:29525625(-) A-I      intronic
chr12:29495109(-) A-I      intronic
chr12:29509175(-) A-I      intronic
chr12:29494468(-) A-I      intronic
chr12:29509119(-) A-I      intronic
chr12:29499299(-) A-I      intronic
chr12:29505475(-) A-I      intronic
chr12:29509047(-) A-I      intronic
chr12:29498833(-) A-I      intronic
chr12:29498730(-) A-I      intronic
chr12:29498839(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED ERGIC2
chr12:29493734(-) A-I exon 3'UTR    22327324
chr12:29495109(-) A-G intron -    22484847
chr12:29498602(-) A-G intron -    22484847
chr12:29498707(-) A-G intron -    22484847
chr12:29498730(-) A-G intron -    22484847
chr12:29498839(-) A-G intron -    22484847
chr12:29499246(-) A-G intron -    22484847
chr12:29499260(-) A-G intron -    22484847
chr12:29499285(-) A-G intron -    22484847
chr12:29499289(-) A-G intron -    22484847
chr12:29499350(-) A-G intron -    22484847
chr12:29499398(-) A-G intron -    22484847
chr12:29505433(-) A-G intron -    22484847
chr12:29505448(-) A-G intron -    22484847
chr12:29505458(-) A-G intron -    22484847
chr12:29505521(-) A-G intron -    22484847
chr12:29505561(-) A-G intron -    22484847
chr12:29509047(-) A-G intron -    22484847
chr12:29525200(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ERGIC2
chr12:29492215-29492216(-) m6A 3'UTR       27773535
chr12:29492238-29492239(-) m6A 3'UTR       27773535
chr12:29492280-29492281(-) m6A 3'UTR       27773535
chr12:29492666-29492667(-) m6A 3'UTR       27773535
chr12:29492675-29492676(-) m6A 3'UTR       27773535
chr12:29492734-29492735(-) m6A 3'UTR       27773535
chr12:29492762-29492763(-) m6A 3'UTR       27773535
chr12:29492770-29492771(-) m6A 3'UTR       27773535
chr12:29492794-29492795(-) m6A 3'UTR       27773535
chr12:29493631-29493632(-) m6A 3'UTR       27773535
chr12:29493641-29493642(-) m6A 3'UTR       27773535
chr12:29493652-29493653(-) m6A 3'UTR       27773535
chr12:29493722-29493723(-) m6A 3'UTR       24981863//27773535//22608085
chr12:29493746-29493747(-) m6A 3'UTR       24981863//27773535//22608085
chr12:29493789-29493790(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr12:29493933-29493934(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr12:29493939-29493940(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr12:29493977-29493978(-) m6A 3'UTR//exon       24284625//24981863//27773535//22608085
chr12:29493994-29493995(-) m6A 3'UTR//exon       24284625//24981863//27773535//22608085
chr12:29494043-29494044(-) m6A 3'UTR//exon       24284625//24981863//27773535//22608085
chr12:29494050-29494051(-) m6A 3'UTR//exon       24284625//24981863//27773535//22608085
chr12:29494064-29494065(-) m6A 3'UTR//exon       24284625//24981863//27773535//22608085
chr12:29494125-29494126(-) m6A 3'UTR//CDS//exon       24981863//27773535//22608085
chr12:29494678-29494679(-) m6A 3'UTR//CDS//exon       24981863//27773535//22608085
chr12:29494693-29494694(-) m6A 3'UTR//CDS//exon       27773535
chr12:29494766-29494767(-) m6A exon//intron       27773535
chr12:29534033-29534034(-) m6A 5'UTR//intron       24981863
chr12:29534059-29534060(-) m6A 5'UTR       24981863
chr12:29534077-29534078(-) m6A 5'UTR       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-126-5p
Exosome Breast milk     22211110
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Blood|B lymphoblastoid cells|Chronic lymphocytic leukemia cells|Endothelial cells|Lymphoma tissue|Mast cells     -
Extracellular vesicle Plasma     32498409
Microvesicle Plasma     19002258
Microvesicle Plasma     23077538
Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
ERGIC2
Chromatin K562 cells     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Membrane K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|K562 cells     -
Ribosome HEK-293 cells     22199352

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-126-5p
Estradiol 5757 Drug interaction    RC00003040
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-126-5p
Cytarabine 6253       25759982
Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885
Cetuximab -       26107137

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-126-5p
Interactor2: ERGIC2

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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