Detail Information

Basic Information:


  VIRBase ID:  

HHID00052927

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-9-3p:           PLEKHF2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-9-3p PLEKHF2
miRBase
Accession/Entrez ID		 MIMAT0000442 79666
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - EAPF//PHAFIN2//ZFYVE18

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-9-3p
rs1176436057 chr1:156420359    C/T
rs1251131659 chr1:156420367    T/C
rs1345765627 chr1:156420365    T/C
rs1428606438 chr1:156420375    T/C
rs534354316 chr1:156420355    C/T
rs1178970449 chr5:88666872    G/A
rs1398529788 chr5:88666878    C/T
rs1409650445 chr5:88666879    T/A
rs1192952757 chr15:89368071    A/G
rs1395768331 chr15:89368081    A/G
rs1395768331 chr15:89368081    A/T
rs1197359739 chr1:156420373    T/C
rs1420873000 chr1:156420370    C/T
rs1329786937 chr5:88666882    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR PLEKHF2
chr8:96157024(+) A-I      intronic
chr8:96156821(+) A-I      intronic
chr8:96157726(+) A-I      intronic
chr8:96154717(+) A-I      intronic
chr8:96157732(+) A-I      intronic
chr8:96157120(+) A-I      intronic
chr8:96157721(+) A-I      intronic
chr8:96167873(+) A-I      3'UTR
chr8:96157012(+) A-I      intronic
chr8:96154718(+) A-I      intronic
chr8:96156974(+) A-I      intronic
chr8:96151667(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED PLEKHF2
chr8:96156975(+) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase PLEKHF2
chr8:96146137-96146138(+) m6A 5'UTR       24981863
chr8:96146212-96146213(+) m6A 5'UTR       24209618//24981863//22608085
chr8:96146319-96146320(+) m6A 5'UTR//intron       22608085
chr8:96166291-96166292(+) m6A CDS       24284625//24209618//24981863//22575960//22608085
chr8:96166330-96166331(+) m6A CDS       24284625//24209618//24981863//22575960//22608085
chr8:96166499-96166500(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr8:96166555-96166556(+) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085
chr8:96166581-96166582(+) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085
chr8:96166689-96166690(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr8:96166703-96166704(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr8:96166915-96166916(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr8:96166945-96166946(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr8:96167024-96167025(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr8:96167137-96167138(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-9-3p
Exosome Jurkat-derived T cell line (J77cl20)     21505438
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Blood     -
Microvesicle Blood|Fibroblasts|Mesenchymal stem cells|Urine     -
PLEKHF2
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleoplasm K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-9-3p
Interactor2: PLEKHF2

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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