Detail Information

Basic Information:


  VIRBase ID:  

HHID00052677

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-191-5p:           B4GALT6:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-191-5p B4GALT6
miRBase
Accession/Entrez ID		 MIMAT0000440 9331
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - B4Gal-T6//beta4Gal-T6

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-191-5p
rs1176148288 chr3:49020676    T/TG
rs1289916556 chr3:49020679    T/C
rs1329624302 chr3:49020680    T/C
rs1410674600 chr3:49020684    G/A
rs747850562 chr3:49020675    C/T
rs1229195621 chr3:49020692    T/C

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR B4GALT6
chr18:29248720(-) A-I      intronic
chr18:29248852(-) A-I      intronic
chr18:29223444(-) A-I      intronic
chr18:29215779(-) A-I      intronic
chr18:29218234(-) A-I      intronic
chr18:29250276(-) A-I      intronic
chr18:29215729(-) A-I      intronic
chr18:29250197(-) A-I      intronic
chr18:29247890(-) A-I      intronic
chr18:29218484(-) A-I      intronic
chr18:29250165(-) A-I      intronic
chr18:29218414(-) A-I      intronic
chr18:29218378(-) A-I      intronic
chr18:29218368(-) A-I      intronic
chr18:29218362(-) A-I      intronic
chr18:29218317(-) A-I      intronic
chr18:29218265(-) A-I      intronic
chr18:29239946(-) A-I      intronic
chr18:29245642(-) A-I      intronic
chr18:29250145(-) A-I      intronic
chr18:29250196(-) A-I      intronic
chr18:29250195(-) A-I      intronic
chr18:29211220(-) A-I      intronic
chr18:29247901(-) A-I      intronic
chr18:29248911(-) A-I      intronic
chr18:29247960(-) A-I      intronic
chr18:29248891(-) A-I      intronic
chr18:29216988(-) A-I      intronic
chr18:29248718(-) A-I      intronic
chr18:29216853(-) A-I      intronic
chr18:29215737(-) A-I      intronic
chr18:29245629(-) A-I      intronic
chr18:29247895(-) A-I      intronic
chr18:29250171(-) A-I      intronic
chr18:29218240(-) A-I      intronic
chr18:29218246(-) A-I      intronic
chr18:29218323(-) A-I      intronic
chr18:29250095(-) A-I      intronic
chr18:29245618(-) A-I      intronic
chr18:29223541(-) A-I      intronic
chr18:29218301(-) A-I      intronic
chr18:29216861(-) A-I      intronic
chr18:29233666(-) A-I      intronic
chr18:29247938(-) A-I      intronic
chr18:29216904(-) A-I      intronic
chr18:29250191(-) A-I      intronic
chr18:29216921(-) A-I      intronic
chr18:29211210(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED B4GALT6
chr18:29250191(-) A-G intron -    22484847
chr18:29250195(-) A-G intron -    22484847
chr18:29250196(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase B4GALT6
chr18:29204940-29204941(-) m6A 3'UTR//exon       24981863//22608085
chr18:29205003-29205004(-) m6A 3'UTR//exon       24981863//22608085
chr18:29205029-29205030(-) m6A 3'UTR//exon       24981863//22608085
chr18:29205063-29205064(-) m6A 3'UTR//exon       24981863//22608085
chr18:29205094-29205095(-) m6A 3'UTR//exon       24981863//22608085
chr18:29205117-29205118(-) m6A 3'UTR//exon       22608085
chr18:29205141-29205142(-) m6A 3'UTR//exon       22608085
chr18:29205387-29205388(-) m6A 3'UTR//exon       24284625//24981863//22608085
chr18:29205432-29205433(-) m6A 3'UTR//exon       24284625//24981863//27773535//22608085
chr18:29205529-29205530(-) m6A 3'UTR//exon       24284625//24209618//24981863//28052920//27773535//27371828//22608085
chr18:29205549-29205550(-) m6A 3'UTR//exon       24284625//24209618//24981863//28052920//27371828//22608085
chr18:29205583-29205584(-) m6A CDS//exon       24284625//24209618//24981863//28052920//22608085
chr18:29205613-29205614(-) m6A CDS//exon       24284625//24209618//24981863//28052920//22608085
chr18:29205625-29205626(-) m6A CDS//exon       24284625//24981863//28052920//22608085
chr18:29205673-29205674(-) m6A CDS//exon       24284625//24209618//24981863//27773535//22608085
chr18:29205678-29205679(-) m6A CDS//exon       24284625//24209618//24981863//27773535//22608085
chr18:29206305-29206306(-) m6A CDS//exon       24284625//24981863//22608085
chr18:29206316-29206317(-) m6A CDS//exon       24284625//24981863//22608085
chr18:29264500-29264501(-) m6A 5'UTR//intron       25456834

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-191-5p
Apoptotic body Human umbilical vein endothelial cells     19996457
Cytoplasm Cell line (HeLa)     21695135
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Human cervical cancer cell line (HeLa)     25760330
Exosome Plasma     19289371
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome B cell line (Raji)|Jurkat-derived T cell line (J77cl20)     21505438
Exosome Breast milk     22211110
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Serum|Urine     25135963
Exosome Blood|B lymphoblastoid cells|Breast milk|Colon tissue|Endothelial cells|Epithelial cells|Kidney tissue|Lymphoma tissue|Mast cells|Seminal fluid|Tongue tissue     -
Extracellular vesicle HEK-293T cells     22849433
Microvesicle Plasma     23077538
Microvesicle Seminal plasma     23539611
Microvesicle Follicular fluid     23666971
Microvesicle Hepatoma cells     23771658
Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleolus HeLa cells     23940654
Nucleolus Breast adenocarcinoma cells (MCF-7)     24918059
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
B4GALT6
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-191-5p
Iodine Green 9956454 Drug sensitive
Sensorad 99342 Drug sensitive
2-(2,4-Difluorophenyl)-4,5,6,7-tetrafluoro-1H-isoindole-1,3(2H)-dione 9905583 Drug sensitive
5-Iodo-8-quinolinol 96111 Drug sensitive
Actinomycin X4357G methoxime 9573583 Drug sensitive
4-(2-Pyridylazo)-N,N-dimethylaniline 81528 Drug sensitive
L-2-Aminobutyric acid 80283 Drug sensitive
Indolo[2,1-b]quinazoline-6,12-dione 73549 Drug sensitive
Redoxal 72571 Drug sensitive
4-(2-Naphthylamino)phenol 7141 Drug sensitive
Tolonium chloride 7083 Drug sensitive
Oxiperomide 68634 Drug sensitive
Azure B 68275 Drug sensitive
Sulbentine 67686 Drug sensitive
Neocuproine 65237 Drug sensitive
Ixabepilone 6445540 Drug sensitive
Vicenistatin 6438888 Drug sensitive
1,3,8-Trihydroxy-6-methoxyanthracene-9,10-dione 636723 Drug resistant
Verrucarin A 6326658 Drug sensitive
1,1'-Diethyl-2,2'-cyanine chloride 5717105 Drug sensitive
Caracemide 54747 Drug sensitive
Artelasticin 5471311 Drug sensitive
Antineoplastic-690266 5469577 Drug sensitive
3-Deazauridine 54684286 Drug sensitive
3,19-(4-Acetamido)benzylidineandrographolide 54612901 Drug sensitive
Herveline O 5459269 Drug sensitive
Betuletol 5459196 Drug sensitive
Cuspidatin C 5459164 Drug sensitive
Thiram 5455 Drug sensitive
Piritrexim isethionate 54368 Drug sensitive
(1E,4E)-1,5-Dipyridin-3-ylpenta-1,4-dien-3-one 5382674 Drug sensitive
Rozex 5353923 Drug sensitive
Hemiasterlin 5352092 Drug sensitive
Indanthren Corinth RK 5351878 Drug sensitive
Dihydro-5-azacytidine 5351280 Drug sensitive
Vorinostat 5311 Drug sensitive
Spiperone 5265 Drug resistant
Kekule 499328 Drug sensitive
Pyrimethamine 4993 Drug sensitive
10-Hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12-dodecahydro-1H-picene-4a-carboxylic acid 495604 Drug sensitive
Propyl gallate 4947 Drug resistant
Tiazofurin 457954 Drug sensitive
Ossirene 451379 Drug sensitive
N-Methyl-1,5-bis(4-cyanophenoxy)-3-aza-pentane 45028719 Drug sensitive
Mycophenolic acid 446541 Drug sensitive
1-(4-(Benzyloxy)phenyl)-3-(3-(1-ethyl-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-3-yl)phenyl)urea 44587530 Drug sensitive
Isopinnatal 44558939 Drug sensitive
1-Benzyl-3-hexadecyl-2-methylimidazolium chloride 44219704 Drug sensitive
Ditercalinium dimethanesulfonate dimethanesulfonate 435243 Drug sensitive
Di-n-octyl-secalonsaure A 430141 Drug sensitive
Cyano pyridine-P-CH3 406496 Drug sensitive
S-(Dimethylarsino)-3-mercapto-1,2-propyl dibenzoate 406481 Drug sensitive
S-(Dimethylarsino)-3-mercapto-1,2-propyl dinonanoate 406480 Drug sensitive
Aminopyrimidine-CH3 406278 Drug sensitive
11-Hydroxyusambarine Chlorhydrate 401426 Drug sensitive
Sparfosic acid 39981 Drug sensitive
Artelastin 399488 Drug sensitive
Phosphine, 1,2-ethanediylbis[bis[2-(methylthio)phenyl]- 397601 Drug sensitive
2-Amino-4-(2-hydroxy-4-methylphenyl)-5-phenylpyrimidine 392744 Drug sensitive
Leflunomide 3899 Drug sensitive
beta-Lapachone 3885 Drug sensitive
Lapachol 3884 Drug sensitive
3-(4-Fluorophenyl)-3-(4-hydroxy-2-methylphenyl)-2-benzofuran-1(3H)-one 387973 Drug resistant
Acetic acid,4,7,10-tetraazacyclododecane-1,7-diyl]bis 387352 Drug sensitive
L-LYS-L-p-NO2Phe-L-Ala-L-p-NO2PheNH2 386384 Drug sensitive
4-Phenacyloxychromen-2-one 386272 Drug resistant
ARQ monoacetate 385441 Drug sensitive
2,7-Bis(methoxycarbonylmethyl)-10-methylphenothiazine 384444 Drug sensitive
3-(4-Fluorophenyl)-3-(4-acetoxy-2-methylphenyl)phthalide 383342 Drug resistant
2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant
2-[[4-[1-(2,4-Diaminopteridin-6-yl)butan-2-yl]benzoyl]amino]-4-methylidenepentanedioic acid 375312 Drug sensitive
3,8-Dimethyl-1,2-naphthoquinone 373912 Drug sensitive
Sanguilutine pseudobase 371258 Drug sensitive
Tris(tropolonato)samarium(III) 366262 Drug sensitive
2-Benzoylaminobenzamide, N-thiazol-2-yl- 355710 Drug sensitive
Maxima isoflavone D 343081 Drug sensitive
4-Selenazolecarboxamide, 2-beta-D-ribofuranosyl- 334706 Drug sensitive
Predorine 333830 Drug sensitive
2,2',3,3'-Tetrahydroxy-1,1'-binaphthyl 316673 Drug sensitive
2,3-Dimethoxy-5-naphthalen-2-ylsulfanylcyclohexa-2,5-diene-1,4-dione 314728 Drug sensitive
Bromocriptine 31101 Drug sensitive
Flurocitabine 3034016 Drug sensitive
1,1-Dimethyl-5-(2-naphthalenyl)dithiobiuret 3004012 Drug sensitive
Dichloroallyl lawsone 277767 Drug sensitive
(15S)-15-Ethyl-1,11-diazapentacyclo[9.6.2.02,7.08,18.015,19]nonadeca-2,4,6,8(18)-tetraen-17-one 2724040 Drug sensitive
6-Bromotoyocamycin 270861 Drug sensitive
2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-N-[2-(methylamino)ethyl]-1H-imidazo[4,5-c]pyridine-7-carboxamide 25023715 Drug resistant
Hydrazine sulfate 24842 Drug sensitive
9H-Purine, 6-(o-chlorobenzylthio)-9-(2-chloroethyl)- 246231 Drug sensitive
Antimycin A3 245869 Drug sensitive
5-Hydroxy-3-phenylpyrano[3,2-c]chromen-2(5H)-one 24205741 Drug sensitive
Prumycin HCl 24197905 Drug resistant
Cinerubin A hcl 24196924 Drug sensitive
9H-Purine, 2-amino-6-(o-chlorobenzylthio)-9-propyl- 239486 Drug sensitive
Drostanolone propionate 224004 Drug sensitive
4-[[(8-Hydroxyquinolin-7-yl)-phenylmethyl]amino]benzoic acid 219564 Drug sensitive
Amsacrine 2179 Drug sensitive
Pirarubicin hydrochloride 20846247 Drug sensitive
8-Hydroxyquinoline 1923 Drug sensitive
Sudan II 18386 Drug sensitive
Azaribine 16574 Drug sensitive
Dihydrotriazine derivative 160202 Drug sensitive
Antineoplastic-633273 15954131 Drug sensitive
Astrazon Orange R 135747272 Drug sensitive
C8, Carbonyl prodigiosine 135540857 Drug sensitive
5-[(E)-[Amino(methyl)amino]azo]-1H-imidazole-4-carboxamide 135493930 Drug sensitive
Emofolin sodium 135475347 Drug sensitive
Raltitrexed 135400182 Drug sensitive
DTIC-Dome 135398738 Drug sensitive
(2Z)-3-Ethyl-2-[(E)-3-(3-ethyl-1,3-benzothiazol-3-ium-2-yl)-2-methylprop-2-enylidene]-1,3-benzothiazole;hydroiodide 129893658 Drug sensitive
(2S,4S,5R)-20-De(1-hydroxypropyl)-6-demethyl-2,6-diethyl-5-hydroxy-20-(1-hydroxybutyl)lysocellin 124081057 Drug sensitive
2,2'-Bioxirane 11254 Drug sensitive
Gentian violet 11057 Drug sensitive
Perillyl alcohol 10819 Drug sensitive
Fusariotoxin T-2 102515111 Drug sensitive
(1S,2R,4R,6S,11R,12S,15R,18S,19R,20R,21S,23R,26R)-15-Hydroxy-11,18,21-trimethyl-5,17,24,28,29-pentaoxanonacyclo[17.9.1.11,20.02,12.04,6.06,11.015,19.018,23.021,26]triacont-8-ene-10,16,25,30-tetrone 101528280 Drug sensitive
tp4ek - Drug resistant
(z) 4-acetoxy-(3,4',5)-trimethoxystilbene - Drug sensitive
1,2,3-thiadiazole, 5-[(4-chlorophenyl)sulfonyl]-4-phenyl- - Drug sensitive
1h-benzimidazole, 5,5'-dithiobis[2-(trifluoromethyl)- (9ci) - Drug sensitive
2-[(3,4-dicloro)anilino]-3-phenyl-5,7-diamino quinoxaline - Drug sensitive
2-methoxy-4-(7-methoxy-2-phenylbenzo[d]imidazo[2,1-b][1,3]thiazol-3-yl)phenol - Drug sensitive
3',4',5'-trimethoxy-3-hydroxy flavone - Drug sensitive
4-(2-pyridinyl)-5h-1,2,3-dithiazole-5-thione - Drug sensitive
4-[4-(3-Methoxy-phenyl)-piperazin-1 -yl]-5H-pyrrolo[3,2-d]pyrimidine - Drug sensitive
4-morpholinecarbodithioic acid, antimony complex - Drug sensitive
4-piperidinone, 3,5-bis[(4-fluorophenyl)methylene]-, (e,e)- - Drug sensitive
4-thiomorpholinecarbodithioic acid, antimony complex - Drug sensitive
5.alpha.,25d-spirostan-3.beta.-ol glycoside - Drug sensitive
6-imino-3-methoxy 4-azaisoindole[2,1-a]quinoxaline - Drug sensitive
7-n,n-dimethylamino brefeldin a hydrochloride - Drug sensitive
benzamide, 5-bromo-2-hydroxy-n-[3-(trifluoromethyl)phenyl]- - Drug sensitive
benzo[1,2-c:4,5-c']dipyrrole-1,3,5,7(2h,6h)-tetraimine - Drug sensitive
benzofurazan, 4-nitro-7-(2-pyridinylthio)-, n-oxide - Drug sensitive
cis-2-hydroxymethyl-4-(5'-bromocytosin-1'-yl)-1,3-dioxolane - Drug sensitive
E)-1-(4-(quinazolin-4-ylamino)phenyl)-3-(2,4,6-trimethoxyphenyl)prop-2-en-1-one - Drug sensitive
indoline, 5-chloro-1,3,3-trimethyl-2-methylene- (8ci) - Drug sensitive
isoflavone, 5,7-dihydroxy-4'-nitro- - Drug sensitive
propan-1-one, 2,3-dichloro-1,3-bis(4-methylphenyl)- - Drug sensitive
purine, 2,6,8-tris(hexylamino)- - Drug sensitive
salicylaldehyde, 5-bromo- (8ci) - Drug sensitive
tellurium, trichloro[1,2-hexanedioato(2-)-o,o']-, ammonium - Drug sensitive
tris(1,3-diphenylpropane-1,3-dionata)gallium(iii) - Drug sensitive
(-)-dactylolide - Drug sensitive
(Z)-3-((2-(4-(trifluoromethyl)phenyl)-3H-benzo[d]imidazol-5-yl)methylene)indolin-2-one - Drug sensitive
(Z)-6-chloro-3-((2-(4-methoxyphenyl)-3H-benzo[d]imidazol-5-yl)methylene)indolin-2-one - Drug sensitive
[bis(aminomethyl)diethylsilane]dichloroplatinum (ii) - Drug sensitive
2-amino-5-chloro-6-(2-thiazolyloxy)-benzimidazole - Drug sensitive
7-propanoyltaxol - Drug sensitive
antineoplastic-641296 - Drug sensitive
antineoplastic-641297 - Drug sensitive
antineoplastic-d665839 - Drug sensitive
aromoline - Drug sensitive
Camptothecin Derivative - Drug sensitive
Carboxyphthalatoplatinum - Drug sensitive
chlorobis(4-ethyltropolonato)bismuth(iii) - Drug sensitive
his 47-methyl ct - Drug sensitive
hymenialdisine - Drug sensitive
insulin-methotrexate conjugate - Drug sensitive
isatin dr - Drug sensitive
leucinostatine d - Drug sensitive
mitaplatin - Drug sensitive
n-myristoyl-(s)-phenylalaninal diethylcetal - Drug sensitive
phosphocitrate penta sodium salt - Drug sensitive
pyrazoline derivative - Drug sensitive
staurosporin analog kt 5944 - Drug sensitive
Uniroyal Compound-38 - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-191-5p
Gemcitabine 60750 Drug interaction    RC00002973
Vincristine 5978 Drug interaction    RC00002969
Prednisone 5865 Drug interaction    RC00002968
Eloxatine 5310940 Drug interaction    RC00002980
Morphine 5288826 Drug interaction    RC00002979
Cholecalciferol 5280795 Drug interaction    RC00002978
Decitabine 451668 Drug interaction    RC00002977
Docosahexaenoic acid 445580 Drug interaction    RC00002976
Trichostatin A 444732 Drug interaction    RC00002975
Paclitaxel 36314 Drug interaction    RC00002972
5-Fluorouracil 3385 Drug interaction    RC00002967
Doxorubicin 31703 Drug interaction    RC00002971
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00002966
Arsenic trioxide 14888 Drug interaction    RC00002970
Docetaxel 148124 Drug interaction    RC00002974
5-aza-2'-deoxycytidine (5-Aza-CdR) + trichostatin A(TSA) - Drug interaction    RC00002983
Aidi injection - Drug interaction    RC00002984
Bio-Oss - Drug interaction    RC00002985
Hydroxamic acid HDACi LAQ824 - Drug interaction    RC00002986
Mistletoe lectin-I - Drug interaction    RC00002987
Natalizumab - Drug interaction    RC00002981
1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00002982
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-191-5p
Cisplatin 5702198       25356050
Paclitaxel 36314       26323677

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-191-5p
Interactor2: B4GALT6

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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