Basic Information:

  VIRBase ID:  

HHID00052582

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-145-5p:  MIMAT0000437          ZFP36:  NM_003407     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-145-5p	ZFP36
miRBase Accession/Entrez ID	MIMAT0000437	7538
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	G0S24//GOS24//NUP475//RNF162A//TIS11//TTP//zfp-36

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-145-5p	rs1191199140 chr5:149430675    G/A rs1394460469 chr5:149430676    G/A rs1402883964 chr5:149430671    C/G rs934436084 chr5:149430661    G/T

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ZFP36	chr19:39897641-39897642(+) m6A CDS//intron       24981863 chr19:39897729-39897730(+) m6A CDS//intron       24981863 chr19:39898093-39898094(+) m6A CDS//intron       25456834//24981863 chr19:39898100-39898101(+) m6A CDS//intron       25456834//24981863 chr19:39898115-39898116(+) m6A CDS//intron       25456834 chr19:39898433-39898434(+) m6A 3'UTR//CDS       25456834 chr19:39898465-39898466(+) m6A 3'UTR//CDS       24284625 chr19:39898673-39898674(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942 chr19:39898688-39898689(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942 chr19:39898792-39898793(+) m6A 3'UTR//CDS       24284625//25456834//24981863//26404942 chr19:39898869-39898870(+) m6A CDS       24284625//24209618//25456834//24981863//26404942 chr19:39898943-39898944(+) m6A CDS       24284625//24209618//25456834//24981863 chr19:39899028-39899029(+) m6A CDS       24284625//25456834//24981863 chr19:39899088-39899089(+) m6A CDS       24284625//25456834//24981863 chr19:39899168-39899169(+) m6A CDS       24284625//24981863 chr19:39899413-39899414(+) m6A 3'UTR       25456834//24981863//26404942 chr19:39899430-39899431(+) m6A 3'UTR       25456834//24981863//26404942 chr19:39899439-39899440(+) m6A 3'UTR       25456834//24981863//26404942 chr19:39899703-39899704(+) m6A 3'UTR       27773535 chr19:39899735-39899736(+) m6A 3'UTR       27773535 chr19:39899804-39899805(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-145-5p	Cytoplasm Human colon cancer cell line (HCT-116)     28964256 Exosome EBV- and KSHV-negative Burkitt lymphoma cell line (Bjab)|EBV-infected lymphoblastoid cell line (LCL)|KSHV-infected lymphoma cell lines (BCBL-1|TY-1)     27611973 Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Exosome Jurkat-derived T cell line (J77cl20)     21505438 Exosome Renal cancer cells     21670082 Exosome Breast milk     22211110 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Serum     25135963 Exosome Cerebrospinal fluid     25420022 Exosome Peripheral blood     32785072 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Skeletal muscle myoblasts     21637849 Nucleus Myoepithelial cells     29073169
	ZFP36	Exosome Blood     - Nucleus HeLa-S3 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-145-5p	Tetraethyleniminobenzo-quinone 95735 Drug resistant 1,9-Pyrazoloanthrone 8515 Drug resistant Fludarabine 657237 Drug resistant 8B-Hydroxy-9B,10B-epoxyverrucarin A 5477536 Drug sensitive [(1H-Benzimidazole-2-yl)dithio]-9H-purine 54613148 Drug resistant Sirolimus 5284616 Drug sensitive Di-n-octyl-secalonsaure A 430141 Drug sensitive Aminopyrimidine-F 406276 Drug sensitive Lapachol 3884 Drug sensitive Ellipticine 3213 Drug sensitive Estramustine 259331 Drug sensitive 5-Nitroso-8-hydroxyquinoline 19103 Drug sensitive (R)-(2,8-Bis(trifluoromethyl)quinolin-4-yl)((S)-piperidin-2-yl)methanol hydrochloride 18660697 Drug resistant Formycin b 135449281 Drug resistant Abiraterone 132971 Drug sensitive 15-Deacetylsergeolide 125729 Drug sensitive 3-(4-(5-Methoxy-1H-benzo[d]imidazol-2-yl)phenyl)-5-(3,4,5-trimethoxyphenyl)-1,2,4-oxadiazole 118624714 Drug sensitive 4-quinazolone, 7-amino-3-(4-methoxyphenyl)-, hydrate - Drug resistant viridomycin - Drug resistant 1,3,6-triphenyl-oxazolo(5,4-d)pyrimidin-2',4(1h,3h)-dion - Drug sensitive 5.alpha.,25d-spirostan-3.beta.-ol glycoside - Drug sensitive naphtho[1,2-b]quinolizinium, 10,13-dimethyl- chloride - Drug sensitive phosphonium, triphenylpropenyl-, bromide, (e)- (8ci) - Drug sensitive ambrosin piperidine diadduct di-n-oxide - Drug sensitive pancratium littorale - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-145-5p	Azacitidine 9444 Drug interaction    RC00002904 Hyaluronidase 91820602 Drug interaction    RC00002927 Rosiglitazone 77999 Drug interaction    RC00002912 Oxaliplatine 6857599 Drug interaction    RC00002924 Irinotecan 60838 Drug interaction    RC00002911 Gemcitabine 60750 Drug interaction    RC00002910 Phenylephrine 6041 Drug interaction    RC00002903 Cholesterol 5997 Drug interaction    RC00002902 Vincristine 5978 Drug interaction    RC00002901 Serine 5951 Drug interaction    RC00002900 Mitomycin 5746 Drug interaction    RC00002899 Temozolomide 5394 Drug interaction    RC00002898 Sunitinib 5329102 Drug interaction    RC00002923 Eloxatine 5310940 Drug interaction    RC00002922 Sodium butyrate 5222465 Drug interaction    RC00002921 2-{[2-Ethoxy-4-(4-hydroxypiperidin-1-yl)phenyl]amino}-5,11-dimethyl-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one 46843772 Drug interaction    RC00002926 Decitabine 451668 Drug interaction    RC00002920 Tretinoin 444795 Drug interaction    RC00002918 Staurosporine 44259 Drug interaction    RC00002909 Vemurafenib 42611257 Drug interaction    RC00002925 Epirubicin 41867 Drug interaction    RC00002908 Ribavirin 37542 Drug interaction    RC00002907 Paclitaxel 36314 Drug interaction    RC00002906 5-Fluorouracil 3385 Drug interaction    RC00002897 Doxorubicin 31703 Drug interaction    RC00002905 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00002896 Verapamil 2520 Drug interaction    RC00002895 Lenalidomide 216326 Drug interaction    RC00002917 Docetaxel 148124 Drug interaction    RC00002916 Pemetrexed 135410875 Drug interaction    RC00002919 Gefitinib 123631 Drug interaction    RC00002915 7-Ethyl-10-hydroxycamptothecin 104842 Drug interaction    RC00002914 Fulvestrant 104741 Drug interaction    RC00002913 Peginterferon alfa-2b - Drug interaction    RC00002928 5-aza-2'-deoxycytidine (5-Aza-CdR) + Doxorubicin - Drug interaction    RC00002929 Genistein + 5-AzaC - Drug interaction    RC00002930 Genistein + 5-AzaC + Trichostatin A(TSA) - Drug interaction    RC00002931 Glucocorticoid - Drug interaction    RC00002932 Interleukin 13 (IL-13) - Drug interaction    RC00002933 Olea europaea leaf extract - Drug interaction    RC00002934 Chemotherapy - Drug interaction    RC00008846

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-145-5p	Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-145-5p
Interactor2: ZFP36

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.