Basic Information:

  VIRBase ID:  

HHID00051464

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-138-5p:  MIMAT0000430          ARL5B:  NM_178815     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-138-5p	ARL5B
miRBase Accession/Entrez ID	MIMAT0000430	221079
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	ARL8

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-138-5p	rs1159226412 chr3:44114256    G/A rs1331169318 chr3:44114250    C/A rs1331169318 chr3:44114250    C/T rs1466470291 chr3:44114249    T/A rs748499444 chr3:44114243    T/C rs1285034653 chr16:56858546    G/A rs1389589086 chr16:56858539    G/A rs1395610282 chr16:56858535    T/C rs749468995 chr16:56858548    C/G rs755213420 chr16:56858549    G/A rs755213420 chr16:56858549    G/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ARL5B	chr10:18952041(+) A-I      intronic chr10:18959344(+) A-I      intronic chr10:18951736(+) A-I      intronic chr10:18959330(+) A-I      intronic chr10:18959338(+) A-I      intronic chr10:18952018(+) A-I      intronic chr10:18959315(+) A-I      intronic chr10:18960250(+) A-I      intronic chr10:18962045(+) A-I      intronic chr10:18960298(+) A-I      intronic chr10:18952032(+) A-I      intronic chr10:18959285(+) A-I      intronic chr10:18959339(+) A-I      intronic chr10:18959361(+) A-I      intronic chr10:18960281(+) A-I      intronic chr10:18960290(+) A-I      intronic chr10:18960333(+) A-I      intronic chr10:18960698(+) A-I      intronic chr10:18958801(+) A-I      intronic chr10:18954184(+) A-I      intronic chr10:18960801(+) A-I      intronic chr10:18960791(+) A-I      intronic chr10:18959301(+) A-I      intronic chr10:18957824(+) A-I      intronic chr10:18960323(+) A-I      intronic chr10:18954126(+) A-I      intronic chr10:18960372(+) A-I      intronic chr10:18957799(+) A-I      intronic chr10:18957959(+) A-I      intronic chr10:18958763(+) A-I      intronic chr10:18958765(+) A-I      intronic chr10:18958906(+) A-I      intronic chr10:18958908(+) A-I      intronic chr10:18954246(+) A-I      intronic chr10:18954142(+) A-I      intronic chr10:18959452(+) A-I      intronic chr10:18954249(+) A-I      intronic chr10:18960355(+) A-I      intronic chr10:18954127(+) A-I      intronic chr10:18962263(+) A-I      intronic chr10:18958843(+) A-I      intronic chr10:18957972(+) A-I      intronic chr10:18958775(+) A-I      intronic chr10:18957747(+) A-I      intronic chr10:18957865(+) A-I      intronic chr10:18958769(+) A-I      intronic chr10:18954175(+) A-I      intronic chr10:18960203(+) A-I      intronic chr10:18959378(+) A-I      intronic chr10:18960795(+) A-I      intronic chr10:18960219(+) A-I      intronic chr10:18958667(+) A-I      intronic chr10:18954245(+) A-I      intronic chr10:18958772(+) A-I      intronic chr10:18960360(+) A-I      intronic chr10:18957873(+) A-I      intronic chr10:18962095(+) A-I      intronic chr10:18958768(+) A-I      intronic chr10:18958666(+) A-I      intronic chr10:18958644(+) A-I      intronic chr10:18958816(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ARL5B	chr10:18957972(+) A-I intron -    22327324 chr10:18957972(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ARL5B	chr10:18948337-18948338(+) m6A 5'UTR       24981863 chr10:18948371-18948372(+) m6A 5'UTR       24981863 chr10:18948509-18948510(+) m6A 5'UTR       24209618 chr10:18948539-18948540(+) m6A 5'UTR       24209618 chr10:18964163-18964164(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22608085 chr10:18964189-18964190(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22608085 chr10:18964251-18964252(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22608085 chr10:18964287-18964288(+) m6A 3'UTR       24284625//24981863//26404942//22608085 chr10:18964293-18964294(+) m6A 3'UTR       24284625//24981863//26404942//22608085 chr10:18964550-18964551(+) m6A 3'UTR       24284625//24981863//26404942//27773535//22608085 chr10:18964571-18964572(+) m6A 3'UTR       24284625//24981863//26404942//27773535//22608085 chr10:18964608-18964609(+) m6A 3'UTR       24284625//24981863//26404942//27773535//22608085 chr10:18964624-18964625(+) m6A 3'UTR       24284625//24981863//26404942//27773535//22608085 chr10:18964629-18964630(+) m6A 3'UTR       24284625//24981863//26404942//27773535//22608085 chr10:18968596-18968597(+) m6A 3'UTR       24981863 chr10:18968633-18968634(+) m6A 3'UTR       24981863//26404942 chr10:18968677-18968678(+) m6A 3'UTR       26404942 chr10:18968704-18968705(+) m6A 3'UTR       26404942 chr10:18970122-18970123(+) m6A 3'UTR       24981863//26404942 chr10:18970135-18970136(+) m6A 3'UTR       24981863//26404942 chr10:18970146-18970147(+) m6A 3'UTR       24981863//26404942 chr10:18970205-18970206(+) m6A 3'UTR       24981863//26404942

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-138-5p	Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Blood|Endothelial cells     - Microvesicle Cerebrospinal fluid     24797360 Microvesicle Blood|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580
	ARL5B	Chromatin K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleoplasm K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-138-5p	Fludarabine 657237 Drug sensitive Pyrazolo[1,5-b]pyridazine deriv. 22 6539364 Drug resistant Psammaplin A 6400741 Drug sensitive Melampodin B acetate 5359212 Drug resistant 4-Cycloheptyl-N-(1-pyridin-2-ylethylideneamino)piperazine-1-carbothioamide 5351332 Drug resistant Reumycin 5351216 Drug sensitive Streptonigrin 5298 Drug sensitive Ayanin 5280682 Drug sensitive 10-Hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12-dodecahydro-1H-picene-4a-carboxylic acid 495604 Drug sensitive Formycin A 447199 Drug sensitive Triacetyl crambescidin 800 hydrochloride 400721 Drug resistant Massoia lactone 39914 Drug resistant 2-(2-(Dimethylamino)ethylamino)naphthazarin 376950 Drug resistant 5,8-Dihydroxy-2-[4-[2-(2-hydroxyethoxy)ethyl]piperazin-1-yl]naphthalene-1,4-dione 376948 Drug resistant Antineoplastic-642316 369949 Drug resistant 6-(Dimethylarsanylsulfanylmethyl)oxane-2,3,4,5-tetrol 311912 Drug resistant N-[1-(Biphenyl-4-yl)ethyl]-3,4-dichlorobenzamide 305114 Drug sensitive 2,4,6-Trichloro-5-ethylpyrimidine 249455 Drug resistant N-(3-(1-Aziridinyl)propyl)-1,4-butanediamine 160394 Drug sensitive [(1R,2R,4R,6E,9R,10S)-2,7-Dimethyl-5,8,14-trioxo-10-prop-1-en-2-yl-15-oxatricyclo[11.2.1.02,4]hexadeca-6,13(16)-dien-9-yl] acetate 15384977 Drug resistant 4-[[(1-Benzylpyrazolo[3,4-d]pyrimidin-4-yl)hydrazinylidene]methyl]-2-methoxyphenol 136091540 Drug sensitive 2,4-Dihydroxybenzaldehyde 2-pyridylhydrazone 135509512 Drug sensitive DTIC-Dome 135398738 Drug sensitive Litmomycin 12310334 Drug resistant Binimetinib 10288191 Drug resistant (3Z,4R)-4-Hydroxy-3-[2-[(1S,3R)-3-[2-[(1S,3S,3'R,4S)-1-hydroxy-4,6,6-trimethylspiro[2,5-dioxabicyclo[2.2.2]octane-3,6'-oxane]-3'-yl]ethyl]-2,2-dimethyl-6-methylidenecyclohexyl]ethylidene]oxolan-2-one 101206903 Drug resistant 12h-benzoxazolo[2,3-b]quinazolin-12-one, 3-nitro- - Drug resistant 2,4-pentanedionato(1,5-cyclooctadiene)rhodium - Drug resistant 21h,23h-porphine, pyridinium deriv., silver complex - Drug resistant 4-morpholinecarbodithioic acid, antimony complex - Drug resistant 7-n,n-dimethylamino brefeldin a hydrochloride - Drug resistant benzo[b]naphtho[2,3-d]furan-6,11-dione, 4-chloro-3-hydroxy - Drug resistant pyrimidine, 2,4,5-trichloro-6-isopropyl- - Drug resistant 2-(1-(4-chlorophenylsulfonyl)-1H-indol-3-yl)-2-oxo-N-(pyridin-4-yl)acetamide - Drug resistant 9-methoxy-5-hydroxycamptothecin - Drug resistant antineoplastic-625543 - Drug resistant b705009k098 - Drug resistant bis(2-nitrophenyl)sulfilimine - Drug resistant ERB-38 Immunotoxin - Drug resistant (z) 4-acetoxy-(3,4',5)-trimethoxystilbene - Drug sensitive 1-naphthalenecarboxamide, n,n'-1,8-(octanediyl)bis- - Drug sensitive 3',4',5'-trimethoxy-3-hydroxy flavone - Drug sensitive 5.alpha.,25d-spirostan-3.beta.-ol glycoside - Drug sensitive 9h-quino[4,3,2-de][1,10]phenanthrolin-9-one, 10-methoxy- - Drug sensitive breast chalone, glycoprotein fraction - Drug sensitive phosphinic acid, bis(1-aziridinyl)-, 2-naphthyl ester - Drug sensitive (-)-furodysinin - Drug sensitive CI-921: amsacrine derivative - Drug sensitive crotoxin cd - Drug sensitive insulin-methotrexate conjugate - Drug sensitive protein toxin c 10 - mw approx. 6700 - Drug sensitive staurosporin analog kt 5944 - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-138-5p	Gemcitabine 60750 Drug interaction    RC00002766 Vincristine 5978 Drug interaction    RC00002763 D-Glucose 5793 Drug interaction    RC00002762 Diethylstilbestrol 448537 Drug interaction    RC00002771 Cyclopamine 442972 Drug interaction    RC00002770 Paclitaxel 36314 Drug interaction    RC00002765 5-Fluorouracil 3385 Drug interaction    RC00002761 Doxorubicin 31703 Drug interaction    RC00002764 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00002760 Docetaxel 148124 Drug interaction    RC00002769 Gefitinib 123631 Drug interaction    RC00002768 Ginsenoside Rh2 119307 Drug interaction    RC00002767 Y15 - Drug interaction    RC00002773 FAK inhibitor - Drug interaction    RC00002772

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-138-5p	Cisplatin 5702198       30535472 Gefitinib 123631       24582749

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-138-5p
Interactor2: ARL5B

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.