Detail Information

Basic Information:


  VIRBase ID:  

HHID00051457

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-138-5p:           RBM38:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-138-5p RBM38
miRBase
Accession/Entrez ID		 MIMAT0000430 55544
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - dJ800J21.2//HSRNASEB//RNPC1//SEB4B//SEB4D

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-138-5p
rs1159226412 chr3:44114256    G/A
rs1331169318 chr3:44114250    C/A
rs1331169318 chr3:44114250    C/T
rs1466470291 chr3:44114249    T/A
rs748499444 chr3:44114243    T/C
rs1285034653 chr16:56858546    G/A
rs1389589086 chr16:56858539    G/A
rs1395610282 chr16:56858535    T/C
rs749468995 chr16:56858548    C/G
rs755213420 chr16:56858549    G/A
rs755213420 chr16:56858549    G/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR RBM38
chr20:55981776(+) A-I      intronic
chr20:55978835(+) A-I      intronic
chr20:55981862(+) A-I      intronic
chr20:55977133(+) A-I      intronic
chr20:55978807(+) A-I      intronic
chr20:55978864(+) A-I      intronic
chr20:55978819(+) A-I      intronic
chr20:55981970(+) A-I      intronic
chr20:55981991(+) A-I      intronic
chr20:55978867(+) A-I      intronic
chr20:55978808(+) A-I      intronic
chr20:55978739(+) A-I      intronic
chr20:55981939(+) A-I      intronic
chr20:55981903(+) A-I      intronic
chr20:55981864(+) A-I      intronic
chr20:55978938(+) A-I      intronic
chr20:55978928(+) A-I      intronic
chr20:55978912(+) A-I      intronic
chr20:55977026(+) A-I      intronic
chr20:55977083(+) A-I      intronic
chr20:55977224(+) A-I      intronic
chr20:55977025(+) A-I      intronic
chr20:55978950(+) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase RBM38
chr20:55966725-55966726(+) m6A CDS       24209618
chr20:55967752-55967753(+) m6A 3'UTR//CDS       24284625
chr20:55967758-55967759(+) m6A 3'UTR//CDS       24284625
chr20:55967791-55967792(+) m6A 3'UTR//CDS       24284625
chr20:55968381-55968382(+) m6A 3'UTR//CDS//intron       24284625
chr20:55982922-55982923(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr20:55982949-55982950(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr20:55983030-55983031(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr20:55983060-55983061(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr20:55983114-55983115(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr20:55983133-55983134(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr20:55983265-55983266(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085
chr20:55983292-55983293(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085
chr20:55983321-55983322(+) m6A 3'UTR       24284625//24209618//24981863//22575960//22608085
chr20:55983344-55983345(+) m6A 3'UTR       24284625//24209618//24981863//22608085
chr20:55983399-55983400(+) m6A 3'UTR       24284625//24209618//24981863//22608085
chr20:55983637-55983638(+) m6A 3'UTR       24284625//24981863
chr20:55983658-55983659(+) m6A 3'UTR       24284625//24981863
chr20:55983765-55983766(+) m6A 3'UTR       24284625//24981863
chr20:55983840-55983841(+) m6A 3'UTR       24284625//24981863
chr20:55983897-55983898(+) m6A 3'UTR       24284625//24981863
chr20:55983954-55983955(+) m6A 3'UTR       24284625
chr20:55984181-55984182(+) m6A 3'UTR       24284625//25456834
chr20:55984239-55984240(+) m6A 3'UTR       24284625//25456834
chr20:55984287-55984288(+) m6A 3'UTR       24284625//25456834

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-138-5p
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Blood|Endothelial cells     -
Microvesicle Cerebrospinal fluid     24797360
Microvesicle Blood|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
RBM38
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleoplasm K562 cells     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-138-5p
Fludarabine 657237 Drug sensitive
Pyrazolo[1,5-b]pyridazine deriv. 22 6539364 Drug resistant
Psammaplin A 6400741 Drug sensitive
Melampodin B acetate 5359212 Drug resistant
4-Cycloheptyl-N-(1-pyridin-2-ylethylideneamino)piperazine-1-carbothioamide 5351332 Drug resistant
Reumycin 5351216 Drug sensitive
Streptonigrin 5298 Drug sensitive
Ayanin 5280682 Drug sensitive
10-Hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12-dodecahydro-1H-picene-4a-carboxylic acid 495604 Drug sensitive
Formycin A 447199 Drug sensitive
Triacetyl crambescidin 800 hydrochloride 400721 Drug resistant
Massoia lactone 39914 Drug resistant
2-(2-(Dimethylamino)ethylamino)naphthazarin 376950 Drug resistant
5,8-Dihydroxy-2-[4-[2-(2-hydroxyethoxy)ethyl]piperazin-1-yl]naphthalene-1,4-dione 376948 Drug resistant
Antineoplastic-642316 369949 Drug resistant
6-(Dimethylarsanylsulfanylmethyl)oxane-2,3,4,5-tetrol 311912 Drug resistant
N-[1-(Biphenyl-4-yl)ethyl]-3,4-dichlorobenzamide 305114 Drug sensitive
2,4,6-Trichloro-5-ethylpyrimidine 249455 Drug resistant
N-(3-(1-Aziridinyl)propyl)-1,4-butanediamine 160394 Drug sensitive
[(1R,2R,4R,6E,9R,10S)-2,7-Dimethyl-5,8,14-trioxo-10-prop-1-en-2-yl-15-oxatricyclo[11.2.1.02,4]hexadeca-6,13(16)-dien-9-yl] acetate 15384977 Drug resistant
4-[[(1-Benzylpyrazolo[3,4-d]pyrimidin-4-yl)hydrazinylidene]methyl]-2-methoxyphenol 136091540 Drug sensitive
2,4-Dihydroxybenzaldehyde 2-pyridylhydrazone 135509512 Drug sensitive
DTIC-Dome 135398738 Drug sensitive
Litmomycin 12310334 Drug resistant
Binimetinib 10288191 Drug resistant
(3Z,4R)-4-Hydroxy-3-[2-[(1S,3R)-3-[2-[(1S,3S,3'R,4S)-1-hydroxy-4,6,6-trimethylspiro[2,5-dioxabicyclo[2.2.2]octane-3,6'-oxane]-3'-yl]ethyl]-2,2-dimethyl-6-methylidenecyclohexyl]ethylidene]oxolan-2-one 101206903 Drug resistant
12h-benzoxazolo[2,3-b]quinazolin-12-one, 3-nitro- - Drug resistant
2,4-pentanedionato(1,5-cyclooctadiene)rhodium - Drug resistant
21h,23h-porphine, pyridinium deriv., silver complex - Drug resistant
4-morpholinecarbodithioic acid, antimony complex - Drug resistant
7-n,n-dimethylamino brefeldin a hydrochloride - Drug resistant
benzo[b]naphtho[2,3-d]furan-6,11-dione, 4-chloro-3-hydroxy - Drug resistant
pyrimidine, 2,4,5-trichloro-6-isopropyl- - Drug resistant
2-(1-(4-chlorophenylsulfonyl)-1H-indol-3-yl)-2-oxo-N-(pyridin-4-yl)acetamide - Drug resistant
9-methoxy-5-hydroxycamptothecin - Drug resistant
antineoplastic-625543 - Drug resistant
b705009k098 - Drug resistant
bis(2-nitrophenyl)sulfilimine - Drug resistant
ERB-38 Immunotoxin - Drug resistant
(z) 4-acetoxy-(3,4',5)-trimethoxystilbene - Drug sensitive
1-naphthalenecarboxamide, n,n'-1,8-(octanediyl)bis- - Drug sensitive
3',4',5'-trimethoxy-3-hydroxy flavone - Drug sensitive
5.alpha.,25d-spirostan-3.beta.-ol glycoside - Drug sensitive
9h-quino[4,3,2-de][1,10]phenanthrolin-9-one, 10-methoxy- - Drug sensitive
breast chalone, glycoprotein fraction - Drug sensitive
phosphinic acid, bis(1-aziridinyl)-, 2-naphthyl ester - Drug sensitive
(-)-furodysinin - Drug sensitive
CI-921: amsacrine derivative - Drug sensitive
crotoxin cd - Drug sensitive
insulin-methotrexate conjugate - Drug sensitive
protein toxin c 10 - mw approx. 6700 - Drug sensitive
staurosporin analog kt 5944 - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-138-5p
Gemcitabine 60750 Drug interaction    RC00002766
Vincristine 5978 Drug interaction    RC00002763
D-Glucose 5793 Drug interaction    RC00002762
Diethylstilbestrol 448537 Drug interaction    RC00002771
Cyclopamine 442972 Drug interaction    RC00002770
Paclitaxel 36314 Drug interaction    RC00002765
5-Fluorouracil 3385 Drug interaction    RC00002761
Doxorubicin 31703 Drug interaction    RC00002764
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00002760
Docetaxel 148124 Drug interaction    RC00002769
Gefitinib 123631 Drug interaction    RC00002768
Ginsenoside Rh2 119307 Drug interaction    RC00002767
Y15 - Drug interaction    RC00002773
FAK inhibitor - Drug interaction    RC00002772
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-138-5p
Cisplatin 5702198       30535472
Gefitinib 123631       24582749

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-138-5p
Interactor2: RBM38

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region CDS
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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