Detail Information

Basic Information:


  VIRBase ID:  

HHID00051449

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-138-5p:           DEK:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-138-5p DEK
miRBase
Accession/Entrez ID		 MIMAT0000430 7913
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - D6S231E

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-138-5p
rs1159226412 chr3:44114256    G/A
rs1331169318 chr3:44114250    C/A
rs1331169318 chr3:44114250    C/T
rs1466470291 chr3:44114249    T/A
rs748499444 chr3:44114243    T/C
rs1285034653 chr16:56858546    G/A
rs1389589086 chr16:56858539    G/A
rs1395610282 chr16:56858535    T/C
rs749468995 chr16:56858548    C/G
rs755213420 chr16:56858549    G/A
rs755213420 chr16:56858549    G/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR DEK
chr6:18238342(-) A-I      intronic
chr6:18250954(-) A-I      intronic
chr6:18257946(-) A-I      intronic
chr6:18257725(-) A-I      intronic
chr6:18238211(-) A-I      intronic
chr6:18238247(-) A-I      intronic
chr6:18254041(-) A-I      intronic
chr6:18254052(-) A-I      intronic
chr6:18238796(-) A-I      intronic
chr6:18238296(-) A-I      intronic
chr6:18238657(-) A-I      intronic
chr6:18238667(-) A-I      intronic
chr6:18254059(-) A-I      intronic
chr6:18254076(-) A-I      intronic
chr6:18238725(-) A-I      intronic
chr6:18238760(-) A-I      intronic
chr6:18254081(-) A-I      intronic
chr6:18238804(-) A-I      intronic
chr6:18238806(-) A-I      intronic
chr6:18238811(-) A-I      intronic
chr6:18238828(-) A-I      intronic
chr6:18239253(-) A-I      intronic
chr6:18239258(-) A-I      intronic
chr6:18239279(-) A-I      intronic
chr6:18240942(-) A-I      intronic
chr6:18240970(-) A-I      intronic
chr6:18242549(-) A-I      intronic
chr6:18250533(-) A-I      intronic
chr6:18250536(-) A-I      intronic
chr6:18238196(-) A-I      intronic
chr6:18238273(-) A-I      intronic
chr6:18254220(-) A-I      intronic
chr6:18254443(-) A-I      intronic
chr6:18254104(-) A-I      intronic
chr6:18238865(-) A-I      intronic
chr6:18241015(-) A-I      intronic
chr6:18242591(-) A-I      intronic
chr6:18238267(-) A-I      intronic
chr6:18239333(-) A-I      intronic
chr6:18238771(-) A-I      intronic
chr6:18239660(-) A-I      intronic
chr6:18238237(-) A-I      intronic
chr6:18256225(-) A-I      intronic
chr6:18238238(-) A-I      intronic
chr6:18241021(-) A-I      intronic
chr6:18257794(-) A-I      intronic
chr6:18238270(-) A-I      intronic
chr6:18238673(-) A-I      intronic
chr6:18226780(-) A-I      intronic
chr6:18238169(-) A-I      intronic
chr6:18238762(-) A-I      intronic
chr6:18250905(-) A-I      intronic
chr6:18250906(-) A-I      intronic
chr6:18248176(-) A-I      intronic
chr6:18242482(-) A-I      intronic
chr6:18239413(-) A-I      intronic
chr6:18238748(-) A-I      intronic
chr6:18238853(-) A-I      intronic
chr6:18248008(-) A-I      intronic
chr6:18238373(-) A-I      intronic
chr6:18238367(-) A-I      intronic
chr6:18226845(-) A-I      intronic
chr6:18239293(-) A-I      intronic
chr6:18238845(-) A-I      intronic
chr6:18250909(-) A-I      intronic
chr6:18239444(-) A-I      intronic
chr6:18226753(-) A-I      intronic
chr6:18226806(-) A-I      intronic
chr6:18238327(-) A-I      intronic
chr6:18250897(-) A-I      intronic
chr6:18238264(-) A-I      intronic
chr6:18240944(-) A-I      intronic
chr6:18242507(-) A-I      intronic
chr6:18239294(-) A-I      intronic
chr6:18254207(-) A-I      intronic
chr6:18252484(-) A-I      intronic
chr6:18238846(-) A-I      intronic
chr6:18254206(-) A-I      intronic
chr6:18242587(-) A-I      intronic
chr6:18250511(-) A-I      intronic
chr6:18235939(-) A-I      intronic
chr6:18226839(-) A-I      intronic
chr6:18248032(-) A-I      intronic
chr6:18238756(-) A-I      intronic
chr6:18238859(-) A-I      intronic
chr6:18254455(-) A-I      intronic
chr6:18238816(-) A-I      intronic
chr6:18238356(-) A-I      intronic
chr6:18254092(-) A-I      intronic
chr6:18254370(-) A-I      intronic
chr6:18253991(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED DEK
chr6:18253404(-) A-G intron -    22484847
chr6:18238195(-) A-G intron -    22484847
chr6:18238327(-) A-G intron -    22484847
chr6:18238356(-) A-G intron -    22484847
chr6:18238367(-) A-G intron -    22484847
chr6:18238705(-) C-T intron -    22484847
chr6:18238756(-) A-G intron -    22484847
chr6:18238762(-) A-G intron -    22484847
chr6:18238765(-) A-G intron -    22484847
chr6:18238771(-) A-G intron -    22484847
chr6:18238816(-) A-G intron -    22484847
chr6:18238841(-) A-G intron -    22484847
chr6:18238842(-) A-G intron -    22484847
chr6:18238845(-) A-G intron -    22484847
chr6:18238846(-) A-G intron -    22484847
chr6:18239293(-) A-G intron -    22484847
chr6:18239294(-) A-G intron -    22484847
chr6:18239413(-) A-G intron -    22484847
chr6:18242507(-) A-G intron -    22484847
chr6:18248008(-) A-G intron -    22484847
chr6:18250511(-) A-G intron -    22484847
chr6:18253991(-) A-G intron -    22484847
chr6:18254206(-) A-G intron -    22484847
chr6:18254370(-) A-G intron -    22484847
chr6:18254450(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase DEK
chr6:18224868-18224869(-) Gm 3'UTR       -
chr6:18224957-18224958(-) m6A 3'UTR       22575960
chr6:18225010-18225011(-) m6A 3'UTR       24981863//26404942//22575960
chr6:18225063-18225064(-) m6A 3'UTR       24981863//26404942//22575960
chr6:18225097-18225098(-) m6A 3'UTR       24981863//26404942
chr6:18225193-18225194(-) m6A 3'UTR       22575960
chr6:18225231-18225232(-) m6A 3'UTR       22575960
chr6:18225244-18225245(-) m6A 3'UTR       22575960
chr6:18225270-18225271(-) m6A 3'UTR       22575960
chr6:18225917-18225918(-) Tm 3'UTR       -
chr6:18225940-18225941(-) m6A 3'UTR       24981863//26404942//27773535
chr6:18226200-18226201(-) m6A 3'UTR//intron       27773535
chr6:18226206-18226207(-) m6A 3'UTR//intron       27773535
chr6:18226361-18226362(-) m6A 3'UTR//intron       24981863
chr6:18226418-18226419(-) m6A CDS       24981863//27773535
chr6:18236697-18236698(-) m6A CDS       24981863//28052920//27773535//22575960//22608085
chr6:18236747-18236748(-) m6A 3'UTR//CDS       24981863//28052920//27773535//22575960//22608085
chr6:18236775-18236776(-) m6A 3'UTR//CDS       24284625//24981863//28052920//27773535//22575960//22608085
chr6:18236799-18236800(-) m6A 3'UTR//CDS       24284625//24981863//28052920//27773535//22575960//22608085
chr6:18237367-18237368(-) m6A exon//intron       24284625//24981863//28052920//27773535//22608085
chr6:18237378-18237379(-) m6A exon//intron       24284625//24981863//28052920//27773535//22608085
chr6:18237406-18237407(-) m6A exon//intron       24981863//28052920//27773535//22608085
chr6:18237625-18237626(-) m6A 3'UTR//CDS//exon       24981863//28052920//27773535//22575960//22608085
chr6:18237711-18237712(-) m6A 3'UTR//CDS//exon       24981863//28052920//27773535//22575960//22608085
chr6:18237717-18237718(-) m6A 3'UTR//CDS//exon       24981863//28052920//27773535//22575960//22608085
chr6:18237734-18237735(-) m6A 3'UTR//CDS//exon       24981863//28052920//27773535//22575960//22608085
chr6:18244774-18244775(-) m6A CDS//intron       24981863//27773535//22608085
chr6:18244812-18244813(-) m6A CDS//intron       24981863//27773535
chr6:18249893-18249894(-) Am CDS//exon       -
chr6:18249927-18249928(-) m6A CDS//exon       24981863
chr6:18249985-18249986(-) m6A CDS//exon       24981863
chr6:18250017-18250018(-) m6A CDS//exon       24981863
chr6:18250048-18250049(-) m6A CDS//exon       24981863
chr6:18256012-18256013(-) m6A CDS//exon       22575960
chr6:18258207-18258208(-) m6A CDS       24981863//27773535
chr6:18258225-18258226(-) m6A CDS       24981863//27773535
chr6:18258233-18258234(-) m6A CDS       24981863//27773535
chr6:18258279-18258280(-) m6A CDS//intron       24209618//24981863//28052920//27773535//27371828
chr6:18264134-18264135(-) Cm CDS//intron       -
chr6:18264152-18264153(-) m6A CDS//intron       24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960
chr6:18264181-18264182(-) m6A CDS//intron       24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960
chr6:18264258-18264259(-) m6A 5'UTR//intron       24209618//25456834//24981863//27371828//27773536//22575960
chr6:18264371-18264372(-) m6A 5'UTR//intron       24209618//24981863//27773536//22575960
chr6:18264662-18264663(-) m6A 5'UTR       24209618//24981863//27371828//27773536//22575960
chr6:18264713-18264714(-) m6A 5'UTR       24209618//24981863//27371828//27773536//22575960
chr6:18264749-18264750(-) Y 5'UTR       25219674
chr6:18264777-18264778(-) m6A 5'UTR       24209618//24981863//27371828//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-138-5p
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Blood|Endothelial cells     -
Microvesicle Cerebrospinal fluid     24797360
Microvesicle Blood|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
DEK
Chromatin K562 cells     -
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells|K562 cells     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-138-5p
Fludarabine 657237 Drug sensitive
Pyrazolo[1,5-b]pyridazine deriv. 22 6539364 Drug resistant
Psammaplin A 6400741 Drug sensitive
Melampodin B acetate 5359212 Drug resistant
4-Cycloheptyl-N-(1-pyridin-2-ylethylideneamino)piperazine-1-carbothioamide 5351332 Drug resistant
Reumycin 5351216 Drug sensitive
Streptonigrin 5298 Drug sensitive
Ayanin 5280682 Drug sensitive
10-Hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12-dodecahydro-1H-picene-4a-carboxylic acid 495604 Drug sensitive
Formycin A 447199 Drug sensitive
Triacetyl crambescidin 800 hydrochloride 400721 Drug resistant
Massoia lactone 39914 Drug resistant
2-(2-(Dimethylamino)ethylamino)naphthazarin 376950 Drug resistant
5,8-Dihydroxy-2-[4-[2-(2-hydroxyethoxy)ethyl]piperazin-1-yl]naphthalene-1,4-dione 376948 Drug resistant
Antineoplastic-642316 369949 Drug resistant
6-(Dimethylarsanylsulfanylmethyl)oxane-2,3,4,5-tetrol 311912 Drug resistant
N-[1-(Biphenyl-4-yl)ethyl]-3,4-dichlorobenzamide 305114 Drug sensitive
2,4,6-Trichloro-5-ethylpyrimidine 249455 Drug resistant
N-(3-(1-Aziridinyl)propyl)-1,4-butanediamine 160394 Drug sensitive
[(1R,2R,4R,6E,9R,10S)-2,7-Dimethyl-5,8,14-trioxo-10-prop-1-en-2-yl-15-oxatricyclo[11.2.1.02,4]hexadeca-6,13(16)-dien-9-yl] acetate 15384977 Drug resistant
4-[[(1-Benzylpyrazolo[3,4-d]pyrimidin-4-yl)hydrazinylidene]methyl]-2-methoxyphenol 136091540 Drug sensitive
2,4-Dihydroxybenzaldehyde 2-pyridylhydrazone 135509512 Drug sensitive
DTIC-Dome 135398738 Drug sensitive
Litmomycin 12310334 Drug resistant
Binimetinib 10288191 Drug resistant
(3Z,4R)-4-Hydroxy-3-[2-[(1S,3R)-3-[2-[(1S,3S,3'R,4S)-1-hydroxy-4,6,6-trimethylspiro[2,5-dioxabicyclo[2.2.2]octane-3,6'-oxane]-3'-yl]ethyl]-2,2-dimethyl-6-methylidenecyclohexyl]ethylidene]oxolan-2-one 101206903 Drug resistant
12h-benzoxazolo[2,3-b]quinazolin-12-one, 3-nitro- - Drug resistant
2,4-pentanedionato(1,5-cyclooctadiene)rhodium - Drug resistant
21h,23h-porphine, pyridinium deriv., silver complex - Drug resistant
4-morpholinecarbodithioic acid, antimony complex - Drug resistant
7-n,n-dimethylamino brefeldin a hydrochloride - Drug resistant
benzo[b]naphtho[2,3-d]furan-6,11-dione, 4-chloro-3-hydroxy - Drug resistant
pyrimidine, 2,4,5-trichloro-6-isopropyl- - Drug resistant
2-(1-(4-chlorophenylsulfonyl)-1H-indol-3-yl)-2-oxo-N-(pyridin-4-yl)acetamide - Drug resistant
9-methoxy-5-hydroxycamptothecin - Drug resistant
antineoplastic-625543 - Drug resistant
b705009k098 - Drug resistant
bis(2-nitrophenyl)sulfilimine - Drug resistant
ERB-38 Immunotoxin - Drug resistant
(z) 4-acetoxy-(3,4',5)-trimethoxystilbene - Drug sensitive
1-naphthalenecarboxamide, n,n'-1,8-(octanediyl)bis- - Drug sensitive
3',4',5'-trimethoxy-3-hydroxy flavone - Drug sensitive
5.alpha.,25d-spirostan-3.beta.-ol glycoside - Drug sensitive
9h-quino[4,3,2-de][1,10]phenanthrolin-9-one, 10-methoxy- - Drug sensitive
breast chalone, glycoprotein fraction - Drug sensitive
phosphinic acid, bis(1-aziridinyl)-, 2-naphthyl ester - Drug sensitive
(-)-furodysinin - Drug sensitive
CI-921: amsacrine derivative - Drug sensitive
crotoxin cd - Drug sensitive
insulin-methotrexate conjugate - Drug sensitive
protein toxin c 10 - mw approx. 6700 - Drug sensitive
staurosporin analog kt 5944 - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-138-5p
Gemcitabine 60750 Drug interaction    RC00002766
Vincristine 5978 Drug interaction    RC00002763
D-Glucose 5793 Drug interaction    RC00002762
Diethylstilbestrol 448537 Drug interaction    RC00002771
Cyclopamine 442972 Drug interaction    RC00002770
Paclitaxel 36314 Drug interaction    RC00002765
5-Fluorouracil 3385 Drug interaction    RC00002761
Doxorubicin 31703 Drug interaction    RC00002764
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00002760
Docetaxel 148124 Drug interaction    RC00002769
Gefitinib 123631 Drug interaction    RC00002768
Ginsenoside Rh2 119307 Drug interaction    RC00002767
Y15 - Drug interaction    RC00002773
FAK inhibitor - Drug interaction    RC00002772
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-138-5p
Cisplatin 5702198       30535472
Gefitinib 123631       24582749

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-138-5p
Interactor2: DEK

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

Starting a new search, please wait ...