Detail Information

Basic Information:


  VIRBase ID:  

HHID00050930

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-124-3p:           ARHGDIA:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-124-3p ARHGDIA
miRBase
Accession/Entrez ID		 MIMAT0000422 396
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - GDIA1//HEL-S-47e//NPHS8//RHOGDI//RHOGDI-1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-124-3p
rs1256263272 chr8:9903400    T/C
rs1482188536 chr8:9903410    C/A
rs753437646 chr8:9903401    G/T
rs759045572 chr8:9903402    G/T
rs764861083 chr8:9903408    A/G
rs759034202 chr8:64379220    G/A
rs1364752547 chr20:63178563    G/A
rs749909250 chr20:63178569    G/A
rs1287398108 chr20:63178559    C/G
rs34059726 chr20:63178555    G/T

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ARHGDIA
chr17:79825735-79825736(-) m6A 3'UTR//exon       24284625//27773535//22575960
chr17:79825746-79825747(-) m6A 3'UTR//exon       24284625//27773535//22575960
chr17:79825906-79825907(-) m6A 3'UTR//intron       24284625//24981863//27773535//22575960
chr17:79826016-79826017(-) m6A 3'UTR//intron       24284625//24981863//27773535//27773536//22575960
chr17:79826067-79826068(-) m6A 3'UTR//intron       24284625//24981863//27773535//27773536//22575960
chr17:79826134-79826135(-) m6A 3'UTR//intron       24284625//27773535//22575960
chr17:79826150-79826151(-) m6A 3'UTR//intron       24284625//27773535//22575960
chr17:79826706-79826707(-) m6A 3'UTR//CDS//intron       24284625//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr17:79826725-79826726(-) m6A 3'UTR//CDS//intron       24284625//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr17:79826755-79826756(-) m6A CDS//exon//intron       24284625//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr17:79826764-79826765(-) m6A CDS//exon//intron       24284625//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr17:79826807-79826808(-) m6A 3'UTR//CDS//exon//intron       24284625//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr17:79826942-79826943(-) m6A 3'UTR//CDS//exon//intron       24284625//27773535//22575960
chr17:79827147-79827148(-) m6A exon//intron       27773535
chr17:79827425-79827426(-) m6A CDS//exon//intron       24284625//24209618//27371828//27773536//22575960
chr17:79827500-79827501(-) m6A CDS//exon//intron       24284625//24209618//27773535//27371828//27773536//22575960
chr17:79827681-79827682(-) m6A CDS//exon       24284625//24209618//24981863//28052920//27773535//27371828//27773536//22575960
chr17:79827751-79827752(-) Gm CDS//exon       -
chr17:79828599-79828600(-) m6A 5'UTR//intron       24209618
chr17:79828718-79828719(-) Y 5'UTR//intron       26075521
chr17:79828830-79828831(-) m6A 5'UTR//intron       24284625//24209618//24981863//27773536//22575960
chr17:79829180-79829181(-) m6A 5'UTR//exon       24284625//24209618//24981863//27773536//22575960
chr17:79829193-79829194(-) m6A 5'UTR//exon       24284625//24209618//24981863//27773536//22575960

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-124-3p
Exosome Plasma     23663360
Exosome Blood     -
Microvesicle Cerebrospinal fluid     24797360
Microvesicle Blood|Fibroblasts|Urine     -
Mitochondrion Cell line (HEK-293)     22984580
ARHGDIA
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Insoluble cytoplasm HCC cell line (HepG2)     -
Nucleus HeLa-S3 cells     -
Ribosome HEK-293 cells     22199352
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-124-3p
N,N-Dimethyltryptamine 6089 Drug interaction    RC00002595
Estradiol 5757 Drug interaction    RC00002594
Vorinostat 5311 Drug interaction    RC00002593
Cocaine 446220 Drug interaction    RC00002602
Paroxetine 43815 Drug interaction    RC00002601
Methylphenidate 4158 Drug interaction    RC00002592
Methadone 4095 Drug interaction    RC00002591
Etoposide 36462 Drug interaction    RC00002600
Harmaline 3564 Drug interaction    RC00002603
Fluoxetine 3386 Drug interaction    RC00002590
Enoxacin 3229 Drug interaction    RC00002589
Doxorubicin 31703 Drug interaction    RC00002599
Desipramine 2995 Drug interaction    RC00002588
Camptothecin 24360 Drug interaction    RC00002598
Cobalt chloride (CoCl2) 24288 Drug interaction    RC00002597
N,N-Dimethyl-5-methoxytryptamine 1832 Drug interaction    RC00002587
Arsenic trioxide 14888 Drug interaction    RC00002596
IR - Drug interaction    RC00002604
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-124-3p
Doxorubicin 31703       30807260

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-124-3p
Interactor2: ARHGDIA

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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