Detail Information

Basic Information:


  VIRBase ID:  

HHID00049689

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-let-7i-5p:           ADRB2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-let-7i-5p ADRB2
miRBase
Accession/Entrez ID		 MIMAT0000415 154
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - ADRB2R//ADRBR//B2AR//BAR//BETA2AR

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-let-7i-5p
rs1207803327 chr12:62603708    C/T
rs1265187764 chr12:62603700    A/G
rs1273095827 chr12:62603710    G/C
rs1343283980 chr12:62603701    GT/G
rs750854486 chr12:62603712    TG/T

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ADRB2
chr5:148206691-148206692(+) m6A CDS       24284625//24981863//22608085
chr5:148206721-148206722(+) m6A CDS       24284625//24981863//22608085
chr5:148206760-148206761(+) m6A CDS       24284625//24981863//22608085
chr5:148206958-148206959(+) m6A CDS       24284625//22608085
chr5:148206980-148206981(+) m6A CDS       24284625//22608085
chr5:148207124-148207125(+) m6A CDS       24284625//25456834//24981863//22608085
chr5:148207164-148207165(+) m6A CDS       24284625//24209618//25456834//24981863//22608085
chr5:148207500-148207501(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr5:148207518-148207519(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr5:148207532-148207533(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr5:148207550-148207551(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr5:148207658-148207659(+) m6A 3'UTR       24284625//24209618//24981863//22575960//22608085
chr5:148207676-148207677(+) m6A 3'UTR       24284625//24981863//22608085
chr5:148207683-148207684(+) m6A 3'UTR       24284625//24981863//22608085
chr5:148207710-148207711(+) m6A 3'UTR       24981863//22608085
chr5:148208019-148208020(+) m6A 3'UTR       24284625//24981863//22608085
chr5:148208043-148208044(+) m6A 3'UTR       24284625//24981863//22608085
chr5:148208058-148208059(+) m6A 3'UTR       24284625//24981863//22608085
chr5:148208064-148208065(+) m6A 3'UTR       24284625//24981863//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-let-7i-5p
Apoptotic body Human umbilical vein endothelial cells     19996457
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytoplasm HeLa cells     22058130
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Hetastatic gastric cancer cell line (AZ-P7a)     20949044
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Primary dendritic cells|T cell line (J77)     21505438
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Human esophageal cancer cell line (EC9706)     25184951
Exosome Blood|B lymphoblastoid cells|Breast milk|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Epithelial cells|Lymphoma tissue|Mast cells|Seminal fluid|Tongue tissue     -
Microvesicle Plasma     23077538
Microvesicle Seminal plasma     23539611
Microvesicle Hepatoma cells     23771658
Microvesicle Blood|Breast cell line|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Skeletal muscle myoblasts     21637849
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleolus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus HeLa cells     22058130
ADRB2
Exosome Blood     -
Nucleus Nasopharyngeal carcinoma cells     20498841

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-let-7i-5p
Formaldehyde 712 Drug interaction    RC00002392
Oxaliplatine 6857599 Drug interaction    RC00002408
Bisphenol A 6623 Drug interaction    RC00002399
Gemcitabine 60750 Drug interaction    RC00002403
Estradiol 5757 Drug interaction    RC00002398
Eloxatine 5310940 Drug interaction    RC00002407
Imatinib 5291 Drug interaction    RC00002397
Decitabine 451668 Drug interaction    RC00002405
Etoposide 36462 Drug interaction    RC00002402
Paclitaxel 36314 Drug interaction    RC00002401
5-Fluorouracil 3385 Drug interaction    RC00002396
Enoxacin 3229 Drug interaction    RC00002395
Doxorubicin 31703 Drug interaction    RC00002400
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00002394
Tamoxifen 2733526 Drug interaction    RC00002406
Verapamil 2520 Drug interaction    RC00002393
Leucovorin 135403648 Drug interaction    RC00002409
Ginsenoside Rh2 119307 Drug interaction    RC00002404
1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00002410
Marine fungal metabolite 1386A - Drug interaction    RC00002411
Mistletoe lectin-I - Drug interaction    RC00002412
Chemotherapy - Drug interaction    RC00008840
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-let-7i-5p
Platinum 23939       25872328

Interaction Network (The top 100 interactions):


Interactor1: hsa-let-7i-5p
Interactor2: ADRB2

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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