Basic Information:

  VIRBase ID:  

HHID00049339

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-222-3p:  MIMAT0000279          ZFP36:  NM_003407     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-222-3p	ZFP36
miRBase Accession/Entrez ID	MIMAT0000279	7538
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	G0S24//GOS24//NUP475//RNF162A//TIS11//TTP//zfp-36

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-222-3p	rs1555936233 chrX:45747049    A/T rs1555936234 chrX:45747051    G/T rs1555936235 chrX:45747052    T/TTTA rs1555936236 chrX:45747053    AGCTGC/A rs782662324 chrX:45747050    T/G

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ZFP36	chr19:39897641-39897642(+) m6A CDS//intron       24981863 chr19:39897729-39897730(+) m6A CDS//intron       24981863 chr19:39898093-39898094(+) m6A CDS//intron       25456834//24981863 chr19:39898100-39898101(+) m6A CDS//intron       25456834//24981863 chr19:39898115-39898116(+) m6A CDS//intron       25456834 chr19:39898433-39898434(+) m6A 3'UTR//CDS       25456834 chr19:39898465-39898466(+) m6A 3'UTR//CDS       24284625 chr19:39898673-39898674(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942 chr19:39898688-39898689(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942 chr19:39898792-39898793(+) m6A 3'UTR//CDS       24284625//25456834//24981863//26404942 chr19:39898869-39898870(+) m6A CDS       24284625//24209618//25456834//24981863//26404942 chr19:39898943-39898944(+) m6A CDS       24284625//24209618//25456834//24981863 chr19:39899028-39899029(+) m6A CDS       24284625//25456834//24981863 chr19:39899088-39899089(+) m6A CDS       24284625//25456834//24981863 chr19:39899168-39899169(+) m6A CDS       24284625//24981863 chr19:39899413-39899414(+) m6A 3'UTR       25456834//24981863//26404942 chr19:39899430-39899431(+) m6A 3'UTR       25456834//24981863//26404942 chr19:39899439-39899440(+) m6A 3'UTR       25456834//24981863//26404942 chr19:39899703-39899704(+) m6A 3'UTR       27773535 chr19:39899735-39899736(+) m6A 3'UTR       27773535 chr19:39899804-39899805(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-222-3p	Apoptotic body Human umbilical vein endothelial cells     19996457 Cytoplasm Cell line (HeLa)     21695135 Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome Human cervical cancer cell line (HeLa)     25760330 Exosome Gemcitabine-resistant cell line (A549-GR)|Gemcitabine-sensitive A549 parental cells (A549-P)     28743280 Exosome Plasma     30458449 Exosome BC cell lines (HCC70|MCF-7|MDA-MB-231)     30728048 Exosome Peripheral blood mononuclear cells     19002258 Exosome Primary dendritic cells|T cell line (J77)     21505438 Exosome Renal cancer cells     21670082 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Human mast cell line (HMC-1)     24009880 Exosome Blood|B lymphoblastoid cells|Breast tissue|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Epithelial cells|Kidney tissue|Mast cells|Tongue tissue     - Extracellular vesicle HEK-293T cells     22849433 Microvesicle Plasma     23077538 Microvesicle Seminal plasma     23539611 Microvesicle Follicular fluid     23666971 Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Colon adenocarcinoma cells     20864815
	ZFP36	Exosome Blood     - Nucleus HeLa-S3 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-222-3p	Kikubasaponin 6712587 Drug sensitive Lovastatin 53232 Drug sensitive Vorinostat 5311 Drug resistant Rustaiyan A 324967 Drug resistant isatin dr - Drug resistant tunicamycin - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-222-3p	Oxaliplatine 6857599 Drug interaction    RC00002227 Fludarabine 657237 Drug interaction    RC00002224 Aniline 6115 Drug interaction    RC00002210 Atorvastatin 60823 Drug interaction    RC00002217 Gemcitabine 60750 Drug interaction    RC00002216 Progesterone 5994 Drug interaction    RC00002209 Vincristine 5978 Drug interaction    RC00002208 Estradiol 5757 Drug interaction    RC00002207 CID 56842234 56842234 Drug interaction    RC00002228 Sunitinib 5329102 Drug interaction    RC00004804 Eloxatine 5310940 Drug interaction    RC00002226 Raloxifene 5035 Drug interaction    RC00002206 Melphalan 460612 Drug interaction    RC00002223 Etoposide 36462 Drug interaction    RC00002215 Paclitaxel 36314 Drug interaction    RC00002214 5-Fluorouracil 3385 Drug interaction    RC00002205 Emodin 3220 Drug interaction    RC00004801 Emodin 3220 Drug interaction    RC00002204 Doxorubicin 31703 Drug interaction    RC00002213 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00002203 Tamoxifen 2733526 Drug interaction    RC00002225 Nandrolone phenpropionate 229455 Drug interaction    RC00002222 Sorafenib 216239 Drug interaction    RC00002221 Arsenic trioxide 14888 Drug interaction    RC00002212 Docetaxel 148124 Drug interaction    RC00002220 Leucovorin 135403648 Drug interaction    RC00002229 Gefitinib 123631 Drug interaction    RC00002219 Androstanolone 10635 Drug interaction    RC00002211 Fulvestrant 104741 Drug interaction    RC00002218 1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00002231 Glucocorticoid - Drug interaction    RC00002232 Mistletoe lectin-I - Drug interaction    RC00002233 TRAIL therapy - Drug interaction    RC00002230

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-222-3p	Cisplatin 5702198       26676926 5-Fluorouracil 3385       25356050

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-222-3p
Interactor2: ZFP36

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.