Detail Information

Basic Information:


  VIRBase ID:  

HHID00049241

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-219a-5p:           TM9SF3:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-219a-5p TM9SF3
miRBase
Accession/Entrez ID		 MIMAT0000276 56889
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - EP70-P-iso//SMBP

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-219a-5p
rs1006626271 chr6:33207872    T/G
rs532850145 chr6:33207865    A/C
rs532850145 chr6:33207865    A/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR TM9SF3
chr10:98300788(-) A-I      intronic
chr10:98300785(-) A-I      intronic
chr10:98300794(-) A-I      intronic
chr10:98300793(-) A-I      intronic
chr10:98329677(-) A-I      intronic
chr10:98323987(-) A-I      intronic
chr10:98340218(-) A-I      intronic
chr10:98330623(-) A-I      intronic
chr10:98322887(-) A-I      intronic
chr10:98322956(-) A-I      intronic
chr10:98340083(-) A-I      intronic
chr10:98330768(-) A-I      intronic
chr10:98340207(-) A-I      intronic
chr10:98338622(-) A-I      intronic
chr10:98338665(-) A-I      intronic
chr10:98338671(-) A-I      intronic
chr10:98323927(-) A-I      intronic
chr10:98344403(-) A-I      intronic
chr10:98322961(-) A-I      intronic
chr10:98330751(-) A-I      intronic
chr10:98340204(-) A-I      intronic
chr10:98338715(-) A-I      intronic
chr10:98323981(-) A-I      intronic
chr10:98296651(-) A-I      intronic
chr10:98300777(-) A-I      intronic
chr10:98340290(-) A-I      intronic
chr10:98340194(-) A-I      intronic
chr10:98338751(-) A-I      intronic
chr10:98340228(-) A-I      intronic
chr10:98340226(-) A-I      intronic
chr10:98323997(-) A-I      intronic
chr10:98338788(-) A-I      intronic
chr10:98338661(-) A-I      intronic
chr10:98297494(-) A-I      intronic
chr10:98340161(-) A-I      intronic
chr10:98328826(-) A-I      intronic
chr10:98329689(-) A-I      intronic
chr10:98338676(-) A-I      intronic
chr10:98330635(-) A-I      intronic
chr10:98338777(-) A-I      intronic
chr10:98338722(-) A-I      intronic
chr10:98329626(-) A-I      intronic
chr10:98340056(-) A-I      intronic
chr10:98297506(-) A-I      intronic
chr10:98338667(-) A-I      intronic
chr10:98297473(-) A-I      intronic
chr10:98329546(-) A-I      intronic
chr10:98332390(-) A-I      intronic
chr10:98323937(-) A-I      intronic
chr10:98338653(-) A-I      intronic
chr10:98323271(-) A-I      intronic
chr10:98340187(-) A-I      intronic
chr10:98322971(-) A-I      intronic
chr10:98299011(-) A-I      intronic
chr10:98298985(-) A-I      intronic
chr10:98328845(-) A-I      intronic
chr10:98342664(-) A-I      intronic
chr10:98340287(-) A-I      intronic
chr10:98344409(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED TM9SF3
chr10:98320668(-) A-I intron -    22327324
chr10:98296691(-) A-I intron -    21960545
chr10:98296716(-) A-I intron -    21960545
chr10:98322971(-) A-I intron -    21960545
chr10:98323937(-) A-I intron -    21960545
chr10:98323997(-) A-I intron -    21960545
chr10:98338621(-) A-I intron -    21960545
chr10:98338712(-) A-I intron -    21960545
chr10:98338722(-) A-I intron -    21960545
chr10:98338777(-) A-I intron -    21960545
chr10:98322971(-) A-G intron -    22484847
chr10:98340161(-) A-G intron -    22484847
chr10:98343775(-) C-T intron -    22484847
chr10:98281484(-) T-C exon 3'UTR    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TM9SF3
chr10:98278050-98278051(-) m6A 3'UTR       24981863//22608085
chr10:98278075-98278076(-) m6A 3'UTR       24981863//22608085
chr10:98278106-98278107(-) m6A 3'UTR       24981863//22608085
chr10:98278149-98278150(-) m6A 3'UTR       22608085
chr10:98278157-98278158(-) m6A 3'UTR       22608085
chr10:98280601-98280602(-) m6A 3'UTR       -
chr10:98280623-98280624(-) m6A 3'UTR       -
chr10:98280646-98280647(-) m6A 3'UTR       -
chr10:98281033-98281034(-) Cm 3'UTR       -
chr10:98281112-98281113(-) m6A 3'UTR       26404942
chr10:98281319-98281320(-) m6A 3'UTR       26404942
chr10:98281367-98281368(-) m6A 3'UTR       26404942
chr10:98281394-98281395(-) m6A 3'UTR       26404942
chr10:98281529-98281530(-) m6A 3'UTR       26404942
chr10:98281659-98281660(-) m6A 3'UTR       26404942
chr10:98281708-98281709(-) m6A 3'UTR       24284625//26404942
chr10:98281731-98281732(-) m6A 3'UTR       24284625//22608085
chr10:98281755-98281756(-) m6A 3'UTR       24284625//22608085
chr10:98281951-98281952(-) m6A 3'UTR       24284625//25456834//24981863//28052920//26404942//27371828//22575960//22608085
chr10:98281966-98281967(-) m6A 3'UTR       24284625//25456834//24981863//28052920//26404942//27371828//22575960//22608085
chr10:98281999-98282000(-) m6A 3'UTR       24284625//25456834//24981863//28052920//26404942//27371828//22575960//22608085
chr10:98282006-98282007(-) m6A 3'UTR       24284625//25456834//24981863//28052920//26404942//27371828//22575960//22608085
chr10:98282016-98282017(-) m6A 3'UTR       24284625//25456834//24981863//28052920//26404942//27371828//22575960//22608085
chr10:98282066-98282067(-) m6A CDS//exon       24284625//24981863//26404942//27371828//22608085
chr10:98321836-98321837(-) m6A CDS//exon       26404942
chr10:98321847-98321848(-) m6A CDS//exon       26404942
chr10:98336381-98336382(-) m6A exon//intron       26404942
chr10:98336453-98336454(-) m6A CDS//exon       26404942//27773535
chr10:98336519-98336520(-) m6A CDS//exon       24209618//26404942//27773535
chr10:98337276-98337277(-) m6A exon//intron       24209618
chr10:98346496-98346497(-) m6A CDS//exon//intron       24209618//27371828//27773536
chr10:98346516-98346517(-) m6A CDS//intron       24209618//27371828//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-219a-5p
Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Exosome Brain tissue     23382797
Exosome Blood     -
Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Microvesicle Colon cancer cell line (LIM1863)|Mesenchymal stem cells|Urine     -
TM9SF3
Chromatin K562 cells     -
Cytosol K562 cells     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-219a-5p
Sensorad 99342 Drug sensitive
Curcumin 969516 Drug sensitive
Thiocyanic acid, 1H-purin-6-yl ester 96185 Drug sensitive
5-Iodo-8-quinolinol 96111 Drug sensitive
5-Fluorouridine 9427 Drug sensitive
4-(2-Pyridylazo)-N,N-dimethylaniline 81528 Drug sensitive
Edatrexate 6917908 Drug sensitive
Thioinosine 676166 Drug sensitive
Dihydroartemisinyl ether, stereoisomer of NSC-685989 6712439 Drug sensitive
Antineoplastic-301477 6711219 Drug sensitive
Rufigallol 65737 Drug sensitive
N-(6-Phenyl-1H-indazol-3-yl)cyclopropanecarboxamide 6539593 Drug sensitive
Thioguanosine 6419960 Drug sensitive
Verrucarin A 6326658 Drug sensitive
Cytarabine 6253 Drug sensitive
Artelasticin 5471311 Drug sensitive
[(1H-Benzimidazole-2-yl)dithio]-9H-purine 54613148 Drug sensitive
21-[2-(N,3,5(10),17(20)-Tetraen-3-ol citrate salt 54612678 Drug sensitive
2,10-Anthrylenedimethylene)-bis[2-thiopseudourea] dihydrochloride 54603799 Drug sensitive
Aspiculamycin hcl 54600418 Drug resistant
4-Cycloheptyl-N-(1-pyridin-2-ylethylideneamino)piperazine-1-carbothioamide 5351332 Drug sensitive
Hydroxy AT 125 5351254 Drug sensitive
Reumycin 5351216 Drug resistant
Spermine hydrochloride 5351186 Drug sensitive
Vorinostat 5311 Drug sensitive
6-Methoxy-7-(2lambda(5)-1,2-triazadienyl)-5,8-quinolinedione 494043 Drug sensitive
Mycophenolic acid 446541 Drug sensitive
[(1R,2S,3S,5R,6R,8S,10E,12R,13S,15R,16S,17R,18S)-18-Benzyl-6-hydroxy-6,8,15,16-tetramethyl-7,20-dioxo-4,14-dioxa-19-azapentacyclo[10.8.0.01,17.03,5.013,15]icos-10-en-2-yl] acetate 44559501 Drug sensitive
5-(Chloromethyl)quinolin-8-ol 416881 Drug sensitive
Asimicinone 393461 Drug sensitive
N-Hydroxy-N-methylpropanethioamide 371713 Drug sensitive
2,7-Dicyanoxanthone 363841 Drug resistant
Thiosangivamycin 3580213 Drug sensitive
Nordracorubin 341882 Drug sensitive
Buellolide 337850 Drug sensitive
Rocaglamide 331783 Drug sensitive
Rustaiyan A 324967 Drug sensitive
6-[(7-Nitro-2,1,3-benzoxadiazol-4-yl)sulfanyl]-7H-purin-2-amine 3246652 Drug sensitive
Ellipticine 3213 Drug sensitive
2,2',3,3'-Tetrahydroxy-1,1'-binaphthyl 316673 Drug sensitive
2-Chloro-3-(dodecylsulfanyl)-5,6-dimethoxycyclohexa-2,5-diene-1,4-dione 312122 Drug sensitive
Stannane, trimethyl[(4-morpholinylthioxomethyl)thio]- 300936 Drug sensitive
2-Hydroxy-4-((2,4,6-triamino-5-pyrimidinyl)diazenyl)phenylarsonic acid 272658 Drug sensitive
D-Arabinose, 5-O-trityl-tribenzoate 265952 Drug sensitive
4-Benzoyl-3H-benzo[f]quinoline-3-carbonitrile 262649 Drug sensitive
Haterumalide NA methyl esters 24204452 Drug resistant
cis-3-O-p-Hydroxycinnamoyl ursolic acid 24203732 Drug sensitive
1-(3-Bromo-phenyl)-3-(pyridin-2-ylsulfanyl)-propenone 24203485 Drug sensitive
6-(Hexynyl)-2(2H)-pyranone 24203137 Drug sensitive
Antibiotic U 29135 24196291 Drug sensitive
Mepacrine mustard dihydrochloride 24180972 Drug sensitive
8-Hydroxyquinoline 1923 Drug sensitive
Sudan II 18386 Drug sensitive
8-Chloro-cyclicamp 17856967 Drug sensitive
Dihydroartemisinin (mixture of alpha and beta isomers) 16399850 Drug sensitive
Antineoplastic-633273 15954131 Drug sensitive
[(1R,2R,4R,6E,9R,10S)-2,7-Dimethyl-5,8,14-trioxo-10-prop-1-en-2-yl-15-oxatricyclo[11.2.1.02,4]hexadeca-6,13(16)-dien-9-yl] acetate 15384977 Drug sensitive
Ellipticine analog 148569 Drug sensitive
8-Chloroadenosine 147569 Drug sensitive
(1S,3S,6'R,7S,15R,16R,17S,18R,19R,20S,21R,22E,26S,28R,30R)-17-[(2S,5S,6S)-5-(Dimethylamino)-6-methyloxan-2-yl]oxy-3,15,16,18,20,21-hexahydroxy-6'-[(2R)-2-hydroxybutyl]-5,5,15,19,21,30-hexamethylspiro[4,25,29-trioxatricyclo[24.3.1.03,7]triaconta-8,22-diene-28,2'-oxane]-24-one 139583769 Drug sensitive
(1R,6R,13S)-16,17-Dimethoxy-6-propan-2-yl-2,7,20-trioxapentacyclo[11.8.0.03,11.04,8.014,19]henicosa-3(11),4(8),9,14,16,18-hexaen-12-one 13845974 Drug sensitive
12-Iminodaunorubicin hcl 135539784 Drug sensitive
7-Nitro-1,2,4-benzotriazin-3-amine 1,4-dioxide 135427573 Drug sensitive
Inosine dialdehyde 135400916 Drug sensitive
Terpentecin 127568 Drug sensitive
Piperidinium europium benzoyl trifluoroacetonate 11979537 Drug sensitive
15,16-Dihydrocuracin A 101683509 Drug sensitive
(3S,6S)-1,4-Dimethyl-3,6-bis[(2R)-3,3,3-trichloro-2-methylpropyl]piperazine-2,5-dione 101425118 Drug sensitive
Chimaphilin 101211 Drug sensitive
Tocladesine 100299 Drug sensitive
(1R,2E,6R,10E,11aS,13S,14aR)-1,13-dihydroxy-6-(2-methoxyethyl)-6,7,8,9,12,13,14,14a-octahydro-1H-cyclopenta[f][1]oxacyclotridecin-4(11aH)-one - Drug resistant
2,3-dihydro-1,2-syn-3-[phenylseleno]brefeldin a - Drug resistant
(Z)-5-chloro-3-((1-(3,5-dimethoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methylene)indolin-2-one - Drug sensitive
1,2,3-thiadiazole, 5-[(4-chlorophenyl)sulfonyl]-4-phenyl- - Drug sensitive
1,8-octanediamine, n,n'-di-9-acridinyl- (9ci) - Drug sensitive
1h-benzimidazole, 5,5'-dithiobis[2-(trifluoromethyl)- (9ci) - Drug sensitive
1h-benzo[a]carbazole-1,4(11h)-dione, 11-phenyl- - Drug sensitive
2h-naphtho[1,2-b]pyran-2-one, 9-hydroxy-4-phenyl- - Drug sensitive
6-hydroxymethyl-1,3,8-trihydroxyanthraquinone - Drug sensitive
7-benzyl-5,7-dihydro-4h-isoxazolo[5,4-e]isoindole - Drug sensitive
9h-purine, 2-amino-6-(2,4-dichlorobenzylthio)-9-isobutyl- - Drug sensitive
9h-quino[4,3,2-de][1,10]phenanthrolin-9-one, 2-methyl- - Drug sensitive
aceanthryleno[1,2-b]quinoxaline, 12-nitro- - Drug sensitive
benzofurazan, 4-nitro-7-(2-pyridinylthio)-, n-oxide - Drug sensitive
bersaldegenin 1,3,5-orthoacetate - Drug sensitive
cyclohexanone, 2,6-bis(piperidinomethyl)- - Drug sensitive
ethyl-2,3-oxido-(5-bromo-2-methoxyphenyl)propionate - Drug sensitive
guanosine, 6-thio-, platinum complex (9ci) - Drug sensitive
l-cysteine, s-[(4-methylphenyl)diphenylmethyl]- (9ci) - Drug sensitive
n,n'-di-9-acridinyl-1,6-hexanediamine - Drug sensitive
sulfide, 2,4-dinitrophenyl 2-nitro-p-tolyl - Drug sensitive
thiourea, n-(1-ethylpropyl)-n'-[(2-thienyl)thioxomethyl]- - Drug sensitive
tris(1,3-diphenylpropane-1,3-dionata)gallium(iii) - Drug sensitive
10-hydroxy-scandine - Drug sensitive
antineoplastic-641297 - Drug sensitive
Indenoisoquinoline derivative - Drug sensitive
largomycin f-ii - Drug sensitive
leucinostatine d - Drug sensitive
n-myristoyl-(s)-phenylalaninal diethylcetal - Drug sensitive
streptorubrin - Drug sensitive
trans-4-{4-[3-(4-chloro-3-trifluoromethyl-phenyl)-ureido]-cyclohexyloxy}-pyridine-2-carboxylic acid methylamide - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-219a-5p
Ethanol 702 Drug interaction    RC00002152
Eloxatine 5310940 Drug interaction    RC00002156
5-Fluorouracil 3385 Drug interaction    RC00002154
Doxorubicin 31703 Drug interaction    RC00002155
Verapamil 2520 Drug interaction    RC00002153
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-219a-5p
Cisplatin 5702198       30999114

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-219a-5p
Interactor2: TM9SF3

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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