Basic Information:

  VIRBase ID:  

HHID00049084

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-214-3p:  MIMAT0000271          PIM1:  NM_002648     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-214-3p	PIM1
miRBase Accession/Entrez ID	MIMAT0000271	5292
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	PIM

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-214-3p	rs1484050967 chr1:172138816    A/G rs1484050967 chr1:172138816    A/T rs760725207 chr1:172138828    T/C rs766486759 chr1:172138829    G/A rs767404661 chr1:172138817    C/T rs750386761 chr1:172138827    G/A rs754055278 chr1:172138831    C/T

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PIM1	chr6:37138982-37138983(+) m6A CDS       24284625 chr6:37141970-37141971(+) m6A 3'UTR//exon       24284625//24209618//24981863//22608085 chr6:37141988-37141989(+) m6A 3'UTR//exon       24284625//24209618//24981863//22608085 chr6:37142129-37142130(+) m6A 3'UTR       24284625//24209618//25456834//24981863 chr6:37142171-37142172(+) m6A 3'UTR       24284625//25456834//24981863 chr6:37142184-37142185(+) m6A 3'UTR       24284625//25456834//24981863 chr6:37142241-37142242(+) m6A 3'UTR       25456834//24981863 chr6:37142261-37142262(+) m6A 3'UTR       25456834 chr6:37142322-37142323(+) m6A 3'UTR       24284625 chr6:37142351-37142352(+) m6A 3'UTR       24284625

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-214-3p	Cytoplasm Nasopharyngeal carcinoma cells     20498841 Exosome Primary ovarian tumor cells|Serum     18589210 Exosome Plasma     19289371 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Follicular fluid     23666971 Microvesicle Fibroblasts|Mesenchymal stem cells     - Mitochondrion Skeletal muscle myoblasts     21637849 Nucleus Nasopharyngeal carcinoma cells     20498841
	PIM1	Chromatin K562 cells     - Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Membrane K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome-free cytosol Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-214-3p	Gemcitabine 60750 Drug interaction    RC00002087 Vincristine 5978 Drug interaction    RC00002082 Prednisone 5865 Drug interaction    RC00002081 Sunitinib 5329102 Drug interaction    RC00002093 Eloxatine 5310940 Drug interaction    RC00002092 Imatinib 5291 Drug interaction    RC00002080 Decitabine 451668 Drug interaction    RC00002091 Trichostatin A 444732 Drug interaction    RC00002090 Naringin 442428 Drug interaction    RC00002089 Desflurane 42113 Drug interaction    RC00002086 Isoflurane 3763 Drug interaction    RC00002079 Paclitaxel 36314 Drug interaction    RC00002085 Doxorubicin 31703 Drug interaction    RC00002084 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00002078 Verapamil 2520 Drug interaction    RC00002077 Arsenic trioxide 14888 Drug interaction    RC00002083 Gefitinib 123631 Drug interaction    RC00002088 5-aza-2'-deoxycytidine (5-Aza-CdR) + trichostatin A(TSA) - Drug interaction    RC00002094 Bio-Oss - Drug interaction    RC00002095 DNA methyltransferases (DNMTs) + 5-azacytidine (5-AzaC) - Drug interaction    RC00002096 Glucocorticoid - Drug interaction    RC00002097

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-214-3p	Cisplatin 5702198       29036598

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-214-3p
Interactor2: PIM1

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.