Basic Information:

  VIRBase ID:  

HHID00049054

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-181a-3p:  MIMAT0000270          CARM1:  NM_001370088     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-181a-3p	CARM1
miRBase Accession/Entrez ID	MIMAT0000270	10498
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	PRMT4

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-181a-3p	rs1246145417 chr1:198859081    G/A rs759769471 chr1:198859080    C/T rs770221900 chr1:198859082    G/A rs777206553 chr1:198859069    G/A rs777206553 chr1:198859069    G/C rs777206553 chr1:198859069    G/T rs936759263 chr1:198859075    A/G rs1179420328 chr1:198859084    C/T rs1381340677 chr1:198859087    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CARM1	chr19:11028988(+) A-I      intronic chr19:11028940(+) A-I      intronic chr19:11029002(+) A-I      intronic chr19:11029043(+) A-I      intronic chr19:11021750(+) A-I      intronic chr19:11021732(+) A-I      intronic chr19:11021767(+) A-I      intronic chr19:11021859(+) A-I      intronic chr19:11027975(+) A-I      intronic chr19:11028918(+) A-I      intronic chr19:11029037(+) A-I      intronic chr19:11028573(+) A-I      intronic chr19:11028563(+) A-I      intronic chr19:11028562(+) A-I      intronic chr19:11024195(+) A-I      intronic chr19:11024146(+) A-I      intronic chr19:11023860(+) A-I      intronic chr19:11021636(+) A-I      intronic chr19:11021618(+) A-I      intronic chr19:11021306(+) A-I      intronic chr19:11021305(+) A-I      intronic chr19:11021303(+) A-I      intronic chr19:11021301(+) A-I      intronic chr19:11021036(+) A-I      intronic chr19:11021030(+) A-I      intronic chr19:11020992(+) A-I      intronic chr19:11020988(+) A-I      intronic chr19:11020898(+) A-I      intronic chr19:11020897(+) A-I      intronic chr19:11020879(+) A-I      intronic chr19:11020319(+) A-I      intronic chr19:11020229(+) A-I      intronic chr19:10986347(+) A-I      intronic chr19:10985621(+) A-I      intronic chr19:10986817(+) A-I      intronic chr19:10986802(+) A-I      intronic chr19:10994615(+) A-I      intronic chr19:10994644(+) A-I      intronic chr19:10995480(+) A-I      intronic chr19:10995481(+) A-I      intronic chr19:10995510(+) A-I      intronic chr19:10995517(+) A-I      intronic chr19:10995591(+) A-I      intronic chr19:10996802(+) A-I      intronic chr19:10996807(+) A-I      intronic chr19:10996832(+) A-I      intronic chr19:10996833(+) A-I      intronic chr19:10997072(+) A-I      intronic chr19:10997119(+) A-I      intronic chr19:10986307(+) A-I      intronic chr19:10986218(+) A-I      intronic chr19:10986181(+) A-I      intronic chr19:10986157(+) A-I      intronic chr19:10986150(+) A-I      intronic chr19:10986120(+) A-I      intronic chr19:10985687(+) A-I      intronic chr19:10997248(+) A-I      intronic chr19:10985545(+) A-I      intronic chr19:10985342(+) A-I      intronic chr19:10997249(+) A-I      intronic chr19:10998380(+) A-I      intronic chr19:11001620(+) A-I      intronic chr19:11005995(+) A-I      intronic chr19:11006016(+) A-I      intronic chr19:11011489(+) A-I      intronic chr19:11011496(+) A-I      intronic chr19:11011499(+) A-I      intronic chr19:11011541(+) A-I      intronic chr19:11011558(+) A-I      intronic chr19:11011621(+) A-I      intronic chr19:11011732(+) A-I      intronic chr19:11011737(+) A-I      intronic chr19:11011761(+) A-I      intronic chr19:11012341(+) A-I      intronic chr19:11012403(+) A-I      intronic chr19:11012416(+) A-I      intronic chr19:11012437(+) A-I      intronic chr19:11012471(+) A-I      intronic chr19:11012613(+) A-I      intronic chr19:11012664(+) A-I      intronic chr19:11012769(+) A-I      intronic chr19:11012770(+) A-I      intronic chr19:10984050(+) A-I      intronic chr19:10984092(+) A-I      intronic chr19:10984111(+) A-I      intronic chr19:10984186(+) A-I      intronic chr19:10984445(+) A-I      intronic chr19:10984452(+) A-I      intronic chr19:10984500(+) A-I      intronic chr19:10984502(+) A-I      intronic chr19:10984514(+) A-I      intronic chr19:10984842(+) A-I      intronic chr19:10985079(+) A-I      intronic chr19:10985087(+) A-I      intronic chr19:10985181(+) A-I      intronic chr19:10985198(+) A-I      intronic chr19:10985205(+) A-I      intronic chr19:10985338(+) A-I      intronic chr19:11013402(+) A-I      intronic chr19:11013495(+) A-I      intronic chr19:11013507(+) A-I      intronic chr19:11013508(+) A-I      intronic chr19:11019996(+) A-I      intronic chr19:11011477(+) A-I      intronic chr19:10994609(+) A-I      intronic chr19:10994532(+) A-I      intronic chr19:10994529(+) A-I      intronic chr19:10994523(+) A-I      intronic chr19:10994508(+) A-I      intronic chr19:10994493(+) A-I      intronic chr19:10994484(+) A-I      intronic chr19:10994465(+) A-I      intronic chr19:10994438(+) A-I      intronic chr19:10994419(+) A-I      intronic chr19:10994409(+) A-I      intronic chr19:10994382(+) A-I      intronic chr19:10994330(+) A-I      intronic chr19:10993427(+) A-I      intronic chr19:10993418(+) A-I      intronic chr19:10993271(+) A-I      intronic chr19:10993269(+) A-I      intronic chr19:10991794(+) A-I      intronic chr19:10991767(+) A-I      intronic chr19:10991696(+) A-I      intronic chr19:10991693(+) A-I      intronic chr19:10991568(+) A-I      intronic chr19:10991213(+) A-I      intronic chr19:10991115(+) A-I      intronic chr19:10991061(+) A-I      intronic chr19:10990583(+) A-I      intronic chr19:10990525(+) A-I      intronic chr19:10990520(+) A-I      intronic chr19:10990415(+) A-I      intronic chr19:10990375(+) A-I      intronic chr19:10988336(+) A-I      intronic chr19:10986970(+) A-I      intronic chr19:10990390(+) A-I      intronic chr19:11011825(+) A-I      intronic chr19:11028950(+) A-I      intronic chr19:11011566(+) A-I      intronic chr19:11023898(+) A-I      intronic chr19:11010866(+) A-I      intronic chr19:11021502(+) A-I      intronic chr19:11024026(+) A-I      intronic chr19:11028552(+) A-I      intronic chr19:11021165(+) A-I      intronic chr19:10984177(+) A-I      intronic chr19:10985290(+) A-I      intronic chr19:10984074(+) A-I      intronic chr19:11013167(+) A-I      intronic chr19:10997360(+) A-I      intronic chr19:10984060(+) A-I      intronic chr19:11028494(+) A-I      intronic chr19:11027885(+) A-I      intronic chr19:10996619(+) A-I      intronic chr19:10990423(+) A-I      intronic chr19:11027976(+) A-I      intronic chr19:11021425(+) A-I      intronic chr19:10994859(+) A-I      intronic chr19:10994809(+) A-I      intronic chr19:11028650(+) A-I      intronic chr19:10994972(+) A-I      intronic chr19:10988178(+) A-I      intronic chr19:10993311(+) A-I      intronic chr19:10997342(+) A-I      intronic chr19:11020875(+) A-I      intronic chr19:10985167(+) A-I      intronic chr19:10995131(+) A-I      intronic chr19:10993249(+) A-I      intronic chr19:11023881(+) A-I      intronic chr19:11012363(+) A-I      intronic chr19:11021359(+) A-I      intronic chr19:11013050(+) A-I      intronic chr19:10988155(+) A-I      intronic chr19:11021514(+) A-I      intronic chr19:10991585(+) A-I      intronic chr19:11005955(+) A-I      intronic chr19:10994534(+) A-I      intronic chr19:11013542(+) A-I      intronic chr19:11000742(+) A-I      intronic chr19:11029179(+) A-I      intronic chr19:10995547(+) A-I      intronic chr19:11027929(+) A-I      intronic chr19:11021145(+) A-I      intronic chr19:10991633(+) A-I      intronic chr19:11028513(+) A-I      intronic chr19:11029695(+) A-I      intronic chr19:11029038(+) A-I      intronic chr19:10994763(+) A-I      intronic chr19:10991091(+) A-I      intronic chr19:10995082(+) A-I      intronic chr19:10985277(+) A-I      intronic chr19:11029041(+) A-I      intronic chr19:11012419(+) A-I      intronic chr19:11001273(+) A-I      intronic chr19:10984171(+) A-I      intronic chr19:11013458(+) A-I      intronic chr19:10993452(+) A-I      intronic chr19:11020946(+) A-I      intronic chr19:11027908(+) A-I      intronic chr19:11027668(+) A-I      intronic chr19:11028568(+) A-I      intronic chr19:10984420(+) A-I      intronic chr19:10993423(+) A-I      intronic chr19:11013192(+) A-I      intronic chr19:10991793(+) A-I      intronic chr19:10985539(+) A-I      intronic chr19:11005981(+) A-I      intronic chr19:11028455(+) A-I      intronic chr19:11029104(+) A-I      intronic chr19:10997009(+) A-I      intronic chr19:11010619(+) A-I      intronic chr19:10985537(+) A-I      intronic chr19:11029027(+) A-I      intronic chr19:10994333(+) A-I      intronic chr19:11028143(+) A-I      intronic chr19:11024155(+) A-I      intronic chr19:10985288(+) A-I      intronic chr19:11012867(+) A-I      intronic chr19:10984577(+) A-I      intronic chr19:10990416(+) A-I      intronic chr19:10993383(+) A-I      intronic chr19:10997448(+) A-I      intronic chr19:11027681(+) A-I      intronic chr19:11029072(+) A-I      intronic chr19:11021667(+) A-I      intronic chr19:11012418(+) A-I      intronic chr19:11028920(+) A-I      intronic chr19:11023979(+) A-I      intronic chr19:11011880(+) A-I      intronic chr19:11010538(+) A-I      intronic chr19:11028571(+) A-I      intronic chr19:11011758(+) A-I      intronic chr19:11023867(+) A-I      intronic chr19:11020195(+) A-I      intronic chr19:11001141(+) A-I      intronic chr19:11021836(+) A-I      intronic chr19:11027687(+) A-I      intronic chr19:11012718(+) A-I      intronic chr19:10985168(+) A-I      intronic chr19:11011722(+) A-I      intronic chr19:11029019(+) A-I      intronic chr19:10985620(+) A-I      intronic chr19:10997370(+) A-I      intronic chr19:11000821(+) A-I      intronic chr19:10985483(+) A-I      intronic chr19:11010841(+) A-I      intronic chr19:11012496(+) A-I      intronic chr19:11023845(+) A-I      intronic chr19:11029741(+) A-I      intronic chr19:11021170(+) A-I      intronic chr19:11028468(+) A-I      intronic chr19:10985555(+) A-I      intronic chr19:11012866(+) A-I      intronic chr19:11012481(+) A-I      intronic chr19:11008922(+) A-I      intronic chr19:10994329(+) A-I      intronic chr19:10985289(+) A-I      intronic chr19:10993317(+) A-I      intronic chr19:11029133(+) A-I      intronic chr19:11010751(+) A-I      intronic chr19:10993446(+) A-I      intronic chr19:11021590(+) A-I      intronic chr19:10994316(+) A-I      intronic chr19:10994804(+) A-I      intronic chr19:11012510(+) A-I      intronic chr19:10994866(+) A-I      intronic chr19:10995381(+) A-I      intronic chr19:11012811(+) A-I      intronic chr19:10994252(+) A-I      intronic chr19:10985547(+) A-I      intronic chr19:11021371(+) A-I      intronic chr19:10985227(+) A-I      intronic chr19:10997045(+) A-I      intronic chr19:11023861(+) A-I      intronic chr19:11011839(+) A-I      intronic chr19:11023957(+) A-I      intronic chr19:10991691(+) A-I      intronic chr19:11029028(+) A-I      intronic chr19:10984083(+) A-I      intronic chr19:10984110(+) A-I      intronic chr19:11027987(+) A-I      intronic chr19:10984093(+) A-I      intronic chr19:11021487(+) A-I      intronic chr19:11021501(+) A-I      intronic chr19:10984094(+) A-I      intronic chr19:10994897(+) A-I      intronic chr19:10988701(+) A-I      intronic chr19:11012799(+) A-I      intronic chr19:10990500(+) A-I      intronic chr19:11021787(+) A-I      intronic chr19:11028463(+) A-I      intronic chr19:10991277(+) A-I      intronic chr19:10994769(+) A-I      intronic chr19:10996999(+) A-I      intronic chr19:10985538(+) A-I      intronic chr19:11029031(+) A-I      intronic chr19:10993481(+) A-I      intronic chr19:11024093(+) A-I      intronic chr19:10998341(+) A-I      intronic chr19:10985629(+) A-I      intronic chr19:11012854(+) A-I      intronic chr19:10994334(+) A-I      intronic chr19:10985540(+) A-I      intronic chr19:11010577(+) A-I      intronic chr19:10991721(+) A-I      intronic chr19:11003853(+) A-I      intronic chr19:11012579(+) A-I      intronic chr19:10985348(+) A-I      intronic chr19:11021598(+) A-I      intronic chr19:11010581(+) A-I      intronic chr19:11028649(+) A-I      intronic chr19:11012557(+) A-I      intronic chr19:10993298(+) A-I      intronic chr19:11012665(+) A-I      intronic chr19:11028548(+) A-I      intronic chr19:10991781(+) A-I      intronic chr19:10985179(+) A-I      intronic chr19:11013044(+) A-I      intronic chr19:10984396(+) A-I      intronic chr19:11010857(+) A-I      intronic chr19:11021841(+) A-I      intronic chr19:11012431(+) A-I      intronic chr19:11029082(+) A-I      intronic chr19:10985639(+) A-I      intronic chr19:11027930(+) A-I      intronic chr19:10985129(+) A-I      intronic chr19:11020302(+) A-I      intronic chr19:10985536(+) A-I      intronic chr19:10985256(+) A-I      intronic chr19:11001257(+) A-I      intronic chr19:11018214(+) A-I      intronic chr19:11012574(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CARM1	chr19:11015664(+) A-I exon CDS    19478186 chr19:10984083(+) A-G intron -    22484847 chr19:10984084(+) A-G intron -    22484847 chr19:10984093(+) A-G intron -    22484847 chr19:10984094(+) A-G intron -    22484847 chr19:10985688(+) A-G intron -    22484847 chr19:11020415(+) A-C intron -    22484847 chr19:11027663(+) A-G intron -    22484847 chr19:11027908(+) A-G intron -    22484847 chr19:11027929(+) A-G intron -    22484847 chr19:11027976(+) A-G intron -    22484847 chr19:11028424(+) T-C intron -    22484847 chr19:11028920(+) A-G intron -    22484847 chr19:11029104(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CARM1	chr19:10982571-10982572(+) m6A CDS       24209618//22575960 chr19:11015667-11015668(+) m6A CDS//intron       22575960 chr19:11029692-11029693(+) m6A exon//intron       27773535 chr19:11029979-11029980(+) m6A exon//intron       27773535 chr19:11030623-11030624(+) Y 3'UTR//CDS//exon       26075521 chr19:11031223-11031224(+) m6A 3'UTR//CDS//exon//intron       22575960 chr19:11031369-11031370(+) m6A 3'UTR//CDS//exon       22575960 chr19:11031374-11031375(+) m6A 3'UTR//CDS//exon       22575960 chr19:11031411-11031412(+) m6A 3'UTR//CDS//exon       22575960 chr19:11032448-11032449(+) m6A 3'UTR//exon       24284625//24981863//22575960 chr19:11032465-11032466(+) m6A 3'UTR//exon       24284625//24981863//22575960 chr19:11032531-11032532(+) m6A 3'UTR//exon       24284625//24981863//22575960 chr19:11032562-11032563(+) m6A 3'UTR//exon       24284625//24981863//22575960 chr19:11032568-11032569(+) m6A 3'UTR//exon       24284625//24981863//22575960 chr19:11032726-11032727(+) m6A 3'UTR       24284625 chr19:11032901-11032902(+) m6A 3'UTR       - chr19:11032919-11032920(+) m6A 3'UTR       - chr19:11032971-11032972(+) m6A 3'UTR       - chr19:11033226-11033227(+) m6A 3'UTR       - chr19:11033232-11033233(+) m6A 3'UTR       - chr19:11033372-11033373(+) m6A 3'UTR       - chr19:11033383-11033384(+) m6A 3'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-181a-3p	Exosome Jurkat-derived T cell line (J77cl20)     21505438 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome B lymphoblastoid cells|Endothelial cells|Lymphoma tissue     - Microvesicle Cerebrospinal fluid     24797360 Microvesicle Fibroblasts|Mesenchymal stem cells     - Mitochondrion Skeletal muscle myoblasts     21637849
	CARM1	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleolus K562 cells     - Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-181a-3p	Curcumin 969516 Drug interaction    RC00002074 Gemcitabine 60750 Drug interaction    RC00002071 Temozolomide 5394 Drug interaction    RC00002068 4-Hydroxynonenal 5283344 Drug interaction    RC00002076 Diethylstilbestrol 448537 Drug interaction    RC00002073 Paclitaxel 36314 Drug interaction    RC00002070 Doxorubicin 31703 Drug interaction    RC00002069 Tamoxifen 2733526 Drug interaction    RC00002075 Gefitinib 123631 Drug interaction    RC00002072

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-181a-3p	Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-181a-3p
Interactor2: CARM1

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.