Detail Information

Basic Information:


  VIRBase ID:  

HHID00049044

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-181a-3p:           KRAS:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-181a-3p KRAS
miRBase
Accession/Entrez ID		 MIMAT0000270 3845
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - 'C-K-RAS//C-K-RAS//c-Ki-ras//c-Ki-ras2//CFC2//K-Ras//K-Ras 2//K-RAS2A//K-RAS2B//K-RAS4A//K-RAS4B//KI-RAS//KRAS1//KRAS2//NS//NS3//OES//RALD//RASK2

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-181a-3p
rs1246145417 chr1:198859081    G/A
rs759769471 chr1:198859080    C/T
rs770221900 chr1:198859082    G/A
rs777206553 chr1:198859069    G/A
rs777206553 chr1:198859069    G/C
rs777206553 chr1:198859069    G/T
rs936759263 chr1:198859075    A/G
rs1179420328 chr1:198859084    C/T
rs1381340677 chr1:198859087    T/C

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR KRAS
chr12:25364397(-) A-I      intronic
chr12:25384258(-) A-I      intronic
chr12:25384200(-) A-I      intronic
chr12:25372046(-) A-I      intronic
chr12:25384290(-) A-I      intronic
chr12:25374360(-) A-I      intronic
chr12:25384190(-) A-I      intronic
chr12:25374361(-) A-I      intronic
chr12:25384240(-) A-I      intronic
chr12:25374327(-) A-I      intronic
chr12:25372011(-) A-I      intronic
chr12:25374275(-) A-I      intronic
chr12:25384234(-) A-I      intronic
chr12:25372052(-) A-I      intronic
chr12:25372051(-) A-I      intronic
chr12:25372048(-) A-I      intronic
chr12:25372037(-) A-I      intronic
chr12:25372042(-) A-I      intronic
chr12:25372043(-) A-I      intronic
chr12:25383424(-) A-I      intronic
chr12:25383462(-) A-I      intronic
chr12:25374331(-) A-I      intronic
chr12:25383413(-) A-I      intronic
chr12:25383360(-) A-I      intronic
chr12:25382978(-) A-I      intronic
chr12:25382867(-) A-I      intronic
chr12:25382827(-) A-I      intronic
chr12:25381858(-) A-I      intronic
chr12:25374975(-) A-I      intronic
chr12:25384132(-) A-I      intronic
chr12:25401045(-) A-I      intronic
chr12:25401203(-) A-I      intronic
chr12:25365438(-) A-I      intronic
chr12:25374971(-) A-I      intronic
chr12:25383515(-) A-I      intronic
chr12:25370746(-) A-I      intronic
chr12:25381830(-) A-I      intronic
chr12:25372001(-) A-I      intronic
chr12:25374258(-) A-I      intronic
chr12:25383499(-) A-I      intronic
chr12:25374264(-) A-I      intronic
chr12:25381750(-) A-I      intronic
chr12:25382964(-) A-I      intronic
chr12:25382915(-) A-I      intronic
chr12:25374961(-) A-I      intronic
chr12:25370728(-) A-I      intronic
chr12:25383418(-) A-I      intronic
chr12:25382779(-) A-I      intronic
chr12:25383510(-) A-I      intronic
chr12:25402183(-) A-I      intronic
chr12:25369459(-) A-I      intronic
chr12:25399380(-) A-I      intronic
chr12:25374252(-) A-I      intronic
chr12:25370742(-) A-I      intronic
chr12:25365781(-) A-I      intronic
chr12:25381735(-) A-I      intronic
chr12:25371969(-) A-I      intronic
chr12:25370776(-) A-I      intronic
chr12:25374400(-) A-I      intronic
chr12:25374342(-) A-I      intronic
chr12:25383306(-) A-I      intronic
chr12:25374234(-) A-I      intronic
chr12:25383493(-) A-I      intronic
chr12:25383365(-) A-I      intronic
chr12:25369311(-) A-I      intronic
chr12:25374263(-) A-I      intronic
chr12:25384160(-) A-I      intronic
chr12:25365830(-) A-I      intronic
chr12:25369468(-) A-I      intronic
chr12:25365829(-) A-I      intronic
chr12:25374304(-) A-I      intronic
chr12:25364479(-) A-I      intronic
chr12:25374395(-) A-I      intronic
chr12:25365845(-) A-I      intronic
chr12:25365441(-) A-I      intronic
chr12:25365803(-) A-I      intronic
chr12:25365735(-) A-I      intronic
chr12:25382886(-) A-I      intronic
chr12:25384213(-) A-I      intronic
chr12:25382928(-) A-I      intronic
chr12:25384174(-) A-I      intronic
chr12:25374256(-) A-I      intronic
chr12:25374423(-) A-I      intronic
chr12:25383480(-) A-I      intronic
chr12:25384289(-) A-I      intronic
chr12:25365741(-) A-I      intronic
chr12:25381825(-) A-I      intronic
chr12:25373896(-) A-I      intronic
chr12:25374290(-) A-I      intronic
chr12:25365415(-) A-I      intronic
chr12:25365746(-) A-I      intronic
chr12:25370828(-) A-I      intronic
chr12:25382935(-) A-I      intronic
chr12:25383479(-) A-I      intronic
chr12:25374935(-) A-I      intronic
chr12:25374371(-) A-I      intronic
chr12:25369347(-) A-I      intronic
chr12:25384184(-) A-I      intronic
chr12:25374340(-) A-I      intronic
chr12:25374895(-) A-I      intronic
chr12:25401160(-) A-I      intronic
chr12:25384248(-) A-I      intronic
chr12:25381776(-) A-I      intronic
chr12:25374372(-) A-I      intronic
chr12:25364422(-) A-I      intronic
chr12:25401321(-) A-I      intronic
chr12:25383557(-) A-I      intronic
chr12:25383559(-) A-I      intronic
chr12:25374295(-) A-I      intronic
chr12:25372145(-) A-I      intronic
chr12:25401161(-) A-I      intronic
chr12:25382940(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED KRAS
chr12:25365741(-) A-I intron -    21960545   //22327324
chr12:25365781(-) A-I intron -    21960545   //22327324
chr12:25365415(-) A-I intron -    21960545
chr12:25365416(-) A-I intron -    21960545
chr12:25365829(-) A-I intron -    21960545
chr12:25365830(-) A-I intron -    21960545
chr12:25365833(-) A-I intron -    21960545
chr12:25369307(-) A-I intron -    21960545
chr12:25369341(-) A-I intron -    21960545
chr12:25369347(-) A-I intron -    21960545
chr12:25370623(-) A-I intron -    21960545
chr12:25370728(-) A-I intron -    21960545
chr12:25370746(-) A-I intron -    21960545
chr12:25370776(-) A-I intron -    21960545
chr12:25370828(-) A-I intron -    21960545
chr12:25382901(-) A-I intron -    21960545
chr12:25383306(-) A-I intron -    21960545
chr12:25383424(-) A-I intron -    21960545
chr12:25383557(-) A-I intron -    21960545
chr12:25360448(-) G-T exon 3'UTR    22484847
chr12:25360449(-) G-T exon 3'UTR    22484847
chr12:25365741(-) A-G intron -    22484847
chr12:25365781(-) A-G intron -    22484847
chr12:25365958(-) T-C intron -    22484847
chr12:25374244(-) T-C intron -    22484847
chr12:25382928(-) A-G intron -    22484847
chr12:25382935(-) A-G intron -    22484847
chr12:25383480(-) A-G intron -    22484847
chr12:25369303(-) T-C intron -    22484847
chr12:25370828(-) A-G intron -    22484847
chr12:25372145(-) A-G intron -    22484847
chr12:25374395(-) A-G intron -    22484847
chr12:25374400(-) A-G intron -    22484847
chr12:25374423(-) A-G intron -    22484847
chr12:25374895(-) A-G intron -    22484847
chr12:25382780(-) T-C intron -    22484847
chr12:25383365(-) A-G intron -    22484847
chr12:25383479(-) A-G intron -    22484847
chr12:25383493(-) A-G intron -    22484847
chr12:25383510(-) A-G intron -    22484847
chr12:25384160(-) A-G intron -    22484847
chr12:25384184(-) A-G intron -    22484847
chr12:25401160(-) A-G intron -    22484847
chr12:25401161(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase KRAS
chr12:25362748-25362749(-) m6A 3'UTR//CDS       24981863//27773535
chr12:25362800-25362801(-) m6A 3'UTR//CDS       24981863//27773535//27371828
chr12:25368415-25368416(-) m6A CDS//intron       27773535//27371828
chr12:25378550-25378551(-) m6A CDS//intron       24981863//27773535//27371828//22608085
chr12:25378555-25378556(-) m6A CDS//intron       24981863//27773535//27371828//22608085
chr12:25378567-25378568(-) m6A CDS//intron       24981863//27773535//27371828//22608085
chr12:25378602-25378603(-) m6A CDS//intron       24981863//27773535//27371828//22608085
chr12:25378613-25378614(-) m6A CDS//intron       24981863//27773535//27371828//22608085
chr12:25378620-25378621(-) m6A CDS//intron       24981863//27773535//27371828//22608085
chr12:25378627-25378628(-) m6A CDS//intron       24981863//27773535//27371828//22608085
chr12:25378683-25378684(-) m6A CDS//intron       24981863//27773535//27371828//22608085
chr12:25378703-25378704(-) m6A CDS//intron       24981863//27773535//27371828//22608085
chr12:25380237-25380238(-) m6A CDS//intron       24981863//26404942//27773535
chr12:25380251-25380252(-) m6A CDS//intron       24981863//26404942//27773535
chr12:25380309-25380310(-) m6A CDS//intron       24981863//26404942//27773535
chr12:25387487-25387488(-) m6A 3'UTR//intron       27773535
chr12:25387524-25387525(-) m6A 3'UTR//intron       27773535
chr12:25398303-25398304(-) m6A CDS       24209618//27371828
chr12:25403761-25403762(-) m6A 5'UTR       24209618//24981863//27371828

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-181a-3p
Exosome Jurkat-derived T cell line (J77cl20)     21505438
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome B lymphoblastoid cells|Endothelial cells|Lymphoma tissue     -
Microvesicle Cerebrospinal fluid     24797360
Microvesicle Fibroblasts|Mesenchymal stem cells     -
Mitochondrion Skeletal muscle myoblasts     21637849
KRAS
Chromatin K562 cells     -
Exosome Serum     -
Mitochondrion HDF cells     16178658
Nucleoplasm K562 cells     -
Nucleus K562 cells     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-181a-3p
Curcumin 969516 Drug interaction    RC00002074
Gemcitabine 60750 Drug interaction    RC00002071
Temozolomide 5394 Drug interaction    RC00002068
4-Hydroxynonenal 5283344 Drug interaction    RC00002076
Diethylstilbestrol 448537 Drug interaction    RC00002073
Paclitaxel 36314 Drug interaction    RC00002070
Doxorubicin 31703 Drug interaction    RC00002069
Tamoxifen 2733526 Drug interaction    RC00002075
Gefitinib 123631 Drug interaction    RC00002072
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-181a-3p
Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       26617885

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-181a-3p
Interactor2: KRAS

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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