Detail Information

Basic Information:


  VIRBase ID:  

HHID00048957

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-205-5p:           STK38L:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-205-5p STK38L
miRBase
Accession/Entrez ID		 MIMAT0000266 23012
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - NDR2

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-205-5p
rs1231010148 chr1:209432181    G/A
rs1259433308 chr1:209432185    C/T
rs1317949521 chr1:209432186    T/C
rs1334380203 chr1:209432175    C/T
rs762041668 chr1:209432180    G/A
rs762041668 chr1:209432180    G/T
rs769579357 chr1:209432177    A/G
rs775223604 chr1:209432179    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR STK38L
chr12:27465011(+) A-I      intronic
chr12:27464952(+) A-I      intronic
chr12:27464913(+) A-I      intronic
chr12:27428410(+) A-I      intronic
chr12:27467187(+) A-I      intronic
chr12:27467223(+) A-I      intronic
chr12:27466501(+) A-I      intronic
chr12:27467245(+) A-I      intronic
chr12:27467255(+) A-I      intronic
chr12:27424813(+) A-I      intronic
chr12:27426941(+) A-I      intronic
chr12:27465965(+) A-I      intronic
chr12:27427065(+) A-I      intronic
chr12:27428346(+) A-I      intronic
chr12:27428377(+) A-I      intronic
chr12:27428396(+) A-I      intronic
chr12:27454317(+) A-I      intronic
chr12:27454318(+) A-I      intronic
chr12:27454321(+) A-I      intronic
chr12:27427059(+) A-I      intronic
chr12:27454322(+) A-I      intronic
chr12:27454394(+) A-I      intronic
chr12:27454400(+) A-I      intronic
chr12:27454405(+) A-I      intronic
chr12:27454454(+) A-I      intronic
chr12:27455734(+) A-I      intronic
chr12:27455784(+) A-I      intronic
chr12:27455803(+) A-I      intronic
chr12:27455839(+) A-I      intronic
chr12:27456931(+) A-I      intronic
chr12:27456993(+) A-I      intronic
chr12:27465927(+) A-I      intronic
chr12:27466030(+) A-I      intronic
chr12:27466536(+) A-I      intronic
chr12:27466551(+) A-I      intronic
chr12:27467079(+) A-I      intronic
chr12:27467105(+) A-I      intronic
chr12:27467109(+) A-I      intronic
chr12:27467120(+) A-I      intronic
chr12:27467148(+) A-I      intronic
chr12:27415985(+) A-I      intronic
chr12:27415534(+) A-I      intronic
chr12:27467299(+) A-I      intronic
chr12:27467305(+) A-I      intronic
chr12:27415540(+) A-I      intronic
chr12:27415571(+) A-I      intronic
chr12:27415633(+) A-I      intronic
chr12:27415763(+) A-I      intronic
chr12:27415871(+) A-I      intronic
chr12:27415958(+) A-I      intronic
chr12:27466389(+) A-I      intronic
chr12:27422715(+) A-I      intronic
chr12:27422845(+) A-I      intronic
chr12:27422856(+) A-I      intronic
chr12:27423540(+) A-I      intronic
chr12:27424694(+) A-I      intronic
chr12:27424762(+) A-I      intronic
chr12:27424772(+) A-I      intronic
chr12:27465997(+) A-I      intronic
chr12:27428453(+) A-I      intronic
chr12:27466392(+) A-I      intronic
chr12:27440132(+) A-I      intronic
chr12:27441067(+) A-I      intronic
chr12:27466358(+) A-I      intronic
chr12:27457107(+) A-I      intronic
chr12:27459861(+) A-I      intronic
chr12:27447203(+) A-I      intronic
chr12:27415831(+) A-I      intronic
chr12:27466018(+) A-I      intronic
chr12:27466060(+) A-I      intronic
chr12:27415836(+) A-I      intronic
chr12:27451200(+) A-I      intronic
chr12:27415511(+) A-I      intronic
chr12:27440998(+) A-I      intronic
chr12:27466464(+) A-I      intronic
chr12:27447768(+) A-I      intronic
chr12:27455685(+) A-I      intronic
chr12:27447773(+) A-I      intronic
chr12:27457013(+) A-I      intronic
chr12:27428456(+) A-I      intronic
chr12:27454331(+) A-I      intronic
chr12:27415817(+) A-I      intronic
chr12:27466590(+) A-I      intronic
chr12:27457007(+) A-I      intronic
chr12:27466454(+) A-I      intronic
chr12:27451265(+) A-I      intronic
chr12:27451133(+) A-I      intronic
chr12:27447901(+) A-I      intronic
chr12:27466499(+) A-I      intronic
chr12:27415531(+) A-I      intronic
chr12:27467133(+) A-I      intronic
chr12:27415587(+) A-I      intronic
chr12:27447365(+) A-I      intronic
chr12:27466481(+) A-I      intronic
chr12:27451261(+) A-I      intronic
chr12:27465918(+) A-I      intronic
chr12:27466513(+) A-I      intronic
chr12:27473261(+) A-I      intronic
chr12:27467213(+) A-I      intronic
chr12:27424822(+) A-I      intronic
chr12:27420300(+) A-I      intronic
chr12:27428452(+) A-I      intronic
chr12:27415783(+) A-I      intronic
chr12:27459864(+) A-I      intronic
chr12:27422797(+) A-I      intronic
chr12:27466027(+) A-I      intronic
chr12:27415832(+) A-I      intronic
chr12:27466480(+) A-I      intronic
chr12:27403785(+) A-I      intronic
chr12:27447710(+) A-I      intronic
chr12:27464877(+) A-I      intronic
chr12:27456933(+) A-I      intronic
chr12:27457112(+) A-I      intronic
chr12:27466588(+) A-I      intronic
chr12:27466021(+) A-I      intronic
chr12:27454461(+) A-I      intronic
chr12:27428381(+) A-I      intronic
chr12:27415563(+) A-I      intronic
chr12:27447877(+) A-I      intronic
chr12:27428546(+) A-I      intronic
chr12:27457017(+) A-I      intronic
chr12:27467259(+) A-I      intronic
chr12:27464997(+) A-I      intronic
chr12:27467244(+) A-I      intronic
chr12:27415553(+) A-I      intronic
chr12:27459774(+) A-I      intronic
chr12:27466319(+) A-I      intronic
chr12:27467275(+) A-I      intronic
chr12:27415782(+) A-I      intronic
chr12:27447191(+) A-I      intronic
chr12:27467100(+) A-I      intronic
chr12:27424816(+) A-I      intronic
chr12:27451146(+) A-I      intronic
chr12:27466568(+) A-I      intronic
chr12:27451225(+) A-I      intronic
chr12:27466444(+) A-I      intronic
chr12:27466070(+) A-I      intronic
chr12:27459697(+) A-I      intronic
chr12:27466456(+) A-I      intronic
chr12:27451330(+) A-I      intronic
chr12:27415495(+) A-I      intronic
chr12:27447180(+) A-I      intronic
chr12:27466126(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED STK38L
chr12:27451133(+) A-I intron -    15258596
chr12:27451146(+) A-I intron -    15258596
chr12:27451200(+) A-I intron -    15258596
chr12:27476394(+) T-G intron -    21725310
chr12:27478128(+) A-C intron -    21725310
chr12:27415563(+) A-G intron -    22484847
chr12:27466027(+) A-G intron -    22484847
chr12:27466060(+) A-G intron -    22484847
chr12:27466126(+) A-G intron -    22484847
chr12:27466358(+) A-G intron -    22484847
chr12:27466454(+) A-G intron -    22484847
chr12:27467259(+) A-G intron -    22484847
chr12:27467275(+) A-G intron -    22484847
chr12:27400768(+) G-T intron -    22484847
chr12:27403785(+) A-G intron -    22484847
chr12:27403950(+) G-A intron -    22484847
chr12:27415495(+) A-G intron -    22484847
chr12:27415511(+) A-G intron -    22484847
chr12:27415531(+) A-G intron -    22484847
chr12:27415553(+) A-G intron -    22484847
chr12:27415587(+) A-G intron -    22484847
chr12:27415783(+) A-G intron -    22484847
chr12:27415817(+) A-G intron -    22484847
chr12:27415831(+) A-G intron -    22484847
chr12:27415832(+) A-G intron -    22484847
chr12:27415877(+) G-A intron -    22484847
chr12:27422797(+) A-G intron -    22484847
chr12:27424816(+) A-G intron -    22484847
chr12:27424822(+) A-G intron -    22484847
chr12:27426943(+) C-T intron -    22484847
chr12:27428452(+) A-G intron -    22484847
chr12:27428453(+) A-G intron -    22484847
chr12:27428456(+) A-G intron -    22484847
chr12:27447174(+) T-C intron -    22484847
chr12:27447180(+) A-G intron -    22484847
chr12:27447203(+) A-G intron -    22484847
chr12:27447365(+) A-G intron -    22484847
chr12:27447901(+) A-G intron -    22484847
chr12:27451225(+) A-G intron -    22484847
chr12:27451265(+) A-G intron -    22484847
chr12:27454331(+) A-G intron -    22484847
chr12:27454461(+) A-G intron -    22484847
chr12:27459692(+) T-A intron -    22484847
chr12:27464877(+) A-G intron -    22484847
chr12:27464997(+) A-G intron -    22484847
chr12:27465918(+) A-G intron -    22484847
chr12:27465992(+) T-C intron -    22484847
chr12:27465997(+) A-G intron -    22484847
chr12:27466018(+) A-G intron -    22484847
chr12:27466021(+) A-G intron -    22484847
chr12:27466070(+) A-G intron -    22484847
chr12:27466392(+) A-G intron -    22484847
chr12:27466456(+) A-G intron -    22484847
chr12:27466464(+) A-G intron -    22484847
chr12:27466481(+) A-G intron -    22484847
chr12:27466499(+) A-G intron -    22484847
chr12:27466513(+) A-G intron -    22484847
chr12:27466568(+) A-G intron -    22484847
chr12:27467244(+) A-G intron -    22484847
chr12:27467353(+) G-A intron -    22484847
chr12:27471752(+) G-A intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase STK38L
chr12:27450782-27450783(+) m6A CDS//exon       24981863
chr12:27450808-27450809(+) m6A exon//intron       24981863
chr12:27450853-27450854(+) m6A exon//intron       24981863
chr12:27461307-27461308(+) m6A 3'UTR//CDS//intron       24981863
chr12:27461331-27461332(+) m6A 3'UTR//CDS//intron       24981863
chr12:27461336-27461337(+) m6A 3'UTR//CDS//intron       24981863
chr12:27470286-27470287(+) m6A 3'UTR//CDS       24981863
chr12:27470322-27470323(+) m6A 3'UTR//CDS       24981863
chr12:27470939-27470940(+) m6A 3'UTR//CDS//exon       24981863
chr12:27472280-27472281(+) m6A 3'UTR//CDS//exon       24981863
chr12:27475276-27475277(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22608085
chr12:27475281-27475282(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22608085
chr12:27475296-27475297(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22608085
chr12:27475419-27475420(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22608085
chr12:27475538-27475539(+) m6A 3'UTR//exon       24284625//24209618//24981863//22608085
chr12:27475637-27475638(+) m6A 3'UTR       24284625//24981863//22608085
chr12:27475712-27475713(+) m6A 3'UTR       24284625//24981863//22608085
chr12:27475742-27475743(+) m6A 3'UTR       24284625//24981863//22608085
chr12:27476030-27476031(+) m6A 3'UTR       27773535
chr12:27476550-27476551(+) m6A 3'UTR       -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-205-5p
Cytoplasm Tumor tissues (Head|Neck)     25422181
Exosome Urine     26576778
Exosome Primary ovarian tumor cells|Serum     18589210
Exosome Plasma     19289371
Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Exosome Ascites fluid|Pleural effusion     21601258
Exosome Breast milk     22211110
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Breast milk|Tongue tissue     -
Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Microvesicle Seminal plasma     23539611
Microvesicle Mesenchymal stem cells|Urine     -
Nucleus Tumor tissues (Head|Neck)     25422181
STK38L
Chromatin K562 cells     -
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Nucleoplasm K562 cells     -
Ribosome HEK-293 cells     22199352
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-205-5p
Midostaurin 9829523 Drug resistant
Thiocyanic acid, 1H-purin-6-yl ester 96185 Drug sensitive
2,4,7-Triamino-6-o-tolylpteridine 95122 Drug resistant
1,5-Methano-11H-furo(3,2-g)pyrano(3,2-b)xanthene-3a(4H)-crotonaldehyde, 1,2,5,7-tetrahydro-8-hydroxy-alpha,2,2,11,11-pentamethyl-13-(3-methyl-2-butenyl)-4,7-dioxo-, trans- 78358492 Drug sensitive
Fludarabine 657237 Drug resistant
Neocuproine 65237 Drug sensitive
3-[4-(1H-Indol-3-yl)-1,3-thiazol-2-yl]-1-methyl-1H-indole 60147979 Drug sensitive
4-[4-(4-Fluorophenyl)-1-piperidin-4-yl-1H-imidazol-5-yl]pyrimidin-2-amine, hydrochloride salt 57399802 Drug sensitive
6-[2-[(2-Methylsulfonylethylamino)methyl]-1,3-thiazol-4-yl]-N-[4-[[3-(trifluoromethyl)phenyl]methoxy]phenyl]quinazolin-4-amine;hydrochloride 57395317 Drug sensitive
1,1'-Diethyl-2,2'-cyanine chloride 5717105 Drug sensitive
Cisplatin 5702198 Drug resistant
Thiopyrimidine-OCH3 5473172 Drug sensitive
(Z)-3-Iodo-1,2-diphenyl-2-propen-1-one 5468683 Drug sensitive
Simvastatin 54454 Drug resistant
5-Phenyl-N-(3,4,5-trimethoxyphenyl)-1,3-oxazol-2-amine 5329854 Drug sensitive
Lovastatin 53232 Drug resistant
Dichloroplatinum; 2-(4-methoxyphenyl)ethanamine 498558 Drug sensitive
Staurosporine, 98% 49831000 Drug resistant
Ossirene 451379 Drug sensitive
9-beta-D-Xylofuranosyladenine 447916 Drug sensitive
Ditercalinium dimethanesulfonate dimethanesulfonate 435243 Drug sensitive
Rogiolol 402519 Drug sensitive
2-Diphenylphosphanylethyl(dipyridin-2-yl)phosphane 400499 Drug sensitive
(2S)-2,6-Diamino-N-[4-(5-amino-6,8-difluoro-7-methyl-4-oxochromen-2-yl)-2-fluorophenyl]hexanamide;methanesulfonic acid 399587 Drug sensitive
Phosphine, 1,2-ethanediylbis[bis[2-(methylthio)phenyl]- 397601 Drug sensitive
Loratadine 3957 Drug sensitive
L-LYS-L-p-NO2Phe-L-Ala-L-p-NO2PheNH2 386384 Drug sensitive
2-(2-(Dimethylamino)ethylamino)naphthazarin 376950 Drug sensitive
N-Hydroxy-N-methylpropanethioamide 371713 Drug sensitive
Thiosangivamycin 3580213 Drug sensitive
Haloprogin 3561 Drug sensitive
Buellolide 337850 Drug sensitive
Phomazarin 318385 Drug resistant
Valproic acid 3121 Drug sensitive
1-(2-Chloroethyl)-3-(2,6-dioxo-3-piperidyl)-1-nitrosourea 26328 Drug resistant
Ancitabine hydrochloride 25050 Drug resistant
Hydrazine sulfate 24842 Drug sensitive
N-[(4R)-4-[(3R,5R,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-Tris(3-aminopropoxy)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentyl]octan-1-amine 24205348 Drug resistant
3-Bromo-4-(2-(4-methoxyphenyl)ethynyl)furan-2(5H)-one 24204187 Drug sensitive
2-Chloro-3-phenoxy-1,4-naphthoquinone 219799 Drug sensitive
2-Acetylimidazo[4,5-b]pyridin 4 tolyl 3 thiosemicarbazone 135440014 Drug sensitive
8-Azaguanine 135403646 Drug resistant
Benzoanthracenone 12300036 Drug resistant
3-(4-(5-Methoxy-1H-benzo[d]imidazol-2-yl)phenyl)-5-(3,4,5-trimethoxyphenyl)-1,2,4-oxadiazole 118624714 Drug sensitive
1-Phenyl-5-(4-(trifluoromethyl)phenyl)-1H-imidazole 11162021 Drug resistant
Cladospirone bisepoxide 10316810 Drug sensitive
6-[4-(1-Cyclohexenyl)-1,3-butadiyn-1-yl]-2(2H)-pyranone 10263039 Drug resistant
(2e,8s,9z)-2,9,16-heptadecatrien-4,6-diyn-1,8-diol - Drug resistant
Camptothecin Derivative - Drug resistant
tunicamycin - Drug resistant
(Z)-5-chloro-3-((1-(3,5-dimethoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methylene)indolin-2-one - Drug sensitive
ethanone, 1-(2-pyrimidinyl)-, (2-benzoxazolyl)hydrazone - Drug sensitive
purine, 2,6,8-tris(hexylamino)- - Drug sensitive
antineoplastic-641296 - Drug sensitive
antineoplastic-641297 - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-205-5p
Oxaliplatine 6857599 Drug interaction    RC00002015
Gemcitabine 60750 Drug interaction    RC00002007
Tyrosine 6057 Drug interaction    RC00002002
Cholesterol 5997 Drug interaction    RC00002001
D-Glucose 5793 Drug interaction    RC00002000
Eloxatine 5310940 Drug interaction    RC00002014
Phenobarbital 4763 Drug interaction    RC00001999
Decitabine 451668 Drug interaction    RC00002013
Epirubicin 41867 Drug interaction    RC00002006
Carboplatinum 38904 Drug interaction    RC00002005
Paclitaxel 36314 Drug interaction    RC00002004
5-Fluorouracil 3385 Drug interaction    RC00001998
Enoxacin 3229 Drug interaction    RC00001997
Doxorubicin 31703 Drug interaction    RC00002003
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001996
Verapamil 2520 Drug interaction    RC00001995
Benzene 241 Drug interaction    RC00001994
Lapatinib 208908 Drug interaction    RC00002012
Erlotinib 176870 Drug interaction    RC00002011
Docetaxel 148124 Drug interaction    RC00002010
Leucovorin 135403648 Drug interaction    RC00002016
Methotrexate 126941 Drug interaction    RC00002009
Gefitinib 123631 Drug interaction    RC00002008
1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00002017
Hydroxamic acid HDACi LAQ824 - Drug interaction    RC00002018
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-205-5p
Paclitaxel 36314       26323677

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-205-5p
Interactor2: STK38L

Evidence Support:


Weak-Evidence HITS-CLIP
Support Database ViRBase

References:


PMID 22473208 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line Jijoye cells Interactor2 expression None
Description Our HITS-CLIP data yield 1185 human 3'UTRs targeted by members of the miR-17~92 cluster in Jijoye cells. Comparison to the 1664 3'UTRs targeted by EBV miRNAs reveals 740 shared genes (44% of EBV targets and 62% of miR-17~92 targets; Figure 6B and Supplementary Table 7). Thus, EBV miRNAs co-target a majority of miR-17~92 regulated mRNAs, which are assigned to a variety of pathways, most notably regulating transcription, apoptosis, and the cell cycle (Figure 6C). Similarly, other abundant immunologically relevant miRNAs, 142-3p and miR-155, co-target with EBV miRNAs a large fraction of their Ago-bound 3'UTRs, representing ~60% of the targets for each of these host miRNAs (Supplementary Figure 5).

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