Basic Information:

  VIRBase ID:  

HHID00048907

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-199b-5p:  MIMAT0000263          NBEAL2:  NM_001365116     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-199b-5p	NBEAL2
miRBase Accession/Entrez ID	MIMAT0000263	23218
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	BDPLT4//GPS

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-199b-5p	rs1024465078 chr9:128244786    C/T rs1052574238 chr9:128244788    G/A rs1399178030 chr9:128244805    G/A rs777889185 chr9:128244784    A/G rs1176138186 chr9:128244804    G/A rs892551318 chr9:128244803    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	NBEAL2	chr3:47049345(+) A-I      NonSyn:Tyr->Cys chr3:47024903(+) A-I      intronic chr3:47024823(+) A-I      intronic chr3:47022768(+) A-I      intronic chr3:47024985(+) A-I      intronic chr3:47025535(+) A-I      intronic chr3:47024831(+) A-I      intronic chr3:47025588(+) A-I      intronic chr3:47025618(+) A-I      intronic chr3:47025587(+) A-I      intronic chr3:47024856(+) A-I      intronic chr3:47022762(+) A-I      intronic chr3:47022702(+) A-I      intronic chr3:47024869(+) A-I      intronic chr3:47022771(+) A-I      intronic chr3:47024983(+) A-I      intronic chr3:47024880(+) A-I      intronic chr3:47024900(+) A-I      intronic chr3:47024939(+) A-I      intronic chr3:47022877(+) A-I      intronic chr3:47025050(+) A-I      intronic chr3:47022680(+) A-I      intronic chr3:47022812(+) A-I      intronic chr3:47022661(+) A-I      intronic chr3:47024929(+) A-I      intronic chr3:47024912(+) A-I      intronic chr3:47025075(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	NBEAL2	chr3:47024912(+) A-G intron -    22484847 chr3:47024929(+) A-G intron -    22484847 chr3:47025050(+) A-G intron -    22484847 chr3:47025556(+) T-C intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	NBEAL2	chr3:47021177-47021178(+) m6A 5'UTR       24981863 chr3:47021215-47021216(+) m6A 5'UTR       24981863 chr3:47036725-47036726(+) m6A CDS       24284625//24981863 chr3:47036855-47036856(+) m6A CDS       24284625//24981863 chr3:47036862-47036863(+) m6A CDS       24284625//24981863 chr3:47037470-47037471(+) m6A CDS       - chr3:47037508-47037509(+) m6A CDS       - chr3:47041723-47041724(+) m6A CDS       24284625//24981863 chr3:47041877-47041878(+) m6A CDS       - chr3:47044562-47044563(+) m6A CDS       - chr3:47044759-47044760(+) m6A CDS       24981863 chr3:47044794-47044795(+) m6A CDS       - chr3:47045320-47045321(+) m6A CDS       - chr3:47045733-47045734(+) m6A CDS       - chr3:47045741-47045742(+) m6A CDS       - chr3:47047687-47047688(+) Gm CDS//exon       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-199b-5p	Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Exosome B cell line (Raji)|Primary dendritic cells|T cell line (J77)     21505438 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Cerebrospinal fluid     24797360 Microvesicle Fibroblasts|Mesenchymal stem cells     -
	NBEAL2	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-199b-5p	[[4-(3-Aminophenyl)-2-pyridyl]methyleneamino]thiourea 9556427 Drug sensitive Acid Green 27 80837 Drug sensitive Jacaranone 73307 Drug sensitive Redoxal 72571 Drug sensitive Piperidinium pentamethylenedithiocarbamate 72508 Drug sensitive 4H-Furo(3,2-g)(1)benzopyran-4,7,9-trione 68083 Drug sensitive Melicopidine 68060 Drug sensitive 3-Hydroxy-3'-nitro-2-naphthanilide 67277 Drug sensitive Baccharinoid B4 6711263 Drug sensitive Ixabepilone 6445540 Drug sensitive Tributyrin 6050 Drug sensitive Verrucarin A, 3'-(acetyloxy)-7'-deoxo-2'-deoxy-4'-hydroxy-7'-(1-hydroxyethyl)- 5933240 Drug sensitive Methyl N-[6-[4-(phenylcarbamoylamino)phenoxy]-1H-benzimidazol-2-yl]carbamate;hydrochloride 57396352 Drug sensitive Cisplatin 5702198 Drug sensitive 8B-Hydroxy-9B,10B-epoxyverrucarin A 5477536 Drug sensitive Tetrocarcin A, sodium salt 54724658 Drug sensitive (8R,9S,13S,14S,17S)-13-Methyl-2-[(E)-prop-1-enyl]-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol 5468270 Drug sensitive Herveline O 5459269 Drug sensitive Dihydro-5-azacytidine 5351280 Drug sensitive 1-Piperidineethanol, alpha-[p-(p-chlorostyryl)phenyl]- 5351150 Drug sensitive 5-Methyl-2-{[(2)-3-phenylprop-2-enoyl]amino}benzamide 53329052 Drug sensitive Centaureidin 5315773 Drug sensitive Herbimycin 5311102 Drug sensitive Erioflorin acetate 5281443 Drug sensitive Spiperone 5265 Drug resistant Dichloroplatinum; 2-(4-methoxyphenyl)ethanamine 498558 Drug sensitive 1-(4-(Benzyloxy)phenyl)-3-(3-(1-ethyl-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-3-yl)phenyl)urea 44587530 Drug sensitive Oxyacanthine 442333 Drug sensitive Isobrucein A 441802 Drug sensitive Glaucarubinone 441796 Drug sensitive Di-n-octyl-secalonsaure A 430141 Drug sensitive Carboplatin 426756 Drug sensitive Cyano pyridine-P-CH3 406496 Drug sensitive S-(Dimethylarsino)-3-mercapto-1,2-propyl dibenzoate 406481 Drug sensitive S-(Diisopropylarsino)-3-mercapto-1,2-propanediol 406478 Drug sensitive Aminopyrimidine-CH3 406278 Drug sensitive 3-(3-Hydroxy-4-methoxybenzyl)-5,7-dihydroxychroman-4-one 404571 Drug sensitive 1,2 Benzo-8-(1-hydroxy-2-methylamino propane)-3-phenoxazone 400530 Drug sensitive Asimicinone 393461 Drug sensitive beta-Lapachone 3885 Drug sensitive Lapachol 3884 Drug sensitive 2-(1-Propynyl)estradiol 388008 Drug sensitive Acetic acid,4,7,10-tetraazacyclododecane-1,7-diyl]bis 387352 Drug sensitive N-(2-Bromo-5-methoxybenzylidene)-6,7-dimethoxy-1-naphthalenamine 387181 Drug sensitive 2-Ethenyl estradiol 381026 Drug sensitive 5,8-Dihydroxy-2-(4-(2-pyridinyl)-1-piperazinyl)naphthoquinone 376947 Drug sensitive 2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant Antineoplastic-656904 376224 Drug sensitive 3,8-Dimethyl-1,2-naphthoquinone 373912 Drug sensitive Antineoplastic-645807 371508 Drug resistant Diethyl p-phenoxybenzalmalonate 370253 Drug sensitive 3,8,13,18,23-Pentaazapentacosane 368998 Drug sensitive 2,7-Dicyanoxanthone 363841 Drug sensitive 3-Nitro-5-formylisoxazole 362479 Drug sensitive 1-Chloro-3-(3-chloropropylsulfonylsulfanyl)propane 355643 Drug sensitive Maxima isoflavone D 343081 Drug sensitive 1-Piperidinesulfonamide, N-(7-amino-2-naphthalenyl)- 333624 Drug sensitive Mercury, (p-carboxyphenyl)(purin-6-ylthio)- 3246339 Drug sensitive 2,3-Bis(iodomethyl)-6-methoxyquinoxaline 286257 Drug sensitive 1-(2-Chloroethyl)-3-(2,6-dioxo-3-piperidyl)-1-nitrosourea 26328 Drug sensitive Hookerianamide K 25016412 Drug sensitive (2-Methoxy-9,10-dihydrophenanthren-3-yl)methyl-dimethyl-(phenylsulfanylmethyl)azanium;bromide 24200489 Drug sensitive Diethylcarbamodithioic acid, sodium salt 21192315 Drug sensitive Methyl 1,6,8,14a-tetrahydroxy-11-[(4-hydroxy-3,5-dimethoxy-6-methyloxan-2-yl)amino]-6a-methoxy-3-methyl-7,9,12,14-tetraoxo-5,6-dihydrobenzo[a]tetracene-2-carboxylate 197261 Drug sensitive 5-Nitroso-8-hydroxyquinoline 19103 Drug sensitive Trihexyltetradecylphosphonium hexafluorophosphate 16212610 Drug sensitive N-(4-(1-Aziridinyl)butyl)-1,3-propanediamine 160395 Drug sensitive Arsenic trioxide 14888 Drug sensitive 1H-2,10a-Ethanophenanthrene, kaur-16-en-15-one deriv. 146156727 Drug sensitive Gold;(2S,3R,4S,5R,6R)-3,4,5-triacetyloxy-6-(acetyloxymethyl)oxane-2-thiolate;triethylphosphanium 138402869 Drug sensitive 8-Azaguanine 135403646 Drug sensitive (2S,4S,5R)-20-De(1-hydroxypropyl)-6-demethyl-2,6-diethyl-5-hydroxy-20-(1-hydroxybutyl)lysocellin 124081057 Drug sensitive Astraphloxin 12299852 Drug sensitive Unii-C616DV5Y11 117587576 Drug sensitive 2,2'-Bioxirane 11254 Drug sensitive (5S,7S)-5,7,9,10-Tetrahydroxy-2-methoxy-7-methyl-6,8-dihydro-5H-anthracene-1,4-dione 11209399 Drug sensitive Acetylenedicarboxamide 10971 Drug sensitive Fusariotoxin T-2 102515111 Drug sensitive (1S,3R,6R,12S,14R,15S,18R,19E,21Z,25R,26S,27R)-6,15-Dihydroxy-18-[(1R)-1-hydroxyethyl]-5,14,26-trimethylspiro[2,10,13,17,24-pentaoxapentacyclo[23.2.1.03,8.08,26.012,14]octacosa-4,19,21-triene-27,2'-oxirane]-11,23-dione 101307863 Drug sensitive tgf.alpha.-pe40 - Drug resistant toxin .delta.53l - Drug resistant tp4ek - Drug resistant 1h-1,2,4-triazole, 3-(4-diazo-4h-imidazol-5-yl)- - Drug sensitive 1-piperidinecarbodithioic acid, antimony complex - Drug sensitive 2,3-dihydro-2,3-dihydroxy-brefeldin a - Drug sensitive 3,4-diphenylisoxazolo[3,4-d]pyridazin-7(6h)-one - Drug sensitive 4'-deoxy-13',17-dinitro-3',4'-epoxy-vincaleukoblastine - Drug sensitive 4-morpholinecarbodithioic acid, antimony complex - Drug sensitive 4-thiomorpholinecarbodithioic acid, antimony complex - Drug sensitive 5,8-quinolinedione, 6-amino-7-bromo- - Drug sensitive 5.alpha.,25d-spirostan-3.beta.-ol glycoside - Drug sensitive benzene, 1,1'-[(1,3-butadiene-1,4-diyl)sulfonyl]bis - Drug sensitive benzo[1,2-b:4,5-b']dithiophene-4,8-diol, dipropionate - Drug sensitive benzo[1,2-c:4,5-c']dipyrrole-1,3,5,7(2h,6h)-tetraimine - Drug sensitive E)-1-(4-(quinazolin-4-ylamino)phenyl)-3-(2,4,6-trimethoxyphenyl)prop-2-en-1-one - Drug sensitive nsc 708783 incorporated in micelles, 0.20% (w/w) of drug - Drug sensitive phosphonium, (3-bromopropyl)triphenyl- bromide - Drug sensitive piceatannol, 4,3',5'-trimethyl,1s0 - Drug sensitive roridin a, 8-hydroxy-9b,10b-epoxy- - Drug sensitive (Z)-6-chloro-3-((2-(4-methoxyphenyl)-3H-benzo[d]imidazol-5-yl)methylene)indolin-2-one - Drug sensitive 1-[(2-phenylethoxy)methyl]-5-ethyl-6-(phenylseleno)uracil - Drug sensitive 2'-deoxy-2'-difluoromethylene-adenosine - Drug sensitive 4-carbo-1-thiazolidine-3-o-gluconyl-.gamma.-lactone - Drug sensitive active compound from cephalodiscus gilchristi - Drug sensitive antineoplastic-615538 - Drug sensitive his 47-methyl ct - Drug sensitive insulin-methotrexate conjugate - Drug sensitive potassium arsenite - Drug sensitive tyrosine kinase inhibitor bte-16 (mw=221.24) - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-199b-5p	Hyaluronidase 91820602 Drug interaction    RC00001945 Alocrest 60780 Drug interaction    RC00001941 Vincristine 5978 Drug interaction    RC00001938 D-Glucose 5793 Drug interaction    RC00001937 Prednisolone 5755 Drug interaction    RC00001936 Eloxatine 5310940 Drug interaction    RC00001944 Imatinib 5291 Drug interaction    RC00001935 4-Hydroxynonenal 5283344 Drug interaction    RC00001943 Enoxacin 3229 Drug interaction    RC00001934 Doxorubicin 31703 Drug interaction    RC00001940 Daunorubicin 30323 Drug interaction    RC00001939 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001933 Verapamil 2520 Drug interaction    RC00001932 Imatinib mesylate 123596 Drug interaction    RC00001942 Asparaginase Escherichia coli - Drug interaction    RC00001946

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-199b-5p	Cisplatin 5702198       24659709 Imatinib 5291       29890129

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-miR-199b-5p	l-685,458       5479543 Dovitinib       135398510

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-199b-5p
Interactor2: NBEAL2

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.