Basic Information:

  VIRBase ID:  

HHID00048886

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-183-5p:  MIMAT0000261          ANLN:  NM_018685     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-183-5p	ANLN
miRBase Accession/Entrez ID	MIMAT0000261	54443
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	FSGS8//scra//Scraps

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-183-5p	rs533122592 chr7:129774975    C/T rs562677522 chr7:129774967    A/G rs562677522 chr7:129774967    A/T rs773861047 chr7:129774970    G/A rs773861047 chr7:129774970    G/C rs1289041712 chr7:129774985    C/T rs1467041622 chr7:129774987    T/C rs773258375 chr7:129774982    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ANLN	chr7:36452199(+) A-I      intronic chr7:36472490(+) A-I      intronic chr7:36468956(+) A-I      intronic chr7:36474377(+) A-I      intronic chr7:36474353(+) A-I      intronic chr7:36452198(+) A-I      intronic chr7:36474326(+) A-I      intronic chr7:36474321(+) A-I      intronic chr7:36441138(+) A-I      intronic chr7:36469044(+) A-I      intronic chr7:36469058(+) A-I      intronic chr7:36487679(+) A-I      intronic chr7:36441814(+) A-I      intronic chr7:36442606(+) A-I      intronic chr7:36442632(+) A-I      intronic chr7:36442667(+) A-I      intronic chr7:36487685(+) A-I      intronic chr7:36443266(+) A-I      intronic chr7:36443327(+) A-I      intronic chr7:36452166(+) A-I      intronic chr7:36452171(+) A-I      intronic chr7:36474336(+) A-I      intronic chr7:36455840(+) A-I      intronic chr7:36487820(+) A-I      intronic chr7:36471552(+) A-I      intronic chr7:36442605(+) A-I      intronic chr7:36474292(+) A-I      intronic chr7:36483692(+) A-I      intronic chr7:36471700(+) A-I      intronic chr7:36487724(+) A-I      intronic chr7:36483737(+) A-I      intronic chr7:36474449(+) A-I      intronic chr7:36441048(+) A-I      intronic chr7:36441087(+) A-I      intronic chr7:36471563(+) A-I      intronic chr7:36478005(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ANLN	chr7:36478089(+) T-C intron -    22484847 chr7:36483737(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ANLN	chr7:36429500-36429501(+) m6A 5'UTR       24284625//25456834//24981863//22575960 chr7:36429533-36429534(+) m6A 5'UTR       24284625//24981863//22575960 chr7:36429554-36429555(+) m6A 5'UTR       24284625//24981863//22575960 chr7:36429569-36429570(+) m6A 5'UTR       24981863//22575960 chr7:36429595-36429596(+) m6A 5'UTR       24981863//22575960 chr7:36438910-36438911(+) Am CDS       - chr7:36445967-36445968(+) m6A CDS//exon       22608085 chr7:36445972-36445973(+) m6A CDS//exon       22608085 chr7:36445985-36445986(+) m6A CDS//exon       22608085 chr7:36446041-36446042(+) Y CDS//exon       26075521 chr7:36447547-36447548(+) m6A 3'UTR//CDS//exon       27773535 chr7:36450127-36450128(+) m6A 3'UTR//CDS//exon       24981863//27773535 chr7:36450174-36450175(+) m6A 3'UTR//CDS//exon       24981863//27773535 chr7:36450214-36450215(+) m6A 3'UTR//CDS//exon       24981863//27773535 chr7:36450269-36450270(+) m6A 3'UTR//CDS//exon//intron       24981863//27773535 chr7:36450681-36450682(+) m6A 3'UTR//CDS//exon//intron       24981863//27773535 chr7:36450743-36450744(+) m6A 3'UTR//CDS//exon//intron       24981863//27773535 chr7:36450756-36450757(+) m6A 3'UTR//CDS//exon//intron       24981863//27773535 chr7:36450766-36450767(+) m6A 3'UTR//CDS//exon//intron       24981863//27773535 chr7:36450771-36450772(+) m6A 3'UTR//CDS//exon//intron       24981863//27773535 chr7:36455369-36455370(+) m6A 3'UTR//CDS//intron       24981863//27773535 chr7:36455398-36455399(+) m6A 3'UTR//CDS//intron       24981863//27773535 chr7:36455417-36455418(+) m6A 3'UTR//CDS//intron       24981863//27773535 chr7:36455454-36455455(+) m6A 3'UTR//CDS//intron       24981863//27773535 chr7:36455485-36455486(+) m6A 3'UTR//CDS//intron       24981863//27773535 chr7:36456751-36456752(+) m6A CDS//exon//intron       24981863//27773535//22575960 chr7:36456775-36456776(+) m6A CDS//intron       24981863//27773535//22575960 chr7:36458949-36458950(+) m6A CDS//intron       24981863//27773535//22575960 chr7:36459005-36459006(+) Am CDS//intron       - chr7:36459009-36459010(+) m6A CDS//intron       24981863//27773535//22575960 chr7:36459064-36459065(+) m6A CDS//intron       24981863//27773535//22575960 chr7:36459797-36459798(+) m6A CDS//intron       22575960 chr7:36459811-36459812(+) m6A CDS//intron       22575960 chr7:36459839-36459840(+) m6A CDS//intron       22575960 chr7:36459858-36459859(+) m6A CDS//intron       22575960 chr7:36460340-36460341(+) m6A CDS//intron       27773535//22575960 chr7:36461467-36461468(+) m6A CDS//intron       27773535//22575960 chr7:36461495-36461496(+) m6A CDS//intron       27773535//22575960 chr7:36461545-36461546(+) m6A CDS//intron       24981863//27773535//22575960 chr7:36461584-36461585(+) m6A CDS//intron       24981863//27773535//22575960 chr7:36462252-36462253(+) m6A CDS//intron       24981863//27773535//22575960 chr7:36462293-36462294(+) m6A CDS//intron       24981863//27773535//22575960 chr7:36464336-36464337(+) m6A CDS       24981863 chr7:36489323-36489324(+) m6A CDS//exon       - chr7:36489405-36489406(+) m6A CDS//exon       - chr7:36489427-36489428(+) m6A CDS//exon       - chr7:36492688-36492689(+) m6A 3'UTR//exon       27773535 chr7:36492712-36492713(+) m6A 3'UTR//exon       27773535 chr7:36492777-36492778(+) m6A 3'UTR//exon       27773535 chr7:36492798-36492799(+) m6A 3'UTR//exon       27773535 chr7:36493102-36493103(+) m6A 3'UTR//exon       27773535 chr7:36493118-36493119(+) m6A 3'UTR//exon       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-183-5p	Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome Peripheral blood mononuclear cells     19002258 Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Jurkat-derived T cell line (J77cl20)     21505438 Exosome Renal cancer cells     21670082 Exosome Breast milk     22211110 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Breast milk|Colon tissue|Epithelial cells|Lymphoma tissue|Tongue tissue     - Extracellular vesicle HEK-293T cells     22849433 Microvesicle Seminal plasma     23539611 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
	ANLN	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-183-5p	Sensorad 99342 Drug sensitive Morpholine-N-dithiocarbamate 72675 Drug sensitive (2R,3R,4S,5R)-2-(6-Benzylsulfanylpurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol 6477178 Drug sensitive (3beta)-3-((4-O-beta-D Glucopyranosyl-beta-D-xylopyranosyl)oxy)-14-hydroxy-19-oxocarda-4,20(22)-dienolide 56840951 Drug sensitive Ternatin 5459184 Drug resistant Rogiolol 402519 Drug sensitive Phosphine, 1,2-ethanediylbis[bis[2-(methylthio)phenyl]- 397601 Drug sensitive N-Hydroxy-N-methylpropanethioamide 371713 Drug sensitive Antineoplastic-645804 371505 Drug sensitive Ellipticine 3213 Drug sensitive Stannane, trimethyl[(4-morpholinylthioxomethyl)thio]- 300936 Drug sensitive Nile Blue 2B 20520 Drug sensitive Acrovestone 159969 Drug sensitive 5-Chloro-2[(E)-2-(4-nitrophenyl)vinyl]-1H-benzimidazole 15373173 Drug sensitive Fusariotoxin T-2 102515111 Drug sensitive 2-bromo-3-ketocastanospermine - Drug resistant (Z)-3-((1-(4-fluoro-3-methoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methylene)indolin-2-one - Drug sensitive (Z)-5-chloro-3-((1-(3,5-dimethoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methylene)indolin-2-one - Drug sensitive 4-morpholinecarbodithioic acid, antimony complex - Drug sensitive 9-acridinamine, n-(4-ethoxyphenyl)-, monohydrochloride - Drug sensitive benzofurazan, 4-nitro-7-(2-pyridinylthio)-, n-oxide - Drug sensitive (s)(-)-methyl perillate - Drug sensitive (Z)-3-((2-(4-(trifluoromethyl)phenyl)-3H-benzo[d]imidazol-5-yl)methylene)indolin-2-one - Drug sensitive Copper(II) complex with a thiosemicarbazone as a ligand - Drug sensitive ovb3-pe - Drug sensitive trans-4-{4-[3-(4-chloro-3-trifluoromethyl-phenyl)-ureido]-cyclohexyloxy}-pyridine-2-carboxylic acid methylamide - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-183-5p	Ethanol 702 Drug interaction    RC00001910 Piceatannol 667639 Drug interaction    RC00001916 Vorinostat 5311 Drug interaction    RC00001913 Imatinib 5291 Drug interaction    RC00001912 Doxorubicin 31703 Drug interaction    RC00001915 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001911 Tamoxifen 2733526 Drug interaction    RC00001917 Arsenic trioxide 14888 Drug interaction    RC00001914 5-aza-2'-deoxycytidine (5-Aza-CdR) + 4-phenylbutyric acid (PBA) - Drug interaction    RC00001918 Hydroxamic acid HDACi LAQ824 - Drug interaction    RC00001919 Mistletoe lectin-I - Drug interaction    RC00001920 Chemotherapy - Drug interaction    RC00008835

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-183-5p	Doxorubicin 31703       30395908

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-183-5p
Interactor2: ANLN

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.