Basic Information:

  VIRBase ID:  

HHID00048879

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-183-5p:  MIMAT0000261          ZNF460:  NM_001330622     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-183-5p	ZNF460
miRBase Accession/Entrez ID	MIMAT0000261	10794
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	HZF8//ZNF272

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-183-5p	rs533122592 chr7:129774975    C/T rs562677522 chr7:129774967    A/G rs562677522 chr7:129774967    A/T rs773861047 chr7:129774970    G/A rs773861047 chr7:129774970    G/C rs1289041712 chr7:129774985    C/T rs1467041622 chr7:129774987    T/C rs773258375 chr7:129774982    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ZNF460	chr19:57801829(+) A-I      intronic chr19:57795150(+) A-I      intronic chr19:57801881(+) A-I      intronic chr19:57794148(+) A-I      intronic chr19:57794156(+) A-I      intronic chr19:57795109(+) A-I      intronic chr19:57795144(+) A-I      intronic chr19:57798120(+) A-I      intronic chr19:57798143(+) A-I      intronic chr19:57798153(+) A-I      intronic chr19:57798154(+) A-I      intronic chr19:57799203(+) A-I      intronic chr19:57799207(+) A-I      intronic chr19:57799214(+) A-I      intronic chr19:57801121(+) A-I      intronic chr19:57801284(+) A-I      intronic chr19:57801353(+) A-I      intronic chr19:57801357(+) A-I      intronic chr19:57801428(+) A-I      intronic chr19:57801866(+) A-I      intronic chr19:57801826(+) A-I      intronic chr19:57801347(+) A-I      intronic chr19:57801528(+) A-I      intronic chr19:57801525(+) A-I      intronic chr19:57799226(+) A-I      intronic chr19:57801811(+) A-I      intronic chr19:57801785(+) A-I      intronic chr19:57801620(+) A-I      intronic chr19:57801541(+) A-I      intronic chr19:57794255(+) A-I      intronic chr19:57799657(+) A-I      intronic chr19:57801323(+) A-I      intronic chr19:57794103(+) A-I      intronic chr19:57801739(+) A-I      intronic chr19:57798144(+) A-I      intronic chr19:57794096(+) A-I      intronic chr19:57801763(+) A-I      intronic chr19:57795104(+) A-I      intronic chr19:57794212(+) A-I      intronic chr19:57794274(+) A-I      intronic chr19:57798877(+) A-I      intronic chr19:57794277(+) A-I      intronic chr19:57799307(+) A-I      intronic chr19:57799210(+) A-I      intronic chr19:57799640(+) A-I      intronic chr19:57794743(+) A-I      intronic chr19:57794638(+) A-I      intronic chr19:57801093(+) A-I      intronic chr19:57799594(+) A-I      intronic chr19:57798874(+) A-I      intronic chr19:57799277(+) A-I      intronic chr19:57795079(+) A-I      intronic chr19:57801527(+) A-I      intronic chr19:57799234(+) A-I      intronic chr19:57801294(+) A-I      intronic chr19:57794252(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ZNF460	chr19:57794277(+) A-I intron -    22327324 chr19:57799640(+) A-I intron -    21960545 chr19:57799656(+) A-I intron -    21960545 chr19:57794277(+) A-G intron -    22484847 chr19:57801270(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ZNF460	chr19:57792086-57792087(+) m6A 5'UTR//intron       24284625 chr19:57792132-57792133(+) m6A 5'UTR//intron       24284625 chr19:57793324-57793325(+) m6A 5'UTR//intron       - chr19:57796020-57796021(+) m6A CDS       24284625//24209618//22575960//22608085 chr19:57802079-57802080(+) m6A CDS       24284625//24209618//22575960//22608085 chr19:57802086-57802087(+) m6A CDS       24284625//24209618//22575960//22608085 chr19:57802142-57802143(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr19:57802232-57802233(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr19:57802239-57802240(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr19:57802243-57802244(+) m6A CDS       25456834//24981863 chr19:57802259-57802260(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr19:57802283-57802284(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr19:57802333-57802334(+) m6A CDS       24284625//24209618//24981863//26404942//22575960//22608085 chr19:57802379-57802380(+) m6A CDS       24284625//24209618//24981863//26404942//22575960//22608085 chr19:57802535-57802536(+) m6A CDS       24284625//24981863//22575960//22608085 chr19:57802603-57802604(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr19:57802641-57802642(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr19:57802686-57802687(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr19:57802826-57802827(+) m6A CDS       24284625//22608085 chr19:57803125-57803126(+) m6A CDS       24284625//24981863//26404942//22608085 chr19:57803286-57803287(+) m6A CDS       24284625//24981863//22575960//22608085 chr19:57803293-57803294(+) m6A CDS       24284625//24981863//22575960//22608085 chr19:57803423-57803424(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr19:57803583-57803584(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr19:57803611-57803612(+) m6A 3'UTR       24284625//24209618//24981863//22575960//22608085 chr19:57803705-57803706(+) m6A 3'UTR       24284625//24209618//24981863//26404942//22575960//22608085 chr19:57803740-57803741(+) m6A 3'UTR       24284625//24209618//24981863//26404942//22575960//22608085 chr19:57803768-57803769(+) m6A 3'UTR       24284625//24209618//24981863//26404942//22575960//22608085 chr19:57803798-57803799(+) m6A 3'UTR       24284625//24209618//24981863//26404942//22575960//22608085 chr19:57803866-57803867(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr19:57803894-57803895(+) m6A 3'UTR       24284625//24981863//26404942//27773535//22575960//22608085 chr19:57803945-57803946(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr19:57803953-57803954(+) m6A 3'UTR       24284625//24209618//24981863//22575960//22608085 chr19:57804009-57804010(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr19:57804081-57804082(+) m6A 3'UTR       24284625//24209618//24981863//22575960//22608085 chr19:57804144-57804145(+) m6A 3'UTR       24284625//24209618//24981863//22575960//22608085 chr19:57804163-57804164(+) m6A 3'UTR       24284625//24209618//24981863//22575960//22608085 chr19:57804593-57804594(+) m6A 3'UTR       24981863//27773535//22608085 chr19:57804610-57804611(+) m6A 3'UTR       24981863//27773535//22608085 chr19:57804645-57804646(+) m6A 3'UTR       24981863//27773535//22608085 chr19:57804658-57804659(+) m6A 3'UTR       24981863//27773535//22608085 chr19:57804746-57804747(+) m6A 3'UTR       24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-183-5p	Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome Peripheral blood mononuclear cells     19002258 Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Jurkat-derived T cell line (J77cl20)     21505438 Exosome Renal cancer cells     21670082 Exosome Breast milk     22211110 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Breast milk|Colon tissue|Epithelial cells|Lymphoma tissue|Tongue tissue     - Extracellular vesicle HEK-293T cells     22849433 Microvesicle Seminal plasma     23539611 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
	ZNF460	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-183-5p	Sensorad 99342 Drug sensitive Morpholine-N-dithiocarbamate 72675 Drug sensitive (2R,3R,4S,5R)-2-(6-Benzylsulfanylpurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol 6477178 Drug sensitive (3beta)-3-((4-O-beta-D Glucopyranosyl-beta-D-xylopyranosyl)oxy)-14-hydroxy-19-oxocarda-4,20(22)-dienolide 56840951 Drug sensitive Ternatin 5459184 Drug resistant Rogiolol 402519 Drug sensitive Phosphine, 1,2-ethanediylbis[bis[2-(methylthio)phenyl]- 397601 Drug sensitive N-Hydroxy-N-methylpropanethioamide 371713 Drug sensitive Antineoplastic-645804 371505 Drug sensitive Ellipticine 3213 Drug sensitive Stannane, trimethyl[(4-morpholinylthioxomethyl)thio]- 300936 Drug sensitive Nile Blue 2B 20520 Drug sensitive Acrovestone 159969 Drug sensitive 5-Chloro-2[(E)-2-(4-nitrophenyl)vinyl]-1H-benzimidazole 15373173 Drug sensitive Fusariotoxin T-2 102515111 Drug sensitive 2-bromo-3-ketocastanospermine - Drug resistant (Z)-3-((1-(4-fluoro-3-methoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methylene)indolin-2-one - Drug sensitive (Z)-5-chloro-3-((1-(3,5-dimethoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methylene)indolin-2-one - Drug sensitive 4-morpholinecarbodithioic acid, antimony complex - Drug sensitive 9-acridinamine, n-(4-ethoxyphenyl)-, monohydrochloride - Drug sensitive benzofurazan, 4-nitro-7-(2-pyridinylthio)-, n-oxide - Drug sensitive (s)(-)-methyl perillate - Drug sensitive (Z)-3-((2-(4-(trifluoromethyl)phenyl)-3H-benzo[d]imidazol-5-yl)methylene)indolin-2-one - Drug sensitive Copper(II) complex with a thiosemicarbazone as a ligand - Drug sensitive ovb3-pe - Drug sensitive trans-4-{4-[3-(4-chloro-3-trifluoromethyl-phenyl)-ureido]-cyclohexyloxy}-pyridine-2-carboxylic acid methylamide - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-183-5p	Ethanol 702 Drug interaction    RC00001910 Piceatannol 667639 Drug interaction    RC00001916 Vorinostat 5311 Drug interaction    RC00001913 Imatinib 5291 Drug interaction    RC00001912 Doxorubicin 31703 Drug interaction    RC00001915 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001911 Tamoxifen 2733526 Drug interaction    RC00001917 Arsenic trioxide 14888 Drug interaction    RC00001914 5-aza-2'-deoxycytidine (5-Aza-CdR) + 4-phenylbutyric acid (PBA) - Drug interaction    RC00001918 Hydroxamic acid HDACi LAQ824 - Drug interaction    RC00001919 Mistletoe lectin-I - Drug interaction    RC00001920 Chemotherapy - Drug interaction    RC00008835

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-183-5p	Doxorubicin 31703       30395908

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-183-5p
Interactor2: ZNF460

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.