Basic Information:

  VIRBase ID:  

HHID00048873

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-183-5p:  MIMAT0000261          ITGB8:  NM_002214     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-183-5p	ITGB8
miRBase Accession/Entrez ID	MIMAT0000261	3696
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-183-5p	rs533122592 chr7:129774975    C/T rs562677522 chr7:129774967    A/G rs562677522 chr7:129774967    A/T rs773861047 chr7:129774970    G/A rs773861047 chr7:129774970    G/C rs1289041712 chr7:129774985    C/T rs1467041622 chr7:129774987    T/C rs773258375 chr7:129774982    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ITGB8	chr7:20378655(+) A-I      intronic chr7:20378674(+) A-I      intronic chr7:20435998(+) A-I      intronic chr7:20378582(+) A-I      intronic chr7:20378230(+) A-I      intronic chr7:20378165(+) A-I      intronic chr7:20378096(+) A-I      intronic chr7:20378117(+) A-I      intronic chr7:20400977(+) A-I      intronic chr7:20400979(+) A-I      intronic chr7:20400982(+) A-I      intronic chr7:20378722(+) A-I      intronic chr7:20436950(+) A-I      intronic chr7:20436936(+) A-I      intronic chr7:20378656(+) A-I      intronic chr7:20436044(+) A-I      intronic chr7:20378639(+) A-I      intronic chr7:20375758(+) A-I      intronic chr7:20378231(+) A-I      intronic chr7:20375709(+) A-I      intronic chr7:20375684(+) A-I      intronic chr7:20378745(+) A-I      intronic chr7:20378650(+) A-I      intronic chr7:20379491(+) A-I      intronic chr7:20379492(+) A-I      intronic chr7:20379531(+) A-I      intronic chr7:20435935(+) A-I      intronic chr7:20378743(+) A-I      intronic chr7:20379417(+) A-I      intronic chr7:20437111(+) A-I      intronic chr7:20436062(+) A-I      intronic chr7:20378135(+) A-I      intronic chr7:20375679(+) A-I      intronic chr7:20437029(+) A-I      intronic chr7:20378094(+) A-I      intronic chr7:20375889(+) A-I      intronic chr7:20375813(+) A-I      intronic chr7:20436867(+) A-I      intronic chr7:20437032(+) A-I      intronic chr7:20389827(+) A-I      intronic chr7:20378040(+) A-I      intronic chr7:20436979(+) A-I      intronic chr7:20378555(+) A-I      intronic chr7:20375835(+) A-I      intronic chr7:20440741(+) A-I      intronic chr7:20379596(+) A-I      intronic chr7:20435884(+) A-I      intronic chr7:20375839(+) A-I      intronic chr7:20378654(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ITGB8	chr7:20388903(+) A-I intron -    21960545 chr7:20388904(+) A-I intron -    21960545 chr7:20389056(+) A-I intron -    21960545 chr7:20407218(+) A-I intron -    21960545 chr7:20375835(+) A-G intron -    22484847 chr7:20375875(+) G-A intron -    22484847 chr7:20375889(+) A-G intron -    22484847 chr7:20378001(+) T-G intron -    22484847 chr7:20378091(+) A-G intron -    22484847 chr7:20378094(+) A-G intron -    22484847 chr7:20378135(+) A-G intron -    22484847 chr7:20379417(+) A-G intron -    22484847 chr7:20379596(+) A-G intron -    22484847 chr7:20389827(+) A-G intron -    22484847 chr7:20389839(+) C-T intron -    22484847 chr7:20425896(+) G-C intron -    22484847 chr7:20436879(+) A-G intron -    22484847 chr7:20436943(+) A-G intron -    22484847 chr7:20436968(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ITGB8	chr7:20370461-20370462(+) m6A 5'UTR       22575960 chr7:20370549-20370550(+) m6A 5'UTR       25456834//24981863//22575960 chr7:20370587-20370588(+) m6A 5'UTR       25456834//24981863//22575960 chr7:20370639-20370640(+) m6A 5'UTR       - chr7:20370918-20370919(+) m6A 5'UTR//exon       24284625//24209618//25456834//24981863//22575960 chr7:20438651-20438652(+) m6A exon//intron       24981863 chr7:20441398-20441399(+) m6A CDS       24981863 chr7:20441414-20441415(+) m6A CDS       24981863 chr7:20441433-20441434(+) m6A CDS       24981863 chr7:20441458-20441459(+) m6A CDS       24981863 chr7:20441479-20441480(+) m6A CDS       24981863 chr7:20441489-20441490(+) m6A CDS       24981863 chr7:20441514-20441515(+) m6A CDS       24981863 chr7:20449328-20449329(+) m6A CDS       - chr7:20449599-20449600(+) m6A CDS       24284625//24981863//22575960//22608085 chr7:20449634-20449635(+) m6A 3'UTR       24284625//24209618//24981863//22575960//22608085 chr7:20449648-20449649(+) m6A 3'UTR       24284625//24209618//24981863//22575960//22608085 chr7:20449705-20449706(+) m6A 3'UTR       24284625//24209618//24981863//22575960 chr7:20449754-20449755(+) m6A 3'UTR       24284625//24209618//24981863//22575960 chr7:20449835-20449836(+) m6A 3'UTR       24284625//24981863//22575960 chr7:20449960-20449961(+) m6A 3'UTR       24284625//24981863 chr7:20450021-20450022(+) m6A 3'UTR       24284625//24981863 chr7:20450069-20450070(+) m6A 3'UTR       24981863 chr7:20450096-20450097(+) m6A 3'UTR       24981863 chr7:20450102-20450103(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-183-5p	Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome Peripheral blood mononuclear cells     19002258 Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Jurkat-derived T cell line (J77cl20)     21505438 Exosome Renal cancer cells     21670082 Exosome Breast milk     22211110 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Breast milk|Colon tissue|Epithelial cells|Lymphoma tissue|Tongue tissue     - Extracellular vesicle HEK-293T cells     22849433 Microvesicle Seminal plasma     23539611 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
	ITGB8	Exosome Blood     - Nucleus HeLa-S3 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-183-5p	Sensorad 99342 Drug sensitive Morpholine-N-dithiocarbamate 72675 Drug sensitive (2R,3R,4S,5R)-2-(6-Benzylsulfanylpurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol 6477178 Drug sensitive (3beta)-3-((4-O-beta-D Glucopyranosyl-beta-D-xylopyranosyl)oxy)-14-hydroxy-19-oxocarda-4,20(22)-dienolide 56840951 Drug sensitive Ternatin 5459184 Drug resistant Rogiolol 402519 Drug sensitive Phosphine, 1,2-ethanediylbis[bis[2-(methylthio)phenyl]- 397601 Drug sensitive N-Hydroxy-N-methylpropanethioamide 371713 Drug sensitive Antineoplastic-645804 371505 Drug sensitive Ellipticine 3213 Drug sensitive Stannane, trimethyl[(4-morpholinylthioxomethyl)thio]- 300936 Drug sensitive Nile Blue 2B 20520 Drug sensitive Acrovestone 159969 Drug sensitive 5-Chloro-2[(E)-2-(4-nitrophenyl)vinyl]-1H-benzimidazole 15373173 Drug sensitive Fusariotoxin T-2 102515111 Drug sensitive 2-bromo-3-ketocastanospermine - Drug resistant (Z)-3-((1-(4-fluoro-3-methoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methylene)indolin-2-one - Drug sensitive (Z)-5-chloro-3-((1-(3,5-dimethoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methylene)indolin-2-one - Drug sensitive 4-morpholinecarbodithioic acid, antimony complex - Drug sensitive 9-acridinamine, n-(4-ethoxyphenyl)-, monohydrochloride - Drug sensitive benzofurazan, 4-nitro-7-(2-pyridinylthio)-, n-oxide - Drug sensitive (s)(-)-methyl perillate - Drug sensitive (Z)-3-((2-(4-(trifluoromethyl)phenyl)-3H-benzo[d]imidazol-5-yl)methylene)indolin-2-one - Drug sensitive Copper(II) complex with a thiosemicarbazone as a ligand - Drug sensitive ovb3-pe - Drug sensitive trans-4-{4-[3-(4-chloro-3-trifluoromethyl-phenyl)-ureido]-cyclohexyloxy}-pyridine-2-carboxylic acid methylamide - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-183-5p	Ethanol 702 Drug interaction    RC00001910 Piceatannol 667639 Drug interaction    RC00001916 Vorinostat 5311 Drug interaction    RC00001913 Imatinib 5291 Drug interaction    RC00001912 Doxorubicin 31703 Drug interaction    RC00001915 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001911 Tamoxifen 2733526 Drug interaction    RC00001917 Arsenic trioxide 14888 Drug interaction    RC00001914 5-aza-2'-deoxycytidine (5-Aza-CdR) + 4-phenylbutyric acid (PBA) - Drug interaction    RC00001918 Hydroxamic acid HDACi LAQ824 - Drug interaction    RC00001919 Mistletoe lectin-I - Drug interaction    RC00001920 Chemotherapy - Drug interaction    RC00008835

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-183-5p	Doxorubicin 31703       30395908

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-183-5p
Interactor2: ITGB8

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.