Detail Information

Basic Information:


  VIRBase ID:  

HHID00048862

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-182-5p:           TSPAN14:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-182-5p TSPAN14
miRBase
Accession/Entrez ID		 MIMAT0000259 81619
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - DC-TM4F2//TM4SF14//tspan-14

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-182-5p
rs1164249188 chr7:129770446    CA/C
rs1232455061 chr7:129770449    T/G
rs1303310695 chr7:129770447    A/C
rs1331665171 chr7:129770448    G/A
rs750597507 chr7:129770453    A/G
rs760187044 chr7:129770452    G/A
rs765932794 chr7:129770462    A/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR TSPAN14
chr10:82235171(+) A-I      intronic
chr10:82235170(+) A-I      intronic
chr10:82243488(+) A-I      intronic
chr10:82217086(+) A-I      intronic
chr10:82217084(+) A-I      intronic
chr10:82243838(+) A-I      intronic
chr10:82217074(+) A-I      intronic
chr10:82243850(+) A-I      intronic
chr10:82215570(+) A-I      intronic
chr10:82216663(+) A-I      intronic
chr10:82243858(+) A-I      intronic
chr10:82243951(+) A-I      intronic
chr10:82235138(+) A-I      intronic
chr10:82243445(+) A-I      intronic
chr10:82226252(+) A-I      5'UTR
chr10:82235175(+) A-I      intronic
chr10:82243925(+) A-I      intronic
chr10:82281995(+) A-I      3'UTR
chr10:82243836(+) A-I      intronic
chr10:82243508(+) A-I      intronic
chr10:82235162(+) A-I      intronic
chr10:82282223(+) A-I      3'UTR
chr10:82282249(+) A-I      3'UTR
chr10:82282120(+) A-I      3'UTR
chr10:82282111(+) A-I      3'UTR
chr10:82282095(+) A-I      3'UTR
chr10:82282071(+) A-I      3'UTR
chr10:82282057(+) A-I      3'UTR
chr10:82282034(+) A-I      3'UTR
chr10:82282017(+) A-I      3'UTR
chr10:82242324(+) A-I      intronic
chr10:82244188(+) A-I      intronic
chr10:82242179(+) A-I      intronic
chr10:82243839(+) A-I      intronic
chr10:82242172(+) A-I      intronic
chr10:82243581(+) A-I      intronic
chr10:82243843(+) A-I      intronic
chr10:82242136(+) A-I      intronic
chr10:82238528(+) A-I      intronic
chr10:82243559(+) A-I      intronic
chr10:82243450(+) A-I      intronic
chr10:82217071(+) A-I      intronic
chr10:82235617(+) A-I      intronic
chr10:82243478(+) A-I      intronic
chr10:82243479(+) A-I      intronic
chr10:82241691(+) A-I      intronic
chr10:82243607(+) A-I      intronic
chr10:82243618(+) A-I      intronic
chr10:82241716(+) A-I      intronic
chr10:82243750(+) A-I      intronic
chr10:82235211(+) A-I      intronic
chr10:82243760(+) A-I      intronic
chr10:82243455(+) A-I      intronic
chr10:82243745(+) A-I      intronic
chr10:82243801(+) A-I      intronic
chr10:82243842(+) A-I      intronic
chr10:82243577(+) A-I      intronic
chr10:82243481(+) A-I      intronic
chr10:82243890(+) A-I      intronic
chr10:82244174(+) A-I      intronic
chr10:82235059(+) A-I      intronic
chr10:82240755(+) A-I      intronic
chr10:82244181(+) A-I      intronic
chr10:82235163(+) A-I      intronic
chr10:82243912(+) A-I      intronic
chr10:82243921(+) A-I      intronic
chr10:82244158(+) A-I      intronic
chr10:82244240(+) A-I      intronic
chr10:82243840(+) A-I      intronic
chr10:82271643(+) A-I      intronic
chr10:82240773(+) A-I      intronic
chr10:82243410(+) A-I      intronic
chr10:82243507(+) A-I      intronic
chr10:82243407(+) A-I      intronic
chr10:82243449(+) A-I      intronic
chr10:82241649(+) A-I      intronic
chr10:82243578(+) A-I      intronic
chr10:82243519(+) A-I      intronic
chr10:82282152(+) A-I      3'UTR
chr10:82282216(+) A-I      3'UTR
chr10:82282033(+) A-I      3'UTR
chr10:82282128(+) A-I      3'UTR
chr10:82282091(+) A-I      3'UTR
chr10:82282038(+) A-I      3'UTR
chr10:82282028(+) A-I      3'UTR
chr10:82281669(+) A-I      3'UTR
chr10:82282179(+) A-I      3'UTR
chr10:82282188(+) A-I      3'UTR
chr10:82282209(+) A-I      3'UTR
chr10:82282173(+) A-I      3'UTR
chr10:82282199(+) A-I      3'UTR
chr10:82235970(+) A-I      intronic
chr10:82243654(+) A-I      intronic
chr10:82235195(+) A-I      intronic
chr10:82271654(+) A-I      intronic
chr10:82244210(+) A-I      intronic
chr10:82243572(+) A-I      intronic
chr10:82244257(+) A-I      intronic
chr10:82241521(+) A-I      intronic
chr10:82243854(+) A-I      intronic
chr10:82240750(+) A-I      intronic
chr10:82243942(+) A-I      intronic
chr10:82235049(+) A-I      intronic
chr10:82243415(+) A-I      intronic
chr10:82243766(+) A-I      intronic
chr10:82243527(+) A-I      intronic
chr10:82270551(+) A-I      intronic
chr10:82243851(+) A-I      intronic
chr10:82243908(+) A-I      intronic
chr10:82240767(+) A-I      intronic
chr10:82215549(+) A-I      intronic
chr10:82235967(+) A-I      intronic
chr10:82246762(+) A-I      intronic
chr10:82243744(+) A-I      intronic
chr10:82252385(+) A-I      intronic
chr10:82235476(+) A-I      intronic
chr10:82240793(+) A-I      intronic
chr10:82236008(+) A-I      intronic
chr10:82244180(+) A-I      intronic
chr10:82231749(+) A-I      intronic
chr10:82235942(+) A-I      intronic
chr10:82216564(+) A-I      intronic
chr10:82243440(+) A-I      intronic
chr10:82228542(+) A-I      intronic
chr10:82235365(+) A-I      intronic
chr10:82235557(+) A-I      intronic
chr10:82243841(+) A-I      intronic
chr10:82241627(+) A-I      intronic
chr10:82244235(+) A-I      intronic
chr10:82243825(+) A-I      intronic
chr10:82243815(+) A-I      intronic
chr10:82243848(+) A-I      intronic
chr10:82235995(+) A-I      intronic
chr10:82241675(+) A-I      intronic
chr10:82243501(+) A-I      intronic
chr10:82243903(+) A-I      intronic
chr10:82235946(+) A-I      intronic
chr10:82241639(+) A-I      intronic
chr10:82235140(+) A-I      intronic
chr10:82243516(+) A-I      intronic
chr10:82240741(+) A-I      intronic
chr10:82243916(+) A-I      intronic
chr10:82235164(+) A-I      intronic
chr10:82244185(+) A-I      intronic
chr10:82243489(+) A-I      intronic
chr10:82240715(+) A-I      intronic
chr10:82235126(+) A-I      intronic
chr10:82243546(+) A-I      intronic
chr10:82244217(+) A-I      intronic
chr10:82243545(+) A-I      intronic
chr10:82228526(+) A-I      intronic
chr10:82235065(+) A-I      intronic
chr10:82274988(+) A-I      intronic
chr10:82282102(+) A-I      3'UTR
chr10:82282105(+) A-I      3'UTR
chr10:82282146(+) A-I      3'UTR
chr10:82282081(+) A-I      3'UTR
chr10:82282011(+) A-I      3'UTR
chr10:82275015(+) A-I      intronic
chr10:82282042(+) A-I      3'UTR
chr10:82275009(+) A-I      intronic
chr10:82282163(+) A-I      3'UTR
chr10:82281533(+) A-I      3'UTR
chr10:82281989(+) A-I      3'UTR
chr10:82281559(+) A-I      3'UTR
chr10:82275092(+) A-I      intronic
chr10:82226285(+) A-I      5'UTR
chr10:82274682(+) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TSPAN14
chr10:82214067-82214068(+) m6A 5'UTR       24209618//24981863
chr10:82219075-82219076(+) m6A 5'UTR//intron       24209618//24981863
chr10:82277697-82277698(+) m6A CDS//exon       24284625//26404942
chr10:82277898-82277899(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr10:82277927-82277928(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr10:82277962-82277963(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr10:82278003-82278004(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr10:82278044-82278045(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr10:82278073-82278074(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr10:82278104-82278105(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr10:82278153-82278154(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr10:82278167-82278168(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr10:82278271-82278272(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr10:82278345-82278346(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr10:82278412-82278413(+) m6A 3'UTR//exon       24209618//25456834//24981863//22575960//22608085
chr10:82278651-82278652(+) m6A 3'UTR//exon       24284625//24209618//24981863//27773535
chr10:82278852-82278853(+) m6A 3'UTR//exon       -
chr10:82279175-82279176(+) m6A 3'UTR//exon       26404942
chr10:82279466-82279467(+) m6A 3'UTR       -
chr10:82279487-82279488(+) m6A 3'UTR       -
chr10:82280428-82280429(+) m6A 3'UTR       24981863
chr10:82280588-82280589(+) m6A 3'UTR       24981863
chr10:82280967-82280968(+) m6A 3'UTR       24284625
chr10:82281005-82281006(+) m6A 3'UTR       24284625
chr10:82281736-82281737(+) m6A 3'UTR       24981863//26404942//27773535
chr10:82281757-82281758(+) m6A 3'UTR       24209618//24981863//26404942//27773535
chr10:82281892-82281893(+) m6A 3'UTR       24209618//24981863//26404942
chr10:82281981-82281982(+) m6A 3'UTR       25456834//24981863
chr10:82282019-82282020(+) m6A 3'UTR       24284625//25456834//24981863
chr10:82282035-82282036(+) m6A 3'UTR       24284625//25456834//24981863
chr10:82282067-82282068(+) m6A 3'UTR       24284625//25456834//24981863
chr10:82282077-82282078(+) m6A 3'UTR       24284625//25456834//24981863
chr10:82282187-82282188(+) m6A 3'UTR       24981863//27773535
chr10:82282196-82282197(+) m6A 3'UTR       24981863//27773535
chr10:82282253-82282254(+) m6A 3'UTR       24981863//27773535
chr10:82282284-82282285(+) m6A 3'UTR       24981863//27773535
chr10:82282310-82282311(+) m6A 3'UTR       24981863//27773535
chr10:82282320-82282321(+) m6A 3'UTR       24981863//27773535
chr10:82282331-82282332(+) m6A 3'UTR       24981863//27773535
chr10:82282370-82282371(+) m6A 3'UTR       24981863//27773535
chr10:82285742-82285743(+) m6A 3'UTR       24981863
chr10:82285750-82285751(+) m6A 3'UTR       24981863
chr10:82285795-82285796(+) m6A 3'UTR       24981863
chr10:82287822-82287823(+) m6A 3'UTR       24981863
chr10:82287863-82287864(+) m6A 3'UTR       24981863
chr10:82288340-82288341(+) m6A 3'UTR       -
chr10:82288443-82288444(+) m6A 3'UTR       -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-182-5p
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Pooled sera     27278097
Exosome Bronchoalveolar lavage fluid|Pooled sera     27278097
Exosome Human milk     28688106
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Jurkat-derived T cell line (J77cl20)     21505438
Exosome Renal cancer cells     21670082
Exosome Breast milk     22211110
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Blood|B lymphoblastoid cells|Breast milk|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Epithelial cells|Kidney tissue|Lymphoma tissue|Mast cells|Tongue tissue     -
Extracellular vesicle HEK-293T cells     22849433
Microvesicle Seminal plasma     23539611
Microvesicle Serum     24797360
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleolus Breast adenocarcinoma cells (MCF-7)     24918059
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Colon adenocarcinoma cells     20864815
TSPAN14
Chromatin K562 cells     -
Cytosol HCC cell line (HepG2)     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Membrane K562 cells     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-182-5p
Sensorad 99342 Drug sensitive
N-(6-Phenyl-1H-indazol-3-yl)cyclopropanecarboxamide 6539593 Drug sensitive
Ixabepilone 6445540 Drug sensitive
(1E,4E)-1,5-Dipyridin-3-ylpenta-1,4-dien-3-one 5382674 Drug sensitive
10-Hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12-dodecahydro-1H-picene-4a-carboxylic acid 495604 Drug sensitive
Tiazofurin 457954 Drug sensitive
Antineoplastic-645804 371505 Drug sensitive
(4-Methoxyphenyl)-(3,4,5-trimethoxyphenyl)methanol 368140 Drug sensitive
Predorine 333830 Drug sensitive
4-Benzoyl-3H-benzo[f]quinoline-3-carbonitrile 262649 Drug sensitive
Nile Blue 2B 20520 Drug sensitive
5-Chloro-2[(E)-2-(4-nitrophenyl)vinyl]-1H-benzimidazole 15373173 Drug sensitive
(Z)-5-chloro-3-((1-(3,5-dimethoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methylene)indolin-2-one - Drug sensitive
benzofurazan, 4-nitro-7-(2-pyridinylthio)-, n-oxide - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-182-5p
Hyaluronidase 91820602 Drug interaction    RC00001904
Formaldehyde 712 Drug interaction    RC00001887
Ethanol 702 Drug interaction    RC00001886
Atorvastatin 60823 Drug interaction    RC00001897
D-Glucose 5793 Drug interaction    RC00001894
Temozolomide 5394 Drug interaction    RC00001893
Vorinostat 5311 Drug interaction    RC00001892
Eloxatine 5310940 Drug interaction    RC00001902
Decitabine 451668 Drug interaction    RC00001900
Trichostatin A 444732 Drug interaction    RC00001899
Paclitaxel 36314 Drug interaction    RC00001896
5-Fluorouracil 3385 Drug interaction    RC00001891
Fentanyl 3345 Drug interaction    RC00001890
Doxorubicin 31703 Drug interaction    RC00001895
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001889
Tamoxifen 2733526 Drug interaction    RC00001901
Verapamil 2520 Drug interaction    RC00001888
Olaparib 23725625 Drug interaction    RC00001903
Aldesleukin - Drug interaction    RC00001905
1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00001906
5-aza-2'-deoxycytidine (5-Aza-CdR) + 4-phenylbutyric acid (PBA) - Drug interaction    RC00001907
5-aza-2'-deoxycytidine (5-Aza-CdR) + trichostatin A(TSA) - Drug interaction    RC00001908
Marine fungal metabolite 1386A - Drug interaction    RC00001909
Chemotherapy - Drug interaction    RC00008834
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-182-5p
Tamoxifen 2733526       31153828
Veliparib 11960529       31063487
Serdemetan 11609586       31063487

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-182-5p
Interactor2: TSPAN14

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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