Basic Information:

  VIRBase ID:  

HHID00048859

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-182-5p:  MIMAT0000259          POMP:  NM_015932     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-182-5p	POMP
miRBase Accession/Entrez ID	MIMAT0000259	51371
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	C13orf12//HSPC014//PNAS-110//PRAAS2//UMP1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-182-5p	rs1164249188 chr7:129770446    CA/C rs1232455061 chr7:129770449    T/G rs1303310695 chr7:129770447    A/C rs1331665171 chr7:129770448    G/A rs750597507 chr7:129770453    A/G rs760187044 chr7:129770452    G/A rs765932794 chr7:129770462    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	POMP	chr13:29248882(+) A-I      intronic chr13:29249580(+) A-I      intronic chr13:29248887(+) A-I      intronic chr13:29245105(+) A-I      intronic chr13:29248912(+) A-I      intronic chr13:29248969(+) A-I      intronic chr13:29248862(+) A-I      intronic chr13:29249072(+) A-I      intronic chr13:29249104(+) A-I      intronic chr13:29249559(+) A-I      intronic chr13:29249101(+) A-I      intronic chr13:29249065(+) A-I      intronic chr13:29248980(+) A-I      intronic chr13:29245064(+) A-I      intronic chr13:29244929(+) A-I      intronic chr13:29244199(+) A-I      intronic chr13:29244197(+) A-I      intronic chr13:29244140(+) A-I      intronic chr13:29244027(+) A-I      intronic chr13:29243704(+) A-I      intronic chr13:29243568(+) A-I      intronic chr13:29249407(+) A-I      intronic chr13:29249131(+) A-I      intronic chr13:29248926(+) A-I      intronic chr13:29244042(+) A-I      intronic chr13:29243616(+) A-I      intronic chr13:29246814(+) A-I      intronic chr13:29243599(+) A-I      intronic chr13:29249091(+) A-I      intronic chr13:29246070(+) A-I      intronic chr13:29248992(+) A-I      intronic chr13:29249115(+) A-I      intronic chr13:29250323(+) A-I      intronic chr13:29245063(+) A-I      intronic chr13:29244167(+) A-I      intronic chr13:29249377(+) A-I      intronic chr13:29249317(+) A-I      intronic chr13:29246743(+) A-I      intronic chr13:29247333(+) A-I      intronic chr13:29249133(+) A-I      intronic chr13:29249395(+) A-I      intronic chr13:29249552(+) A-I      intronic chr13:29241448(+) A-I      intronic chr13:29243613(+) A-I      intronic chr13:29249537(+) A-I      intronic chr13:29249183(+) A-I      intronic chr13:29244124(+) A-I      intronic chr13:29244041(+) A-I      intronic chr13:29249069(+) A-I      intronic chr13:29243645(+) A-I      intronic chr13:29249486(+) A-I      intronic chr13:29248914(+) A-I      intronic chr13:29243556(+) A-I      intronic chr13:29249136(+) A-I      intronic chr13:29249187(+) A-I      intronic chr13:29249082(+) A-I      intronic chr13:29249417(+) A-I      intronic chr13:29249403(+) A-I      intronic chr13:29249357(+) A-I      intronic chr13:29250348(+) A-I      intronic chr13:29246784(+) A-I      intronic chr13:29249528(+) A-I      intronic chr13:29249105(+) A-I      intronic chr13:29249078(+) A-I      intronic chr13:29249124(+) A-I      intronic chr13:29243654(+) A-I      intronic chr13:29246779(+) A-I      intronic chr13:29249358(+) A-I      intronic chr13:29249096(+) A-I      intronic chr13:29248990(+) A-I      intronic chr13:29248920(+) A-I      intronic chr13:29244126(+) A-I      intronic chr13:29249378(+) A-I      intronic chr13:29243737(+) A-I      intronic chr13:29248918(+) A-I      intronic chr13:29249184(+) A-I      intronic chr13:29243703(+) A-I      intronic chr13:29249459(+) A-I      intronic chr13:29243536(+) A-I      intronic chr13:29247391(+) A-I      intronic chr13:29246809(+) A-I      intronic chr13:29248956(+) A-I      intronic chr13:29249514(+) A-I      intronic chr13:29248921(+) A-I      intronic chr13:29243652(+) A-I      intronic chr13:29248995(+) A-I      intronic chr13:29244222(+) A-I      intronic chr13:29243612(+) A-I      intronic chr13:29248961(+) A-I      intronic chr13:29243580(+) A-I      intronic chr13:29249055(+) A-I      intronic chr13:29243582(+) A-I      intronic chr13:29246824(+) A-I      intronic chr13:29243642(+) A-I      intronic chr13:29248929(+) A-I      intronic chr13:29243574(+) A-I      intronic chr13:29244162(+) A-I      intronic chr13:29249171(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	POMP	chr13:29244126(+) A-I intron -    22327324 chr13:29249055(+) A-I intron -    22327324 chr13:29243703(+) A-I intron -    21960545 chr13:29243613(+) A-G intron -    22484847 chr13:29243616(+) A-G intron -    22484847 chr13:29243703(+) A-G intron -    22484847 chr13:29244126(+) A-G intron -    22484847 chr13:29244167(+) A-G intron -    22484847 chr13:29244244(+) C-T intron -    22484847 chr13:29249055(+) A-G intron -    22484847 chr13:29249069(+) A-G intron -    22484847 chr13:29249357(+) A-G intron -    22484847 chr13:29249395(+) A-G intron -    22484847 chr13:29249514(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	POMP	chr13:29233976-29233977(+) m6A exon//intron       24284625//25456834//24981863//27773535//22608085 chr13:29233999-29234000(+) m6A exon//intron       24284625//25456834//24981863//27773535//22608085 chr13:29236557-29236558(+) m6A CDS//exon       24981863//27773535 chr13:29236577-29236578(+) m6A CDS//exon       24981863//27773535 chr13:29236596-29236597(+) m6A CDS//exon       24981863//27773535 chr13:29236611-29236612(+) m6A CDS//exon       24981863//27773535 chr13:29238666-29238667(+) m6A CDS//exon       27773535 chr13:29242652-29242653(+) m6A CDS//exon       26404942//27773535 chr13:29246541-29246542(+) m6A CDS//exon       26404942//27773535 chr13:29252223-29252224(+) m6A CDS//exon       27773535 chr13:29252258-29252259(+) m6A 3'UTR//exon       27773535 chr13:29252457-29252458(+) m6A 3'UTR//exon       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-182-5p	Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome Pooled sera     27278097 Exosome Bronchoalveolar lavage fluid|Pooled sera     27278097 Exosome Human milk     28688106 Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Jurkat-derived T cell line (J77cl20)     21505438 Exosome Renal cancer cells     21670082 Exosome Breast milk     22211110 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Blood|B lymphoblastoid cells|Breast milk|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Epithelial cells|Kidney tissue|Lymphoma tissue|Mast cells|Tongue tissue     - Extracellular vesicle HEK-293T cells     22849433 Microvesicle Seminal plasma     23539611 Microvesicle Serum     24797360 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleolus Breast adenocarcinoma cells (MCF-7)     24918059 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Colon adenocarcinoma cells     20864815
	POMP	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleus HeLa-S3 cells|K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-182-5p	Sensorad 99342 Drug sensitive N-(6-Phenyl-1H-indazol-3-yl)cyclopropanecarboxamide 6539593 Drug sensitive Ixabepilone 6445540 Drug sensitive (1E,4E)-1,5-Dipyridin-3-ylpenta-1,4-dien-3-one 5382674 Drug sensitive 10-Hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12-dodecahydro-1H-picene-4a-carboxylic acid 495604 Drug sensitive Tiazofurin 457954 Drug sensitive Antineoplastic-645804 371505 Drug sensitive (4-Methoxyphenyl)-(3,4,5-trimethoxyphenyl)methanol 368140 Drug sensitive Predorine 333830 Drug sensitive 4-Benzoyl-3H-benzo[f]quinoline-3-carbonitrile 262649 Drug sensitive Nile Blue 2B 20520 Drug sensitive 5-Chloro-2[(E)-2-(4-nitrophenyl)vinyl]-1H-benzimidazole 15373173 Drug sensitive (Z)-5-chloro-3-((1-(3,5-dimethoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methylene)indolin-2-one - Drug sensitive benzofurazan, 4-nitro-7-(2-pyridinylthio)-, n-oxide - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-182-5p	Hyaluronidase 91820602 Drug interaction    RC00001904 Formaldehyde 712 Drug interaction    RC00001887 Ethanol 702 Drug interaction    RC00001886 Atorvastatin 60823 Drug interaction    RC00001897 D-Glucose 5793 Drug interaction    RC00001894 Temozolomide 5394 Drug interaction    RC00001893 Vorinostat 5311 Drug interaction    RC00001892 Eloxatine 5310940 Drug interaction    RC00001902 Decitabine 451668 Drug interaction    RC00001900 Trichostatin A 444732 Drug interaction    RC00001899 Paclitaxel 36314 Drug interaction    RC00001896 5-Fluorouracil 3385 Drug interaction    RC00001891 Fentanyl 3345 Drug interaction    RC00001890 Doxorubicin 31703 Drug interaction    RC00001895 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001889 Tamoxifen 2733526 Drug interaction    RC00001901 Verapamil 2520 Drug interaction    RC00001888 Olaparib 23725625 Drug interaction    RC00001903 Aldesleukin - Drug interaction    RC00001905 1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00001906 5-aza-2'-deoxycytidine (5-Aza-CdR) + 4-phenylbutyric acid (PBA) - Drug interaction    RC00001907 5-aza-2'-deoxycytidine (5-Aza-CdR) + trichostatin A(TSA) - Drug interaction    RC00001908 Marine fungal metabolite 1386A - Drug interaction    RC00001909 Chemotherapy - Drug interaction    RC00008834

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-182-5p	Tamoxifen 2733526       31153828 Veliparib 11960529       31063487 Serdemetan 11609586       31063487

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-182-5p
Interactor2: POMP

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.