Basic Information:

  VIRBase ID:  

HHID00048857

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-182-5p:  MIMAT0000259          ZDHHC5:  NM_015457     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-182-5p	ZDHHC5
miRBase Accession/Entrez ID	MIMAT0000259	25921
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	DHHC5//ZNF375

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-182-5p	rs1164249188 chr7:129770446    CA/C rs1232455061 chr7:129770449    T/G rs1303310695 chr7:129770447    A/C rs1331665171 chr7:129770448    G/A rs750597507 chr7:129770453    A/G rs760187044 chr7:129770452    G/A rs765932794 chr7:129770462    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ZDHHC5	chr11:57451634(+) A-I      intronic chr11:57454955(+) A-I      intronic chr11:57451606(+) A-I      intronic chr11:57437773(+) A-I      intronic chr11:57462605(+) A-I      intronic chr11:57437948(+) A-I      intronic chr11:57454334(+) A-I      intronic chr11:57463190(+) A-I      intronic chr11:57447742(+) A-I      intronic chr11:57455030(+) A-I      intronic chr11:57461999(+) A-I      intronic chr11:57462788(+) A-I      intronic chr11:57461903(+) A-I      intronic chr11:57454995(+) A-I      intronic chr11:57441176(+) A-I      intronic chr11:57438440(+) A-I      intronic chr11:57438315(+) A-I      intronic chr11:57454565(+) A-I      intronic chr11:57454992(+) A-I      intronic chr11:57446141(+) A-I      intronic chr11:57454503(+) A-I      intronic chr11:57454420(+) A-I      intronic chr11:57447649(+) A-I      intronic chr11:57454396(+) A-I      intronic chr11:57454383(+) A-I      intronic chr11:57454326(+) A-I      intronic chr11:57451906(+) A-I      intronic chr11:57454923(+) A-I      intronic chr11:57454993(+) A-I      intronic chr11:57451963(+) A-I      intronic chr11:57454407(+) A-I      intronic chr11:57437863(+) A-I      intronic chr11:57446708(+) A-I      intronic chr11:57446152(+) A-I      intronic chr11:57454828(+) A-I      intronic chr11:57437686(+) A-I      intronic chr11:57451910(+) A-I      intronic chr11:57451801(+) A-I      intronic chr11:57451806(+) A-I      intronic chr11:57447812(+) A-I      intronic chr11:57454805(+) A-I      intronic chr11:57446169(+) A-I      intronic chr11:57453673(+) A-I      intronic chr11:57451857(+) A-I      intronic chr11:57451651(+) A-I      intronic chr11:57455423(+) A-I      intronic chr11:57454538(+) A-I      intronic chr11:57461567(+) A-I      intronic chr11:57462314(+) A-I      intronic chr11:57441143(+) A-I      intronic chr11:57455482(+) A-I      intronic chr11:57453985(+) A-I      intronic chr11:57437782(+) A-I      intronic chr11:57451937(+) A-I      intronic chr11:57438382(+) A-I      intronic chr11:57446773(+) A-I      intronic chr11:57447858(+) A-I      intronic chr11:57438313(+) A-I      intronic chr11:57453900(+) A-I      intronic chr11:57446763(+) A-I      intronic chr11:57437676(+) A-I      intronic chr11:57451584(+) A-I      intronic chr11:57454577(+) A-I      intronic chr11:57438383(+) A-I      intronic chr11:57437839(+) A-I      intronic chr11:57462309(+) A-I      intronic chr11:57446155(+) A-I      intronic chr11:57437822(+) A-I      intronic chr11:57454958(+) A-I      intronic chr11:57454897(+) A-I      intronic chr11:57437760(+) A-I      intronic chr11:57446230(+) A-I      intronic chr11:57437779(+) A-I      intronic chr11:57446195(+) A-I      intronic chr11:57454364(+) A-I      intronic chr11:57437674(+) A-I      intronic chr11:57451907(+) A-I      intronic chr11:57451557(+) A-I      intronic chr11:57462595(+) A-I      intronic chr11:57454922(+) A-I      intronic chr11:57437855(+) A-I      intronic chr11:57453905(+) A-I      intronic chr11:57441099(+) A-I      intronic chr11:57454403(+) A-I      intronic chr11:57451866(+) A-I      intronic chr11:57446908(+) A-I      intronic chr11:57462102(+) A-I      intronic chr11:57446902(+) A-I      intronic chr11:57454402(+) A-I      intronic chr11:57453888(+) A-I      intronic chr11:57455312(+) A-I      intronic chr11:57453927(+) A-I      intronic chr11:57454475(+) A-I      intronic chr11:57453892(+) A-I      intronic chr11:57451586(+) A-I      intronic chr11:57452440(+) A-I      intronic chr11:57463009(+) A-I      intronic chr11:57441327(+) A-I      intronic chr11:57437758(+) A-I      intronic chr11:57452957(+) A-I      intronic chr11:57452363(+) A-I      intronic chr11:57451896(+) A-I      intronic chr11:57451686(+) A-I      intronic chr11:57446199(+) A-I      intronic chr11:57453998(+) A-I      intronic chr11:57446253(+) A-I      intronic chr11:57453971(+) A-I      intronic chr11:57437823(+) A-I      intronic chr11:57437768(+) A-I      intronic chr11:57452972(+) A-I      intronic chr11:57462772(+) A-I      intronic chr11:57463000(+) A-I      intronic chr11:57461732(+) A-I      intronic chr11:57436993(+) A-I      intronic chr11:57453968(+) A-I      intronic chr11:57451936(+) A-I      intronic chr11:57453438(+) A-I      intronic chr11:57447829(+) A-I      intronic chr11:57454864(+) A-I      intronic chr11:57462054(+) A-I      intronic chr11:57453732(+) A-I      intronic chr11:57462055(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ZDHHC5	chr11:57437779(+) A-G intron -    22484847 chr11:57437782(+) A-G intron -    22484847 chr11:57451937(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ZDHHC5	chr11:57435403-57435404(+) m6A 5'UTR       25456834//24981863 chr11:57435440-57435441(+) m6A 5'UTR       24209618//25456834//24981863 chr11:57435476-57435477(+) m6A 5'UTR       24209618//25456834//24981863 chr11:57435811-57435812(+) m6A exon//intron       24284625//24209618//24981863//22608085 chr11:57439497-57439498(+) m6A 5'UTR//exon//intron       24209618//25456834//24981863//22608085 chr11:57439515-57439516(+) m6A 5'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//27773535//22608085 chr11:57439538-57439539(+) m6A 5'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//27773535//22608085 chr11:57439556-57439557(+) m6A 5'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//27773535//22608085 chr11:57439574-57439575(+) m6A 5'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//27773535//22608085 chr11:57439580-57439581(+) m6A 5'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//27773535//22608085 chr11:57439591-57439592(+) m6A 5'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//27773535//22608085 chr11:57439613-57439614(+) m6A 5'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//27773535//22608085 chr11:57439673-57439674(+) m6A 5'UTR//exon//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr11:57439716-57439717(+) m6A 5'UTR//exon//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr11:57439728-57439729(+) m6A 5'UTR//exon//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr11:57439772-57439773(+) m6A 5'UTR//exon//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr11:57439829-57439830(+) m6A 5'UTR//exon//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr11:57439836-57439837(+) m6A 5'UTR//exon//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr11:57439880-57439881(+) m6A 5'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr11:57439894-57439895(+) m6A 5'UTR//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr11:57439943-57439944(+) m6A 5'UTR//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr11:57439957-57439958(+) m6A 5'UTR//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr11:57439963-57439964(+) m6A 5'UTR//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr11:57439973-57439974(+) m6A 5'UTR//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr11:57440038-57440039(+) m6A 5'UTR//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr11:57440081-57440082(+) m6A 5'UTR//intron       24284625//24209618//24981863//26404942//22575960//22608085 chr11:57440175-57440176(+) m6A 5'UTR//intron       24284625//24209618//26404942//22575960 chr11:57463438-57463439(+) m6A CDS//exon       24284625 chr11:57463461-57463462(+) m6A CDS//exon       24284625 chr11:57463487-57463488(+) m6A CDS//exon       24284625//22575960 chr11:57464253-57464254(+) m6A CDS//exon       24284625//22575960 chr11:57466043-57466044(+) m6A CDS//exon       24284625 chr11:57466116-57466117(+) m6A CDS//exon       24284625 chr11:57466294-57466295(+) m6A CDS//exon       24284625//24981863//22575960//22608085 chr11:57466340-57466341(+) m6A CDS//exon       24284625//24981863//22575960//22608085 chr11:57466382-57466383(+) m6A CDS//exon       24284625//24981863//22575960//22608085 chr11:57466596-57466597(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr11:57466610-57466611(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr11:57466699-57466700(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr11:57466776-57466777(+) m6A CDS//exon       24284625//24981863//22608085 chr11:57466852-57466853(+) m6A CDS//exon       24284625 chr11:57466859-57466860(+) m1A CDS//exon       26863410 chr11:57467356-57467357(+) m6A CDS//exon       24284625 chr11:57467601-57467602(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr11:57467612-57467613(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr11:57467689-57467690(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr11:57467723-57467724(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr11:57467746-57467747(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr11:57467751-57467752(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr11:57467760-57467761(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr11:57467790-57467791(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr11:57467806-57467807(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr11:57467999-57468000(+) m6A 3'UTR//exon       27773535 chr11:57468280-57468281(+) m6A 3'UTR//exon       24284625

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-182-5p	Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome Pooled sera     27278097 Exosome Bronchoalveolar lavage fluid|Pooled sera     27278097 Exosome Human milk     28688106 Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Jurkat-derived T cell line (J77cl20)     21505438 Exosome Renal cancer cells     21670082 Exosome Breast milk     22211110 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Blood|B lymphoblastoid cells|Breast milk|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Epithelial cells|Kidney tissue|Lymphoma tissue|Mast cells|Tongue tissue     - Extracellular vesicle HEK-293T cells     22849433 Microvesicle Seminal plasma     23539611 Microvesicle Serum     24797360 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleolus Breast adenocarcinoma cells (MCF-7)     24918059 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Colon adenocarcinoma cells     20864815
	ZDHHC5	Chromatin K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-182-5p	Sensorad 99342 Drug sensitive N-(6-Phenyl-1H-indazol-3-yl)cyclopropanecarboxamide 6539593 Drug sensitive Ixabepilone 6445540 Drug sensitive (1E,4E)-1,5-Dipyridin-3-ylpenta-1,4-dien-3-one 5382674 Drug sensitive 10-Hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12-dodecahydro-1H-picene-4a-carboxylic acid 495604 Drug sensitive Tiazofurin 457954 Drug sensitive Antineoplastic-645804 371505 Drug sensitive (4-Methoxyphenyl)-(3,4,5-trimethoxyphenyl)methanol 368140 Drug sensitive Predorine 333830 Drug sensitive 4-Benzoyl-3H-benzo[f]quinoline-3-carbonitrile 262649 Drug sensitive Nile Blue 2B 20520 Drug sensitive 5-Chloro-2[(E)-2-(4-nitrophenyl)vinyl]-1H-benzimidazole 15373173 Drug sensitive (Z)-5-chloro-3-((1-(3,5-dimethoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methylene)indolin-2-one - Drug sensitive benzofurazan, 4-nitro-7-(2-pyridinylthio)-, n-oxide - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-182-5p	Hyaluronidase 91820602 Drug interaction    RC00001904 Formaldehyde 712 Drug interaction    RC00001887 Ethanol 702 Drug interaction    RC00001886 Atorvastatin 60823 Drug interaction    RC00001897 D-Glucose 5793 Drug interaction    RC00001894 Temozolomide 5394 Drug interaction    RC00001893 Vorinostat 5311 Drug interaction    RC00001892 Eloxatine 5310940 Drug interaction    RC00001902 Decitabine 451668 Drug interaction    RC00001900 Trichostatin A 444732 Drug interaction    RC00001899 Paclitaxel 36314 Drug interaction    RC00001896 5-Fluorouracil 3385 Drug interaction    RC00001891 Fentanyl 3345 Drug interaction    RC00001890 Doxorubicin 31703 Drug interaction    RC00001895 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001889 Tamoxifen 2733526 Drug interaction    RC00001901 Verapamil 2520 Drug interaction    RC00001888 Olaparib 23725625 Drug interaction    RC00001903 Aldesleukin - Drug interaction    RC00001905 1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00001906 5-aza-2'-deoxycytidine (5-Aza-CdR) + 4-phenylbutyric acid (PBA) - Drug interaction    RC00001907 5-aza-2'-deoxycytidine (5-Aza-CdR) + trichostatin A(TSA) - Drug interaction    RC00001908 Marine fungal metabolite 1386A - Drug interaction    RC00001909 Chemotherapy - Drug interaction    RC00008834

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-182-5p	Tamoxifen 2733526       31153828 Veliparib 11960529       31063487 Serdemetan 11609586       31063487

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-182-5p
Interactor2: ZDHHC5

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.