Basic Information:

  VIRBase ID:  

HHID00048855

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-182-5p:  MIMAT0000259          SGK3:  NM_013257     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-182-5p	SGK3
miRBase Accession/Entrez ID	MIMAT0000259	23678
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CISK//SGK2//SGKL

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-182-5p	rs1164249188 chr7:129770446    CA/C rs1232455061 chr7:129770449    T/G rs1303310695 chr7:129770447    A/C rs1331665171 chr7:129770448    G/A rs750597507 chr7:129770453    A/G rs760187044 chr7:129770452    G/A rs765932794 chr7:129770462    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SGK3	chr8:67771405(+) A-I      intronic chr8:67771351(+) A-I      intronic chr8:67769816(+) A-I      intronic chr8:67769237(+) A-I      intronic chr8:67769197(+) A-I      intronic chr8:67767461(+) A-I      intronic chr8:67767137(+) A-I      intronic chr8:67763669(+) A-I      intronic chr8:67758749(+) A-I      intronic chr8:67758734(+) A-I      intronic chr8:67757792(+) A-I      intronic chr8:67757784(+) A-I      intronic chr8:67757455(+) A-I      intronic chr8:67756186(+) A-I      intronic chr8:67756178(+) A-I      intronic chr8:67756161(+) A-I      intronic chr8:67756154(+) A-I      intronic chr8:67756019(+) A-I      intronic chr8:67755156(+) A-I      intronic chr8:67755155(+) A-I      intronic chr8:67754662(+) A-I      intronic chr8:67750510(+) A-I      intronic chr8:67750418(+) A-I      intronic chr8:67750344(+) A-I      intronic chr8:67749915(+) A-I      intronic chr8:67748791(+) A-I      intronic chr8:67746957(+) A-I      intronic chr8:67746126(+) A-I      intronic chr8:67746115(+) A-I      intronic chr8:67745991(+) A-I      intronic chr8:67745990(+) A-I      intronic chr8:67744911(+) A-I      intronic chr8:67740244(+) A-I      intronic chr8:67740232(+) A-I      intronic chr8:67740207(+) A-I      intronic chr8:67740170(+) A-I      intronic chr8:67740130(+) A-I      intronic chr8:67740104(+) A-I      intronic chr8:67740098(+) A-I      intronic chr8:67740097(+) A-I      intronic chr8:67739542(+) A-I      intronic chr8:67739523(+) A-I      intronic chr8:67739506(+) A-I      intronic chr8:67739497(+) A-I      intronic chr8:67739496(+) A-I      intronic chr8:67739407(+) A-I      intronic chr8:67738980(+) A-I      intronic chr8:67738468(+) A-I      intronic chr8:67738410(+) A-I      intronic chr8:67738405(+) A-I      intronic chr8:67738334(+) A-I      intronic chr8:67738333(+) A-I      intronic chr8:67730256(+) A-I      intronic chr8:67730252(+) A-I      intronic chr8:67730114(+) A-I      intronic chr8:67729317(+) A-I      intronic chr8:67729165(+) A-I      intronic chr8:67729140(+) A-I      intronic chr8:67724591(+) A-I      intronic chr8:67723436(+) A-I      intronic chr8:67722726(+) A-I      intronic chr8:67722721(+) A-I      intronic chr8:67722687(+) A-I      intronic chr8:67721355(+) A-I      intronic chr8:67720848(+) A-I      intronic chr8:67718937(+) A-I      intronic chr8:67718933(+) A-I      intronic chr8:67718852(+) A-I      intronic chr8:67716031(+) A-I      intronic chr8:67715588(+) A-I      intronic chr8:67715584(+) A-I      intronic chr8:67714695(+) A-I      intronic chr8:67711918(+) A-I      intronic chr8:67711538(+) A-I      intronic chr8:67711510(+) A-I      intronic chr8:67711509(+) A-I      intronic chr8:67711503(+) A-I      intronic chr8:67711487(+) A-I      intronic chr8:67702315(+) A-I      intronic chr8:67702288(+) A-I      intronic chr8:67676345(+) A-I      intronic chr8:67674393(+) A-I      intronic chr8:67673132(+) A-I      intronic chr8:67665127(+) A-I      intronic chr8:67655893(+) A-I      intronic chr8:67655886(+) A-I      intronic chr8:67653873(+) A-I      intronic chr8:67653870(+) A-I      intronic chr8:67653830(+) A-I      intronic chr8:67653655(+) A-I      intronic chr8:67651072(+) A-I      intronic chr8:67648772(+) A-I      intronic chr8:67642137(+) A-I      intronic chr8:67640592(+) A-I      intronic chr8:67636632(+) A-I      intronic chr8:67635915(+) A-I      intronic chr8:67635840(+) A-I      intronic chr8:67635791(+) A-I      intronic chr8:67633136(+) A-I      intronic chr8:67633115(+) A-I      intronic chr8:67632912(+) A-I      intronic chr8:67632712(+) A-I      intronic chr8:67631613(+) A-I      intronic chr8:67630212(+) A-I      intronic chr8:67630146(+) A-I      intronic chr8:67630139(+) A-I      intronic chr8:67629555(+) A-I      intronic chr8:67629365(+) A-I      intronic chr8:67627764(+) A-I      intronic chr8:67636646(+) A-I      intronic chr8:67723474(+) A-I      intronic chr8:67730279(+) A-I      intronic chr8:67739415(+) A-I      intronic chr8:67739416(+) A-I      intronic chr8:67739421(+) A-I      intronic chr8:67739431(+) A-I      intronic chr8:67739439(+) A-I      intronic chr8:67739441(+) A-I      intronic chr8:67739455(+) A-I      intronic chr8:67739456(+) A-I      intronic chr8:67739458(+) A-I      intronic chr8:67739459(+) A-I      intronic chr8:67739461(+) A-I      intronic chr8:67739471(+) A-I      intronic chr8:67740126(+) A-I      intronic chr8:67740205(+) A-I      intronic chr8:67740208(+) A-I      intronic chr8:67740209(+) A-I      intronic chr8:67749869(+) A-I      intronic chr8:67749888(+) A-I      intronic chr8:67749908(+) A-I      intronic chr8:67755979(+) A-I      intronic chr8:67755982(+) A-I      intronic chr8:67756000(+) A-I      intronic chr8:67680085(+) A-I      intronic chr8:67680108(+) A-I      intronic chr8:67680111(+) A-I      intronic chr8:67771474(+) A-I      intronic chr8:67773261(+) A-I      3'UTR chr8:67773205(+) A-I      3'UTR chr8:67773227(+) A-I      3'UTR chr8:67773278(+) A-I      3'UTR chr8:67773267(+) A-I      3'UTR chr8:67773237(+) A-I      3'UTR chr8:67773243(+) A-I      3'UTR chr8:67773247(+) A-I      3'UTR chr8:67773215(+) A-I      3'UTR chr8:67670503(+) A-I      intronic chr8:67757609(+) A-I      intronic chr8:67749758(+) A-I      intronic chr8:67725444(+) A-I      intronic chr8:67763697(+) A-I      intronic chr8:67655946(+) A-I      intronic chr8:67740304(+) A-I      intronic chr8:67755145(+) A-I      intronic chr8:67729817(+) A-I      intronic chr8:67767712(+) A-I      intronic chr8:67641008(+) A-I      intronic chr8:67769920(+) A-I      intronic chr8:67649496(+) A-I      intronic chr8:67769815(+) A-I      intronic chr8:67725366(+) A-I      intronic chr8:67723390(+) A-I      intronic chr8:67771448(+) A-I      intronic chr8:67753035(+) A-I      intronic chr8:67729797(+) A-I      intronic chr8:67739009(+) A-I      intronic chr8:67695839(+) A-I      intronic chr8:67767517(+) A-I      intronic chr8:67749898(+) A-I      intronic chr8:67730260(+) A-I      intronic chr8:67640936(+) A-I      intronic chr8:67723363(+) A-I      intronic chr8:67723412(+) A-I      intronic chr8:67739037(+) A-I      intronic chr8:67634657(+) A-I      intronic chr8:67649539(+) A-I      intronic chr8:67674598(+) A-I      intronic chr8:67740212(+) A-I      intronic chr8:67649498(+) A-I      intronic chr8:67636476(+) A-I      intronic chr8:67644612(+) A-I      intronic chr8:67730199(+) A-I      intronic chr8:67770446(+) A-I      intronic chr8:67636369(+) A-I      intronic chr8:67746066(+) A-I      intronic chr8:67769280(+) A-I      intronic chr8:67714818(+) A-I      intronic chr8:67650125(+) A-I      intronic chr8:67635960(+) A-I      intronic chr8:67757819(+) A-I      intronic chr8:67635558(+) A-I      intronic chr8:67676242(+) A-I      intronic chr8:67740112(+) A-I      intronic chr8:67665137(+) A-I      intronic chr8:67758643(+) A-I      intronic chr8:67750521(+) A-I      intronic chr8:67641295(+) A-I      intronic chr8:67755143(+) A-I      intronic chr8:67704859(+) A-I      intronic chr8:67739077(+) A-I      intronic chr8:67750442(+) A-I      intronic chr8:67750466(+) A-I      intronic chr8:67673358(+) A-I      intronic chr8:67749035(+) A-I      intronic chr8:67769072(+) A-I      intronic chr8:67730232(+) A-I      intronic chr8:67755970(+) A-I      intronic chr8:67699231(+) A-I      intronic chr8:67712127(+) A-I      intronic chr8:67673115(+) A-I      intronic chr8:67768478(+) A-I      intronic chr8:67757513(+) A-I      intronic chr8:67762097(+) A-I      intronic chr8:67635536(+) A-I      intronic chr8:67749815(+) A-I      intronic chr8:67749859(+) A-I      intronic chr8:67758032(+) A-I      intronic chr8:67729753(+) A-I      intronic chr8:67758581(+) A-I      intronic chr8:67721337(+) A-I      intronic chr8:67769879(+) A-I      intronic chr8:67749754(+) A-I      intronic chr8:67630032(+) A-I      intronic chr8:67767200(+) A-I      intronic chr8:67723384(+) A-I      intronic chr8:67740103(+) A-I      intronic chr8:67748755(+) A-I      intronic chr8:67763451(+) A-I      intronic chr8:67738264(+) A-I      intronic chr8:67747054(+) A-I      intronic chr8:67729249(+) A-I      intronic chr8:67747384(+) A-I      intronic chr8:67757764(+) A-I      intronic chr8:67642153(+) A-I      intronic chr8:67749974(+) A-I      intronic chr8:67729102(+) A-I      intronic chr8:67755286(+) A-I      intronic chr8:67756078(+) A-I      intronic chr8:67772514(+) A-I      3'UTR chr8:67718998(+) A-I      intronic chr8:67654786(+) A-I      intronic chr8:67755149(+) A-I      intronic chr8:67649499(+) A-I      intronic chr8:67712059(+) A-I      intronic chr8:67712322(+) A-I      intronic chr8:67730319(+) A-I      intronic chr8:67757982(+) A-I      intronic chr8:67769768(+) A-I      intronic chr8:67631654(+) A-I      intronic chr8:67649538(+) A-I      intronic chr8:67756157(+) A-I      intronic chr8:67754475(+) A-I      intronic chr8:67634663(+) A-I      intronic chr8:67747358(+) A-I      intronic chr8:67723488(+) A-I      intronic chr8:67755089(+) A-I      intronic chr8:67636429(+) A-I      intronic chr8:67750440(+) A-I      intronic chr8:67729329(+) A-I      intronic chr8:67749076(+) A-I      intronic chr8:67718955(+) A-I      intronic chr8:67729335(+) A-I      intronic chr8:67749939(+) A-I      intronic chr8:67747060(+) A-I      intronic chr8:67749868(+) A-I      intronic chr8:67723467(+) A-I      intronic chr8:67755118(+) A-I      intronic chr8:67642155(+) A-I      intronic chr8:67640707(+) A-I      intronic chr8:67755185(+) A-I      intronic chr8:67636489(+) A-I      intronic chr8:67755199(+) A-I      intronic chr8:67738931(+) A-I      intronic chr8:67650061(+) A-I      intronic chr8:67758723(+) A-I      intronic chr8:67662978(+) A-I      intronic chr8:67637310(+) A-I      intronic chr8:67767122(+) A-I      intronic chr8:67758667(+) A-I      intronic chr8:67676174(+) A-I      intronic chr8:67749814(+) A-I      intronic chr8:67755251(+) A-I      intronic chr8:67756150(+) A-I      intronic chr8:67668846(+) A-I      intronic chr8:67769868(+) A-I      intronic chr8:67730348(+) A-I      intronic chr8:67638889(+) A-I      intronic chr8:67739397(+) A-I      intronic chr8:67653659(+) A-I      intronic chr8:67669533(+) A-I      intronic chr8:67704375(+) A-I      intronic chr8:67629172(+) A-I      intronic chr8:67756067(+) A-I      intronic chr8:67730299(+) A-I      intronic chr8:67729777(+) A-I      intronic chr8:67758028(+) A-I      intronic chr8:67746056(+) A-I      intronic chr8:67755146(+) A-I      intronic chr8:67749961(+) A-I      intronic chr8:67635499(+) A-I      intronic chr8:67650131(+) A-I      intronic chr8:67649944(+) A-I      intronic chr8:67650034(+) A-I      intronic chr8:67768509(+) A-I      intronic chr8:67762096(+) A-I      intronic chr8:67711957(+) A-I      intronic chr8:67729069(+) A-I      intronic chr8:67767685(+) A-I      intronic chr8:67674631(+) A-I      intronic chr8:67659862(+) A-I      intronic chr8:67750484(+) A-I      intronic chr8:67769953(+) A-I      intronic chr8:67636373(+) A-I      intronic chr8:67743763(+) A-I      intronic chr8:67721191(+) A-I      intronic chr8:67767134(+) A-I      intronic chr8:67755070(+) A-I      intronic chr8:67704864(+) A-I      intronic chr8:67763668(+) A-I      intronic chr8:67730293(+) A-I      intronic chr8:67749817(+) A-I      intronic chr8:67676224(+) A-I      intronic chr8:67630787(+) A-I      intronic chr8:67755288(+) A-I      intronic chr8:67739378(+) A-I      intronic chr8:67763648(+) A-I      intronic chr8:67664104(+) A-I      intronic chr8:67770523(+) A-I      intronic chr8:67729519(+) A-I      intronic chr8:67673884(+) A-I      intronic chr8:67743687(+) A-I      intronic chr8:67723316(+) A-I      intronic chr8:67674754(+) A-I      intronic chr8:67712022(+) A-I      intronic chr8:67638922(+) A-I      intronic chr8:67711555(+) A-I      intronic chr8:67636450(+) A-I      intronic chr8:67767129(+) A-I      intronic chr8:67743675(+) A-I      intronic chr8:67649522(+) A-I      intronic chr8:67730225(+) A-I      intronic chr8:67639018(+) A-I      intronic chr8:67720867(+) A-I      intronic chr8:67712321(+) A-I      intronic chr8:67737768(+) A-I      intronic chr8:67763708(+) A-I      intronic chr8:67729793(+) A-I      intronic chr8:67730109(+) A-I      intronic chr8:67740280(+) A-I      intronic chr8:67757555(+) A-I      intronic chr8:67654799(+) A-I      intronic chr8:67745438(+) A-I      intronic chr8:67640796(+) A-I      intronic chr8:67768403(+) A-I      intronic chr8:67730142(+) A-I      intronic chr8:67749766(+) A-I      intronic chr8:67636347(+) A-I      intronic chr8:67756096(+) A-I      intronic chr8:67670989(+) A-I      intronic chr8:67717114(+) A-I      intronic chr8:67631251(+) A-I      intronic chr8:67769073(+) A-I      intronic chr8:67629389(+) A-I      intronic chr8:67763681(+) A-I      intronic chr8:67748756(+) A-I      intronic chr8:67771312(+) A-I      intronic chr8:67770524(+) A-I      intronic chr8:67635805(+) A-I      intronic chr8:67637308(+) A-I      intronic chr8:67631593(+) A-I      intronic chr8:67768402(+) A-I      intronic chr8:67629319(+) A-I      intronic chr8:67764594(+) A-I      intronic chr8:67763701(+) A-I      intronic chr8:67729727(+) A-I      intronic chr8:67723473(+) A-I      intronic chr8:67740173(+) A-I      intronic chr8:67678661(+) A-I      intronic chr8:67641048(+) A-I      intronic chr8:67744958(+) A-I      intronic chr8:67748825(+) A-I      intronic chr8:67755154(+) A-I      intronic chr8:67665948(+) A-I      intronic chr8:67666044(+) A-I      intronic chr8:67740238(+) A-I      intronic chr8:67631598(+) A-I      intronic chr8:67755239(+) A-I      intronic chr8:67763471(+) A-I      intronic chr8:67730325(+) A-I      intronic chr8:67749851(+) A-I      intronic chr8:67769166(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	SGK3	chr8:67773441(+) A-I exon 3'UTR    19478186

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SGK3	chr8:67624696-67624697(+) m6A 5'UTR       24981863 chr8:67624701-67624702(+) m6A 5'UTR       24981863 chr8:67624720-67624721(+) m6A 5'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-182-5p	Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome Pooled sera     27278097 Exosome Bronchoalveolar lavage fluid|Pooled sera     27278097 Exosome Human milk     28688106 Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Jurkat-derived T cell line (J77cl20)     21505438 Exosome Renal cancer cells     21670082 Exosome Breast milk     22211110 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Blood|B lymphoblastoid cells|Breast milk|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Epithelial cells|Kidney tissue|Lymphoma tissue|Mast cells|Tongue tissue     - Extracellular vesicle HEK-293T cells     22849433 Microvesicle Seminal plasma     23539611 Microvesicle Serum     24797360 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleolus Breast adenocarcinoma cells (MCF-7)     24918059 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Colon adenocarcinoma cells     20864815
	SGK3	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-182-5p	Sensorad 99342 Drug sensitive N-(6-Phenyl-1H-indazol-3-yl)cyclopropanecarboxamide 6539593 Drug sensitive Ixabepilone 6445540 Drug sensitive (1E,4E)-1,5-Dipyridin-3-ylpenta-1,4-dien-3-one 5382674 Drug sensitive 10-Hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12-dodecahydro-1H-picene-4a-carboxylic acid 495604 Drug sensitive Tiazofurin 457954 Drug sensitive Antineoplastic-645804 371505 Drug sensitive (4-Methoxyphenyl)-(3,4,5-trimethoxyphenyl)methanol 368140 Drug sensitive Predorine 333830 Drug sensitive 4-Benzoyl-3H-benzo[f]quinoline-3-carbonitrile 262649 Drug sensitive Nile Blue 2B 20520 Drug sensitive 5-Chloro-2[(E)-2-(4-nitrophenyl)vinyl]-1H-benzimidazole 15373173 Drug sensitive (Z)-5-chloro-3-((1-(3,5-dimethoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methylene)indolin-2-one - Drug sensitive benzofurazan, 4-nitro-7-(2-pyridinylthio)-, n-oxide - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-182-5p	Hyaluronidase 91820602 Drug interaction    RC00001904 Formaldehyde 712 Drug interaction    RC00001887 Ethanol 702 Drug interaction    RC00001886 Atorvastatin 60823 Drug interaction    RC00001897 D-Glucose 5793 Drug interaction    RC00001894 Temozolomide 5394 Drug interaction    RC00001893 Vorinostat 5311 Drug interaction    RC00001892 Eloxatine 5310940 Drug interaction    RC00001902 Decitabine 451668 Drug interaction    RC00001900 Trichostatin A 444732 Drug interaction    RC00001899 Paclitaxel 36314 Drug interaction    RC00001896 5-Fluorouracil 3385 Drug interaction    RC00001891 Fentanyl 3345 Drug interaction    RC00001890 Doxorubicin 31703 Drug interaction    RC00001895 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001889 Tamoxifen 2733526 Drug interaction    RC00001901 Verapamil 2520 Drug interaction    RC00001888 Olaparib 23725625 Drug interaction    RC00001903 Aldesleukin - Drug interaction    RC00001905 1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00001906 5-aza-2'-deoxycytidine (5-Aza-CdR) + 4-phenylbutyric acid (PBA) - Drug interaction    RC00001907 5-aza-2'-deoxycytidine (5-Aza-CdR) + trichostatin A(TSA) - Drug interaction    RC00001908 Marine fungal metabolite 1386A - Drug interaction    RC00001909 Chemotherapy - Drug interaction    RC00008834

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-182-5p	Tamoxifen 2733526       31153828 Veliparib 11960529       31063487 Serdemetan 11609586       31063487

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-182-5p
Interactor2: SGK3

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.