Basic Information:

  VIRBase ID:  

HHID00048854

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-182-5p:  MIMAT0000259          NNT:  NM_001331026     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-182-5p	NNT
miRBase Accession/Entrez ID	MIMAT0000259	23530
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	GCCD4

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-182-5p	rs1164249188 chr7:129770446    CA/C rs1232455061 chr7:129770449    T/G rs1303310695 chr7:129770447    A/C rs1331665171 chr7:129770448    G/A rs750597507 chr7:129770453    A/G rs760187044 chr7:129770452    G/A rs765932794 chr7:129770462    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	NNT	chr5:43681711(+) A-I      intronic chr5:43681619(+) A-I      intronic chr5:43681627(+) A-I      intronic chr5:43681631(+) A-I      intronic chr5:43681702(+) A-I      intronic chr5:43605524(+) A-I      intronic chr5:43681113(+) A-I      intronic chr5:43681170(+) A-I      intronic chr5:43681251(+) A-I      intronic chr5:43681287(+) A-I      intronic chr5:43605471(+) A-I      intronic chr5:43681519(+) A-I      intronic chr5:43681540(+) A-I      intronic chr5:43681580(+) A-I      intronic chr5:43604818(+) A-I      intronic chr5:43681177(+) A-I      intronic chr5:43681107(+) A-I      intronic chr5:43604886(+) A-I      intronic chr5:43681108(+) A-I      intronic chr5:43681570(+) A-I      intronic chr5:43604835(+) A-I      intronic chr5:43681160(+) A-I      intronic chr5:43681606(+) A-I      intronic chr5:43681531(+) A-I      intronic chr5:43604891(+) A-I      intronic chr5:43608313(+) A-I      intronic chr5:43681196(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	NNT	chr5:43659697(+) G-A intron -    22484847 chr5:43681107(+) A-G intron -    22484847 chr5:43681108(+) A-G intron -    22484847 chr5:43681160(+) A-G intron -    22484847 chr5:43681177(+) A-G intron -    22484847 chr5:43681196(+) A-G intron -    22484847 chr5:43681531(+) A-G intron -    22484847 chr5:43681570(+) A-G intron -    22484847 chr5:43681676(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	NNT	chr5:43602900-43602901(+) m6A 5'UTR//intron       24284625 chr5:43602912-43602913(+) m6A 5'UTR//intron       24284625 chr5:43602966-43602967(+) m6A 5'UTR//intron       24284625 chr5:43616006-43616007(+) m6A CDS       - chr5:43628321-43628322(+) Y CDS       26075521 chr5:43644411-43644412(+) m6A CDS       24981863 chr5:43644737-43644738(+) m6A CDS       24981863 chr5:43704557-43704558(+) m6A 3'UTR       24284625//24981863//22608085 chr5:43704625-43704626(+) m6A 3'UTR       24284625//24981863//22608085 chr5:43704646-43704647(+) m6A 3'UTR       24284625//24981863//22608085 chr5:43704842-43704843(+) m6A 3'UTR       22575960 chr5:43704864-43704865(+) m6A 3'UTR       22575960 chr5:43704905-43704906(+) m6A 3'UTR       22575960 chr5:43704962-43704963(+) m6A 3'UTR       22575960 chr5:43704972-43704973(+) m6A 3'UTR       22575960 chr5:43705108-43705109(+) m6A 3'UTR       24981863 chr5:43705136-43705137(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-182-5p	Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome Pooled sera     27278097 Exosome Bronchoalveolar lavage fluid|Pooled sera     27278097 Exosome Human milk     28688106 Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Jurkat-derived T cell line (J77cl20)     21505438 Exosome Renal cancer cells     21670082 Exosome Breast milk     22211110 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Blood|B lymphoblastoid cells|Breast milk|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Epithelial cells|Kidney tissue|Lymphoma tissue|Mast cells|Tongue tissue     - Extracellular vesicle HEK-293T cells     22849433 Microvesicle Seminal plasma     23539611 Microvesicle Serum     24797360 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleolus Breast adenocarcinoma cells (MCF-7)     24918059 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Colon adenocarcinoma cells     20864815
	NNT	Chromatin K562 cells     - Cytosol K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Membrane HCC cell line (HepG2)|K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-182-5p	Sensorad 99342 Drug sensitive N-(6-Phenyl-1H-indazol-3-yl)cyclopropanecarboxamide 6539593 Drug sensitive Ixabepilone 6445540 Drug sensitive (1E,4E)-1,5-Dipyridin-3-ylpenta-1,4-dien-3-one 5382674 Drug sensitive 10-Hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12-dodecahydro-1H-picene-4a-carboxylic acid 495604 Drug sensitive Tiazofurin 457954 Drug sensitive Antineoplastic-645804 371505 Drug sensitive (4-Methoxyphenyl)-(3,4,5-trimethoxyphenyl)methanol 368140 Drug sensitive Predorine 333830 Drug sensitive 4-Benzoyl-3H-benzo[f]quinoline-3-carbonitrile 262649 Drug sensitive Nile Blue 2B 20520 Drug sensitive 5-Chloro-2[(E)-2-(4-nitrophenyl)vinyl]-1H-benzimidazole 15373173 Drug sensitive (Z)-5-chloro-3-((1-(3,5-dimethoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methylene)indolin-2-one - Drug sensitive benzofurazan, 4-nitro-7-(2-pyridinylthio)-, n-oxide - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-182-5p	Hyaluronidase 91820602 Drug interaction    RC00001904 Formaldehyde 712 Drug interaction    RC00001887 Ethanol 702 Drug interaction    RC00001886 Atorvastatin 60823 Drug interaction    RC00001897 D-Glucose 5793 Drug interaction    RC00001894 Temozolomide 5394 Drug interaction    RC00001893 Vorinostat 5311 Drug interaction    RC00001892 Eloxatine 5310940 Drug interaction    RC00001902 Decitabine 451668 Drug interaction    RC00001900 Trichostatin A 444732 Drug interaction    RC00001899 Paclitaxel 36314 Drug interaction    RC00001896 5-Fluorouracil 3385 Drug interaction    RC00001891 Fentanyl 3345 Drug interaction    RC00001890 Doxorubicin 31703 Drug interaction    RC00001895 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001889 Tamoxifen 2733526 Drug interaction    RC00001901 Verapamil 2520 Drug interaction    RC00001888 Olaparib 23725625 Drug interaction    RC00001903 Aldesleukin - Drug interaction    RC00001905 1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00001906 5-aza-2'-deoxycytidine (5-Aza-CdR) + 4-phenylbutyric acid (PBA) - Drug interaction    RC00001907 5-aza-2'-deoxycytidine (5-Aza-CdR) + trichostatin A(TSA) - Drug interaction    RC00001908 Marine fungal metabolite 1386A - Drug interaction    RC00001909 Chemotherapy - Drug interaction    RC00008834

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-182-5p	Tamoxifen 2733526       31153828 Veliparib 11960529       31063487 Serdemetan 11609586       31063487

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-182-5p
Interactor2: NNT

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.