Basic Information:

  VIRBase ID:  

HHID00048851

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-182-5p:  MIMAT0000259          MGLL:  NM_001388313     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-182-5p	MGLL
miRBase Accession/Entrez ID	MIMAT0000259	11343
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	HU-K5//HUK5//MAGL//MGL

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-182-5p	rs1164249188 chr7:129770446    CA/C rs1232455061 chr7:129770449    T/G rs1303310695 chr7:129770447    A/C rs1331665171 chr7:129770448    G/A rs750597507 chr7:129770453    A/G rs760187044 chr7:129770452    G/A rs765932794 chr7:129770462    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	MGLL	chr3:127490392(-) A-I      intronic chr3:127512936(-) A-I      intronic chr3:127414298(-) A-I      intronic chr3:127456048(-) A-I      intronic chr3:127414311(-) A-I      intronic chr3:127415395(-) A-I      intronic chr3:127414323(-) A-I      intronic chr3:127414324(-) A-I      intronic chr3:127415394(-) A-I      intronic chr3:127513053(-) A-I      intronic chr3:127415385(-) A-I      intronic chr3:127415325(-) A-I      intronic chr3:127415304(-) A-I      intronic chr3:127513188(-) A-I      intronic chr3:127461755(-) A-I      intronic chr3:127511380(-) A-I      intronic chr3:127511302(-) A-I      intronic chr3:127511296(-) A-I      intronic chr3:127511294(-) A-I      intronic chr3:127511287(-) A-I      intronic chr3:127508459(-) A-I      intronic chr3:127508458(-) A-I      intronic chr3:127498224(-) A-I      intronic chr3:127497983(-) A-I      intronic chr3:127461885(-) A-I      intronic chr3:127497961(-) A-I      intronic chr3:127497841(-) A-I      intronic chr3:127489115(-) A-I      intronic chr3:127489137(-) A-I      intronic chr3:127512632(-) A-I      intronic chr3:127485813(-) A-I      intronic chr3:127489138(-) A-I      intronic chr3:127490268(-) A-I      intronic chr3:127490284(-) A-I      intronic chr3:127490288(-) A-I      intronic chr3:127490472(-) A-I      intronic chr3:127497739(-) A-I      intronic chr3:127485795(-) A-I      intronic chr3:127485696(-) A-I      intronic chr3:127485657(-) A-I      intronic chr3:127497830(-) A-I      intronic chr3:127461939(-) A-I      intronic chr3:127461931(-) A-I      intronic chr3:127525625(-) A-I      intronic chr3:127489047(-) A-I      intronic chr3:127488973(-) A-I      intronic chr3:127461429(-) A-I      intronic chr3:127525648(-) A-I      intronic chr3:127488192(-) A-I      intronic chr3:127488111(-) A-I      intronic chr3:127547404(-) A-I      intronic chr3:127547510(-) A-I      intronic chr3:127461228(-) A-I      intronic chr3:127511489(-) A-I      intronic chr3:127488108(-) A-I      intronic chr3:127488107(-) A-I      intronic chr3:127512516(-) A-I      intronic chr3:127512569(-) A-I      intronic chr3:127457061(-) A-I      intronic chr3:127456899(-) A-I      intronic chr3:127456662(-) A-I      intronic chr3:127456620(-) A-I      intronic chr3:127456584(-) A-I      intronic chr3:127457098(-) A-I      intronic chr3:127457097(-) A-I      intronic chr3:127450118(-) A-I      intronic chr3:127488082(-) A-I      intronic chr3:127446387(-) A-I      intronic chr3:127446372(-) A-I      intronic chr3:127444882(-) A-I      intronic chr3:127415372(-) A-I      intronic chr3:127414492(-) A-I      intronic chr3:127414293(-) A-I      intronic chr3:127512598(-) A-I      intronic chr3:127512623(-) A-I      intronic chr3:127490289(-) A-I      intronic chr3:127512651(-) A-I      intronic chr3:127485827(-) A-I      intronic chr3:127512655(-) A-I      intronic chr3:127512656(-) A-I      intronic chr3:127513067(-) A-I      intronic chr3:127516666(-) A-I      intronic chr3:127520132(-) A-I      intronic chr3:127520215(-) A-I      intronic chr3:127520216(-) A-I      intronic chr3:127520342(-) A-I      intronic chr3:127522087(-) A-I      intronic chr3:127489032(-) A-I      intronic chr3:127522095(-) A-I      intronic chr3:127489092(-) A-I      intronic chr3:127511464(-) A-I      intronic chr3:127511408(-) A-I      intronic chr3:127414465(-) A-I      intronic chr3:127526743(-) A-I      intronic chr3:127461253(-) A-I      intronic chr3:127519962(-) A-I      intronic chr3:127444856(-) A-I      intronic chr3:127498127(-) A-I      intronic chr3:127461170(-) A-I      intronic chr3:127498017(-) A-I      intronic chr3:127497877(-) A-I      intronic chr3:127455811(-) A-I      intronic chr3:127415397(-) A-I      intronic chr3:127497965(-) A-I      intronic chr3:127419840(-) A-I      intronic chr3:127424572(-) A-I      intronic chr3:127461689(-) A-I      intronic chr3:127488002(-) A-I      intronic chr3:127497865(-) A-I      intronic chr3:127513066(-) A-I      intronic chr3:127461241(-) A-I      intronic chr3:127446511(-) A-I      intronic chr3:127415368(-) A-I      intronic chr3:127497702(-) A-I      intronic chr3:127461754(-) A-I      intronic chr3:127497797(-) A-I      intronic chr3:127415377(-) A-I      intronic chr3:127457004(-) A-I      intronic chr3:127497733(-) A-I      intronic chr3:127415353(-) A-I      intronic chr3:127445355(-) A-I      intronic chr3:127444664(-) A-I      intronic chr3:127445428(-) A-I      intronic chr3:127446433(-) A-I      intronic chr3:127485802(-) A-I      intronic chr3:127456625(-) A-I      intronic chr3:127526808(-) A-I      intronic chr3:127497735(-) A-I      intronic chr3:127513179(-) A-I      intronic chr3:127445359(-) A-I      intronic chr3:127545202(-) A-I      intronic chr3:127461346(-) A-I      intronic chr3:127461854(-) A-I      intronic chr3:127445546(-) A-I      intronic chr3:127497992(-) A-I      intronic chr3:127424536(-) A-I      intronic chr3:127513029(-) A-I      intronic chr3:127421702(-) A-I      intronic chr3:127498024(-) A-I      intronic chr3:127521960(-) A-I      intronic chr3:127498184(-) A-I      intronic chr3:127415342(-) A-I      intronic chr3:127497759(-) A-I      intronic chr3:127516669(-) A-I      intronic chr3:127526875(-) A-I      intronic chr3:127461876(-) A-I      intronic chr3:127424581(-) A-I      intronic chr3:127445545(-) A-I      intronic chr3:127461853(-) A-I      intronic chr3:127512584(-) A-I      intronic chr3:127445436(-) A-I      intronic chr3:127414478(-) A-I      intronic chr3:127498207(-) A-I      intronic chr3:127513122(-) A-I      intronic chr3:127461350(-) A-I      intronic chr3:127456963(-) A-I      intronic chr3:127415532(-) A-I      intronic chr3:127498110(-) A-I      intronic chr3:127444724(-) A-I      intronic chr3:127424423(-) A-I      intronic chr3:127419801(-) A-I      intronic chr3:127497871(-) A-I      intronic chr3:127419975(-) A-I      intronic chr3:127414504(-) A-I      intronic chr3:127498147(-) A-I      intronic chr3:127526876(-) A-I      intronic chr3:127415530(-) A-I      intronic chr3:127421676(-) A-I      intronic chr3:127456626(-) A-I      intronic chr3:127424507(-) A-I      intronic chr3:127490478(-) A-I      intronic chr3:127456705(-) A-I      intronic chr3:127490377(-) A-I      intronic chr3:127457044(-) A-I      intronic chr3:127415543(-) A-I      intronic chr3:127414530(-) A-I      intronic chr3:127490426(-) A-I      intronic chr3:127461877(-) A-I      intronic chr3:127461795(-) A-I      intronic chr3:127446292(-) A-I      intronic chr3:127519957(-) A-I      intronic chr3:127489027(-) A-I      intronic chr3:127490340(-) A-I      intronic chr3:127512987(-) A-I      intronic chr3:127488038(-) A-I      intronic chr3:127512533(-) A-I      intronic chr3:127525704(-) A-I      intronic chr3:127513166(-) A-I      intronic chr3:127525626(-) A-I      intronic chr3:127512935(-) A-I      intronic chr3:127522069(-) A-I      intronic chr3:127477939(-) A-I      intronic chr3:127446498(-) A-I      intronic chr3:127461381(-) A-I      intronic chr3:127461174(-) A-I      intronic chr3:127498086(-) A-I      intronic chr3:127461176(-) A-I      intronic chr3:127490480(-) A-I      intronic chr3:127488028(-) A-I      intronic chr3:127525682(-) A-I      intronic chr3:127497952(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	MGLL	chr3:127415368(-) A-I intron -    22327324 chr3:127415377(-) A-I intron -    22327324 chr3:127456081(-) A-G intron -    22484847 chr3:127456285(-) A-G intron -    22484847 chr3:127456318(-) A-G intron -    22484847 chr3:127414465(-) A-G intron -    22484847 chr3:127415368(-) A-G intron -    22484847 chr3:127415377(-) A-G intron -    22484847 chr3:127415543(-) A-G intron -    22484847 chr3:127419840(-) A-G intron -    22484847 chr3:127419975(-) A-G intron -    22484847 chr3:127420058(-) G-T intron -    22484847 chr3:127421675(-) A-G intron -    22484847 chr3:127421676(-) A-G intron -    22484847 chr3:127421717(-) A-G intron -    22484847 chr3:127424385(-) A-G intron -    22484847 chr3:127424619(-) G-T intron -    22484847 chr3:127444808(-) A-G intron -    22484847 chr3:127444816(-) A-G intron -    22484847 chr3:127444856(-) A-G intron -    22484847 chr3:127445428(-) A-G intron -    22484847 chr3:127445436(-) A-G intron -    22484847 chr3:127445545(-) A-G intron -    22484847 chr3:127445546(-) A-G intron -    22484847 chr3:127446454(-) A-G intron -    22484847 chr3:127455811(-) A-G intron -    22484847 chr3:127456625(-) A-G intron -    22484847 chr3:127456626(-) A-G intron -    22484847 chr3:127456705(-) A-G intron -    22484847 chr3:127457004(-) A-G intron -    22484847 chr3:127457022(-) A-G intron -    22484847 chr3:127457032(-) A-G intron -    22484847 chr3:127457044(-) A-G intron -    22484847 chr3:127457130(-) A-G intron -    22484847 chr3:127461241(-) A-G intron -    22484847 chr3:127461253(-) A-G intron -    22484847 chr3:127461267(-) A-G intron -    22484847 chr3:127461311(-) A-G intron -    22484847 chr3:127461350(-) A-G intron -    22484847 chr3:127461351(-) A-G intron -    22484847 chr3:127461381(-) A-G intron -    22484847 chr3:127461432(-) G-T intron -    22484847 chr3:127461754(-) A-G intron -    22484847 chr3:127461853(-) A-G intron -    22484847 chr3:127461854(-) A-G intron -    22484847 chr3:127461876(-) A-G intron -    22484847 chr3:127461877(-) A-G intron -    22484847 chr3:127485838(-) A-G intron -    22484847 chr3:127485924(-) T-G intron -    22484847 chr3:127485925(-) G-T intron -    22484847 chr3:127488028(-) A-G intron -    22484847 chr3:127488038(-) A-G intron -    22484847 chr3:127488118(-) A-G intron -    22484847 chr3:127489027(-) A-G intron -    22484847 chr3:127489030(-) A-G intron -    22484847 chr3:127489132(-) A-G intron -    22484847 chr3:127490340(-) A-G intron -    22484847 chr3:127490478(-) A-G intron -    22484847 chr3:127497638(-) A-G intron -    22484847 chr3:127497655(-) A-G intron -    22484847 chr3:127497668(-) A-G intron -    22484847 chr3:127497697(-) A-G intron -    22484847 chr3:127497702(-) A-G intron -    22484847 chr3:127497733(-) A-G intron -    22484847 chr3:127497735(-) A-G intron -    22484847 chr3:127497759(-) A-G intron -    22484847 chr3:127497797(-) A-G intron -    22484847 chr3:127497865(-) A-G intron -    22484847 chr3:127497871(-) A-G intron -    22484847 chr3:127497952(-) A-G intron -    22484847 chr3:127497965(-) A-G intron -    22484847 chr3:127497992(-) A-G intron -    22484847 chr3:127498017(-) A-G intron -    22484847 chr3:127498024(-) A-G intron -    22484847 chr3:127498086(-) A-G intron -    22484847 chr3:127498110(-) A-G intron -    22484847 chr3:127498127(-) A-G intron -    22484847 chr3:127498147(-) A-G intron -    22484847 chr3:127498148(-) A-G intron -    22484847 chr3:127498153(-) A-G intron -    22484847 chr3:127498184(-) A-G intron -    22484847 chr3:127498207(-) A-G intron -    22484847 chr3:127512582(-) A-G intron -    22484847 chr3:127512584(-) A-G intron -    22484847 chr3:127512985(-) A-G intron -    22484847 chr3:127512987(-) A-G intron -    22484847 chr3:127513166(-) A-G intron -    22484847 chr3:127513179(-) A-G intron -    22484847 chr3:127516669(-) A-G intron -    22484847 chr3:127519957(-) A-G intron -    22484847 chr3:127519962(-) A-G intron -    22484847 chr3:127519965(-) A-G intron -    22484847 chr3:127522069(-) A-G intron -    22484847 chr3:127525613(-) A-G intron -    22484847 chr3:127525682(-) A-G intron -    22484847 chr3:127525704(-) A-G intron -    22484847 chr3:127526743(-) A-G intron -    22484847 chr3:127526875(-) A-G intron -    22484847 chr3:127528407(-) A-C intron -    22484847 chr3:127449113(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	MGLL	chr3:127408154-127408155(-) m6A 3'UTR       28052920 chr3:127408416-127408417(-) m6A 3'UTR       27773535 chr3:127408495-127408496(-) m6A 3'UTR       27773535 chr3:127408813-127408814(-) m6A 3'UTR       24981863//27773535 chr3:127408858-127408859(-) m6A 3'UTR       27773535 chr3:127409027-127409028(-) m6A 3'UTR       27773535 chr3:127409044-127409045(-) m6A 3'UTR       27773535 chr3:127409384-127409385(-) m6A 3'UTR       27773535 chr3:127410129-127410130(-) m6A 3'UTR       24981863 chr3:127410134-127410135(-) m6A 3'UTR       24981863 chr3:127410206-127410207(-) m6A 3'UTR       24981863//27773535 chr3:127410391-127410392(-) m6A 3'UTR       24981863 chr3:127410403-127410404(-) m6A 3'UTR       24981863 chr3:127410451-127410452(-) m6A 3'UTR       24981863 chr3:127410543-127410544(-) m6A 3'UTR       24981863//27773535 chr3:127410688-127410689(-) m6A 3'UTR       24981863//27773535 chr3:127410695-127410696(-) m6A 3'UTR       24981863//27773535 chr3:127411057-127411058(-) m6A CDS//exon       24981863 chr3:127411072-127411073(-) m6A CDS//exon       24981863 chr3:127411092-127411093(-) m6A CDS//exon       24981863 chr3:127414013-127414014(-) m6A CDS//exon//intron       27773535 chr3:127429423-127429424(-) m6A CDS//exon//intron       27773535 chr3:127429470-127429471(-) m6A CDS//exon//intron       27773535 chr3:127441312-127441313(-) m6A CDS//exon       27773535 chr3:127441398-127441399(-) m6A CDS//exon       27773535//27371828 chr3:127454562-127454563(-) m6A CDS//intron       27773535//27371828 chr3:127454614-127454615(-) m6A CDS//intron       27773535//27371828 chr3:127454729-127454730(-) m6A 5'UTR//intron       - chr3:127454759-127454760(-) m6A 5'UTR//intron       - chr3:127454824-127454825(-) m6A 5'UTR//intron       - chr3:127454849-127454850(-) m6A 5'UTR//intron       - chr3:127454906-127454907(-) m6A 5'UTR//intron       - chr3:127454927-127454928(-) m6A 5'UTR//intron       - chr3:127454944-127454945(-) m6A 5'UTR//intron       - chr3:127454952-127454953(-) m6A 5'UTR//intron       - chr3:127540553-127540554(-) m6A CDS//exon       27773535 chr3:127540580-127540581(-) m6A CDS//exon       27773535 chr3:127540608-127540609(-) m6A CDS//exon       27773535 chr3:127540633-127540634(-) m6A CDS//exon       27773535 chr3:127540671-127540672(-) m6A 5'UTR//CDS//exon       27773535 chr3:127540868-127540869(-) m6A 5'UTR//intron       - chr3:127540913-127540914(-) m6A 5'UTR//intron       - chr3:127540935-127540936(-) m6A 5'UTR//intron       - chr3:127541413-127541414(-) m6A 5'UTR//intron       24981863 chr3:127541665-127541666(-) m6A 5'UTR//intron       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-182-5p	Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome Pooled sera     27278097 Exosome Bronchoalveolar lavage fluid|Pooled sera     27278097 Exosome Human milk     28688106 Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Jurkat-derived T cell line (J77cl20)     21505438 Exosome Renal cancer cells     21670082 Exosome Breast milk     22211110 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Blood|B lymphoblastoid cells|Breast milk|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Epithelial cells|Kidney tissue|Lymphoma tissue|Mast cells|Tongue tissue     - Extracellular vesicle HEK-293T cells     22849433 Microvesicle Seminal plasma     23539611 Microvesicle Serum     24797360 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleolus Breast adenocarcinoma cells (MCF-7)     24918059 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Colon adenocarcinoma cells     20864815
	MGLL	Exosome Blood     - Nucleus HeLa-S3 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-182-5p	Sensorad 99342 Drug sensitive N-(6-Phenyl-1H-indazol-3-yl)cyclopropanecarboxamide 6539593 Drug sensitive Ixabepilone 6445540 Drug sensitive (1E,4E)-1,5-Dipyridin-3-ylpenta-1,4-dien-3-one 5382674 Drug sensitive 10-Hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12-dodecahydro-1H-picene-4a-carboxylic acid 495604 Drug sensitive Tiazofurin 457954 Drug sensitive Antineoplastic-645804 371505 Drug sensitive (4-Methoxyphenyl)-(3,4,5-trimethoxyphenyl)methanol 368140 Drug sensitive Predorine 333830 Drug sensitive 4-Benzoyl-3H-benzo[f]quinoline-3-carbonitrile 262649 Drug sensitive Nile Blue 2B 20520 Drug sensitive 5-Chloro-2[(E)-2-(4-nitrophenyl)vinyl]-1H-benzimidazole 15373173 Drug sensitive (Z)-5-chloro-3-((1-(3,5-dimethoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methylene)indolin-2-one - Drug sensitive benzofurazan, 4-nitro-7-(2-pyridinylthio)-, n-oxide - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-182-5p	Hyaluronidase 91820602 Drug interaction    RC00001904 Formaldehyde 712 Drug interaction    RC00001887 Ethanol 702 Drug interaction    RC00001886 Atorvastatin 60823 Drug interaction    RC00001897 D-Glucose 5793 Drug interaction    RC00001894 Temozolomide 5394 Drug interaction    RC00001893 Vorinostat 5311 Drug interaction    RC00001892 Eloxatine 5310940 Drug interaction    RC00001902 Decitabine 451668 Drug interaction    RC00001900 Trichostatin A 444732 Drug interaction    RC00001899 Paclitaxel 36314 Drug interaction    RC00001896 5-Fluorouracil 3385 Drug interaction    RC00001891 Fentanyl 3345 Drug interaction    RC00001890 Doxorubicin 31703 Drug interaction    RC00001895 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001889 Tamoxifen 2733526 Drug interaction    RC00001901 Verapamil 2520 Drug interaction    RC00001888 Olaparib 23725625 Drug interaction    RC00001903 Aldesleukin - Drug interaction    RC00001905 1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00001906 5-aza-2'-deoxycytidine (5-Aza-CdR) + 4-phenylbutyric acid (PBA) - Drug interaction    RC00001907 5-aza-2'-deoxycytidine (5-Aza-CdR) + trichostatin A(TSA) - Drug interaction    RC00001908 Marine fungal metabolite 1386A - Drug interaction    RC00001909 Chemotherapy - Drug interaction    RC00008834

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-182-5p	Tamoxifen 2733526       31153828 Veliparib 11960529       31063487 Serdemetan 11609586       31063487

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-182-5p
Interactor2: MGLL

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.