Detail Information

Basic Information:


  VIRBase ID:  

HHID00048845

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-182-5p:           SMAD7:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-182-5p SMAD7
miRBase
Accession/Entrez ID		 MIMAT0000259 4092
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - CRCS3//MADH7//MADH8

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-182-5p
rs1164249188 chr7:129770446    CA/C
rs1232455061 chr7:129770449    T/G
rs1303310695 chr7:129770447    A/C
rs1331665171 chr7:129770448    G/A
rs750597507 chr7:129770453    A/G
rs760187044 chr7:129770452    G/A
rs765932794 chr7:129770462    A/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR SMAD7
chr18:46471683(-) A-I      intronic
chr18:46471684(-) A-I      intronic
chr18:46452397(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase SMAD7
chr18:46446322-46446323(-) m6A 3'UTR       27773535
chr18:46446397-46446398(-) m6A 3'UTR//exon       27773535
chr18:46446514-46446515(-) m6A 3'UTR//exon       24981863//27773535
chr18:46446528-46446529(-) m6A 3'UTR//exon       24981863//27773535
chr18:46446584-46446585(-) m6A 3'UTR//exon       24981863
chr18:46446627-46446628(-) m6A 3'UTR//exon       24981863
chr18:46447079-46447080(-) m6A 3'UTR//exon       27773535
chr18:46447085-46447086(-) m6A 3'UTR//exon       27773535
chr18:46447134-46447135(-) m6A 3'UTR//exon       27773535
chr18:46447450-46447451(-) m6A 3'UTR//exon       27773535
chr18:46447495-46447496(-) m6A 3'UTR//exon       27773535
chr18:46447644-46447645(-) m6A 3'UTR//exon       24981863//27773535
chr18:46447693-46447694(-) m6A 3'UTR//exon       25456834//24981863//27371828
chr18:46447725-46447726(-) m6A 3'UTR//exon       25456834//24981863//27371828//22608085
chr18:46447970-46447971(-) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//27773536//22575960//22608085
chr18:46447979-46447980(-) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//27773536//22575960//22608085
chr18:46448111-46448112(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr18:46448125-46448126(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr18:46474760-46474761(-) m6A CDS       27773535
chr18:46475602-46475603(-) m6A 5'UTR//intron       27773535
chr18:46475678-46475679(-) m6A 5'UTR//intron       27773535
chr18:46476185-46476186(-) m6A CDS       24284625//27773535
chr18:46476396-46476397(-) m6A CDS       24209618//25456834//24981863//27773536//22575960
chr18:46476488-46476489(-) m6A CDS       24209618//25456834//24981863//27371828//27773536//22575960//22608085
chr18:46476663-46476664(-) m6A CDS       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085
chr18:46476784-46476785(-) m6A CDS       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085
chr18:46476971-46476972(-) m6A 5'UTR       24209618//24981863//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-182-5p
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Pooled sera     27278097
Exosome Bronchoalveolar lavage fluid|Pooled sera     27278097
Exosome Human milk     28688106
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Jurkat-derived T cell line (J77cl20)     21505438
Exosome Renal cancer cells     21670082
Exosome Breast milk     22211110
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Blood|B lymphoblastoid cells|Breast milk|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Epithelial cells|Kidney tissue|Lymphoma tissue|Mast cells|Tongue tissue     -
Extracellular vesicle HEK-293T cells     22849433
Microvesicle Seminal plasma     23539611
Microvesicle Serum     24797360
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleolus Breast adenocarcinoma cells (MCF-7)     24918059
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Colon adenocarcinoma cells     20864815
SMAD7
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleoplasm K562 cells     -
Ribosome HEK-293 cells     22199352

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-182-5p
Sensorad 99342 Drug sensitive
N-(6-Phenyl-1H-indazol-3-yl)cyclopropanecarboxamide 6539593 Drug sensitive
Ixabepilone 6445540 Drug sensitive
(1E,4E)-1,5-Dipyridin-3-ylpenta-1,4-dien-3-one 5382674 Drug sensitive
10-Hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12-dodecahydro-1H-picene-4a-carboxylic acid 495604 Drug sensitive
Tiazofurin 457954 Drug sensitive
Antineoplastic-645804 371505 Drug sensitive
(4-Methoxyphenyl)-(3,4,5-trimethoxyphenyl)methanol 368140 Drug sensitive
Predorine 333830 Drug sensitive
4-Benzoyl-3H-benzo[f]quinoline-3-carbonitrile 262649 Drug sensitive
Nile Blue 2B 20520 Drug sensitive
5-Chloro-2[(E)-2-(4-nitrophenyl)vinyl]-1H-benzimidazole 15373173 Drug sensitive
(Z)-5-chloro-3-((1-(3,5-dimethoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methylene)indolin-2-one - Drug sensitive
benzofurazan, 4-nitro-7-(2-pyridinylthio)-, n-oxide - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-182-5p
Hyaluronidase 91820602 Drug interaction    RC00001904
Formaldehyde 712 Drug interaction    RC00001887
Ethanol 702 Drug interaction    RC00001886
Atorvastatin 60823 Drug interaction    RC00001897
D-Glucose 5793 Drug interaction    RC00001894
Temozolomide 5394 Drug interaction    RC00001893
Vorinostat 5311 Drug interaction    RC00001892
Eloxatine 5310940 Drug interaction    RC00001902
Decitabine 451668 Drug interaction    RC00001900
Trichostatin A 444732 Drug interaction    RC00001899
Paclitaxel 36314 Drug interaction    RC00001896
5-Fluorouracil 3385 Drug interaction    RC00001891
Fentanyl 3345 Drug interaction    RC00001890
Doxorubicin 31703 Drug interaction    RC00001895
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001889
Tamoxifen 2733526 Drug interaction    RC00001901
Verapamil 2520 Drug interaction    RC00001888
Olaparib 23725625 Drug interaction    RC00001903
Aldesleukin - Drug interaction    RC00001905
1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00001906
5-aza-2'-deoxycytidine (5-Aza-CdR) + 4-phenylbutyric acid (PBA) - Drug interaction    RC00001907
5-aza-2'-deoxycytidine (5-Aza-CdR) + trichostatin A(TSA) - Drug interaction    RC00001908
Marine fungal metabolite 1386A - Drug interaction    RC00001909
Chemotherapy - Drug interaction    RC00008834
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-182-5p
Tamoxifen 2733526       31153828
Veliparib 11960529       31063487
Serdemetan 11609586       31063487

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-182-5p
Interactor2: SMAD7

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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