Detail Information

Basic Information:


  VIRBase ID:  

HHID00048843

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-182-5p:           HES1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-182-5p HES1
miRBase
Accession/Entrez ID		 MIMAT0000259 3280
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - bHLHb39//HES-1//HHL//HRY

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-182-5p
rs1164249188 chr7:129770446    CA/C
rs1232455061 chr7:129770449    T/G
rs1303310695 chr7:129770447    A/C
rs1331665171 chr7:129770448    G/A
rs750597507 chr7:129770453    A/G
rs760187044 chr7:129770452    G/A
rs765932794 chr7:129770462    A/G

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase HES1
chr3:193854003-193854004(+) m6A 5'UTR//exon       24981863//26404942//27773535//22608085
chr3:193854043-193854044(+) m6A 5'UTR//exon       24981863//26404942//27773535//22608085
chr3:193854091-193854092(+) m6A 5'UTR//exon       24981863//27773535//22608085
chr3:193854097-193854098(+) m6A 5'UTR//exon       24981863//27773535//22608085
chr3:193854121-193854122(+) m6A 5'UTR//exon       24981863//27773535
chr3:193854249-193854250(+) m6A CDS//exon       24981863//27773535
chr3:193854256-193854257(+) m6A CDS//exon       24981863//27773535
chr3:193854471-193854472(+) m6A CDS//exon       24981863
chr3:193854539-193854540(+) m6A exon//intron       24981863
chr3:193854780-193854781(+) m6A CDS//exon       24284625
chr3:193854813-193854814(+) m6A CDS//exon       24284625
chr3:193855486-193855487(+) m6A CDS       -
chr3:193855694-193855695(+) m6A CDS       24209618
chr3:193855993-193855994(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr3:193856017-193856018(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr3:193856049-193856050(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr3:193856078-193856079(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr3:193856085-193856086(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr3:193856091-193856092(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr3:193856115-193856116(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-182-5p
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Pooled sera     27278097
Exosome Bronchoalveolar lavage fluid|Pooled sera     27278097
Exosome Human milk     28688106
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Jurkat-derived T cell line (J77cl20)     21505438
Exosome Renal cancer cells     21670082
Exosome Breast milk     22211110
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Blood|B lymphoblastoid cells|Breast milk|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Epithelial cells|Kidney tissue|Lymphoma tissue|Mast cells|Tongue tissue     -
Extracellular vesicle HEK-293T cells     22849433
Microvesicle Seminal plasma     23539611
Microvesicle Serum     24797360
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleolus Breast adenocarcinoma cells (MCF-7)     24918059
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Colon adenocarcinoma cells     20864815
HES1
Exosome Blood     -
Nucleus HeLa-S3 cells     -
Ribosome-free cytosol Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-182-5p
Sensorad 99342 Drug sensitive
N-(6-Phenyl-1H-indazol-3-yl)cyclopropanecarboxamide 6539593 Drug sensitive
Ixabepilone 6445540 Drug sensitive
(1E,4E)-1,5-Dipyridin-3-ylpenta-1,4-dien-3-one 5382674 Drug sensitive
10-Hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12-dodecahydro-1H-picene-4a-carboxylic acid 495604 Drug sensitive
Tiazofurin 457954 Drug sensitive
Antineoplastic-645804 371505 Drug sensitive
(4-Methoxyphenyl)-(3,4,5-trimethoxyphenyl)methanol 368140 Drug sensitive
Predorine 333830 Drug sensitive
4-Benzoyl-3H-benzo[f]quinoline-3-carbonitrile 262649 Drug sensitive
Nile Blue 2B 20520 Drug sensitive
5-Chloro-2[(E)-2-(4-nitrophenyl)vinyl]-1H-benzimidazole 15373173 Drug sensitive
(Z)-5-chloro-3-((1-(3,5-dimethoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methylene)indolin-2-one - Drug sensitive
benzofurazan, 4-nitro-7-(2-pyridinylthio)-, n-oxide - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-182-5p
Hyaluronidase 91820602 Drug interaction    RC00001904
Formaldehyde 712 Drug interaction    RC00001887
Ethanol 702 Drug interaction    RC00001886
Atorvastatin 60823 Drug interaction    RC00001897
D-Glucose 5793 Drug interaction    RC00001894
Temozolomide 5394 Drug interaction    RC00001893
Vorinostat 5311 Drug interaction    RC00001892
Eloxatine 5310940 Drug interaction    RC00001902
Decitabine 451668 Drug interaction    RC00001900
Trichostatin A 444732 Drug interaction    RC00001899
Paclitaxel 36314 Drug interaction    RC00001896
5-Fluorouracil 3385 Drug interaction    RC00001891
Fentanyl 3345 Drug interaction    RC00001890
Doxorubicin 31703 Drug interaction    RC00001895
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001889
Tamoxifen 2733526 Drug interaction    RC00001901
Verapamil 2520 Drug interaction    RC00001888
Olaparib 23725625 Drug interaction    RC00001903
Aldesleukin - Drug interaction    RC00001905
1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00001906
5-aza-2'-deoxycytidine (5-Aza-CdR) + 4-phenylbutyric acid (PBA) - Drug interaction    RC00001907
5-aza-2'-deoxycytidine (5-Aza-CdR) + trichostatin A(TSA) - Drug interaction    RC00001908
Marine fungal metabolite 1386A - Drug interaction    RC00001909
Chemotherapy - Drug interaction    RC00008834
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-182-5p
Tamoxifen 2733526       31153828
Veliparib 11960529       31063487
Serdemetan 11609586       31063487

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-182-5p
Interactor2: HES1

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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