Basic Information:

  VIRBase ID:  

HHID00048842

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-182-5p:  MIMAT0000259          DDX3X:  NR_126094     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-182-5p	DDX3X
miRBase Accession/Entrez ID	MIMAT0000259	1654
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CAP-Rf//DBX//DDX14//DDX3//HLP2//MRX102//MRXSSB

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-182-5p	rs1164249188 chr7:129770446    CA/C rs1232455061 chr7:129770449    T/G rs1303310695 chr7:129770447    A/C rs1331665171 chr7:129770448    G/A rs750597507 chr7:129770453    A/G rs760187044 chr7:129770452    G/A rs765932794 chr7:129770462    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	DDX3X	chrX:41200368(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	DDX3X	chrX:41192893-41192894(+) m6A 5'UTR//exon       24981863 chrX:41192928-41192929(+) m6A 5'UTR//exon       24981863//27773535 chrX:41192942-41192943(+) m1A 5'UTR//exon       26863196 chrX:41192973-41192974(+) m6A 5'UTR//exon//intron       24981863//27773535 chrX:41192979-41192980(+) m6A 5'UTR//exon//intron       24981863//27773535 chrX:41193134-41193135(+) m6A 5'UTR//intron       24284625//24209618//24981863 chrX:41193148-41193149(+) m6A 5'UTR//intron       24284625//24209618//24981863 chrX:41193191-41193192(+) m6A 5'UTR//intron       24284625//24209618//24981863 chrX:41193197-41193198(+) m6A 5'UTR//intron       24284625//24209618//24981863 chrX:41193229-41193230(+) m6A 5'UTR//intron       24284625//24981863 chrX:41193247-41193248(+) m6A 5'UTR//intron       24284625//24981863 chrX:41193274-41193275(+) m6A 5'UTR//intron       24284625//24981863 chrX:41193453-41193454(+) m6A 5'UTR//exon//intron       24284625//25456834//24981863//26404942//22575960//22608085 chrX:41193478-41193479(+) m6A 5'UTR//exon//intron       24284625//25456834//24981863//26404942//27773535//22575960//22608085 chrX:41193542-41193543(+) m6A CDS//exon//intron       24284625//25456834//24981863//27773535//22575960//22608085 chrX:41193982-41193983(+) m6A exon//intron       24981863 chrX:41196673-41196674(+) m6A CDS//exon       24284625//24981863 chrX:41196679-41196680(+) m6A CDS//exon       24284625//24981863 chrX:41198318-41198319(+) m6A CDS//exon//intron       24981863//26404942 chrX:41200751-41200752(+) m6A CDS//exon       24981863//26404942//22575960 chrX:41201833-41201834(+) m6A CDS//exon//intron       22575960 chrX:41201876-41201877(+) m6A CDS//exon//intron       22575960 chrX:41201903-41201904(+) m6A CDS//exon//intron       22575960 chrX:41201992-41201993(+) m6A CDS//exon//intron       22575960 chrX:41202505-41202506(+) m6A CDS//exon//intron       26404942//22575960 chrX:41203308-41203309(+) m6A CDS//exon//intron       22575960 chrX:41203561-41203562(+) m6A CDS//exon//intron       22575960 chrX:41203642-41203643(+) m6A CDS//exon//intron       22575960 chrX:41204504-41204505(+) m6A CDS//exon//intron       22575960 chrX:41206226-41206227(+) m6A CDS//intron       26404942 chrX:41206596-41206597(+) m6A CDS//intron       24209618//26404942//22575960 chrX:41207001-41207002(+) m6A 3'UTR//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chrX:41207017-41207018(+) m6A 3'UTR//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chrX:41207037-41207038(+) m6A 3'UTR//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chrX:41207061-41207062(+) m6A 3'UTR//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chrX:41207144-41207145(+) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chrX:41207179-41207180(+) m6A 3'UTR//intron       24284625//24209618//24981863//26404942//27773535//22608085 chrX:41207231-41207232(+) m6A 3'UTR//intron       24284625//24209618//24981863//26404942//27773535//22608085 chrX:41207296-41207297(+) m6A 3'UTR//intron       24284625//24209618//24981863//27773535 chrX:41207373-41207374(+) m6A 3'UTR//intron       26404942//27773535 chrX:41207390-41207391(+) m6A 3'UTR//intron       26404942//27773535 chrX:41207459-41207460(+) m6A 3'UTR//intron       26404942 chrX:41207512-41207513(+) m6A 3'UTR//intron       26404942//27773535 chrX:41207562-41207563(+) m6A 3'UTR//intron       26404942//27773535 chrX:41207986-41207987(+) m6A 3'UTR//intron       22575960 chrX:41208065-41208066(+) m6A 3'UTR//intron       22575960 chrX:41208946-41208947(+) m6A 3'UTR//intron       27773535 chrX:41208968-41208969(+) m6A 3'UTR//intron       27773535 chrX:41209013-41209014(+) m6A 3'UTR//intron       27773535 chrX:41209081-41209082(+) m6A 3'UTR//intron       27773535 chrX:41209091-41209092(+) m6A 3'UTR//intron       27773535 chrX:41209199-41209200(+) m6A 3'UTR//intron       27773535 chrX:41209327-41209328(+) m6A 3'UTR//intron       27773535 chrX:41209349-41209350(+) m6A 3'UTR//intron       27773535 chrX:41209451-41209452(+) m6A 3'UTR//intron       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-182-5p	Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome Pooled sera     27278097 Exosome Bronchoalveolar lavage fluid|Pooled sera     27278097 Exosome Human milk     28688106 Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Jurkat-derived T cell line (J77cl20)     21505438 Exosome Renal cancer cells     21670082 Exosome Breast milk     22211110 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Blood|B lymphoblastoid cells|Breast milk|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Epithelial cells|Kidney tissue|Lymphoma tissue|Mast cells|Tongue tissue     - Extracellular vesicle HEK-293T cells     22849433 Microvesicle Seminal plasma     23539611 Microvesicle Serum     24797360 Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleolus Breast adenocarcinoma cells (MCF-7)     24918059 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Colon adenocarcinoma cells     20864815
	DDX3X	Chromatin K562 cells     - Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol K562 cells     - Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)|K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-182-5p	Sensorad 99342 Drug sensitive N-(6-Phenyl-1H-indazol-3-yl)cyclopropanecarboxamide 6539593 Drug sensitive Ixabepilone 6445540 Drug sensitive (1E,4E)-1,5-Dipyridin-3-ylpenta-1,4-dien-3-one 5382674 Drug sensitive 10-Hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12-dodecahydro-1H-picene-4a-carboxylic acid 495604 Drug sensitive Tiazofurin 457954 Drug sensitive Antineoplastic-645804 371505 Drug sensitive (4-Methoxyphenyl)-(3,4,5-trimethoxyphenyl)methanol 368140 Drug sensitive Predorine 333830 Drug sensitive 4-Benzoyl-3H-benzo[f]quinoline-3-carbonitrile 262649 Drug sensitive Nile Blue 2B 20520 Drug sensitive 5-Chloro-2[(E)-2-(4-nitrophenyl)vinyl]-1H-benzimidazole 15373173 Drug sensitive (Z)-5-chloro-3-((1-(3,5-dimethoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methylene)indolin-2-one - Drug sensitive benzofurazan, 4-nitro-7-(2-pyridinylthio)-, n-oxide - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-182-5p	Hyaluronidase 91820602 Drug interaction    RC00001904 Formaldehyde 712 Drug interaction    RC00001887 Ethanol 702 Drug interaction    RC00001886 Atorvastatin 60823 Drug interaction    RC00001897 D-Glucose 5793 Drug interaction    RC00001894 Temozolomide 5394 Drug interaction    RC00001893 Vorinostat 5311 Drug interaction    RC00001892 Eloxatine 5310940 Drug interaction    RC00001902 Decitabine 451668 Drug interaction    RC00001900 Trichostatin A 444732 Drug interaction    RC00001899 Paclitaxel 36314 Drug interaction    RC00001896 5-Fluorouracil 3385 Drug interaction    RC00001891 Fentanyl 3345 Drug interaction    RC00001890 Doxorubicin 31703 Drug interaction    RC00001895 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001889 Tamoxifen 2733526 Drug interaction    RC00001901 Verapamil 2520 Drug interaction    RC00001888 Olaparib 23725625 Drug interaction    RC00001903 Aldesleukin - Drug interaction    RC00001905 1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00001906 5-aza-2'-deoxycytidine (5-Aza-CdR) + 4-phenylbutyric acid (PBA) - Drug interaction    RC00001907 5-aza-2'-deoxycytidine (5-Aza-CdR) + trichostatin A(TSA) - Drug interaction    RC00001908 Marine fungal metabolite 1386A - Drug interaction    RC00001909 Chemotherapy - Drug interaction    RC00008834

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-182-5p	Tamoxifen 2733526       31153828 Veliparib 11960529       31063487 Serdemetan 11609586       31063487

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-182-5p
Interactor2: DDX3X

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.