Detail Information

Basic Information:


  VIRBase ID:  

HHID00048841

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-182-5p:           CCR7:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-182-5p CCR7
miRBase
Accession/Entrez ID		 MIMAT0000259 1236
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - BLR2//CC-CKR-7//CCR-7//CD197//CDw197//CMKBR7//EBI1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-182-5p
rs1164249188 chr7:129770446    CA/C
rs1232455061 chr7:129770449    T/G
rs1303310695 chr7:129770447    A/C
rs1331665171 chr7:129770448    G/A
rs750597507 chr7:129770453    A/G
rs760187044 chr7:129770452    G/A
rs765932794 chr7:129770462    A/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR CCR7
chr17:38713987(-) A-I      intronic
chr17:38713981(-) A-I      intronic
chr17:38713982(-) A-I      intronic
chr17:38714005(-) A-I      intronic
chr17:38713986(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase CCR7
chr17:38710149-38710150(-) m6A 3'UTR       24981863//28052920//27371828
chr17:38710156-38710157(-) m6A 3'UTR       24981863//28052920//27371828
chr17:38710237-38710238(-) m6A 3'UTR       27371828
chr17:38710482-38710483(-) m6A 3'UTR       24981863//28052920//26404942//27371828
chr17:38710495-38710496(-) m6A 3'UTR       24981863//28052920//26404942//27371828
chr17:38710510-38710511(-) m6A 3'UTR       24981863//28052920//26404942//27371828
chr17:38710537-38710538(-) m6A 3'UTR       25456834//24981863//28052920//26404942//27371828
chr17:38710555-38710556(-) m6A 3'UTR       25456834//24981863//28052920//26404942//27371828
chr17:38710574-38710575(-) m6A 3'UTR       25456834//24981863//28052920//26404942//27371828
chr17:38710590-38710591(-) m6A 3'UTR       25456834//24981863//28052920//26404942//27371828
chr17:38710604-38710605(-) m6A 3'UTR       25456834//24981863//28052920//26404942//27371828
chr17:38710623-38710624(-) m6A 3'UTR       24981863//28052920//26404942//27371828
chr17:38710706-38710707(-) m6A 3'UTR       24981863//28052920//26404942//27371828
chr17:38710727-38710728(-) m6A 3'UTR       24981863//28052920//26404942//27371828
chr17:38710734-38710735(-) m6A 3'UTR       24981863//28052920//26404942//27371828
chr17:38710755-38710756(-) m6A 3'UTR       24981863//28052920//26404942//27371828
chr17:38710772-38710773(-) m6A 3'UTR       24981863//28052920//26404942//27371828
chr17:38710796-38710797(-) m6A 3'UTR       24981863//28052920//26404942//27371828
chr17:38710913-38710914(-) m6A 3'UTR       25456834//24981863//28052920//26404942//27371828
chr17:38710966-38710967(-) m6A 3'UTR       24981863//28052920//26404942//27371828
chr17:38710975-38710976(-) m6A 3'UTR       24981863//28052920//26404942//27371828
chr17:38711016-38711017(-) m6A CDS       24981863//28052920//27371828
chr17:38711102-38711103(-) m6A CDS       27371828
chr17:38711819-38711820(-) m6A CDS       28052920//26404942
chr17:38711859-38711860(-) m6A CDS       28052920//26404942
chr17:38711966-38711967(-) m6A 5'UTR//CDS       24284625//24981863//28052920//26404942//27371828
chr17:38712011-38712012(-) m6A 5'UTR//CDS       24284625//24981863//28052920//26404942//27371828
chr17:38712026-38712027(-) m6A 5'UTR//CDS       24284625//24981863//28052920//26404942//27371828
chr17:38715189-38715190(-) m6A 5'UTR//CDS//intron       28052920//27371828
chr17:38716998-38716999(-) m6A 5'UTR//intron       27371828
chr17:38717003-38717004(-) m6A 5'UTR//intron       27371828
chr17:38717013-38717014(-) m6A 5'UTR//intron       27371828
chr17:38717070-38717071(-) m6A 5'UTR//intron       -
chr17:38717106-38717107(-) m6A 5'UTR//intron       -
chr17:38717189-38717190(-) m6A 5'UTR//intron       -
chr17:38717195-38717196(-) m6A 5'UTR//intron       -
chr17:38717227-38717228(-) m6A 5'UTR//intron       -
chr17:38721656-38721657(-) m6A 5'UTR//CDS       -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-182-5p
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Pooled sera     27278097
Exosome Bronchoalveolar lavage fluid|Pooled sera     27278097
Exosome Human milk     28688106
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Jurkat-derived T cell line (J77cl20)     21505438
Exosome Renal cancer cells     21670082
Exosome Breast milk     22211110
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Blood|B lymphoblastoid cells|Breast milk|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Epithelial cells|Kidney tissue|Lymphoma tissue|Mast cells|Tongue tissue     -
Extracellular vesicle HEK-293T cells     22849433
Microvesicle Seminal plasma     23539611
Microvesicle Serum     24797360
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleolus Breast adenocarcinoma cells (MCF-7)     24918059
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Colon adenocarcinoma cells     20864815
CCR7
Exosome Blood     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-182-5p
Sensorad 99342 Drug sensitive
N-(6-Phenyl-1H-indazol-3-yl)cyclopropanecarboxamide 6539593 Drug sensitive
Ixabepilone 6445540 Drug sensitive
(1E,4E)-1,5-Dipyridin-3-ylpenta-1,4-dien-3-one 5382674 Drug sensitive
10-Hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12-dodecahydro-1H-picene-4a-carboxylic acid 495604 Drug sensitive
Tiazofurin 457954 Drug sensitive
Antineoplastic-645804 371505 Drug sensitive
(4-Methoxyphenyl)-(3,4,5-trimethoxyphenyl)methanol 368140 Drug sensitive
Predorine 333830 Drug sensitive
4-Benzoyl-3H-benzo[f]quinoline-3-carbonitrile 262649 Drug sensitive
Nile Blue 2B 20520 Drug sensitive
5-Chloro-2[(E)-2-(4-nitrophenyl)vinyl]-1H-benzimidazole 15373173 Drug sensitive
(Z)-5-chloro-3-((1-(3,5-dimethoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methylene)indolin-2-one - Drug sensitive
benzofurazan, 4-nitro-7-(2-pyridinylthio)-, n-oxide - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-182-5p
Hyaluronidase 91820602 Drug interaction    RC00001904
Formaldehyde 712 Drug interaction    RC00001887
Ethanol 702 Drug interaction    RC00001886
Atorvastatin 60823 Drug interaction    RC00001897
D-Glucose 5793 Drug interaction    RC00001894
Temozolomide 5394 Drug interaction    RC00001893
Vorinostat 5311 Drug interaction    RC00001892
Eloxatine 5310940 Drug interaction    RC00001902
Decitabine 451668 Drug interaction    RC00001900
Trichostatin A 444732 Drug interaction    RC00001899
Paclitaxel 36314 Drug interaction    RC00001896
5-Fluorouracil 3385 Drug interaction    RC00001891
Fentanyl 3345 Drug interaction    RC00001890
Doxorubicin 31703 Drug interaction    RC00001895
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001889
Tamoxifen 2733526 Drug interaction    RC00001901
Verapamil 2520 Drug interaction    RC00001888
Olaparib 23725625 Drug interaction    RC00001903
Aldesleukin - Drug interaction    RC00001905
1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00001906
5-aza-2'-deoxycytidine (5-Aza-CdR) + 4-phenylbutyric acid (PBA) - Drug interaction    RC00001907
5-aza-2'-deoxycytidine (5-Aza-CdR) + trichostatin A(TSA) - Drug interaction    RC00001908
Marine fungal metabolite 1386A - Drug interaction    RC00001909
Chemotherapy - Drug interaction    RC00008834
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-182-5p
Tamoxifen 2733526       31153828
Veliparib 11960529       31063487
Serdemetan 11609586       31063487

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-182-5p
Interactor2: CCR7

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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