Detail Information

Basic Information:


  VIRBase ID:  

HHID00048840

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-182-5p:           CHD4:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-182-5p CHD4
miRBase
Accession/Entrez ID		 MIMAT0000259 1108
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - CHD-4//Mi-2b//Mi2-BETA//SIHIWES

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-182-5p
rs1164249188 chr7:129770446    CA/C
rs1232455061 chr7:129770449    T/G
rs1303310695 chr7:129770447    A/C
rs1331665171 chr7:129770448    G/A
rs750597507 chr7:129770453    A/G
rs760187044 chr7:129770452    G/A
rs765932794 chr7:129770462    A/G

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR CHD4
chr12:6685657(-) A-I      intronic
chr12:6685651(-) A-I      intronic
chr12:6685650(-) A-I      intronic
chr12:6685649(-) A-I      intronic
chr12:6685675(-) A-I      intronic
chr12:6685658(-) A-I      intronic
chr12:6694620(-) A-I      intronic
chr12:6685379(-) A-I      intronic
chr12:6685374(-) A-I      intronic
chr12:6688521(-) A-I      intronic
chr12:6695184(-) A-I      intronic
chr12:6685360(-) A-I      intronic
chr12:6681972(-) A-I      intronic
chr12:6681955(-) A-I      intronic
chr12:6694556(-) A-I      intronic
chr12:6695804(-) A-I      intronic
chr12:6695095(-) A-I      intronic
chr12:6694827(-) A-I      intronic
chr12:6695828(-) A-I      intronic
chr12:6681799(-) A-I      intronic
chr12:6694676(-) A-I      intronic
chr12:6681946(-) A-I      intronic
chr12:6680809(-) A-I      intronic
chr12:6680921(-) A-I      intronic
chr12:6694791(-) A-I      intronic
chr12:6694561(-) A-I      intronic
chr12:6694872(-) A-I      intronic
chr12:6688751(-) A-I      intronic
chr12:6681443(-) A-I      intronic
chr12:6688612(-) A-I      intronic
chr12:6694518(-) A-I      intronic
chr12:6694869(-) A-I      intronic
chr12:6695375(-) A-I      intronic
chr12:6695855(-) A-I      intronic
chr12:6685708(-) A-I      intronic
chr12:6686179(-) A-I      intronic
chr12:6685677(-) A-I      intronic
chr12:6686241(-) A-I      intronic
chr12:6686235(-) A-I      intronic
chr12:6685674(-) A-I      intronic
chr12:6694815(-) A-I      intronic
chr12:6694632(-) A-I      intronic
chr12:6681839(-) A-I      intronic
chr12:6681164(-) A-I      intronic
chr12:6680826(-) A-I      intronic
chr12:6681679(-) A-I      intronic
chr12:6681751(-) A-I      intronic
chr12:6694519(-) A-I      intronic
chr12:6695817(-) A-I      intronic
chr12:6696040(-) A-I      intronic
chr12:6699984(-) A-I      intronic
chr12:6694547(-) A-I      intronic
chr12:6694651(-) A-I      intronic
chr12:6704892(-) A-I      intronic
chr12:6686342(-) A-I      intronic
chr12:6686263(-) A-I      intronic
chr12:6686199(-) A-I      intronic
chr12:6680747(-) A-I      intronic
chr12:6686224(-) A-I      intronic
chr12:6685869(-) A-I      intronic
chr12:6681806(-) A-I      intronic
chr12:6695637(-) A-I      intronic
chr12:6695674(-) A-I      intronic
chr12:6681444(-) A-I      intronic
chr12:6686328(-) A-I      intronic
chr12:6695722(-) A-I      intronic
chr12:6695939(-) A-I      intronic
chr12:6695320(-) A-I      intronic
chr12:6680882(-) A-I      intronic
chr12:6686192(-) A-I      intronic
chr12:6696153(-) A-I      intronic
chr12:6695480(-) A-I      intronic
chr12:6681412(-) A-I      intronic
chr12:6695183(-) A-I      intronic
chr12:6694582(-) A-I      intronic
chr12:6685641(-) A-I      intronic
chr12:6681426(-) A-I      intronic
chr12:6695911(-) A-I      intronic
chr12:6694625(-) A-I      intronic
chr12:6685619(-) A-I      intronic
chr12:6681998(-) A-I      intronic
chr12:6695444(-) A-I      intronic
chr12:6708491(-) A-I      intronic
chr12:6681862(-) A-I      intronic
chr12:6694588(-) A-I      intronic
chr12:6696043(-) A-I      intronic
chr12:6695798(-) A-I      intronic
chr12:6685699(-) A-I      intronic
chr12:6681350(-) A-I      intronic
chr12:6686326(-) A-I      intronic
chr12:6696137(-) A-I      intronic
chr12:6696082(-) A-I      intronic
chr12:6684609(-) A-I      intronic
chr12:6680842(-) A-I      intronic
chr12:6695618(-) A-I      intronic
chr12:6695197(-) A-I      intronic
chr12:6695179(-) A-I      intronic
chr12:6685331(-) A-I      intronic
chr12:6685478(-) A-I      intronic
chr12:6696136(-) A-I      intronic
chr12:6681338(-) A-I      intronic
chr12:6696024(-) A-I      intronic
chr12:6694627(-) A-I      intronic
chr12:6681429(-) A-I      intronic
chr12:6681400(-) A-I      intronic
chr12:6699208(-) A-I      intronic
chr12:6695166(-) A-I      intronic
chr12:6685461(-) A-I      intronic
chr12:6685669(-) A-I      intronic
chr12:6681861(-) A-I      intronic
chr12:6686322(-) A-I      intronic
chr12:6686136(-) A-I      intronic
chr12:6694949(-) A-I      intronic
chr12:6694855(-) A-I      intronic
chr12:6695442(-) A-I      intronic
chr12:6683759(-) A-I      intronic
chr12:6695558(-) A-I      intronic
chr12:6695931(-) A-I      intronic
chr12:6695670(-) A-I      intronic
chr12:6686505(-) A-I      intronic
chr12:6681864(-) A-I      intronic
chr12:6694488(-) A-I      intronic
chr12:6708487(-) A-I      intronic
chr12:6695830(-) A-I      intronic
chr12:6695098(-) A-I      intronic
chr12:6681848(-) A-I      intronic
chr12:6685700(-) A-I      intronic
chr12:6685654(-) A-I      intronic
chr12:6685388(-) A-I      intronic
chr12:6694536(-) A-I      intronic
chr12:6696002(-) A-I      intronic
chr12:6696028(-) A-I      intronic
chr12:6685485(-) A-I      intronic
chr12:6680770(-) A-I      intronic
chr12:6694540(-) A-I      intronic
chr12:6681662(-) A-I      intronic
chr12:6697911(-) A-I      intronic
chr12:6695321(-) A-I      intronic
chr12:6686528(-) A-I      intronic
chr12:6685591(-) A-I      intronic
chr12:6695699(-) A-I      intronic
chr12:6694653(-) A-I      intronic
chr12:6695101(-) A-I      intronic
chr12:6685609(-) A-I      intronic
chr12:6686240(-) A-I      intronic
chr12:6686214(-) A-I      intronic
chr12:6685343(-) A-I      intronic
chr12:6680780(-) A-I      intronic
chr12:6680864(-) A-I      intronic
chr12:6686200(-) A-I      intronic
chr12:6680795(-) A-I      intronic
chr12:6685645(-) A-I      intronic
chr12:6685625(-) A-I      intronic
chr12:6695646(-) A-I      intronic
chr12:6686466(-) A-I      intronic
chr12:6685676(-) A-I      intronic
chr12:6696058(-) A-I      intronic
chr12:6685594(-) A-I      intronic
chr12:6704871(-) A-I      intronic
chr12:6686471(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED CHD4
chr12:6685594(-) A-I intron -    21960545
chr12:6680795(-) A-G intron -    22484847
chr12:6685669(-) A-G intron -    22484847
chr12:6685674(-) A-G intron -    22484847
chr12:6685700(-) A-G intron -    22484847
chr12:6686200(-) A-G intron -    22484847
chr12:6686528(-) A-G intron -    22484847
chr12:6695442(-) A-G intron -    22484847
chr12:6696124(-) T-C intron -    22484847
chr12:6696125(-) T-C intron -    22484847
chr12:6696126(-) T-C intron -    22484847
chr12:6696138(-) T-C intron -    22484847
chr12:6681412(-) A-G intron -    22484847
chr12:6681751(-) A-G intron -    22484847
chr12:6681861(-) A-G intron -    22484847
chr12:6681864(-) A-G intron -    22484847
chr12:6681998(-) A-G intron -    22484847
chr12:6684507(-) T-C intron -    22484847
chr12:6685331(-) A-G intron -    22484847
chr12:6685343(-) A-G intron -    22484847
chr12:6685388(-) A-G intron -    22484847
chr12:6685594(-) A-G intron -    22484847
chr12:6685619(-) A-G intron -    22484847
chr12:6685676(-) A-G intron -    22484847
chr12:6686192(-) A-G intron -    22484847
chr12:6686199(-) A-G intron -    22484847
chr12:6686505(-) A-G intron -    22484847
chr12:6694519(-) A-G intron -    22484847
chr12:6694536(-) A-G intron -    22484847
chr12:6694547(-) A-G intron -    22484847
chr12:6694588(-) A-G intron -    22484847
chr12:6694627(-) A-G intron -    22484847
chr12:6694632(-) A-G intron -    22484847
chr12:6694815(-) A-G intron -    22484847
chr12:6694855(-) A-G intron -    22484847
chr12:6695098(-) A-G intron -    22484847
chr12:6695127(-) T-C intron -    22484847
chr12:6695166(-) A-G intron -    22484847
chr12:6695320(-) A-G intron -    22484847
chr12:6695321(-) A-G intron -    22484847
chr12:6695444(-) A-G intron -    22484847
chr12:6695480(-) A-G intron -    22484847
chr12:6695558(-) A-G intron -    22484847
chr12:6695637(-) A-G intron -    22484847
chr12:6695699(-) A-G intron -    22484847
chr12:6695817(-) A-G intron -    22484847
chr12:6696002(-) A-G intron -    22484847
chr12:6696136(-) A-G intron -    22484847
chr12:6696137(-) A-G intron -    22484847
chr12:6696153(-) A-G intron -    22484847
chr12:6704954(-) G-T intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase CHD4
chr12:6679555-6679556(-) m6A 3'UTR//exon       24284625//25456834//24981863//22575960//22608085
chr12:6679594-6679595(-) m6A 3'UTR//exon       24284625//25456834//24981863//22575960//22608085
chr12:6679649-6679650(-) m6A 3'UTR//exon       24284625//25456834//24981863//22575960//22608085
chr12:6679713-6679714(-) m6A 3'UTR//exon       24284625//24981863//27773535//22575960
chr12:6679754-6679755(-) m6A 3'UTR//exon       24284625//27773535//22575960
chr12:6679832-6679833(-) m6A 3'UTR//exon       24284625//27773535
chr12:6680049-6680050(-) m6A CDS//exon       24284625//27773535
chr12:6680062-6680063(-) m6A CDS//exon       24284625//27773535
chr12:6687249-6687250(-) m6A CDS       27773535
chr12:6687614-6687615(-) m6A CDS       24981863//28052920//26404942//27773535//27371828
chr12:6687632-6687633(-) m6A CDS       24209618//24981863//28052920//27773535//27371828//22608085
chr12:6687648-6687649(-) m6A CDS       24209618//24981863//28052920//27773535//27371828//22608085
chr12:6687658-6687659(-) m6A CDS       24209618//24981863//28052920//27773535//27371828//22608085
chr12:6687696-6687697(-) m1A CDS       26863196
chr12:6688016-6688017(-) m6A CDS//exon       24209618//24981863//28052920//27773535//27371828//22575960//22608085
chr12:6690221-6690222(-) m6A CDS//exon       24209618//24981863//28052920//27773535//27371828//22608085
chr12:6690231-6690232(-) m6A CDS//exon       24209618//24981863//28052920//27773535//27371828//22608085
chr12:6690239-6690240(-) m6A CDS//exon       24209618//24981863//28052920//27773535//27371828//22608085
chr12:6690288-6690289(-) m6A CDS//exon       24209618//24981863//28052920//27773535//27371828//22575960//22608085
chr12:6690467-6690468(-) m6A CDS//intron       24209618//24981863//28052920//27773535//22575960
chr12:6690852-6690853(-) m6A CDS//intron       27773535
chr12:6690877-6690878(-) m6A CDS//intron       27773535
chr12:6692368-6692369(-) m6A CDS//exon//intron       24981863//27773535
chr12:6692400-6692401(-) m6A CDS//exon//intron       24981863//27773535
chr12:6692511-6692512(-) m6A CDS//exon//intron       24981863//27773535
chr12:6696628-6696629(-) m6A CDS//exon//intron       24981863//27773535
chr12:6696635-6696636(-) m6A CDS//exon//intron       24981863//27773535
chr12:6696638-6696639(-) Gm CDS//exon//intron       -
chr12:6696652-6696653(-) m6A CDS//exon//intron       24981863//27773535
chr12:6696718-6696719(-) m6A CDS//exon//intron       27773535
chr12:6696905-6696906(-) m6A CDS//exon//intron       27773535
chr12:6696944-6696945(-) m6A CDS//exon//intron       27773535
chr12:6696961-6696962(-) m6A CDS//exon//intron       27773535
chr12:6700963-6700964(-) Y CDS//exon       26075521
chr12:6702269-6702270(-) m6A CDS       27773535
chr12:6703764-6703765(-) m6A CDS       27773535//22575960
chr12:6705258-6705259(-) m6A CDS//exon       27773535//22575960
chr12:6705297-6705298(-) m6A CDS//exon       27773535//22575960
chr12:6707097-6707098(-) m6A CDS//exon       27773535//22575960
chr12:6707132-6707133(-) Gm CDS//exon       -
chr12:6707146-6707147(-) m6A CDS//exon       24981863//27773535//22575960
chr12:6707152-6707153(-) m6A CDS//exon       24981863//27773535//22575960
chr12:6707191-6707192(-) m6A CDS//exon       24981863//27773535//22575960
chr12:6707233-6707234(-) m6A CDS       24981863//27773535//22575960
chr12:6707393-6707394(-) m6A CDS       27773535//22575960
chr12:6709040-6709041(-) m6A CDS//exon       24284625//27773535//22575960
chr12:6709101-6709102(-) m6A CDS//exon       24284625//24981863//27773535//27371828//22575960
chr12:6709143-6709144(-) m6A CDS//exon       24284625//24981863//27773535//27371828//22575960
chr12:6709512-6709513(-) m6A CDS//exon       24284625//24981863//27773535//22575960
chr12:6709525-6709526(-) m6A CDS//intron       24284625//27773535
chr12:6709720-6709721(-) m6A CDS//exon       27773535
chr12:6709727-6709728(-) m6A CDS//exon       27773535
chr12:6710157-6710158(-) m6A CDS//exon       24981863//27773535
chr12:6710469-6710470(-) m6A CDS       24981863//27773535
chr12:6710850-6710851(-) m6A CDS       24981863//27773535//27371828
chr12:6710885-6710886(-) m6A CDS       24981863//27773535//27371828//27773536
chr12:6710900-6710901(-) m6A CDS       24284625//24981863//28052920//27773535//27371828//27773536
chr12:6711184-6711185(-) m1A CDS//exon       26863196
chr12:6711192-6711193(-) Am CDS//exon       -
chr12:6711200-6711201(-) m6A CDS//exon       24284625//24209618//24981863//28052920//27773535//27371828//27773536
chr12:6711208-6711209(-) m1A CDS//exon       26863196
chr12:6711217-6711218(-) m1A CDS//exon       26863196
chr12:6711252-6711253(-) m6A CDS//exon       24284625//24209618//24981863//28052920//27773535//27371828//27773536//22575960
chr12:6711312-6711313(-) m6A CDS//exon       24284625//24209618//24981863//28052920//27773535//27371828//27773536//22575960
chr12:6711578-6711579(-) m6A CDS//exon       24284625//24209618//24981863//28052920//27773535//27371828//27773536//22575960
chr12:6711586-6711587(-) m6A CDS//exon       24284625//24209618//24981863//28052920//27773535//27371828//27773536
chr12:6711603-6711604(-) m1A CDS//exon       26863196
chr12:6711621-6711622(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828//27773536
chr12:6711627-6711628(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828//27773536
chr12:6711650-6711651(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828//27773536
chr12:6712113-6712114(-) m6A exon//intron       24284625//24209618//24981863//27773535//27371828//27773536
chr12:6712121-6712122(-) m6A exon//intron       24284625//24209618//24981863//27773535//27371828//27773536
chr12:6712190-6712191(-) m6A exon//intron       24284625//24209618//24981863//27773535//27371828//27773536
chr12:6712197-6712198(-) m6A exon//intron       24284625//24209618//24981863//27773535//27371828//27773536
chr12:6712267-6712268(-) m6A exon//intron       24209618//24981863
chr12:6715441-6715442(-) Cm CDS       -
chr12:6715465-6715466(-) m6A CDS       24284625//24209618//24981863//27371828//27773536
chr12:6715752-6715753(-) m6A 5'UTR//intron       24284625//24209618//25456834//24981863//27371828//27773536//22575960
chr12:6716492-6716493(-) m6A 5'UTR       24209618//25456834//24981863//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-182-5p
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome Pooled sera     27278097
Exosome Bronchoalveolar lavage fluid|Pooled sera     27278097
Exosome Human milk     28688106
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Jurkat-derived T cell line (J77cl20)     21505438
Exosome Renal cancer cells     21670082
Exosome Breast milk     22211110
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Blood|B lymphoblastoid cells|Breast milk|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Epithelial cells|Kidney tissue|Lymphoma tissue|Mast cells|Tongue tissue     -
Extracellular vesicle HEK-293T cells     22849433
Microvesicle Seminal plasma     23539611
Microvesicle Serum     24797360
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleolus Breast adenocarcinoma cells (MCF-7)     24918059
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Colon adenocarcinoma cells     20864815
CHD4
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol K562 cells     -
Exosome Blood     -
Insoluble cytoplasm K562 cells     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus Colon cancer cells     24393600
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-182-5p
Sensorad 99342 Drug sensitive
N-(6-Phenyl-1H-indazol-3-yl)cyclopropanecarboxamide 6539593 Drug sensitive
Ixabepilone 6445540 Drug sensitive
(1E,4E)-1,5-Dipyridin-3-ylpenta-1,4-dien-3-one 5382674 Drug sensitive
10-Hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12-dodecahydro-1H-picene-4a-carboxylic acid 495604 Drug sensitive
Tiazofurin 457954 Drug sensitive
Antineoplastic-645804 371505 Drug sensitive
(4-Methoxyphenyl)-(3,4,5-trimethoxyphenyl)methanol 368140 Drug sensitive
Predorine 333830 Drug sensitive
4-Benzoyl-3H-benzo[f]quinoline-3-carbonitrile 262649 Drug sensitive
Nile Blue 2B 20520 Drug sensitive
5-Chloro-2[(E)-2-(4-nitrophenyl)vinyl]-1H-benzimidazole 15373173 Drug sensitive
(Z)-5-chloro-3-((1-(3,5-dimethoxyphenyl)-9H-pyrido[3,4-b]indol-3-yl)methylene)indolin-2-one - Drug sensitive
benzofurazan, 4-nitro-7-(2-pyridinylthio)-, n-oxide - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-182-5p
Hyaluronidase 91820602 Drug interaction    RC00001904
Formaldehyde 712 Drug interaction    RC00001887
Ethanol 702 Drug interaction    RC00001886
Atorvastatin 60823 Drug interaction    RC00001897
D-Glucose 5793 Drug interaction    RC00001894
Temozolomide 5394 Drug interaction    RC00001893
Vorinostat 5311 Drug interaction    RC00001892
Eloxatine 5310940 Drug interaction    RC00001902
Decitabine 451668 Drug interaction    RC00001900
Trichostatin A 444732 Drug interaction    RC00001899
Paclitaxel 36314 Drug interaction    RC00001896
5-Fluorouracil 3385 Drug interaction    RC00001891
Fentanyl 3345 Drug interaction    RC00001890
Doxorubicin 31703 Drug interaction    RC00001895
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001889
Tamoxifen 2733526 Drug interaction    RC00001901
Verapamil 2520 Drug interaction    RC00001888
Olaparib 23725625 Drug interaction    RC00001903
Aldesleukin - Drug interaction    RC00001905
1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00001906
5-aza-2'-deoxycytidine (5-Aza-CdR) + 4-phenylbutyric acid (PBA) - Drug interaction    RC00001907
5-aza-2'-deoxycytidine (5-Aza-CdR) + trichostatin A(TSA) - Drug interaction    RC00001908
Marine fungal metabolite 1386A - Drug interaction    RC00001909
Chemotherapy - Drug interaction    RC00008834
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-182-5p
Tamoxifen 2733526       31153828
Veliparib 11960529       31063487
Serdemetan 11609586       31063487

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-182-5p
Interactor2: CHD4

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region CDS
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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