Basic Information:

  VIRBase ID:  

HHID00048655

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-181b-5p:  MIMAT0000257          GLCCI1:  NM_138426     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-181b-5p	GLCCI1
miRBase Accession/Entrez ID	MIMAT0000257	113263
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	FAM117C//GCTR//GIG18//TSSN1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-181b-5p	rs1205413123 chr1:198858926    C/A rs1256400288 chr1:198858930    C/A rs1264082334 chr1:198858938    A/C rs1323404832 chr1:198858936    G/A rs1385750980 chr1:198858937    C/T rs1482775835 chr1:198858931    C/T rs772751969 chr1:198858932    G/A rs1351686016 chr9:124693736    C/T rs1434920325 chr9:124693740    C/A rs368826167 chr9:124693735    G/C rs543189963 chr9:124693741    G/A rs754985289 chr9:124693743    T/C rs758726581 chr9:124693733    T/C rs958593822 chr1:198858942    A/C rs556757681 chr9:124693732    A/G rs765712905 chr9:124693731    C/G rs765712905 chr9:124693731    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	GLCCI1	chr7:8056044(+) A-I      intronic chr7:8055988(+) A-I      intronic chr7:8055984(+) A-I      intronic chr7:8055978(+) A-I      intronic chr7:8055952(+) A-I      intronic chr7:8053905(+) A-I      intronic chr7:8048019(+) A-I      intronic chr7:8038057(+) A-I      intronic chr7:8027282(+) A-I      intronic chr7:8027269(+) A-I      intronic chr7:8027264(+) A-I      intronic chr7:8019705(+) A-I      intronic chr7:8081433(+) A-I      intronic chr7:8016405(+) A-I      intronic chr7:8016393(+) A-I      intronic chr7:8020672(+) A-I      intronic chr7:8020643(+) A-I      intronic chr7:8079493(+) A-I      intronic chr7:8079507(+) A-I      intronic chr7:8081498(+) A-I      intronic chr7:8100937(+) A-I      intronic chr7:8082194(+) A-I      intronic chr7:8084269(+) A-I      intronic chr7:8082275(+) A-I      intronic chr7:8102894(+) A-I      intronic chr7:8081362(+) A-I      intronic chr7:8081333(+) A-I      intronic chr7:8084153(+) A-I      intronic chr7:8084156(+) A-I      intronic chr7:8084158(+) A-I      intronic chr7:8084270(+) A-I      intronic chr7:8107808(+) A-I      intronic chr7:8107859(+) A-I      intronic chr7:8107873(+) A-I      intronic chr7:8107940(+) A-I      intronic chr7:8081278(+) A-I      intronic chr7:8080012(+) A-I      intronic chr7:8081370(+) A-I      intronic chr7:8102965(+) A-I      intronic chr7:8066932(+) A-I      intronic chr7:8037926(+) A-I      intronic chr7:8107860(+) A-I      intronic chr7:8080085(+) A-I      intronic chr7:8048053(+) A-I      intronic chr7:8079934(+) A-I      intronic chr7:8037951(+) A-I      intronic chr7:8050709(+) A-I      intronic chr7:8079977(+) A-I      intronic chr7:8053694(+) A-I      intronic chr7:8082185(+) A-I      intronic chr7:8015963(+) A-I      intronic chr7:8015990(+) A-I      intronic chr7:8019617(+) A-I      intronic chr7:8079914(+) A-I      intronic chr7:8102868(+) A-I      intronic chr7:8082187(+) A-I      intronic chr7:8053719(+) A-I      intronic chr7:8019714(+) A-I      intronic chr7:8081422(+) A-I      intronic chr7:8015989(+) A-I      intronic chr7:8079572(+) A-I      intronic chr7:8082217(+) A-I      intronic chr7:8027244(+) A-I      intronic chr7:8035007(+) A-I      intronic chr7:8082247(+) A-I      intronic chr7:8107784(+) A-I      intronic chr7:8081346(+) A-I      intronic chr7:8080035(+) A-I      intronic chr7:8104621(+) A-I      intronic chr7:8066862(+) A-I      intronic chr7:8023771(+) A-I      intronic chr7:8103350(+) A-I      intronic chr7:8079577(+) A-I      intronic chr7:8016423(+) A-I      intronic chr7:8103487(+) A-I      intronic chr7:8107724(+) A-I      intronic chr7:8081411(+) A-I      intronic chr7:8107771(+) A-I      intronic chr7:8107769(+) A-I      intronic chr7:8039118(+) A-I      intronic chr7:8083837(+) A-I      intronic chr7:8081412(+) A-I      intronic chr7:8102985(+) A-I      intronic chr7:8081431(+) A-I      intronic chr7:8081499(+) A-I      intronic chr7:8053720(+) A-I      intronic chr7:8079873(+) A-I      intronic chr7:8081378(+) A-I      intronic chr7:8037912(+) A-I      intronic chr7:8053681(+) A-I      intronic chr7:8081249(+) A-I      intronic chr7:8016396(+) A-I      intronic chr7:8047939(+) A-I      intronic chr7:8026049(+) A-I      intronic chr7:8027280(+) A-I      intronic chr7:8103461(+) A-I      intronic chr7:8053759(+) A-I      intronic chr7:8095699(+) A-I      intronic chr7:8050615(+) A-I      intronic chr7:8016305(+) A-I      intronic chr7:8107793(+) A-I      intronic chr7:8101397(+) A-I      intronic chr7:8107727(+) A-I      intronic chr7:8053676(+) A-I      intronic chr7:8081350(+) A-I      intronic chr7:8055946(+) A-I      intronic chr7:8083849(+) A-I      intronic chr7:8027299(+) A-I      intronic chr7:8107823(+) A-I      intronic chr7:8107857(+) A-I      intronic chr7:8107869(+) A-I      intronic chr7:8081321(+) A-I      intronic chr7:8037473(+) A-I      intronic chr7:8027275(+) A-I      intronic chr7:8103050(+) A-I      intronic chr7:8100749(+) A-I      intronic chr7:8037377(+) A-I      intronic chr7:8027352(+) A-I      intronic chr7:8023766(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	GLCCI1	chr7:8020298(+) A-I intron -    22327324 chr7:8020305(+) A-I intron -    22327324 chr7:8020324(+) A-I intron -    22327324 chr7:8020441(+) A-I intron -    22327324 chr7:8020673(+) A-I intron -    22327324 chr7:8020689(+) A-I intron -    22327324 chr7:8020697(+) A-I intron -    22327324 chr7:8034485(+) A-I intron -    22327324 chr7:8081412(+) A-I intron -    22327324 chr7:8081499(+) A-I intron -    22327324 chr7:8082185(+) A-I intron -    22327324 chr7:8082247(+) A-I intron -    22327324 chr7:8103461(+) A-I intron -    21960545 chr7:8046880(+) T-C intron -    22484847 chr7:8015897(+) A-G intron -    22484847 chr7:8016058(+) T-C intron -    22484847 chr7:8016107(+) T-A intron -    22484847 chr7:8016108(+) C-A intron -    22484847 chr7:8016109(+) T-A intron -    22484847 chr7:8016110(+) C-A intron -    22484847 chr7:8016396(+) A-G intron -    22484847 chr7:8019620(+) A-G intron -    22484847 chr7:8025881(+) T-C intron -    22484847 chr7:8026049(+) A-G intron -    22484847 chr7:8027275(+) A-G intron -    22484847 chr7:8027280(+) A-G intron -    22484847 chr7:8027299(+) A-G intron -    22484847 chr7:8027319(+) A-G intron -    22484847 chr7:8033722(+) A-T intron -    22484847 chr7:8033807(+) T-C intron -    22484847 chr7:8037377(+) A-G intron -    22484847 chr7:8037473(+) A-G intron -    22484847 chr7:8037951(+) A-G intron -    22484847 chr7:8047939(+) A-G intron -    22484847 chr7:8048009(+) A-G intron -    22484847 chr7:8048015(+) A-G intron -    22484847 chr7:8048016(+) A-G intron -    22484847 chr7:8053676(+) A-G intron -    22484847 chr7:8053681(+) A-G intron -    22484847 chr7:8053694(+) A-G intron -    22484847 chr7:8053719(+) A-G intron -    22484847 chr7:8053720(+) A-G intron -    22484847 chr7:8053749(+) A-G intron -    22484847 chr7:8053759(+) A-G intron -    22484847 chr7:8055946(+) A-G intron -    22484847 chr7:8061167(+) T-C intron -    22484847 chr7:8062869(+) T-C intron -    22484847 chr7:8064920(+) A-G intron -    22484847 chr7:8079873(+) A-G intron -    22484847 chr7:8079934(+) A-G intron -    22484847 chr7:8079969(+) A-G intron -    22484847 chr7:8080005(+) A-G intron -    22484847 chr7:8080009(+) A-G intron -    22484847 chr7:8080035(+) A-G intron -    22484847 chr7:8080085(+) A-G intron -    22484847 chr7:8081249(+) A-G intron -    22484847 chr7:8081321(+) A-G intron -    22484847 chr7:8081346(+) A-G intron -    22484847 chr7:8081347(+) A-G intron -    22484847 chr7:8081350(+) A-G intron -    22484847 chr7:8081378(+) A-G intron -    22484847 chr7:8081411(+) A-G intron -    22484847 chr7:8081412(+) A-G intron -    22484847 chr7:8081422(+) A-G intron -    22484847 chr7:8081499(+) A-G intron -    22484847 chr7:8082171(+) A-G intron -    22484847 chr7:8082185(+) A-G intron -    22484847 chr7:8082187(+) A-G intron -    22484847 chr7:8082217(+) A-G intron -    22484847 chr7:8082247(+) A-G intron -    22484847 chr7:8083837(+) A-G intron -    22484847 chr7:8083849(+) A-G intron -    22484847 chr7:8084111(+) A-G intron -    22484847 chr7:8092974(+) G-T intron -    22484847 chr7:8101396(+) A-G intron -    22484847 chr7:8101397(+) A-G intron -    22484847 chr7:8102814(+) T-C intron -    22484847 chr7:8102865(+) C-T intron -    22484847 chr7:8103360(+) C-T intron -    22484847 chr7:8103361(+) A-C intron -    22484847 chr7:8103427(+) A-T intron -    22484847 chr7:8103487(+) A-G intron -    22484847 chr7:8104453(+) A-T intron -    22484847 chr7:8107704(+) A-G intron -    22484847 chr7:8107724(+) A-G intron -    22484847 chr7:8107769(+) A-G intron -    22484847 chr7:8107771(+) A-G intron -    22484847 chr7:8107777(+) A-G intron -    22484847 chr7:8107793(+) A-G intron -    22484847 chr7:8107857(+) A-G intron -    22484847 chr7:8107860(+) A-G intron -    22484847 chr7:8107912(+) G-A intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	GLCCI1	chr7:8008493-8008494(+) m6A 5'UTR       - chr7:8008842-8008843(+) m6A 5'UTR       - chr7:8010106-8010107(+) m6A exon//intron       - chr7:8021692-8021693(+) m6A intron       22608085 chr7:8021697-8021698(+) m6A intron       22608085 chr7:8021704-8021705(+) m6A intron       22608085 chr7:8021772-8021773(+) m6A intron       22608085 chr7:8021805-8021806(+) m6A intron       22608085 chr7:8095097-8095098(+) Y CDS//exon       26075521 chr7:8125869-8125870(+) m6A CDS//exon//intron       24284625//24209618//22608085 chr7:8125915-8125916(+) m6A CDS//exon//intron       24284625//24209618//24981863//22608085 chr7:8125959-8125960(+) m6A CDS//exon//intron       24284625//24209618//24981863//22608085 chr7:8126119-8126120(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr7:8126133-8126134(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr7:8126151-8126152(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr7:8126211-8126212(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr7:8126223-8126224(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr7:8126242-8126243(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr7:8126251-8126252(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr7:8126300-8126301(+) m6A 3'UTR//exon//intron       24284625//24209618//24981863//22575960//22608085 chr7:8126323-8126324(+) m6A 3'UTR//exon//intron       24284625//24209618//24981863//22575960//22608085 chr7:8126398-8126399(+) m6A 3'UTR//exon//intron       24284625//24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-181b-5p	Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome Human cervical cancer cell line (HeLa)     25760330 Exosome Primary dendritic cells|T cell line (J77)     21505438 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Breast cancer cell lines (MCF-7|MDA-MB-231)     24468161 Exosome Blood|B lymphoblastoid cells|Breast milk|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Epithelial cells|Kidney tissue|Lymphoma tissue|Tongue tissue     - Microvesicle Seminal plasma     23539611 Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleolus Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Nasopharyngeal carcinoma cells     20498841
	GLCCI1	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol K562 cells     - Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome HEK-293 cells     22199352

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-181b-5p	Saintopin E 9864639 Drug sensitive [[4-(3-Aminophenyl)-2-pyridyl]methyleneamino]thiourea 9556427 Drug sensitive 2-Amino-3H-phenoxazin-3-one 72725 Drug resistant 2'-Bromo-4'-epi-daunorubicin 6711997 Drug sensitive Fludarabine 657237 Drug sensitive Psammaplin A 6400741 Drug sensitive Bizelesin 60794 Drug sensitive (Z)-6-(2-(Pyridin-2-ylmethylene)hydrazinyl)-9H-purine 60147744 Drug sensitive Triethylenemelamine 5799 Drug sensitive Mitomycin 5746 Drug sensitive Vorinostat 5311 Drug sensitive Dioxadet 48858 Drug sensitive Epidoxoform 46877760 Drug sensitive 1,4-Benzoquinone 4650 Drug sensitive Melphalan 460612 Drug sensitive Benzofurazan, 4-(4-methyl-1-piperazinyl)-7-nitro-, 3-oxide 42640 Drug sensitive Diaziquone 42616 Drug sensitive Mitoxantrone 4212 Drug sensitive 3-Acetoxymethyl-1-methyl-5-methoxyindole-4,7-dione 404937 Drug resistant N,N-Bis(2-chloropropyl)-N-methylammonium chloride 381678 Drug sensitive Antineoplastic-D648114 372647 Drug sensitive Antineoplastic-645804 371505 Drug resistant Acridomide 364442 Drug sensitive 4-Aza-2'-phenyl-5alpha-cholestano[3,2-c]pyrazole 363170 Drug sensitive 6,7-Diacetoxyisoflavan 353129 Drug sensitive Etoprine 29142 Drug resistant Chlorambucil 2708 Drug sensitive Deoxycamptothecin 266552 Drug sensitive 1-(2-Chloroethyl)-3-(2,6-dioxo-3-piperidyl)-1-nitrosourea 26328 Drug sensitive Camptothecin 24360 Drug sensitive Dechlorinated rebeccamycin 24203043 Drug sensitive Amsacrine 2179 Drug sensitive N-(4-(1-Aziridinyl)butyl)-1,3-propanediamine 160395 Drug sensitive N-(3-(1-Aziridinyl)propyl)-1,4-butanediamine 160394 Drug sensitive 1,2:5,6-Dianhydrogalactitol 15942827 Drug sensitive 4-N,N-Bis(2-chloroethyl)amino-2-tolualdehyde 141295 Drug sensitive N-[(1S,4R,7S,11R,14S,17R,20S,24R,27S)-2,4,12,15,17,25-Hexamethyl-27-methylsulfanyl-3,6,10,13,16,19,23,26-octaoxo-11,24-di(propan-2-yl)-20-(quinoxaline-2-carbonylamino)-9,22-dioxa-28-thia-2,5,12,15,18,25-hexazabicyclo[12.12.3]nonacosan-7-yl]quinoxaline-2-carboxamide 138402870 Drug sensitive Oxanthrazole 135502299 Drug sensitive 5-Hydroxypicolinaldehyde thiosemicarbazone 135453292 Drug sensitive 8-Azaguanine 135403646 Drug sensitive DTIC-Dome 135398738 Drug sensitive Saintopin 131350 Drug sensitive Cytochalasin q 11970174 Drug sensitive Unii-6FH145297U 11541062 Drug sensitive 2,2'-Bioxirane 11254 Drug sensitive Acetylenedicarboxamide 10971 Drug sensitive Perillyl alcohol 10819 Drug sensitive N,N-Bis(2-chloroethyl)-p-toluidine 100400 Drug sensitive 2,2'-thienyl selenophenyl-5',2-thiophene-5,5-dialdehyde - Drug resistant naphthalene-1,2-dione, 1,2-dihydro-4-[(3-pyridinyl)amino]- - Drug resistant chlorazin - Drug resistant ovb3-pe - Drug resistant (1s,2e,4r,6r,7e,10r,11e)-2,7,11-cembratriene-4,6,10-triol - Drug sensitive 1,4-bis(n-cysteinyldiethylamino)-5,8-dihydroxy anthraquinon - Drug sensitive aquatris(1,3-diphenylpropane-1,3-dionato)neodymium(iii) - Drug sensitive benzo[1,2-c:4,5-c']dipyrrole-1,3,5,7(2h,6h)-tetraimine - Drug sensitive cholestan-5.alpha.-ol-3,6-dione - Drug sensitive analog of cc-1065 - Drug sensitive Camptothecin Derivative - Drug sensitive Chlorozotocin - Drug sensitive from cephalodiscus gilchristi - Drug sensitive hymenialdisine - Drug sensitive Indenoisoquinoline derivative - Drug sensitive potassium[trichloro(isopropylamine)platinum] - Drug sensitive trans-dichlorobis(tricyclohexylphosphine)palladium - Drug sensitive trimethyl(phenylthio)stannane - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-181b-5p	Curcumin 969516 Drug interaction    RC00001863 Formaldehyde 712 Drug interaction    RC00001843 Fludarabine 657237 Drug interaction    RC00001862 Cytarabine 6253 Drug interaction    RC00001850 Gemcitabine 60750 Drug interaction    RC00001854 Vincristine 5978 Drug interaction    RC00001849 Temozolomide 5394 Drug interaction    RC00001848 Eloxatine 5310940 Drug interaction    RC00001866 Imatinib 5291 Drug interaction    RC00001847 Morphine 5288826 Drug interaction    RC00001865 Teniposide 452548 Drug interaction    RC00001861 Tretinoin 444795 Drug interaction    RC00001860 Trichostatin A 444732 Drug interaction    RC00001859 Paclitaxel 36314 Drug interaction    RC00001853 Enoxacin 3229 Drug interaction    RC00001846 Doxorubicin 31703 Drug interaction    RC00001852 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001845 Tamoxifen 2733526 Drug interaction    RC00001864 Celecoxib 2662 Drug interaction    RC00001844 Sorafenib 216239 Drug interaction    RC00001858 Arsenic trioxide 14888 Drug interaction    RC00001851 Docetaxel 148124 Drug interaction    RC00001857 Gefitinib 123631 Drug interaction    RC00001856 Ginsenoside Rh2 119307 Drug interaction    RC00001855 modified ALLIC BFM 2002 protocol - Drug interaction    RC00001867 Aidi injection - Drug interaction    RC00001868 Marine fungal metabolite 1386A - Drug interaction    RC00001869 Olea europaea leaf extract - Drug interaction    RC00001870

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-181b-5p	Cisplatin 5702198       25356050 Temozolomide 5394       30551476 Paclitaxel 36314       26323677 Doxorubicin 31703       24759738 Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       24759738

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-181b-5p
Interactor2: GLCCI1

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.