Basic Information:

  VIRBase ID:  

HHID00048490

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-181a-5p:  MIMAT0000256          GLCCI1:  NM_138426     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-181a-5p	GLCCI1
miRBase Accession/Entrez ID	MIMAT0000256	113263
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	FAM117C//GCTR//GIG18//TSSN1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-181a-5p	rs1406655910 chr1:198859120    C/T rs868055902 chr1:198859121    G/A rs1249847028 chr9:124692490    G/A rs1409955599 chr9:124692491    C/A rs745991765 chr9:124692496    G/A rs749545428 chr9:124692480    A/T rs779228370 chr9:124692489    C/T rs1201117339 chr9:124692487    A/G rs757530482 chr9:124692482    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	GLCCI1	chr7:8056044(+) A-I      intronic chr7:8055988(+) A-I      intronic chr7:8055984(+) A-I      intronic chr7:8055978(+) A-I      intronic chr7:8055952(+) A-I      intronic chr7:8053905(+) A-I      intronic chr7:8048019(+) A-I      intronic chr7:8038057(+) A-I      intronic chr7:8027282(+) A-I      intronic chr7:8027269(+) A-I      intronic chr7:8027264(+) A-I      intronic chr7:8019705(+) A-I      intronic chr7:8081433(+) A-I      intronic chr7:8016405(+) A-I      intronic chr7:8016393(+) A-I      intronic chr7:8020672(+) A-I      intronic chr7:8020643(+) A-I      intronic chr7:8079493(+) A-I      intronic chr7:8079507(+) A-I      intronic chr7:8081498(+) A-I      intronic chr7:8100937(+) A-I      intronic chr7:8082194(+) A-I      intronic chr7:8084269(+) A-I      intronic chr7:8082275(+) A-I      intronic chr7:8102894(+) A-I      intronic chr7:8081362(+) A-I      intronic chr7:8081333(+) A-I      intronic chr7:8084153(+) A-I      intronic chr7:8084156(+) A-I      intronic chr7:8084158(+) A-I      intronic chr7:8084270(+) A-I      intronic chr7:8107808(+) A-I      intronic chr7:8107859(+) A-I      intronic chr7:8107873(+) A-I      intronic chr7:8107940(+) A-I      intronic chr7:8081278(+) A-I      intronic chr7:8080012(+) A-I      intronic chr7:8081370(+) A-I      intronic chr7:8102965(+) A-I      intronic chr7:8066932(+) A-I      intronic chr7:8037926(+) A-I      intronic chr7:8107860(+) A-I      intronic chr7:8080085(+) A-I      intronic chr7:8048053(+) A-I      intronic chr7:8079934(+) A-I      intronic chr7:8037951(+) A-I      intronic chr7:8050709(+) A-I      intronic chr7:8079977(+) A-I      intronic chr7:8053694(+) A-I      intronic chr7:8082185(+) A-I      intronic chr7:8015963(+) A-I      intronic chr7:8015990(+) A-I      intronic chr7:8019617(+) A-I      intronic chr7:8079914(+) A-I      intronic chr7:8102868(+) A-I      intronic chr7:8082187(+) A-I      intronic chr7:8053719(+) A-I      intronic chr7:8019714(+) A-I      intronic chr7:8081422(+) A-I      intronic chr7:8015989(+) A-I      intronic chr7:8079572(+) A-I      intronic chr7:8082217(+) A-I      intronic chr7:8027244(+) A-I      intronic chr7:8035007(+) A-I      intronic chr7:8082247(+) A-I      intronic chr7:8107784(+) A-I      intronic chr7:8081346(+) A-I      intronic chr7:8080035(+) A-I      intronic chr7:8104621(+) A-I      intronic chr7:8066862(+) A-I      intronic chr7:8023771(+) A-I      intronic chr7:8103350(+) A-I      intronic chr7:8079577(+) A-I      intronic chr7:8016423(+) A-I      intronic chr7:8103487(+) A-I      intronic chr7:8107724(+) A-I      intronic chr7:8081411(+) A-I      intronic chr7:8107771(+) A-I      intronic chr7:8107769(+) A-I      intronic chr7:8039118(+) A-I      intronic chr7:8083837(+) A-I      intronic chr7:8081412(+) A-I      intronic chr7:8102985(+) A-I      intronic chr7:8081431(+) A-I      intronic chr7:8081499(+) A-I      intronic chr7:8053720(+) A-I      intronic chr7:8079873(+) A-I      intronic chr7:8081378(+) A-I      intronic chr7:8037912(+) A-I      intronic chr7:8053681(+) A-I      intronic chr7:8081249(+) A-I      intronic chr7:8016396(+) A-I      intronic chr7:8047939(+) A-I      intronic chr7:8026049(+) A-I      intronic chr7:8027280(+) A-I      intronic chr7:8103461(+) A-I      intronic chr7:8053759(+) A-I      intronic chr7:8095699(+) A-I      intronic chr7:8050615(+) A-I      intronic chr7:8016305(+) A-I      intronic chr7:8107793(+) A-I      intronic chr7:8101397(+) A-I      intronic chr7:8107727(+) A-I      intronic chr7:8053676(+) A-I      intronic chr7:8081350(+) A-I      intronic chr7:8055946(+) A-I      intronic chr7:8083849(+) A-I      intronic chr7:8027299(+) A-I      intronic chr7:8107823(+) A-I      intronic chr7:8107857(+) A-I      intronic chr7:8107869(+) A-I      intronic chr7:8081321(+) A-I      intronic chr7:8037473(+) A-I      intronic chr7:8027275(+) A-I      intronic chr7:8103050(+) A-I      intronic chr7:8100749(+) A-I      intronic chr7:8037377(+) A-I      intronic chr7:8027352(+) A-I      intronic chr7:8023766(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	GLCCI1	chr7:8020298(+) A-I intron -    22327324 chr7:8020305(+) A-I intron -    22327324 chr7:8020324(+) A-I intron -    22327324 chr7:8020441(+) A-I intron -    22327324 chr7:8020673(+) A-I intron -    22327324 chr7:8020689(+) A-I intron -    22327324 chr7:8020697(+) A-I intron -    22327324 chr7:8034485(+) A-I intron -    22327324 chr7:8081412(+) A-I intron -    22327324 chr7:8081499(+) A-I intron -    22327324 chr7:8082185(+) A-I intron -    22327324 chr7:8082247(+) A-I intron -    22327324 chr7:8103461(+) A-I intron -    21960545 chr7:8046880(+) T-C intron -    22484847 chr7:8015897(+) A-G intron -    22484847 chr7:8016058(+) T-C intron -    22484847 chr7:8016107(+) T-A intron -    22484847 chr7:8016108(+) C-A intron -    22484847 chr7:8016109(+) T-A intron -    22484847 chr7:8016110(+) C-A intron -    22484847 chr7:8016396(+) A-G intron -    22484847 chr7:8019620(+) A-G intron -    22484847 chr7:8025881(+) T-C intron -    22484847 chr7:8026049(+) A-G intron -    22484847 chr7:8027275(+) A-G intron -    22484847 chr7:8027280(+) A-G intron -    22484847 chr7:8027299(+) A-G intron -    22484847 chr7:8027319(+) A-G intron -    22484847 chr7:8033722(+) A-T intron -    22484847 chr7:8033807(+) T-C intron -    22484847 chr7:8037377(+) A-G intron -    22484847 chr7:8037473(+) A-G intron -    22484847 chr7:8037951(+) A-G intron -    22484847 chr7:8047939(+) A-G intron -    22484847 chr7:8048009(+) A-G intron -    22484847 chr7:8048015(+) A-G intron -    22484847 chr7:8048016(+) A-G intron -    22484847 chr7:8053676(+) A-G intron -    22484847 chr7:8053681(+) A-G intron -    22484847 chr7:8053694(+) A-G intron -    22484847 chr7:8053719(+) A-G intron -    22484847 chr7:8053720(+) A-G intron -    22484847 chr7:8053749(+) A-G intron -    22484847 chr7:8053759(+) A-G intron -    22484847 chr7:8055946(+) A-G intron -    22484847 chr7:8061167(+) T-C intron -    22484847 chr7:8062869(+) T-C intron -    22484847 chr7:8064920(+) A-G intron -    22484847 chr7:8079873(+) A-G intron -    22484847 chr7:8079934(+) A-G intron -    22484847 chr7:8079969(+) A-G intron -    22484847 chr7:8080005(+) A-G intron -    22484847 chr7:8080009(+) A-G intron -    22484847 chr7:8080035(+) A-G intron -    22484847 chr7:8080085(+) A-G intron -    22484847 chr7:8081249(+) A-G intron -    22484847 chr7:8081321(+) A-G intron -    22484847 chr7:8081346(+) A-G intron -    22484847 chr7:8081347(+) A-G intron -    22484847 chr7:8081350(+) A-G intron -    22484847 chr7:8081378(+) A-G intron -    22484847 chr7:8081411(+) A-G intron -    22484847 chr7:8081412(+) A-G intron -    22484847 chr7:8081422(+) A-G intron -    22484847 chr7:8081499(+) A-G intron -    22484847 chr7:8082171(+) A-G intron -    22484847 chr7:8082185(+) A-G intron -    22484847 chr7:8082187(+) A-G intron -    22484847 chr7:8082217(+) A-G intron -    22484847 chr7:8082247(+) A-G intron -    22484847 chr7:8083837(+) A-G intron -    22484847 chr7:8083849(+) A-G intron -    22484847 chr7:8084111(+) A-G intron -    22484847 chr7:8092974(+) G-T intron -    22484847 chr7:8101396(+) A-G intron -    22484847 chr7:8101397(+) A-G intron -    22484847 chr7:8102814(+) T-C intron -    22484847 chr7:8102865(+) C-T intron -    22484847 chr7:8103360(+) C-T intron -    22484847 chr7:8103361(+) A-C intron -    22484847 chr7:8103427(+) A-T intron -    22484847 chr7:8103487(+) A-G intron -    22484847 chr7:8104453(+) A-T intron -    22484847 chr7:8107704(+) A-G intron -    22484847 chr7:8107724(+) A-G intron -    22484847 chr7:8107769(+) A-G intron -    22484847 chr7:8107771(+) A-G intron -    22484847 chr7:8107777(+) A-G intron -    22484847 chr7:8107793(+) A-G intron -    22484847 chr7:8107857(+) A-G intron -    22484847 chr7:8107860(+) A-G intron -    22484847 chr7:8107912(+) G-A intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	GLCCI1	chr7:8008493-8008494(+) m6A 5'UTR       - chr7:8008842-8008843(+) m6A 5'UTR       - chr7:8010106-8010107(+) m6A exon//intron       - chr7:8021692-8021693(+) m6A intron       22608085 chr7:8021697-8021698(+) m6A intron       22608085 chr7:8021704-8021705(+) m6A intron       22608085 chr7:8021772-8021773(+) m6A intron       22608085 chr7:8021805-8021806(+) m6A intron       22608085 chr7:8095097-8095098(+) Y CDS//exon       26075521 chr7:8125869-8125870(+) m6A CDS//exon//intron       24284625//24209618//22608085 chr7:8125915-8125916(+) m6A CDS//exon//intron       24284625//24209618//24981863//22608085 chr7:8125959-8125960(+) m6A CDS//exon//intron       24284625//24209618//24981863//22608085 chr7:8126119-8126120(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr7:8126133-8126134(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr7:8126151-8126152(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr7:8126211-8126212(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr7:8126223-8126224(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr7:8126242-8126243(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr7:8126251-8126252(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr7:8126300-8126301(+) m6A 3'UTR//exon//intron       24284625//24209618//24981863//22575960//22608085 chr7:8126323-8126324(+) m6A 3'UTR//exon//intron       24284625//24209618//24981863//22575960//22608085 chr7:8126398-8126399(+) m6A 3'UTR//exon//intron       24284625//24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-181a-5p	Apoptotic body Human umbilical vein endothelial cells     19996457 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Primary dendritic cells|T cell line (J77)     21505438 Exosome Ovarian follicular fluid     22116803 Exosome Plasma     23663360 Exosome Human esophageal cancer cell line (EC9706)     25184951 Exosome Blood|B lymphoblastoid cells|Breast milk|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Epithelial cells|Kidney tissue|Lymphoma tissue|Mast cells|Tongue tissue     - Microvesicle Seminal plasma     23539611 Microvesicle Cerebrospinal fluid     24797360 Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion HEK-293 cells|HeLa cells|Myotube     27396686 Mitochondrion HEK-293 cells|HeLa cells|Skeletal muscle cells     27563705 Mitochondrion Human umbilical vein endothelial cells     30348904 Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Nasopharyngeal carcinoma cells     20498841
	GLCCI1	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol K562 cells     - Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome HEK-293 cells     22199352

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-181a-5p	Saintopin E 9864639 Drug sensitive [[4-(3-Aminophenyl)-2-pyridyl]methyleneamino]thiourea 9556427 Drug sensitive Pentamidine isethionate 8813 Drug resistant 2-Amino-3H-phenoxazin-3-one 72725 Drug resistant 2'-Bromo-4'-epi-daunorubicin 6711997 Drug sensitive Psammaplin A 6400741 Drug sensitive (Z)-6-(2-(Pyridin-2-ylmethylene)hydrazinyl)-9H-purine 60147744 Drug sensitive Triethylenemelamine 5799 Drug sensitive Mitomycin 5746 Drug sensitive Epidoxoform 46877760 Drug sensitive Diaziquone 42616 Drug sensitive 3-Acetoxymethyl-1-methyl-5-methoxyindole-4,7-dione 404937 Drug resistant 2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant Antineoplastic-D648114 372647 Drug sensitive Acridomide 364442 Drug sensitive 4-Aza-2'-phenyl-5alpha-cholestano[3,2-c]pyrazole 363170 Drug sensitive 6,7-Diacetoxyisoflavan 353129 Drug sensitive Deoxycamptothecin 266552 Drug sensitive Salarin C 24867082 Drug resistant N-[(1S,4R,7S,11R,14S,17R,20S,24R,27S)-2,4,12,15,17,25-Hexamethyl-27-methylsulfanyl-3,6,10,13,16,19,23,26-octaoxo-11,24-di(propan-2-yl)-20-(quinoxaline-2-carbonylamino)-9,22-dioxa-28-thia-2,5,12,15,18,25-hexazabicyclo[12.12.3]nonacosan-7-yl]quinoxaline-2-carboxamide 138402870 Drug sensitive Gold;(2S,3R,4S,5R,6R)-3,4,5-triacetyloxy-6-(acetyloxymethyl)oxane-2-thiolate;triethylphosphanium 138402869 Drug sensitive Oxanthrazole 135502299 Drug sensitive Cysteine, S-[(4-aminocarbonyl-1H-imidazol-5-yl)azo]- 135493928 Drug sensitive DTIC-Dome 135398738 Drug sensitive Saintopin 131350 Drug sensitive Cytochalasin q 11970174 Drug sensitive Unii-6FH145297U 11541062 Drug sensitive 2,2'-Bioxirane 11254 Drug sensitive Perillyl alcohol 10819 Drug sensitive N,N-Bis(2-chloroethyl)-p-toluidine 100400 Drug sensitive naphthalene-1,2-dione, 1,2-dihydro-4-[(3-pyridinyl)amino]- - Drug resistant chlorazin - Drug resistant ovb3-pe - Drug resistant (1s,2e,4r,6r,7e,10r,11e)-2,7,11-cembratriene-4,6,10-triol - Drug sensitive (3-(4-bromophenyl)-5-(1,3-diphenyl-1H-pyrazol-4-yl)-4,5-dihydropyrazol-1-yl)(4-methoxyphenyl)methanone - Drug sensitive 1,4-bis(n-cysteinyldiethylamino)-5,8-dihydroxy anthraquinon - Drug sensitive aquatris(1,3-diphenylpropane-1,3-dionato)neodymium(iii) - Drug sensitive cholestan-5.alpha.-ol-3,6-dione - Drug sensitive tris(1,3-diphenylpropane-1,3-dionata)gallium(iii) - Drug sensitive active compound from cephalodiscus gilchristi - Drug sensitive Camptothecin Derivative - Drug sensitive Chlorozotocin - Drug sensitive from cephalodiscus gilchristi - Drug sensitive hymenialdisine - Drug sensitive trans-dichlorobis(tricyclohexylphosphine)palladium - Drug sensitive trimethyl(phenylthio)stannane - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-181a-5p	Curcumin 969516 Drug interaction    RC00001828 Bufalin 9547215 Drug interaction    RC00001833 Formaldehyde 712 Drug interaction    RC00001796 Oxaliplatine 6857599 Drug interaction    RC00001832 Fludarabine 657237 Drug interaction    RC00001827 Cytarabine 6253 Drug interaction    RC00001807 Gemcitabine 60750 Drug interaction    RC00001814 Vincristine 5978 Drug interaction    RC00001806 Mitomycin 5746 Drug interaction    RC00001805 Dexamethasone 5743 Drug interaction    RC00001804 Temozolomide 5394 Drug interaction    RC00001803 Sunitinib 5329102 Drug interaction    RC00001831 Eloxatine 5310940 Drug interaction    RC00001830 Imatinib 5291 Drug interaction    RC00001802 Decitabine 451668 Drug interaction    RC00001826 Cocaine 446220 Drug interaction    RC00001825 Oleic acid 445639 Drug interaction    RC00001824 Docosahexaenoic acid 445580 Drug interaction    RC00001823 Tretinoin 444795 Drug interaction    RC00001822 Trichostatin A 444732 Drug interaction    RC00001821 Idarubicin 42890 Drug interaction    RC00001837 Mitoxantrone 4212 Drug interaction    RC00001801 Carboplatinum 38904 Drug interaction    RC00001813 Paclitaxel 36314 Drug interaction    RC00001812 5-Fluorouracil 3385 Drug interaction    RC00001800 Enoxacin 3229 Drug interaction    RC00001799 Doxorubicin 31703 Drug interaction    RC00001811 Daunorubicin 30323 Drug interaction    RC00001810 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001798 Tamoxifen 2733526 Drug interaction    RC00001829 Verapamil 2520 Drug interaction    RC00001797 Camptothecin 24360 Drug interaction    RC00001809 Sorafenib 216239 Drug interaction    RC00001820 Arsenic trioxide 14888 Drug interaction    RC00001808 Docetaxel 148124 Drug interaction    RC00001819 Leucovorin 135403648 Drug interaction    RC00001834 Gefitinib 123631 Drug interaction    RC00001818 Ginsenoside Rh2 119307 Drug interaction    RC00001817 Triptolide 107985 Drug interaction    RC00001816 Chemotherapy - Drug interaction    RC00008833 AMG511 - Drug interaction    RC00001835 GSK1070916 - Drug interaction    RC00001836 modified ALLIC BFM 2002 protocol - Drug interaction    RC00001838 XL765 - Drug interaction    RC00001839 1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00001840 Glucocorticoid - Drug interaction    RC00001841 Marine fungal metabolite 1386A - Drug interaction    RC00001842

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-181a-5p	Cisplatin 5702198       25356050 Paclitaxel 36314       26323677 Doxorubicin 31703       24759738 Methyl (9R,10S,11S,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate 134755071       24759738

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-181a-5p
Interactor2: GLCCI1

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.