Basic Information:

  VIRBase ID:  

HHID00048169

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-30d-5p:  MIMAT0000245          REEP3:  NM_001001330     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-30d-5p	REEP3
miRBase Accession/Entrez ID	MIMAT0000245	221035
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	C10orf74//Yip2b

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-30d-5p	rs1203910650 chr8:134804928    G/A rs1244539439 chr8:134804930    G/T rs1441595222 chr8:134804927    C/A rs1441595222 chr8:134804927    C/T rs374432132 chr8:134804931    G/A rs776972352 chr8:134804925    G/A rs1187386485 chr8:134804934    G/A rs1373057893 chr8:134804937    TACA/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	REEP3	chr10:65378171(+) A-I      intronic chr10:65378145(+) A-I      intronic chr10:65372132(+) A-I      intronic chr10:65372119(+) A-I      intronic chr10:65372117(+) A-I      intronic chr10:65371657(+) A-I      intronic chr10:65371655(+) A-I      intronic chr10:65371645(+) A-I      intronic chr10:65371629(+) A-I      intronic chr10:65371625(+) A-I      intronic chr10:65371615(+) A-I      intronic chr10:65371611(+) A-I      intronic chr10:65371610(+) A-I      intronic chr10:65370712(+) A-I      intronic chr10:65370701(+) A-I      intronic chr10:65370681(+) A-I      intronic chr10:65370673(+) A-I      intronic chr10:65370671(+) A-I      intronic chr10:65340692(+) A-I      intronic chr10:65340679(+) A-I      intronic chr10:65340649(+) A-I      intronic chr10:65340635(+) A-I      intronic chr10:65330719(+) A-I      intronic chr10:65330697(+) A-I      intronic chr10:65330679(+) A-I      intronic chr10:65375508(+) A-I      intronic chr10:65285279(+) A-I      intronic chr10:65284284(+) A-I      intronic chr10:65284277(+) A-I      intronic chr10:65283211(+) A-I      intronic chr10:65371612(+) A-I      intronic chr10:65382663(+) A-I      3'UTR chr10:65382656(+) A-I      3'UTR chr10:65382650(+) A-I      3'UTR chr10:65382633(+) A-I      3'UTR chr10:65382597(+) A-I      3'UTR chr10:65378198(+) A-I      intronic chr10:65378192(+) A-I      intronic chr10:65371641(+) A-I      intronic chr10:65366167(+) A-I      intronic chr10:65283316(+) A-I      intronic chr10:65285282(+) A-I      intronic chr10:65371642(+) A-I      intronic chr10:65371958(+) A-I      intronic chr10:65372014(+) A-I      intronic chr10:65372301(+) A-I      intronic chr10:65372391(+) A-I      intronic chr10:65372952(+) A-I      intronic chr10:65294156(+) A-I      intronic chr10:65294150(+) A-I      intronic chr10:65372955(+) A-I      intronic chr10:65289362(+) A-I      intronic chr10:65294072(+) A-I      intronic chr10:65372969(+) A-I      intronic chr10:65373009(+) A-I      intronic chr10:65373017(+) A-I      intronic chr10:65283315(+) A-I      intronic chr10:65338843(+) A-I      intronic chr10:65287420(+) A-I      intronic chr10:65285243(+) A-I      intronic chr10:65366273(+) A-I      intronic chr10:65373032(+) A-I      intronic chr10:65373044(+) A-I      intronic chr10:65372295(+) A-I      intronic chr10:65373022(+) A-I      intronic chr10:65298457(+) A-I      intronic chr10:65372833(+) A-I      intronic chr10:65298396(+) A-I      intronic chr10:65372836(+) A-I      intronic chr10:65328545(+) A-I      intronic chr10:65361417(+) A-I      intronic chr10:65372115(+) A-I      intronic chr10:65328516(+) A-I      intronic chr10:65318369(+) A-I      intronic chr10:65324900(+) A-I      intronic chr10:65324857(+) A-I      intronic chr10:65292245(+) A-I      intronic chr10:65284268(+) A-I      intronic chr10:65292508(+) A-I      intronic chr10:65324212(+) A-I      intronic chr10:65338953(+) A-I      intronic chr10:65337916(+) A-I      intronic chr10:65292522(+) A-I      intronic chr10:65284669(+) A-I      intronic chr10:65294153(+) A-I      intronic chr10:65338921(+) A-I      intronic chr10:65283250(+) A-I      intronic chr10:65292543(+) A-I      intronic chr10:65303185(+) A-I      intronic chr10:65366163(+) A-I      intronic chr10:65303182(+) A-I      intronic chr10:65318340(+) A-I      intronic chr10:65338988(+) A-I      intronic chr10:65343025(+) A-I      intronic chr10:65284732(+) A-I      intronic chr10:65352426(+) A-I      intronic chr10:65338416(+) A-I      intronic chr10:65284272(+) A-I      intronic chr10:65339078(+) A-I      intronic chr10:65303181(+) A-I      intronic chr10:65303173(+) A-I      intronic chr10:65339012(+) A-I      intronic chr10:65289372(+) A-I      intronic chr10:65284737(+) A-I      intronic chr10:65294059(+) A-I      intronic chr10:65303156(+) A-I      intronic chr10:65284651(+) A-I      intronic chr10:65303133(+) A-I      intronic chr10:65303111(+) A-I      intronic chr10:65303109(+) A-I      intronic chr10:65301940(+) A-I      intronic chr10:65301926(+) A-I      intronic chr10:65301871(+) A-I      intronic chr10:65300615(+) A-I      intronic chr10:65298423(+) A-I      intronic chr10:65352464(+) A-I      intronic chr10:65372071(+) A-I      intronic chr10:65338841(+) A-I      intronic chr10:65338991(+) A-I      intronic chr10:65284262(+) A-I      intronic chr10:65341291(+) A-I      intronic chr10:65341319(+) A-I      intronic chr10:65338895(+) A-I      intronic chr10:65337977(+) A-I      intronic chr10:65338871(+) A-I      intronic chr10:65352465(+) A-I      intronic chr10:65294172(+) A-I      intronic chr10:65372009(+) A-I      intronic chr10:65352661(+) A-I      intronic chr10:65356641(+) A-I      intronic chr10:65360877(+) A-I      intronic chr10:65372060(+) A-I      intronic chr10:65337908(+) A-I      intronic chr10:65284403(+) A-I      intronic chr10:65340673(+) A-I      intronic chr10:65370645(+) A-I      intronic chr10:65284278(+) A-I      intronic chr10:65329598(+) A-I      intronic chr10:65284751(+) A-I      intronic chr10:65372444(+) A-I      intronic chr10:65329597(+) A-I      intronic chr10:65329468(+) A-I      intronic chr10:65329453(+) A-I      intronic chr10:65341396(+) A-I      intronic chr10:65382647(+) A-I      3'UTR chr10:65382596(+) A-I      3'UTR chr10:65372210(+) A-I      intronic chr10:65338343(+) A-I      intronic chr10:65337940(+) A-I      intronic chr10:65324883(+) A-I      intronic chr10:65372430(+) A-I      intronic chr10:65300581(+) A-I      intronic chr10:65330754(+) A-I      intronic chr10:65366281(+) A-I      intronic chr10:65292561(+) A-I      intronic chr10:65284408(+) A-I      intronic chr10:65309230(+) A-I      intronic chr10:65371675(+) A-I      intronic chr10:65375557(+) A-I      intronic chr10:65372216(+) A-I      intronic chr10:65356555(+) A-I      intronic chr10:65293607(+) A-I      intronic chr10:65369262(+) A-I      intronic chr10:65339053(+) A-I      intronic chr10:65342891(+) A-I      intronic chr10:65294080(+) A-I      intronic chr10:65338849(+) A-I      intronic chr10:65372152(+) A-I      intronic chr10:65361656(+) A-I      intronic chr10:65309269(+) A-I      intronic chr10:65375553(+) A-I      intronic chr10:65285318(+) A-I      intronic chr10:65338996(+) A-I      intronic chr10:65338456(+) A-I      intronic chr10:65338925(+) A-I      intronic chr10:65324249(+) A-I      intronic chr10:65303104(+) A-I      intronic chr10:65372404(+) A-I      intronic chr10:65366169(+) A-I      intronic chr10:65366272(+) A-I      intronic chr10:65372289(+) A-I      intronic chr10:65285227(+) A-I      intronic chr10:65284643(+) A-I      intronic chr10:65284296(+) A-I      intronic chr10:65372028(+) A-I      intronic chr10:65328604(+) A-I      intronic chr10:65284297(+) A-I      intronic chr10:65337989(+) A-I      intronic chr10:65338356(+) A-I      intronic chr10:65372058(+) A-I      intronic chr10:65369453(+) A-I      intronic chr10:65284389(+) A-I      intronic chr10:65285242(+) A-I      intronic chr10:65338270(+) A-I      intronic chr10:65338334(+) A-I      intronic chr10:65284705(+) A-I      intronic chr10:65292527(+) A-I      intronic chr10:65338487(+) A-I      intronic chr10:65369374(+) A-I      intronic chr10:65339056(+) A-I      intronic chr10:65338339(+) A-I      intronic chr10:65372398(+) A-I      intronic chr10:65372166(+) A-I      intronic chr10:65330819(+) A-I      intronic chr10:65283337(+) A-I      intronic chr10:65293548(+) A-I      intronic chr10:65375444(+) A-I      intronic chr10:65370685(+) A-I      intronic chr10:65283263(+) A-I      intronic chr10:65294230(+) A-I      intronic chr10:65283286(+) A-I      intronic chr10:65372167(+) A-I      intronic chr10:65283190(+) A-I      intronic chr10:65371649(+) A-I      intronic chr10:65366182(+) A-I      intronic chr10:65361583(+) A-I      intronic chr10:65294028(+) A-I      intronic chr10:65338892(+) A-I      intronic chr10:65366258(+) A-I      intronic chr10:65360652(+) A-I      intronic chr10:65322227(+) A-I      intronic chr10:65372021(+) A-I      intronic chr10:65338263(+) A-I      intronic chr10:65366196(+) A-I      intronic chr10:65330696(+) A-I      intronic chr10:65292614(+) A-I      intronic chr10:65324983(+) A-I      intronic chr10:65284351(+) A-I      intronic chr10:65293658(+) A-I      intronic chr10:65372875(+) A-I      intronic chr10:65362979(+) A-I      intronic chr10:65360864(+) A-I      intronic chr10:65292511(+) A-I      intronic chr10:65284687(+) A-I      intronic chr10:65294144(+) A-I      intronic chr10:65309221(+) A-I      intronic chr10:65382739(+) A-I      3'UTR chr10:65338394(+) A-I      intronic chr10:65293568(+) A-I      intronic chr10:65369195(+) A-I      intronic chr10:65283380(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	REEP3	chr10:65284651(+) A-G intron -    22484847 chr10:65368966(+) A-C intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	REEP3	chr10:65281127-65281128(+) m6A 5'UTR       24981863 chr10:65370026-65370027(+) m6A 3'UTR//CDS       24981863//27773535 chr10:65370032-65370033(+) m6A 3'UTR//CDS       24981863//27773535 chr10:65370071-65370072(+) m6A 3'UTR//CDS       24981863//27773535 chr10:65379449-65379450(+) m6A 3'UTR//CDS       24981863//27773535 chr10:65379539-65379540(+) m6A 3'UTR//CDS       24981863//27773535//22575960

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-30d-5p	Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome HCC tissues     30542726 Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Renal cancer cells     21670082 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Human mast cell line (HMC-1)     24009880 Exosome Cerebrospinal fluid     25420022 Exosome Blood|B lymphoblastoid cells|Breast milk|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Epithelial cells|Kidney tissue|Lymphoma tissue|Mast cells|Seminal fluid|Tongue tissue     - Extracellular vesicle HEK-293T cells     22849433 Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Plasma     23077538 Microvesicle Seminal plasma     23539611 Microvesicle Follicular fluid     23666971 Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleolus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
	REEP3	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)     - Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-30d-5p	Midostaurin 9829523 Drug resistant Herveline O 5459269 Drug sensitive Cuspidatin C 5459164 Drug sensitive 2,7-Bis(methoxycarbonylmethyl)-10-methylphenothiazine 384444 Drug sensitive 2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant Antimycin A3 245869 Drug sensitive 5-Hydroxy-3-phenylpyrano[3,2-c]chromen-2(5H)-one 24205741 Drug sensitive 4,5-Bis(4-methoxyphenyl)-1,5-dihydroimidazol-2-one 231112 Drug sensitive Kinetin riboside 20345 Drug resistant Astrazon Orange R 135747272 Drug sensitive Cladospirone bisepoxide 10316810 Drug sensitive (3Z,4R)-4-Hydroxy-3-[2-[(1S,3R)-3-[2-[(1S,3S,3'R,4S)-1-hydroxy-4,6,6-trimethylspiro[2,5-dioxabicyclo[2.2.2]octane-3,6'-oxane]-3'-yl]ethyl]-2,2-dimethyl-6-methylidenecyclohexyl]ethylidene]oxolan-2-one 101206903 Drug sensitive antineoplastic-d655481 - Drug resistant 4-[4-(3-Methoxy-phenyl)-piperazin-1 -yl]-5H-pyrrolo[3,2-d]pyrimidine - Drug sensitive 4-morpholinecarbodithioic acid, antimony complex - Drug sensitive 7-n,n-dimethylamino brefeldin a hydrochloride - Drug sensitive E)-1-(4-(quinazolin-4-ylamino)phenyl)-3-(2,4,6-trimethoxyphenyl)prop-2-en-1-one - Drug sensitive isatin dr - Drug sensitive tetra(isobutenyl)antimony bromide - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-30d-5p	Gemcitabine 60750 Drug interaction    RC00001621 Sunitinib 5329102 Drug interaction    RC00001626 Eloxatine 5310940 Drug interaction    RC00001625 Trichostatin A 444732 Drug interaction    RC00001624 Paroxetine 43815 Drug interaction    RC00001620 Etoposide 36462 Drug interaction    RC00001619 5-Fluorouracil 3385 Drug interaction    RC00001617 Doxorubicin 31703 Drug interaction    RC00001618 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001616 Verapamil 2520 Drug interaction    RC00001615 N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00001627 Bicalutamide 2375 Drug interaction    RC00001614 Docetaxel 148124 Drug interaction    RC00001623 1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00001628 Trastuzumab - Drug interaction    RC00001629

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-30d-5p	N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-30d-5p
Interactor2: REEP3

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.