Basic Information:

  VIRBase ID:  

HHID00048157

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-30d-5p:  MIMAT0000245          PPARGC1B:  NM_001172698     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-30d-5p	PPARGC1B
miRBase Accession/Entrez ID	MIMAT0000245	133522
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	ERRL1//PERC//PGC-1(beta)//PGC1B

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-30d-5p	rs1203910650 chr8:134804928    G/A rs1244539439 chr8:134804930    G/T rs1441595222 chr8:134804927    C/A rs1441595222 chr8:134804927    C/T rs374432132 chr8:134804931    G/A rs776972352 chr8:134804925    G/A rs1187386485 chr8:134804934    G/A rs1373057893 chr8:134804937    TACA/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PPARGC1B	chr5:149118277(+) A-I      intronic chr5:149118286(+) A-I      intronic chr5:149118332(+) A-I      intronic chr5:149118369(+) A-I      intronic chr5:149118421(+) A-I      intronic chr5:149124594(+) A-I      intronic chr5:149124598(+) A-I      intronic chr5:149124666(+) A-I      intronic chr5:149124699(+) A-I      intronic chr5:149132190(+) A-I      intronic chr5:149132261(+) A-I      intronic chr5:149132281(+) A-I      intronic chr5:149132342(+) A-I      intronic chr5:149132357(+) A-I      intronic chr5:149132850(+) A-I      intronic chr5:149132869(+) A-I      intronic chr5:149132870(+) A-I      intronic chr5:149132954(+) A-I      intronic chr5:149132991(+) A-I      intronic chr5:149134384(+) A-I      intronic chr5:149134414(+) A-I      intronic chr5:149134444(+) A-I      intronic chr5:149134445(+) A-I      intronic chr5:149134449(+) A-I      intronic chr5:149134462(+) A-I      intronic chr5:149134484(+) A-I      intronic chr5:149134692(+) A-I      intronic chr5:149134693(+) A-I      intronic chr5:149134694(+) A-I      intronic chr5:149134700(+) A-I      intronic chr5:149134706(+) A-I      intronic chr5:149134707(+) A-I      intronic chr5:149135306(+) A-I      intronic chr5:149135761(+) A-I      intronic chr5:149135769(+) A-I      intronic chr5:149135888(+) A-I      intronic chr5:149135895(+) A-I      intronic chr5:149142450(+) A-I      intronic chr5:149142462(+) A-I      intronic chr5:149147857(+) A-I      intronic chr5:149147967(+) A-I      intronic chr5:149150239(+) A-I      intronic chr5:149150246(+) A-I      intronic chr5:149160634(+) A-I      intronic chr5:149165759(+) A-I      intronic chr5:149179501(+) A-I      intronic chr5:149179505(+) A-I      intronic chr5:149189193(+) A-I      intronic chr5:149124647(+) A-I      intronic chr5:149113731(+) A-I      intronic chr5:149113862(+) A-I      intronic chr5:149113908(+) A-I      intronic chr5:149117371(+) A-I      intronic chr5:149117376(+) A-I      intronic chr5:149117392(+) A-I      intronic chr5:149117398(+) A-I      intronic chr5:149117399(+) A-I      intronic chr5:149117405(+) A-I      intronic chr5:149117406(+) A-I      intronic chr5:149117418(+) A-I      intronic chr5:149117453(+) A-I      intronic chr5:149117466(+) A-I      intronic chr5:149117472(+) A-I      intronic chr5:149117506(+) A-I      intronic chr5:149117512(+) A-I      intronic chr5:149134893(+) A-I      intronic chr5:149133386(+) A-I      intronic chr5:149134448(+) A-I      intronic chr5:149117520(+) A-I      intronic chr5:149133437(+) A-I      intronic chr5:149135824(+) A-I      intronic chr5:149150241(+) A-I      intronic chr5:149135763(+) A-I      intronic chr5:149148107(+) A-I      intronic chr5:149118264(+) A-I      intronic chr5:149177416(+) A-I      intronic chr5:149118301(+) A-I      intronic chr5:149147915(+) A-I      intronic chr5:149166035(+) A-I      intronic chr5:149115626(+) A-I      intronic chr5:149117436(+) A-I      intronic chr5:149196796(+) A-I      intronic chr5:149117446(+) A-I      intronic chr5:149122899(+) A-I      intronic chr5:149177395(+) A-I      intronic chr5:149134457(+) A-I      intronic chr5:149118221(+) A-I      intronic chr5:149179500(+) A-I      intronic chr5:149150172(+) A-I      intronic chr5:149117469(+) A-I      intronic chr5:149133440(+) A-I      intronic chr5:149117302(+) A-I      intronic chr5:149134823(+) A-I      intronic chr5:149133479(+) A-I      intronic chr5:149215635(+) A-I      intronic chr5:149135964(+) A-I      intronic chr5:149166020(+) A-I      intronic chr5:149124738(+) A-I      intronic chr5:149118289(+) A-I      intronic chr5:149134511(+) A-I      intronic chr5:149185183(+) A-I      intronic chr5:149117410(+) A-I      intronic chr5:149132341(+) A-I      intronic chr5:149124577(+) A-I      intronic chr5:149118299(+) A-I      intronic chr5:149211615(+) A-I      intronic chr5:149135884(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	PPARGC1B	chr5:149112315(+) A-G intron -    22484847 chr5:149112342(+) A-G intron -    22484847 chr5:149148667(+) A-G intron -    22484847 chr5:149113634(+) T-C intron -    22484847 chr5:149117302(+) A-G intron -    22484847 chr5:149117310(+) G-A intron -    22484847 chr5:149117410(+) A-G intron -    22484847 chr5:149117436(+) A-G intron -    22484847 chr5:149117446(+) A-G intron -    22484847 chr5:149117469(+) A-G intron -    22484847 chr5:149117520(+) A-G intron -    22484847 chr5:149118221(+) A-G intron -    22484847 chr5:149118264(+) A-G intron -    22484847 chr5:149118289(+) A-G intron -    22484847 chr5:149118299(+) A-G intron -    22484847 chr5:149118301(+) A-G intron -    22484847 chr5:149118343(+) A-G intron -    22484847 chr5:149118362(+) A-G intron -    22484847 chr5:149124577(+) A-G intron -    22484847 chr5:149132341(+) A-G intron -    22484847 chr5:149133386(+) A-G intron -    22484847 chr5:149134448(+) A-G intron -    22484847 chr5:149134490(+) A-G intron -    22484847 chr5:149134511(+) A-G intron -    22484847 chr5:149134823(+) A-G intron -    22484847 chr5:149135307(+) A-G intron -    22484847 chr5:149135763(+) A-G intron -    22484847 chr5:149135784(+) A-G intron -    22484847 chr5:149135805(+) A-G intron -    22484847 chr5:149135868(+) A-G intron -    22484847 chr5:149135884(+) A-G intron -    22484847 chr5:149135964(+) A-G intron -    22484847 chr5:149148107(+) A-G intron -    22484847 chr5:149150172(+) A-G intron -    22484847 chr5:149150241(+) A-G intron -    22484847 chr5:149165495(+) C-T intron -    22484847 chr5:149170680(+) T-C intron -    22484847 chr5:149177337(+) A-G intron -    22484847 chr5:149177364(+) A-G intron -    22484847 chr5:149177395(+) A-G intron -    22484847 chr5:149179500(+) A-G intron -    22484847 chr5:149179524(+) A-G intron -    22484847 chr5:149185183(+) A-G intron -    22484847 chr5:149208629(+) G-A intron -    22484847 chr5:149209436(+) G-T intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PPARGC1B	chr5:149119562-149119563(+) m6A exon//intron       24284625 chr5:149119593-149119594(+) m6A exon//intron       24284625 chr5:149119605-149119606(+) m6A exon//intron       24284625 chr5:149119614-149119615(+) m6A exon//intron       24284625 chr5:149200039-149200040(+) m6A CDS       24284625 chr5:149200116-149200117(+) m6A CDS       24284625 chr5:149200124-149200125(+) m6A CDS       24284625 chr5:149200129-149200130(+) m6A CDS       24284625 chr5:149206277-149206278(+) m6A CDS       24284625 chr5:149210392-149210393(+) m6A CDS//intron       24284625 chr5:149212222-149212223(+) m6A CDS       24284625 chr5:149212234-149212235(+) m6A CDS       24284625 chr5:149212280-149212281(+) m6A CDS       24284625 chr5:149212375-149212376(+) m6A CDS       24284625//25456834//24981863//22608085 chr5:149212393-149212394(+) m6A CDS       24284625//25456834//24981863//22608085 chr5:149212432-149212433(+) m6A CDS       24284625//25456834//24981863//22608085 chr5:149212456-149212457(+) m6A CDS       24284625//24209618//25456834//24981863//22608085 chr5:149212483-149212484(+) m6A CDS       24284625//24209618//25456834//24981863//22608085 chr5:149212557-149212558(+) m6A CDS       24284625//24209618//25456834 chr5:149212670-149212671(+) m6A CDS       24284625 chr5:149212706-149212707(+) m6A CDS       24284625 chr5:149212774-149212775(+) m6A CDS       24284625//24981863//22608085 chr5:149212853-149212854(+) m6A CDS       24284625//24209618//25456834//24981863//22608085 chr5:149212910-149212911(+) m6A CDS       24284625//24209618//25456834//24981863//22608085 chr5:149212942-149212943(+) m1A CDS       26863196 chr5:149212963-149212964(+) m1A CDS       26863196 chr5:149213078-149213079(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr5:149213083-149213084(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr5:149213221-149213222(+) m6A CDS       24284625//25456834//24981863//22608085 chr5:149213233-149213234(+) m6A CDS       24284625//25456834//24981863//22608085 chr5:149213252-149213253(+) m6A CDS       24284625//25456834//24981863//22608085 chr5:149213299-149213300(+) m6A CDS       24284625//25456834//22608085 chr5:149213311-149213312(+) m6A CDS       24284625//25456834//22608085 chr5:149214897-149214898(+) m6A CDS       24284625 chr5:149215880-149215881(+) m6A CDS       24284625 chr5:149215885-149215886(+) m6A CDS       24284625 chr5:149216089-149216090(+) m6A CDS       24284625//22608085 chr5:149216179-149216180(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr5:149216236-149216237(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr5:149216269-149216270(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr5:149216287-149216288(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr5:149216315-149216316(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr5:149216334-149216335(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr5:149216353-149216354(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr5:149216398-149216399(+) m6A CDS       24284625//25456834//24981863//22608085 chr5:149216488-149216489(+) m6A CDS       24284625//25456834//24981863//22608085 chr5:149216629-149216630(+) m6A CDS       24284625 chr5:149219629-149219630(+) m6A CDS       24284625 chr5:149225490-149225491(+) m6A CDS//intron       24284625 chr5:149225511-149225512(+) m6A CDS//intron       24284625 chr5:149225543-149225544(+) m6A CDS//intron       24284625 chr5:149225548-149225549(+) m6A CDS//intron       24284625 chr5:149225572-149225573(+) m6A 3'UTR//intron       24284625 chr5:149225638-149225639(+) m6A 3'UTR//intron       24284625//22608085 chr5:149225763-149225764(+) m6A 3'UTR//intron       - chr5:149225842-149225843(+) m6A 3'UTR//intron       - chr5:149226186-149226187(+) m6A 3'UTR//intron       22608085 chr5:149226218-149226219(+) m6A 3'UTR//intron       22608085 chr5:149226260-149226261(+) m6A 3'UTR//intron       22608085 chr5:149226637-149226638(+) m6A 3'UTR//intron       - chr5:149226805-149226806(+) m6A 3'UTR//intron       24284625//25456834//22608085 chr5:149226822-149226823(+) m6A 3'UTR//intron       24284625//25456834//22608085 chr5:149227160-149227161(+) m6A 3'UTR//exon       24284625//25456834//24981863//22608085 chr5:149227232-149227233(+) m6A 3'UTR//exon       24284625//25456834//24981863//22608085 chr5:149227247-149227248(+) m6A 3'UTR//exon       24284625//25456834//24981863//22608085 chr5:149227254-149227255(+) m6A 3'UTR//exon       24284625//25456834//24981863//22608085 chr5:149227297-149227298(+) m6A 3'UTR//exon       24284625//25456834//24981863//22608085 chr5:149227448-149227449(+) m6A 3'UTR       24284625//24981863 chr5:149227526-149227527(+) m6A 3'UTR       24981863 chr5:149227533-149227534(+) m6A 3'UTR       24981863 chr5:149231343-149231344(+) m6A 3'UTR       24284625 chr5:149231375-149231376(+) m6A 3'UTR       24284625 chr5:149232846-149232847(+) m6A 3'UTR       24981863//22608085 chr5:149232878-149232879(+) m6A 3'UTR       24981863//22608085 chr5:149232922-149232923(+) m6A 3'UTR       24981863//22608085 chr5:149232946-149232947(+) m6A 3'UTR       22608085 chr5:149232959-149232960(+) m6A 3'UTR       22608085 chr5:149232996-149232997(+) m6A 3'UTR       22608085 chr5:149233006-149233007(+) m6A 3'UTR       22608085 chr5:149233332-149233333(+) m6A 3'UTR       - chr5:149233361-149233362(+) m6A 3'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-30d-5p	Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome HCC tissues     30542726 Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Renal cancer cells     21670082 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Human mast cell line (HMC-1)     24009880 Exosome Cerebrospinal fluid     25420022 Exosome Blood|B lymphoblastoid cells|Breast milk|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Epithelial cells|Kidney tissue|Lymphoma tissue|Mast cells|Seminal fluid|Tongue tissue     - Extracellular vesicle HEK-293T cells     22849433 Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Plasma     23077538 Microvesicle Seminal plasma     23539611 Microvesicle Follicular fluid     23666971 Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleolus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
	PPARGC1B	Chromatin K562 cells     - Cytosol K562 cells     - Exosome Blood     - Membrane K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-30d-5p	Midostaurin 9829523 Drug resistant Herveline O 5459269 Drug sensitive Cuspidatin C 5459164 Drug sensitive 2,7-Bis(methoxycarbonylmethyl)-10-methylphenothiazine 384444 Drug sensitive 2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant Antimycin A3 245869 Drug sensitive 5-Hydroxy-3-phenylpyrano[3,2-c]chromen-2(5H)-one 24205741 Drug sensitive 4,5-Bis(4-methoxyphenyl)-1,5-dihydroimidazol-2-one 231112 Drug sensitive Kinetin riboside 20345 Drug resistant Astrazon Orange R 135747272 Drug sensitive Cladospirone bisepoxide 10316810 Drug sensitive (3Z,4R)-4-Hydroxy-3-[2-[(1S,3R)-3-[2-[(1S,3S,3'R,4S)-1-hydroxy-4,6,6-trimethylspiro[2,5-dioxabicyclo[2.2.2]octane-3,6'-oxane]-3'-yl]ethyl]-2,2-dimethyl-6-methylidenecyclohexyl]ethylidene]oxolan-2-one 101206903 Drug sensitive antineoplastic-d655481 - Drug resistant 4-[4-(3-Methoxy-phenyl)-piperazin-1 -yl]-5H-pyrrolo[3,2-d]pyrimidine - Drug sensitive 4-morpholinecarbodithioic acid, antimony complex - Drug sensitive 7-n,n-dimethylamino brefeldin a hydrochloride - Drug sensitive E)-1-(4-(quinazolin-4-ylamino)phenyl)-3-(2,4,6-trimethoxyphenyl)prop-2-en-1-one - Drug sensitive isatin dr - Drug sensitive tetra(isobutenyl)antimony bromide - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-30d-5p	Gemcitabine 60750 Drug interaction    RC00001621 Sunitinib 5329102 Drug interaction    RC00001626 Eloxatine 5310940 Drug interaction    RC00001625 Trichostatin A 444732 Drug interaction    RC00001624 Paroxetine 43815 Drug interaction    RC00001620 Etoposide 36462 Drug interaction    RC00001619 5-Fluorouracil 3385 Drug interaction    RC00001617 Doxorubicin 31703 Drug interaction    RC00001618 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001616 Verapamil 2520 Drug interaction    RC00001615 N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00001627 Bicalutamide 2375 Drug interaction    RC00001614 Docetaxel 148124 Drug interaction    RC00001623 1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00001628 Trastuzumab - Drug interaction    RC00001629

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-30d-5p	N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-30d-5p
Interactor2: PPARGC1B

Evidence Support:

Weak-Evidence	HITS-CLIP
Support Database	ViRBase

References:

PMID	22473208	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	Jijoye cells	Interactor2 expression	None
Description	Our HITS-CLIP data yield 1185 human 3'UTRs targeted by members of the miR-17~92 cluster in Jijoye cells. Comparison to the 1664 3'UTRs targeted by EBV miRNAs reveals 740 shared genes (44% of EBV targets and 62% of miR-17~92 targets; Figure 6B and Supplementary Table 7). Thus, EBV miRNAs co-target a majority of miR-17~92 regulated mRNAs, which are assigned to a variety of pathways, most notably regulating transcription, apoptosis, and the cell cycle (Figure 6C). Similarly, other abundant immunologically relevant miRNAs, 142-3p and miR-155, co-target with EBV miRNAs a large fraction of their Ago-bound 3'UTRs, representing ~60% of the targets for each of these host miRNAs (Supplementary Figure 5).