Detail Information

Basic Information:


  VIRBase ID:  

HHID00048144

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5725

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-30d-5p:           FAM104A:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-30d-5p FAM104A
miRBase
Accession/Entrez ID		 MIMAT0000245 84923
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - -

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-30d-5p
rs1203910650 chr8:134804928    G/A
rs1244539439 chr8:134804930    G/T
rs1441595222 chr8:134804927    C/A
rs1441595222 chr8:134804927    C/T
rs374432132 chr8:134804931    G/A
rs776972352 chr8:134804925    G/A
rs1187386485 chr8:134804934    G/A
rs1373057893 chr8:134804937    TACA/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR FAM104A
chr17:71226729(-) A-I      intronic
chr17:71226703(-) A-I      intronic
chr17:71220497(-) A-I      intronic
chr17:71220515(-) A-I      intronic
chr17:71220532(-) A-I      intronic
chr17:71222079(-) A-I      intronic
chr17:71220527(-) A-I      intronic
chr17:71222212(-) A-I      intronic
chr17:71222312(-) A-I      intronic
chr17:71222313(-) A-I      intronic
chr17:71225842(-) A-I      intronic
chr17:71225848(-) A-I      intronic
chr17:71225993(-) A-I      intronic
chr17:71226631(-) A-I      intronic
chr17:71226643(-) A-I      intronic
chr17:71226646(-) A-I      intronic
chr17:71226737(-) A-I      intronic
chr17:71226739(-) A-I      intronic
chr17:71226787(-) A-I      intronic
chr17:71211461(-) A-I      intronic
chr17:71211465(-) A-I      intronic
chr17:71211546(-) A-I      intronic
chr17:71213842(-) A-I      intronic
chr17:71214902(-) A-I      intronic
chr17:71214969(-) A-I      intronic
chr17:71215208(-) A-I      intronic
chr17:71215230(-) A-I      intronic
chr17:71215283(-) A-I      intronic
chr17:71215284(-) A-I      intronic
chr17:71215286(-) A-I      intronic
chr17:71215584(-) A-I      intronic
chr17:71215649(-) A-I      intronic
chr17:71215670(-) A-I      intronic
chr17:71215726(-) A-I      intronic
chr17:71216644(-) A-I      intronic
chr17:71216722(-) A-I      intronic
chr17:71216811(-) A-I      intronic
chr17:71216830(-) A-I      intronic
chr17:71217110(-) A-I      intronic
chr17:71217170(-) A-I      intronic
chr17:71217176(-) A-I      intronic
chr17:71217241(-) A-I      intronic
chr17:71220348(-) A-I      intronic
chr17:71206851(-) A-I      intronic
chr17:71219998(-) A-I      intronic
chr17:71226340(-) A-I      intronic
chr17:71226706(-) A-I      intronic
chr17:71226713(-) A-I      intronic
chr17:71218010(-) A-I      intronic
chr17:71225898(-) A-I      intronic
chr17:71216005(-) A-I      intronic
chr17:71226179(-) A-I      intronic
chr17:71226709(-) A-I      intronic
chr17:71216708(-) A-I      intronic
chr17:71218007(-) A-I      intronic
chr17:71216686(-) A-I      intronic
chr17:71222315(-) A-I      intronic
chr17:71222277(-) A-I      intronic
chr17:71213384(-) A-I      intronic
chr17:71216766(-) A-I      intronic
chr17:71226786(-) A-I      intronic
chr17:71213212(-) A-I      intronic
chr17:71206966(-) A-I      intronic
chr17:71216859(-) A-I      intronic
chr17:71211686(-) A-I      intronic
chr17:71220320(-) A-I      intronic
chr17:71226373(-) A-I      intronic
chr17:71214861(-) A-I      intronic
chr17:71211487(-) A-I      intronic
chr17:71206869(-) A-I      intronic
chr17:71226791(-) A-I      intronic
chr17:71225924(-) A-I      intronic
chr17:71218660(-) A-I      intronic
chr17:71225921(-) A-I      intronic
chr17:71226650(-) A-I      intronic
chr17:71215783(-) A-I      intronic
chr17:71222329(-) A-I      intronic
chr17:71216676(-) A-I      intronic
chr17:71220508(-) A-I      intronic
chr17:71208094(-) A-I      intronic
chr17:71206989(-) A-I      intronic
chr17:71211545(-) A-I      intronic
chr17:71226353(-) A-I      intronic
chr17:71208087(-) A-I      intronic
chr17:71226715(-) A-I      intronic
chr17:71222179(-) A-I      intronic
chr17:71216763(-) A-I      intronic
chr17:71220037(-) A-I      intronic
chr17:71217175(-) A-I      intronic
chr17:71207819(-) A-I      intronic
chr17:71214779(-) A-I      intronic
chr17:71213490(-) A-I      intronic
chr17:71226421(-) A-I      intronic
chr17:71226251(-) A-I      intronic
chr17:71219992(-) A-I      intronic
chr17:71206855(-) A-I      intronic
chr17:71211612(-) A-I      intronic
chr17:71226567(-) A-I      intronic
chr17:71224487(-) A-I      intronic
chr17:71222307(-) A-I      intronic
chr17:71211685(-) A-I      intronic
chr17:71215630(-) A-I      intronic
chr17:71206942(-) A-I      intronic
chr17:71222291(-) A-I      intronic
chr17:71226335(-) A-I      intronic
chr17:71213370(-) A-I      intronic
chr17:71206828(-) A-I      intronic
chr17:71206823(-) A-I      intronic
chr17:71226366(-) A-I      intronic
chr17:71226712(-) A-I      intronic
chr17:71213750(-) A-I      intronic
chr17:71206938(-) A-I      intronic
chr17:71218073(-) A-I      intronic
chr17:71207453(-) A-I      intronic
chr17:71211560(-) A-I      intronic
chr17:71222178(-) A-I      intronic
chr17:71222210(-) A-I      intronic
chr17:71222133(-) A-I      intronic
chr17:71226651(-) A-I      intronic
chr17:71225748(-) A-I      intronic
chr17:71215677(-) A-I      intronic
chr17:71220476(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED FAM104A
chr17:71226709(-) A-I intron -    22327324
chr17:71206869(-) A-G intron -    22484847
chr17:71206942(-) A-G intron -    22484847
chr17:71211612(-) A-G intron -    22484847
chr17:71225921(-) A-G intron -    22484847
chr17:71226650(-) A-G intron -    22484847
chr17:71226651(-) A-G intron -    22484847
chr17:71226706(-) A-G intron -    22484847
chr17:71226709(-) A-G intron -    22484847
chr17:71226715(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase FAM104A
chr17:71203549-71203550(-) m6A 3'UTR       27773535
chr17:71203713-71203714(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22608085
chr17:71203728-71203729(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22608085
chr17:71203733-71203734(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22608085
chr17:71203748-71203749(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22608085
chr17:71203792-71203793(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr17:71203804-71203805(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr17:71203909-71203910(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr17:71203930-71203931(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr17:71203951-71203952(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr17:71204070-71204071(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr17:71204107-71204108(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr17:71204147-71204148(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr17:71204170-71204171(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr17:71204215-71204216(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr17:71204236-71204237(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr17:71204256-71204257(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr17:71204279-71204280(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr17:71204286-71204287(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr17:71204315-71204316(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr17:71204456-71204457(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr17:71204492-71204493(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr17:71204506-71204507(-) m6A 3'UTR       24284625//24209618//24981863//28052920//27773535//27371828//22608085
chr17:71204606-71204607(-) m6A 3'UTR       24284625//24209618//24981863//27773535//27371828//22608085
chr17:71204690-71204691(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085
chr17:71204757-71204758(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr17:71204795-71204796(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr17:71204896-71204897(-) m6A 3'UTR       24284625//24981863//22575960//22608085
chr17:71204949-71204950(-) m6A 3'UTR       24284625//24981863//22608085
chr17:71204962-71204963(-) m6A 3'UTR       24284625//24981863//22608085
chr17:71205333-71205334(-) m6A 3'UTR       27773535
chr17:71205360-71205361(-) m6A 3'UTR       27773535
chr17:71205400-71205401(-) m6A 3'UTR       27773535
chr17:71205634-71205635(-) m6A 3'UTR//exon       24284625//25456834//24981863//26404942//22608085
chr17:71205723-71205724(-) m6A 3'UTR//CDS//exon       24284625//24981863//27371828//27773536
chr17:71205810-71205811(-) m6A 3'UTR//CDS//exon       24284625//27371828//27773536
chr17:71205845-71205846(-) m6A CDS//exon       24284625//27371828//27773536
chr17:71208832-71208833(-) m6A CDS//intron       24284625
chr17:71208843-71208844(-) m6A CDS//intron       24284625
chr17:71208847-71208848(-) m6A CDS//intron       24284625
chr17:71208859-71208860(-) m6A CDS//intron       24284625
chr17:71223310-71223311(-) m6A 5'UTR//CDS//exon//intron       27371828
chr17:71223334-71223335(-) m6A 5'UTR//CDS//exon//intron       27371828
chr17:71223353-71223354(-) m6A 5'UTR//CDS//exon//intron       27371828
chr17:71223373-71223374(-) m6A 5'UTR//CDS//exon//intron       27371828
chr17:71223376-71223377(-) m1A 5'UTR//CDS//exon//intron       26863196
chr17:71228311-71228312(-) m6A CDS//intron       24284625//25456834//24981863//27371828//27773536
chr17:71232810-71232811(-) m6A exon       24284625//24981863
chr17:71232838-71232839(-) m6A exon       24284625//24981863
chr17:71232881-71232882(-) m6A exon       24284625//24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-30d-5p
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome HCC tissues     30542726
Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Renal cancer cells     21670082
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Cerebrospinal fluid     25420022
Exosome Blood|B lymphoblastoid cells|Breast milk|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Epithelial cells|Kidney tissue|Lymphoma tissue|Mast cells|Seminal fluid|Tongue tissue     -
Extracellular vesicle HEK-293T cells     22849433
Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Microvesicle Plasma     23077538
Microvesicle Seminal plasma     23539611
Microvesicle Follicular fluid     23666971
Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleolus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
FAM104A
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-30d-5p
Midostaurin 9829523 Drug resistant
Herveline O 5459269 Drug sensitive
Cuspidatin C 5459164 Drug sensitive
2,7-Bis(methoxycarbonylmethyl)-10-methylphenothiazine 384444 Drug sensitive
2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant
Antimycin A3 245869 Drug sensitive
5-Hydroxy-3-phenylpyrano[3,2-c]chromen-2(5H)-one 24205741 Drug sensitive
4,5-Bis(4-methoxyphenyl)-1,5-dihydroimidazol-2-one 231112 Drug sensitive
Kinetin riboside 20345 Drug resistant
Astrazon Orange R 135747272 Drug sensitive
Cladospirone bisepoxide 10316810 Drug sensitive
(3Z,4R)-4-Hydroxy-3-[2-[(1S,3R)-3-[2-[(1S,3S,3'R,4S)-1-hydroxy-4,6,6-trimethylspiro[2,5-dioxabicyclo[2.2.2]octane-3,6'-oxane]-3'-yl]ethyl]-2,2-dimethyl-6-methylidenecyclohexyl]ethylidene]oxolan-2-one 101206903 Drug sensitive
antineoplastic-d655481 - Drug resistant
4-[4-(3-Methoxy-phenyl)-piperazin-1 -yl]-5H-pyrrolo[3,2-d]pyrimidine - Drug sensitive
4-morpholinecarbodithioic acid, antimony complex - Drug sensitive
7-n,n-dimethylamino brefeldin a hydrochloride - Drug sensitive
E)-1-(4-(quinazolin-4-ylamino)phenyl)-3-(2,4,6-trimethoxyphenyl)prop-2-en-1-one - Drug sensitive
isatin dr - Drug sensitive
tetra(isobutenyl)antimony bromide - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-30d-5p
Gemcitabine 60750 Drug interaction    RC00001621
Sunitinib 5329102 Drug interaction    RC00001626
Eloxatine 5310940 Drug interaction    RC00001625
Trichostatin A 444732 Drug interaction    RC00001624
Paroxetine 43815 Drug interaction    RC00001620
Etoposide 36462 Drug interaction    RC00001619
5-Fluorouracil 3385 Drug interaction    RC00001617
Doxorubicin 31703 Drug interaction    RC00001618
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001616
Verapamil 2520 Drug interaction    RC00001615
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00001627
Bicalutamide 2375 Drug interaction    RC00001614
Docetaxel 148124 Drug interaction    RC00001623
1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00001628
Trastuzumab - Drug interaction    RC00001629
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-30d-5p
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-30d-5p
Interactor2: FAM104A

Evidence Support:


Weak-Evidence HITS-CLIP//PAR-CLIP
Support Database ViRBase

References:


PMID 22473208 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line Jijoye cells Interactor2 expression None
Description Our HITS-CLIP data yield 1185 human 3'UTRs targeted by members of the miR-17~92 cluster in Jijoye cells. Comparison to the 1664 3'UTRs targeted by EBV miRNAs reveals 740 shared genes (44% of EBV targets and 62% of miR-17~92 targets; Figure 6B and Supplementary Table 7). Thus, EBV miRNAs co-target a majority of miR-17~92 regulated mRNAs, which are assigned to a variety of pathways, most notably regulating transcription, apoptosis, and the cell cycle (Figure 6C). Similarly, other abundant immunologically relevant miRNAs, 142-3p and miR-155, co-target with EBV miRNAs a large fraction of their Ago-bound 3'UTRs, representing ~60% of the targets for each of these host miRNAs (Supplementary Figure 5).

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