Basic Information:

  VIRBase ID:  

HHID00048136

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-30d-5p:  MIMAT0000245          TXNDC5:  NM_022085     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-30d-5p	TXNDC5
miRBase Accession/Entrez ID	MIMAT0000245	81567
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	ENDOPDI//ERP46//HCC-2//HCC2//PDIA15//STRF8//UNQ364

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-30d-5p	rs1203910650 chr8:134804928    G/A rs1244539439 chr8:134804930    G/T rs1441595222 chr8:134804927    C/A rs1441595222 chr8:134804927    C/T rs374432132 chr8:134804931    G/A rs776972352 chr8:134804925    G/A rs1187386485 chr8:134804934    G/A rs1373057893 chr8:134804937    TACA/T

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TXNDC5	chr6:7882611-7882612(-) m6A 3'UTR//exon       24981863//26404942 chr6:7882658-7882659(-) m6A 3'UTR//exon       24981863//26404942 chr6:7882867-7882868(-) m6A 3'UTR//exon       26404942//22575960 chr6:7883049-7883050(-) m6A 3'UTR//exon       24284625//24981863//26404942//22575960//22608085 chr6:7883083-7883084(-) m6A 3'UTR//exon       24284625//24981863//26404942//22575960//22608085 chr6:7883149-7883150(-) m6A 3'UTR//exon       24284625//24981863 chr6:7883267-7883268(-) m6A 3'UTR//exon       24284625 chr6:7883373-7883374(-) m6A 3'UTR//exon       24284625//24981863//26404942//22575960 chr6:7883382-7883383(-) m6A CDS//exon       24284625//24981863//26404942//22575960 chr6:7883428-7883429(-) m6A CDS//exon       24284625//24981863//26404942//22575960 chr6:7884628-7884629(-) m6A CDS//exon       24284625//22575960 chr6:7884681-7884682(-) m6A CDS//exon       22575960 chr6:7884704-7884705(-) m6A CDS//exon       22575960 chr6:7888990-7888991(-) m6A CDS//exon       24981863//26404942//27773536//22575960 chr6:7889005-7889006(-) m6A CDS//exon       24981863//26404942//27773536//22575960 chr6:7889113-7889114(-) m6A exon//intron       24981863//26404942//27773536//22575960 chr6:7889125-7889126(-) m6A exon//intron       24981863//26404942//27773536//22575960 chr6:7889184-7889185(-) m6A exon//intron       27773536 chr6:7889437-7889438(-) m6A exon//intron       24284625 chr6:7889453-7889454(-) m6A exon//intron       24284625 chr6:7889459-7889460(-) m6A exon//intron       24284625 chr6:7889776-7889777(-) m6A CDS       27773536//22575960//22608085 chr6:7889790-7889791(-) m6A CDS       27773536//22575960 chr6:7891870-7891871(-) m6A CDS       22575960 chr6:7891880-7891881(-) m6A CDS       22575960 chr6:7895414-7895415(-) m6A CDS//exon       27773535//22575960 chr6:7898846-7898847(-) Gm intron       - chr6:7899828-7899829(-) m6A CDS//exon       27773535//22575960 chr6:7899842-7899843(-) m6A CDS//exon       27773535//22575960 chr6:7899852-7899853(-) m6A CDS//exon       27773535//22575960 chr6:7899860-7899861(-) m6A CDS//exon       27773535//22575960 chr6:7899957-7899958(-) m6A exon//intron       27773535 chr6:7904860-7904861(-) m6A CDS       26404942//27773535//22575960 chr6:7904898-7904899(-) Cm 5'UTR//CDS       - chr6:7904908-7904909(-) m6A 5'UTR//CDS       26404942//27773535//22575960 chr6:7904949-7904950(-) m6A 5'UTR//CDS       24284625//24209618//27773535//22575960 chr6:7910054-7910055(-) m6A 5'UTR//intron       24284625//24209618//22575960 chr6:7910102-7910103(-) m6A 5'UTR//intron       24284625//24209618//27773536 chr6:7910197-7910198(-) m6A 5'UTR//intron       24209618//27773536 chr6:7910833-7910834(-) m6A CDS       24284625//24209618//27371828//27773536//22575960 chr6:7910838-7910839(-) m6A CDS       24284625//24209618//27371828//27773536//22575960

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-30d-5p	Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome HCC tissues     30542726 Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Renal cancer cells     21670082 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Human mast cell line (HMC-1)     24009880 Exosome Cerebrospinal fluid     25420022 Exosome Blood|B lymphoblastoid cells|Breast milk|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Epithelial cells|Kidney tissue|Lymphoma tissue|Mast cells|Seminal fluid|Tongue tissue     - Extracellular vesicle HEK-293T cells     22849433 Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Plasma     23077538 Microvesicle Seminal plasma     23539611 Microvesicle Follicular fluid     23666971 Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleolus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
	TXNDC5	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|HeLa-S3 cells     - Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-30d-5p	Midostaurin 9829523 Drug resistant Herveline O 5459269 Drug sensitive Cuspidatin C 5459164 Drug sensitive 2,7-Bis(methoxycarbonylmethyl)-10-methylphenothiazine 384444 Drug sensitive 2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant Antimycin A3 245869 Drug sensitive 5-Hydroxy-3-phenylpyrano[3,2-c]chromen-2(5H)-one 24205741 Drug sensitive 4,5-Bis(4-methoxyphenyl)-1,5-dihydroimidazol-2-one 231112 Drug sensitive Kinetin riboside 20345 Drug resistant Astrazon Orange R 135747272 Drug sensitive Cladospirone bisepoxide 10316810 Drug sensitive (3Z,4R)-4-Hydroxy-3-[2-[(1S,3R)-3-[2-[(1S,3S,3'R,4S)-1-hydroxy-4,6,6-trimethylspiro[2,5-dioxabicyclo[2.2.2]octane-3,6'-oxane]-3'-yl]ethyl]-2,2-dimethyl-6-methylidenecyclohexyl]ethylidene]oxolan-2-one 101206903 Drug sensitive antineoplastic-d655481 - Drug resistant 4-[4-(3-Methoxy-phenyl)-piperazin-1 -yl]-5H-pyrrolo[3,2-d]pyrimidine - Drug sensitive 4-morpholinecarbodithioic acid, antimony complex - Drug sensitive 7-n,n-dimethylamino brefeldin a hydrochloride - Drug sensitive E)-1-(4-(quinazolin-4-ylamino)phenyl)-3-(2,4,6-trimethoxyphenyl)prop-2-en-1-one - Drug sensitive isatin dr - Drug sensitive tetra(isobutenyl)antimony bromide - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-30d-5p	Gemcitabine 60750 Drug interaction    RC00001621 Sunitinib 5329102 Drug interaction    RC00001626 Eloxatine 5310940 Drug interaction    RC00001625 Trichostatin A 444732 Drug interaction    RC00001624 Paroxetine 43815 Drug interaction    RC00001620 Etoposide 36462 Drug interaction    RC00001619 5-Fluorouracil 3385 Drug interaction    RC00001617 Doxorubicin 31703 Drug interaction    RC00001618 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001616 Verapamil 2520 Drug interaction    RC00001615 N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00001627 Bicalutamide 2375 Drug interaction    RC00001614 Docetaxel 148124 Drug interaction    RC00001623 1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00001628 Trastuzumab - Drug interaction    RC00001629

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-30d-5p	N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-30d-5p
Interactor2: TXNDC5

Evidence Support:

Weak-Evidence	HITS-CLIP
Support Database	ViRBase

References:

PMID	22473208	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	Jijoye cells	Interactor2 expression	None
Description	Our HITS-CLIP data yield 1185 human 3'UTRs targeted by members of the miR-17~92 cluster in Jijoye cells. Comparison to the 1664 3'UTRs targeted by EBV miRNAs reveals 740 shared genes (44% of EBV targets and 62% of miR-17~92 targets; Figure 6B and Supplementary Table 7). Thus, EBV miRNAs co-target a majority of miR-17~92 regulated mRNAs, which are assigned to a variety of pathways, most notably regulating transcription, apoptosis, and the cell cycle (Figure 6C). Similarly, other abundant immunologically relevant miRNAs, 142-3p and miR-155, co-target with EBV miRNAs a large fraction of their Ago-bound 3'UTRs, representing ~60% of the targets for each of these host miRNAs (Supplementary Figure 5).