Basic Information:

  VIRBase ID:  

HHID00048129

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-30d-5p:  MIMAT0000245          LPCAT1:  NM_024830     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-30d-5p	LPCAT1
miRBase Accession/Entrez ID	MIMAT0000245	79888
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	AGPAT10//AGPAT9//AYTL2//lpcat//LPCAT-1//lysoPAFAT//PFAAP3

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-30d-5p	rs1203910650 chr8:134804928    G/A rs1244539439 chr8:134804930    G/T rs1441595222 chr8:134804927    C/A rs1441595222 chr8:134804927    C/T rs374432132 chr8:134804931    G/A rs776972352 chr8:134804925    G/A rs1187386485 chr8:134804934    G/A rs1373057893 chr8:134804937    TACA/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	LPCAT1	chr5:1486807(-) A-I      intronic chr5:1518548(-) A-I      intronic chr5:1496304(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	LPCAT1	chr5:1469667(-) C-T intron -    22484847 chr5:1496224(-) T-G intron -    22484847 chr5:1496304(-) A-G intron -    22484847 chr5:1496357(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	LPCAT1	chr5:1456779-1456780(-) m6A 3'UTR       27773535 chr5:1456815-1456816(-) m6A 3'UTR       27773535 chr5:1456833-1456834(-) m6A 3'UTR       27773535 chr5:1456885-1456886(-) m6A 3'UTR       27773535 chr5:1456898-1456899(-) m6A 3'UTR       27773535 chr5:1456908-1456909(-) m6A 3'UTR       27773535 chr5:1456961-1456962(-) m6A 3'UTR       27773535 chr5:1457014-1457015(-) m6A 3'UTR       27773535 chr5:1457019-1457020(-) m6A 3'UTR       27773535 chr5:1457103-1457104(-) m6A 3'UTR       27773535 chr5:1457149-1457150(-) m6A 3'UTR       27773535 chr5:1461507-1461508(-) m6A 3'UTR       24284625//25456834//24981863 chr5:1461562-1461563(-) m6A 3'UTR//exon//intron       24284625//25456834//24981863//28052920//27371828//22608085 chr5:1461590-1461591(-) m6A 3'UTR//exon//intron       24284625//25456834//24981863//28052920//27371828//22608085 chr5:1461633-1461634(-) m6A 3'UTR//exon//intron       24284625//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr5:1461672-1461673(-) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr5:1461709-1461710(-) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr5:1461725-1461726(-) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr5:1461753-1461754(-) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr5:1461830-1461831(-) m6A 3'UTR//exon//intron       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr5:1461922-1461923(-) m6A 3'UTR//exon//intron       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr5:1461945-1461946(-) m6A 3'UTR//exon//intron       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr5:1462070-1462071(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr5:1462104-1462105(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr5:1462123-1462124(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr5:1462137-1462138(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr5:1462189-1462190(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr5:1462199-1462200(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr5:1462384-1462385(-) m6A 3'UTR//exon       24284625//24981863//27773535 chr5:1462415-1462416(-) m6A 3'UTR//exon       24284625//24981863//27773535 chr5:1462605-1462606(-) m6A 3'UTR//exon       24284625 chr5:1463526-1463527(-) m6A 3'UTR//exon       24284625//27773536 chr5:1463568-1463569(-) Gm 3'UTR//exon       - chr5:1463585-1463586(-) m6A 3'UTR//exon       24284625//24209618//24981863//27371828//22575960//22608085 chr5:1463725-1463726(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27371828//27773536//22575960//22608085 chr5:1463763-1463764(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27371828//27773536//22575960//22608085 chr5:1463808-1463809(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27371828//27773536//22575960//22608085 chr5:1463860-1463861(-) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085 chr5:1463884-1463885(-) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085 chr5:1467326-1467327(-) m6A exon//intron       24284625//27371828 chr5:1467373-1467374(-) m6A exon//intron       24284625 chr5:1467421-1467422(-) m6A exon//intron       24284625 chr5:1470962-1470963(-) m6A CDS       24284625 chr5:1470969-1470970(-) m6A CDS       24284625 chr5:1471019-1471020(-) m6A CDS       24284625//27371828 chr5:1474093-1474094(-) m6A CDS       24284625//27371828 chr5:1474192-1474193(-) m6A CDS       24284625 chr5:1474218-1474219(-) m6A CDS       24284625 chr5:1474697-1474698(-) Y CDS       25219674 chr5:1476300-1476301(-) Tm intron       - chr5:1489893-1489894(-) Gm CDS//exon       - chr5:1495020-1495021(-) m6A CDS//exon       24284625 chr5:1501604-1501605(-) m6A CDS//exon       24284625 chr5:1521464-1521465(-) m6A exon//intron       24284625 chr5:1521491-1521492(-) m6A exon//intron       24284625 chr5:1521501-1521502(-) m6A exon//intron       24284625 chr5:1523870-1523871(-) m6A CDS       27773536 chr5:1523938-1523939(-) m6A CDS       27773536//22575960 chr5:1524034-1524035(-) m6A 5'UTR       27773536

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-30d-5p	Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome HCC tissues     30542726 Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Renal cancer cells     21670082 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Human mast cell line (HMC-1)     24009880 Exosome Cerebrospinal fluid     25420022 Exosome Blood|B lymphoblastoid cells|Breast milk|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Epithelial cells|Kidney tissue|Lymphoma tissue|Mast cells|Seminal fluid|Tongue tissue     - Extracellular vesicle HEK-293T cells     22849433 Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Plasma     23077538 Microvesicle Seminal plasma     23539611 Microvesicle Follicular fluid     23666971 Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleolus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
	LPCAT1	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-30d-5p	Midostaurin 9829523 Drug resistant Herveline O 5459269 Drug sensitive Cuspidatin C 5459164 Drug sensitive 2,7-Bis(methoxycarbonylmethyl)-10-methylphenothiazine 384444 Drug sensitive 2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant Antimycin A3 245869 Drug sensitive 5-Hydroxy-3-phenylpyrano[3,2-c]chromen-2(5H)-one 24205741 Drug sensitive 4,5-Bis(4-methoxyphenyl)-1,5-dihydroimidazol-2-one 231112 Drug sensitive Kinetin riboside 20345 Drug resistant Astrazon Orange R 135747272 Drug sensitive Cladospirone bisepoxide 10316810 Drug sensitive (3Z,4R)-4-Hydroxy-3-[2-[(1S,3R)-3-[2-[(1S,3S,3'R,4S)-1-hydroxy-4,6,6-trimethylspiro[2,5-dioxabicyclo[2.2.2]octane-3,6'-oxane]-3'-yl]ethyl]-2,2-dimethyl-6-methylidenecyclohexyl]ethylidene]oxolan-2-one 101206903 Drug sensitive antineoplastic-d655481 - Drug resistant 4-[4-(3-Methoxy-phenyl)-piperazin-1 -yl]-5H-pyrrolo[3,2-d]pyrimidine - Drug sensitive 4-morpholinecarbodithioic acid, antimony complex - Drug sensitive 7-n,n-dimethylamino brefeldin a hydrochloride - Drug sensitive E)-1-(4-(quinazolin-4-ylamino)phenyl)-3-(2,4,6-trimethoxyphenyl)prop-2-en-1-one - Drug sensitive isatin dr - Drug sensitive tetra(isobutenyl)antimony bromide - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-30d-5p	Gemcitabine 60750 Drug interaction    RC00001621 Sunitinib 5329102 Drug interaction    RC00001626 Eloxatine 5310940 Drug interaction    RC00001625 Trichostatin A 444732 Drug interaction    RC00001624 Paroxetine 43815 Drug interaction    RC00001620 Etoposide 36462 Drug interaction    RC00001619 5-Fluorouracil 3385 Drug interaction    RC00001617 Doxorubicin 31703 Drug interaction    RC00001618 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001616 Verapamil 2520 Drug interaction    RC00001615 N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00001627 Bicalutamide 2375 Drug interaction    RC00001614 Docetaxel 148124 Drug interaction    RC00001623 1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00001628 Trastuzumab - Drug interaction    RC00001629

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-30d-5p	N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-30d-5p
Interactor2: LPCAT1

Evidence Support:

Weak-Evidence	HITS-CLIP
Support Database	ViRBase

References:

PMID	22473208	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	Jijoye cells	Interactor2 expression	None
Description	Our HITS-CLIP data yield 1185 human 3'UTRs targeted by members of the miR-17~92 cluster in Jijoye cells. Comparison to the 1664 3'UTRs targeted by EBV miRNAs reveals 740 shared genes (44% of EBV targets and 62% of miR-17~92 targets; Figure 6B and Supplementary Table 7). Thus, EBV miRNAs co-target a majority of miR-17~92 regulated mRNAs, which are assigned to a variety of pathways, most notably regulating transcription, apoptosis, and the cell cycle (Figure 6C). Similarly, other abundant immunologically relevant miRNAs, 142-3p and miR-155, co-target with EBV miRNAs a large fraction of their Ago-bound 3'UTRs, representing ~60% of the targets for each of these host miRNAs (Supplementary Figure 5).