Basic Information:

  VIRBase ID:  

HHID00048113

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-30d-5p:  MIMAT0000245          MIB1:  NM_020774     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-30d-5p	MIB1
miRBase Accession/Entrez ID	MIMAT0000245	57534
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	DIP-1//DIP1//LVNC7//MIB//ZZANK2//ZZZ6

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-30d-5p	rs1203910650 chr8:134804928    G/A rs1244539439 chr8:134804930    G/T rs1441595222 chr8:134804927    C/A rs1441595222 chr8:134804927    C/T rs374432132 chr8:134804931    G/A rs776972352 chr8:134804925    G/A rs1187386485 chr8:134804934    G/A rs1373057893 chr8:134804937    TACA/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	MIB1	chr18:19330943(+) A-I      intronic chr18:19330948(+) A-I      intronic chr18:19330957(+) A-I      intronic chr18:19330972(+) A-I      intronic chr18:19330993(+) A-I      intronic chr18:19387270(+) A-I      intronic chr18:19387282(+) A-I      intronic chr18:19385964(+) A-I      intronic chr18:19387313(+) A-I      intronic chr18:19394429(+) A-I      intronic chr18:19440889(+) A-I      intronic chr18:19440945(+) A-I      intronic chr18:19419569(+) A-I      intronic chr18:19387289(+) A-I      intronic chr18:19331008(+) A-I      intronic chr18:19330982(+) A-I      intronic chr18:19330981(+) A-I      intronic chr18:19330925(+) A-I      intronic chr18:19330351(+) A-I      intronic chr18:19329846(+) A-I      intronic chr18:19329701(+) A-I      intronic chr18:19441975(+) A-I      intronic chr18:19441930(+) A-I      intronic chr18:19441927(+) A-I      intronic chr18:19440942(+) A-I      intronic chr18:19440926(+) A-I      intronic chr18:19439756(+) A-I      intronic chr18:19439707(+) A-I      intronic chr18:19439703(+) A-I      intronic chr18:19439689(+) A-I      intronic chr18:19439685(+) A-I      intronic chr18:19439674(+) A-I      intronic chr18:19421959(+) A-I      intronic chr18:19421958(+) A-I      intronic chr18:19421256(+) A-I      intronic chr18:19421253(+) A-I      intronic chr18:19421221(+) A-I      intronic chr18:19419919(+) A-I      intronic chr18:19419596(+) A-I      intronic chr18:19419585(+) A-I      intronic chr18:19419530(+) A-I      intronic chr18:19419527(+) A-I      intronic chr18:19416209(+) A-I      intronic chr18:19416208(+) A-I      intronic chr18:19416201(+) A-I      intronic chr18:19416199(+) A-I      intronic chr18:19416198(+) A-I      intronic chr18:19416150(+) A-I      intronic chr18:19399262(+) A-I      intronic chr18:19399261(+) A-I      intronic chr18:19399183(+) A-I      intronic chr18:19399099(+) A-I      intronic chr18:19398802(+) A-I      intronic chr18:19398625(+) A-I      intronic chr18:19398515(+) A-I      intronic chr18:19394464(+) A-I      intronic chr18:19387272(+) A-I      intronic chr18:19387239(+) A-I      intronic chr18:19387236(+) A-I      intronic chr18:19387231(+) A-I      intronic chr18:19387227(+) A-I      intronic chr18:19387191(+) A-I      intronic chr18:19331358(+) A-I      intronic chr18:19387142(+) A-I      intronic chr18:19387136(+) A-I      intronic chr18:19386751(+) A-I      intronic chr18:19386262(+) A-I      intronic chr18:19386261(+) A-I      intronic chr18:19369592(+) A-I      intronic chr18:19369591(+) A-I      intronic chr18:19357728(+) A-I      intronic chr18:19357358(+) A-I      intronic chr18:19357274(+) A-I      intronic chr18:19357259(+) A-I      intronic chr18:19356903(+) A-I      intronic chr18:19356888(+) A-I      intronic chr18:19356883(+) A-I      intronic chr18:19356779(+) A-I      intronic chr18:19355996(+) A-I      intronic chr18:19421231(+) A-I      intronic chr18:19355994(+) A-I      intronic chr18:19355439(+) A-I      intronic chr18:19355438(+) A-I      intronic chr18:19355389(+) A-I      intronic chr18:19355342(+) A-I      intronic chr18:19355306(+) A-I      intronic chr18:19355275(+) A-I      intronic chr18:19355245(+) A-I      intronic chr18:19355167(+) A-I      intronic chr18:19355149(+) A-I      intronic chr18:19354545(+) A-I      intronic chr18:19354507(+) A-I      intronic chr18:19354498(+) A-I      intronic chr18:19354364(+) A-I      intronic chr18:19343937(+) A-I      intronic chr18:19337669(+) A-I      intronic chr18:19337668(+) A-I      intronic chr18:19337644(+) A-I      intronic chr18:19336645(+) A-I      intronic chr18:19333660(+) A-I      intronic chr18:19331419(+) A-I      intronic chr18:19331405(+) A-I      intronic chr18:19331118(+) A-I      intronic chr18:19331069(+) A-I      intronic chr18:19331044(+) A-I      intronic chr18:19440879(+) A-I      intronic chr18:19398643(+) A-I      intronic chr18:19399209(+) A-I      intronic chr18:19356827(+) A-I      intronic chr18:19355088(+) A-I      intronic chr18:19337260(+) A-I      intronic chr18:19439594(+) A-I      intronic chr18:19354429(+) A-I      intronic chr18:19440336(+) A-I      intronic chr18:19331407(+) A-I      intronic chr18:19419698(+) A-I      intronic chr18:19331409(+) A-I      intronic chr18:19399049(+) A-I      intronic chr18:19357655(+) A-I      intronic chr18:19387213(+) A-I      intronic chr18:19399200(+) A-I      intronic chr18:19328581(+) A-I      intronic chr18:19387230(+) A-I      intronic chr18:19385074(+) A-I      intronic chr18:19357538(+) A-I      intronic chr18:19387190(+) A-I      intronic chr18:19357266(+) A-I      intronic chr18:19355319(+) A-I      intronic chr18:19331048(+) A-I      intronic chr18:19441906(+) A-I      intronic chr18:19439770(+) A-I      intronic chr18:19337212(+) A-I      intronic chr18:19416104(+) A-I      intronic chr18:19357699(+) A-I      intronic chr18:19355405(+) A-I      intronic chr18:19386726(+) A-I      intronic chr18:19357616(+) A-I      intronic chr18:19398566(+) A-I      intronic chr18:19387234(+) A-I      intronic chr18:19440245(+) A-I      intronic chr18:19399198(+) A-I      intronic chr18:19331038(+) A-I      intronic chr18:19356243(+) A-I      intronic chr18:19386347(+) A-I      intronic chr18:19355313(+) A-I      intronic chr18:19441989(+) A-I      intronic chr18:19330933(+) A-I      intronic chr18:19357306(+) A-I      intronic chr18:19416270(+) A-I      intronic chr18:19386117(+) A-I      intronic chr18:19355113(+) A-I      intronic chr18:19394615(+) A-I      intronic chr18:19357202(+) A-I      intronic chr18:19354532(+) A-I      intronic chr18:19330903(+) A-I      intronic chr18:19394604(+) A-I      intronic chr18:19386640(+) A-I      intronic chr18:19394421(+) A-I      intronic chr18:19394680(+) A-I      intronic chr18:19386781(+) A-I      intronic chr18:19421248(+) A-I      intronic chr18:19354294(+) A-I      intronic chr18:19354512(+) A-I      intronic chr18:19357194(+) A-I      intronic chr18:19354434(+) A-I      intronic chr18:19398817(+) A-I      intronic chr18:19357233(+) A-I      intronic chr18:19387193(+) A-I      intronic chr18:19330884(+) A-I      intronic chr18:19398776(+) A-I      intronic chr18:19337661(+) A-I      intronic chr18:19330699(+) A-I      intronic chr18:19330487(+) A-I      intronic chr18:19394447(+) A-I      intronic chr18:19336555(+) A-I      intronic chr18:19398781(+) A-I      intronic chr18:19419589(+) A-I      intronic chr18:19355966(+) A-I      intronic chr18:19398555(+) A-I      intronic chr18:19361492(+) A-I      intronic chr18:19357596(+) A-I      intronic chr18:19440975(+) A-I      intronic chr18:19440906(+) A-I      intronic chr18:19355383(+) A-I      intronic chr18:19331348(+) A-I      intronic chr18:19441963(+) A-I      intronic chr18:19355973(+) A-I      intronic chr18:19337236(+) A-I      intronic chr18:19387137(+) A-I      intronic chr18:19354385(+) A-I      intronic chr18:19399132(+) A-I      intronic chr18:19329626(+) A-I      intronic chr18:19440126(+) A-I      intronic chr18:19337667(+) A-I      intronic chr18:19394469(+) A-I      intronic chr18:19443846(+) A-I      intronic chr18:19387318(+) A-I      intronic chr18:19398564(+) A-I      intronic chr18:19386766(+) A-I      intronic chr18:19330589(+) A-I      intronic chr18:19439242(+) A-I      intronic chr18:19357634(+) A-I      intronic chr18:19354366(+) A-I      intronic chr18:19387389(+) A-I      intronic chr18:19386789(+) A-I      intronic chr18:19386856(+) A-I      intronic chr18:19329702(+) A-I      intronic chr18:19386383(+) A-I      intronic chr18:19419497(+) A-I      intronic chr18:19394527(+) A-I      intronic chr18:19441966(+) A-I      intronic chr18:19419519(+) A-I      intronic chr18:19419684(+) A-I      intronic chr18:19394477(+) A-I      intronic chr18:19357293(+) A-I      intronic chr18:19330902(+) A-I      intronic chr18:19421982(+) A-I      intronic chr18:19354388(+) A-I      intronic chr18:19330919(+) A-I      intronic chr18:19357615(+) A-I      intronic chr18:19346761(+) A-I      intronic chr18:19354398(+) A-I      intronic chr18:19419559(+) A-I      intronic chr18:19395210(+) A-I      intronic chr18:19337709(+) A-I      intronic chr18:19350009(+) A-I      intronic chr18:19337254(+) A-I      intronic chr18:19394405(+) A-I      intronic chr18:19331340(+) A-I      intronic chr18:19355465(+) A-I      intronic chr18:19355334(+) A-I      intronic chr18:19443750(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	MIB1	chr18:19405668(+) A-I intron -    16594986 chr18:19331012(+) A-G intron -    22484847 chr18:19336526(+) A-G intron -    22484847 chr18:19357716(+) A-G intron -    22484847 chr18:19361603(+) T-A intron -    22484847 chr18:19387318(+) A-G intron -    22484847 chr18:19421976(+) A-G intron -    22484847 chr18:19421982(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	MIB1	chr18:19321383-19321384(+) m6A 5'UTR//intron       24209618 chr18:19321611-19321612(+) m6A CDS//intron       24209618//25456834//24981863//22608085 chr18:19321701-19321702(+) m6A CDS//intron       24209618//25456834//24981863//22575960//22608085 chr18:19321758-19321759(+) m6A CDS//intron       24209618//25456834//24981863//22575960//22608085 chr18:19345749-19345750(+) m6A CDS//exon       22608085 chr18:19348666-19348667(+) m6A CDS//exon       24209618//24981863 chr18:19353600-19353601(+) m6A CDS//exon       24209618//24981863 chr18:19445264-19445265(+) m6A 3'UTR       24981863 chr18:19445311-19445312(+) m6A 3'UTR       24981863 chr18:19447867-19447868(+) m6A 3'UTR       24981863 chr18:19450245-19450246(+) Y 3'UTR       26075521

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-30d-5p	Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome HCC tissues     30542726 Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Renal cancer cells     21670082 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Human mast cell line (HMC-1)     24009880 Exosome Cerebrospinal fluid     25420022 Exosome Blood|B lymphoblastoid cells|Breast milk|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Epithelial cells|Kidney tissue|Lymphoma tissue|Mast cells|Seminal fluid|Tongue tissue     - Extracellular vesicle HEK-293T cells     22849433 Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Plasma     23077538 Microvesicle Seminal plasma     23539611 Microvesicle Follicular fluid     23666971 Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleolus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
	MIB1	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Exosome Blood     - Membrane HCC cell line (HepG2)|K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|K562 cells     - Ribosome HEK-293 cells     22199352

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-30d-5p	Midostaurin 9829523 Drug resistant Herveline O 5459269 Drug sensitive Cuspidatin C 5459164 Drug sensitive 2,7-Bis(methoxycarbonylmethyl)-10-methylphenothiazine 384444 Drug sensitive 2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant Antimycin A3 245869 Drug sensitive 5-Hydroxy-3-phenylpyrano[3,2-c]chromen-2(5H)-one 24205741 Drug sensitive 4,5-Bis(4-methoxyphenyl)-1,5-dihydroimidazol-2-one 231112 Drug sensitive Kinetin riboside 20345 Drug resistant Astrazon Orange R 135747272 Drug sensitive Cladospirone bisepoxide 10316810 Drug sensitive (3Z,4R)-4-Hydroxy-3-[2-[(1S,3R)-3-[2-[(1S,3S,3'R,4S)-1-hydroxy-4,6,6-trimethylspiro[2,5-dioxabicyclo[2.2.2]octane-3,6'-oxane]-3'-yl]ethyl]-2,2-dimethyl-6-methylidenecyclohexyl]ethylidene]oxolan-2-one 101206903 Drug sensitive antineoplastic-d655481 - Drug resistant 4-[4-(3-Methoxy-phenyl)-piperazin-1 -yl]-5H-pyrrolo[3,2-d]pyrimidine - Drug sensitive 4-morpholinecarbodithioic acid, antimony complex - Drug sensitive 7-n,n-dimethylamino brefeldin a hydrochloride - Drug sensitive E)-1-(4-(quinazolin-4-ylamino)phenyl)-3-(2,4,6-trimethoxyphenyl)prop-2-en-1-one - Drug sensitive isatin dr - Drug sensitive tetra(isobutenyl)antimony bromide - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-30d-5p	Gemcitabine 60750 Drug interaction    RC00001621 Sunitinib 5329102 Drug interaction    RC00001626 Eloxatine 5310940 Drug interaction    RC00001625 Trichostatin A 444732 Drug interaction    RC00001624 Paroxetine 43815 Drug interaction    RC00001620 Etoposide 36462 Drug interaction    RC00001619 5-Fluorouracil 3385 Drug interaction    RC00001617 Doxorubicin 31703 Drug interaction    RC00001618 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001616 Verapamil 2520 Drug interaction    RC00001615 N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00001627 Bicalutamide 2375 Drug interaction    RC00001614 Docetaxel 148124 Drug interaction    RC00001623 1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00001628 Trastuzumab - Drug interaction    RC00001629

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-30d-5p	N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-30d-5p
Interactor2: MIB1

Evidence Support:

Weak-Evidence	HITS-CLIP
Support Database	ViRBase

References:

PMID	22473208	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	Jijoye cells	Interactor2 expression	None
Description	Our HITS-CLIP data yield 1185 human 3'UTRs targeted by members of the miR-17~92 cluster in Jijoye cells. Comparison to the 1664 3'UTRs targeted by EBV miRNAs reveals 740 shared genes (44% of EBV targets and 62% of miR-17~92 targets; Figure 6B and Supplementary Table 7). Thus, EBV miRNAs co-target a majority of miR-17~92 regulated mRNAs, which are assigned to a variety of pathways, most notably regulating transcription, apoptosis, and the cell cycle (Figure 6C). Similarly, other abundant immunologically relevant miRNAs, 142-3p and miR-155, co-target with EBV miRNAs a large fraction of their Ago-bound 3'UTRs, representing ~60% of the targets for each of these host miRNAs (Supplementary Figure 5).