Basic Information:

  VIRBase ID:  

HHID00048105

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-30d-5p:  MIMAT0000245          CDC37L1:  NM_017913     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-30d-5p	CDC37L1
miRBase Accession/Entrez ID	MIMAT0000245	55664
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CDC37B//HARC

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-30d-5p	rs1203910650 chr8:134804928    G/A rs1244539439 chr8:134804930    G/T rs1441595222 chr8:134804927    C/A rs1441595222 chr8:134804927    C/T rs374432132 chr8:134804931    G/A rs776972352 chr8:134804925    G/A rs1187386485 chr8:134804934    G/A rs1373057893 chr8:134804937    TACA/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CDC37L1	chr9:4693277(+) A-I      intronic chr9:4693403(+) A-I      intronic chr9:4694179(+) A-I      intronic chr9:4694183(+) A-I      intronic chr9:4694184(+) A-I      intronic chr9:4694314(+) A-I      intronic chr9:4694611(+) A-I      intronic chr9:4695284(+) A-I      intronic chr9:4695335(+) A-I      intronic chr9:4695510(+) A-I      intronic chr9:4695511(+) A-I      intronic chr9:4695749(+) A-I      intronic chr9:4695773(+) A-I      intronic chr9:4695958(+) A-I      intronic chr9:4695966(+) A-I      intronic chr9:4694763(+) A-I      intronic chr9:4681458(+) A-I      intronic chr9:4681459(+) A-I      intronic chr9:4681484(+) A-I      intronic chr9:4681529(+) A-I      intronic chr9:4681533(+) A-I      intronic chr9:4681606(+) A-I      intronic chr9:4682457(+) A-I      intronic chr9:4682526(+) A-I      intronic chr9:4682534(+) A-I      intronic chr9:4682564(+) A-I      intronic chr9:4682599(+) A-I      intronic chr9:4684119(+) A-I      intronic chr9:4684137(+) A-I      intronic chr9:4684163(+) A-I      intronic chr9:4684190(+) A-I      intronic chr9:4684270(+) A-I      intronic chr9:4687558(+) A-I      intronic chr9:4688067(+) A-I      intronic chr9:4688139(+) A-I      intronic chr9:4688180(+) A-I      intronic chr9:4688197(+) A-I      intronic chr9:4693205(+) A-I      intronic chr9:4693260(+) A-I      intronic chr9:4695285(+) A-I      intronic chr9:4695774(+) A-I      intronic chr9:4681575(+) A-I      intronic chr9:4694791(+) A-I      intronic chr9:4694343(+) A-I      intronic chr9:4688129(+) A-I      intronic chr9:4684031(+) A-I      intronic chr9:4695204(+) A-I      intronic chr9:4687605(+) A-I      intronic chr9:4695612(+) A-I      intronic chr9:4693204(+) A-I      intronic chr9:4695917(+) A-I      intronic chr9:4694102(+) A-I      intronic chr9:4687421(+) A-I      intronic chr9:4694300(+) A-I      intronic chr9:4687564(+) A-I      intronic chr9:4696466(+) A-I      intronic chr9:4694101(+) A-I      intronic chr9:4694790(+) A-I      intronic chr9:4695264(+) A-I      intronic chr9:4693240(+) A-I      intronic chr9:4695208(+) A-I      intronic chr9:4688117(+) A-I      intronic chr9:4694289(+) A-I      intronic chr9:4681568(+) A-I      intronic chr9:4695530(+) A-I      intronic chr9:4694785(+) A-I      intronic chr9:4696046(+) A-I      intronic chr9:4693222(+) A-I      intronic chr9:4695757(+) A-I      intronic chr9:4694751(+) A-I      intronic chr9:4694618(+) A-I      intronic chr9:4693363(+) A-I      intronic chr9:4687580(+) A-I      intronic chr9:4694159(+) A-I      intronic chr9:4687445(+) A-I      intronic chr9:4694340(+) A-I      intronic chr9:4695697(+) A-I      intronic chr9:4695759(+) A-I      intronic chr9:4694174(+) A-I      intronic chr9:4693385(+) A-I      intronic chr9:4682224(+) A-I      intronic chr9:4694180(+) A-I      intronic chr9:4687432(+) A-I      intronic chr9:4695855(+) A-I      intronic chr9:4693418(+) A-I      intronic chr9:4695586(+) A-I      intronic chr9:4688075(+) A-I      intronic chr9:4694173(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CDC37L1	chr9:4702216(+) A-I intron -    21960545 chr9:4694149(+) T-C intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CDC37L1	chr9:4679658-4679659(+) m6A 5'UTR       24981863 chr9:4679750-4679751(+) m6A 5'UTR//exon       24981863 chr9:4679765-4679766(+) m6A 5'UTR//exon       24981863 chr9:4679772-4679773(+) m6A CDS//exon       24981863 chr9:4679793-4679794(+) m6A CDS//exon       24981863 chr9:4684974-4684975(+) m6A CDS//exon       - chr9:4685035-4685036(+) m6A CDS//exon       24981863//27773535 chr9:4685049-4685050(+) m6A CDS//exon       24981863//27773535 chr9:4706059-4706060(+) m6A CDS       24284625//24981863//22608085 chr9:4706087-4706088(+) m6A CDS       24284625//24981863//22608085 chr9:4706101-4706102(+) m6A CDS       24284625//24981863//22608085 chr9:4706122-4706123(+) m6A 3'UTR       24284625//24981863//22608085 chr9:4706163-4706164(+) m6A 3'UTR       24284625//24981863//22608085 chr9:4706336-4706337(+) m6A 3'UTR       27773535 chr9:4706341-4706342(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-30d-5p	Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome HCC tissues     30542726 Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Renal cancer cells     21670082 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Human mast cell line (HMC-1)     24009880 Exosome Cerebrospinal fluid     25420022 Exosome Blood|B lymphoblastoid cells|Breast milk|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Epithelial cells|Kidney tissue|Lymphoma tissue|Mast cells|Seminal fluid|Tongue tissue     - Extracellular vesicle HEK-293T cells     22849433 Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Plasma     23077538 Microvesicle Seminal plasma     23539611 Microvesicle Follicular fluid     23666971 Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleolus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
	CDC37L1	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleoplasm K562 cells     - Ribosome HEK-293 cells     22199352

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-30d-5p	Midostaurin 9829523 Drug resistant Herveline O 5459269 Drug sensitive Cuspidatin C 5459164 Drug sensitive 2,7-Bis(methoxycarbonylmethyl)-10-methylphenothiazine 384444 Drug sensitive 2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant Antimycin A3 245869 Drug sensitive 5-Hydroxy-3-phenylpyrano[3,2-c]chromen-2(5H)-one 24205741 Drug sensitive 4,5-Bis(4-methoxyphenyl)-1,5-dihydroimidazol-2-one 231112 Drug sensitive Kinetin riboside 20345 Drug resistant Astrazon Orange R 135747272 Drug sensitive Cladospirone bisepoxide 10316810 Drug sensitive (3Z,4R)-4-Hydroxy-3-[2-[(1S,3R)-3-[2-[(1S,3S,3'R,4S)-1-hydroxy-4,6,6-trimethylspiro[2,5-dioxabicyclo[2.2.2]octane-3,6'-oxane]-3'-yl]ethyl]-2,2-dimethyl-6-methylidenecyclohexyl]ethylidene]oxolan-2-one 101206903 Drug sensitive antineoplastic-d655481 - Drug resistant 4-[4-(3-Methoxy-phenyl)-piperazin-1 -yl]-5H-pyrrolo[3,2-d]pyrimidine - Drug sensitive 4-morpholinecarbodithioic acid, antimony complex - Drug sensitive 7-n,n-dimethylamino brefeldin a hydrochloride - Drug sensitive E)-1-(4-(quinazolin-4-ylamino)phenyl)-3-(2,4,6-trimethoxyphenyl)prop-2-en-1-one - Drug sensitive isatin dr - Drug sensitive tetra(isobutenyl)antimony bromide - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-30d-5p	Gemcitabine 60750 Drug interaction    RC00001621 Sunitinib 5329102 Drug interaction    RC00001626 Eloxatine 5310940 Drug interaction    RC00001625 Trichostatin A 444732 Drug interaction    RC00001624 Paroxetine 43815 Drug interaction    RC00001620 Etoposide 36462 Drug interaction    RC00001619 5-Fluorouracil 3385 Drug interaction    RC00001617 Doxorubicin 31703 Drug interaction    RC00001618 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001616 Verapamil 2520 Drug interaction    RC00001615 N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00001627 Bicalutamide 2375 Drug interaction    RC00001614 Docetaxel 148124 Drug interaction    RC00001623 1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00001628 Trastuzumab - Drug interaction    RC00001629

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-30d-5p	N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-30d-5p
Interactor2: CDC37L1

Evidence Support:

Weak-Evidence	HITS-CLIP
Support Database	ViRBase

References:

PMID	22473208	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	Jijoye cells	Interactor2 expression	None
Description	Our HITS-CLIP data yield 1185 human 3'UTRs targeted by members of the miR-17~92 cluster in Jijoye cells. Comparison to the 1664 3'UTRs targeted by EBV miRNAs reveals 740 shared genes (44% of EBV targets and 62% of miR-17~92 targets; Figure 6B and Supplementary Table 7). Thus, EBV miRNAs co-target a majority of miR-17~92 regulated mRNAs, which are assigned to a variety of pathways, most notably regulating transcription, apoptosis, and the cell cycle (Figure 6C). Similarly, other abundant immunologically relevant miRNAs, 142-3p and miR-155, co-target with EBV miRNAs a large fraction of their Ago-bound 3'UTRs, representing ~60% of the targets for each of these host miRNAs (Supplementary Figure 5).