Detail Information

Basic Information:


  VIRBase ID:  

HHID00048053

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5725

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-30d-5p:           HIC2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-30d-5p HIC2
miRBase
Accession/Entrez ID		 MIMAT0000245 23119
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - HRG22//ZBTB30//ZNF907

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-30d-5p
rs1203910650 chr8:134804928    G/A
rs1244539439 chr8:134804930    G/T
rs1441595222 chr8:134804927    C/A
rs1441595222 chr8:134804927    C/T
rs374432132 chr8:134804931    G/A
rs776972352 chr8:134804925    G/A
rs1187386485 chr8:134804934    G/A
rs1373057893 chr8:134804937    TACA/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR HIC2
chr22:21786780(+) A-I      intronic
chr22:21786953(+) A-I      intronic
chr22:21786826(+) A-I      intronic
chr22:21786815(+) A-I      intronic
chr22:21786779(+) A-I      intronic
chr22:21780813(+) A-I      intronic
chr22:21779803(+) A-I      intronic
chr22:21780811(+) A-I      intronic
chr22:21780251(+) A-I      intronic
chr22:21786751(+) A-I      intronic
chr22:21779727(+) A-I      intronic
chr22:21779787(+) A-I      intronic
chr22:21785147(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED HIC2
chr22:21786751(+) A-I intron -    15342557
chr22:21786779(+) A-I intron -    15342557
chr22:21786780(+) A-I intron -    15342557
chr22:21786815(+) A-I intron -    15342557
chr22:21786826(+) A-I intron -    15342557
chr22:21786838(+) A-I intron -    15342557

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase HIC2
chr22:21799236-21799237(+) m6A CDS       24284625
chr22:21799293-21799294(+) m6A CDS       24284625
chr22:21799304-21799305(+) m6A CDS       24284625
chr22:21799344-21799345(+) m6A CDS       24284625//24209618//22608085
chr22:21799434-21799435(+) m6A CDS       24284625//24209618//25456834//24981863//22608085
chr22:21799440-21799441(+) m6A CDS       24284625//24209618//25456834//24981863//22608085
chr22:21799476-21799477(+) m6A CDS       24284625//25456834//24981863//22608085
chr22:21799597-21799598(+) m6A CDS       24284625//25456834//24981863//22608085
chr22:21799783-21799784(+) m6A CDS       25456834//24981863//22608085
chr22:21799926-21799927(+) m6A CDS       24284625//25456834//22608085
chr22:21800121-21800122(+) m6A CDS       24284625//25456834//24981863//22608085
chr22:21800295-21800296(+) m6A CDS       24284625//25456834//24981863//22608085
chr22:21800406-21800407(+) m6A CDS       24284625//24209618//25456834//24981863//22608085
chr22:21800499-21800500(+) m6A CDS       24284625//24209618//25456834//24981863//22608085
chr22:21800570-21800571(+) m6A CDS       24284625//24209618//25456834//24981863//22608085
chr22:21800618-21800619(+) m6A CDS       24284625//24209618//25456834//24981863//22608085
chr22:21800652-21800653(+) m6A CDS       24284625//24209618//25456834//24981863//22608085
chr22:21800720-21800721(+) m6A CDS       24284625//24209618//25456834//24981863//22608085
chr22:21800730-21800731(+) m6A CDS       24284625//24209618//25456834//24981863//22608085
chr22:21800944-21800945(+) m6A CDS       24284625//25456834//24981863//22608085
chr22:21801041-21801042(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085
chr22:21801077-21801078(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085
chr22:21801120-21801121(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085
chr22:21801189-21801190(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085
chr22:21801327-21801328(+) m6A 3'UTR       25456834
chr22:21803060-21803061(+) m6A 3'UTR       24284625
chr22:21803067-21803068(+) m6A 3'UTR       24284625
chr22:21803072-21803073(+) m6A 3'UTR       24284625
chr22:21803108-21803109(+) m6A 3'UTR       24284625
chr22:21803123-21803124(+) m6A 3'UTR       24284625
chr22:21803131-21803132(+) m6A 3'UTR       24284625
chr22:21803323-21803324(+) m6A 3'UTR       -
chr22:21803332-21803333(+) m6A 3'UTR       -
chr22:21803655-21803656(+) m6A 3'UTR       24981863
chr22:21803701-21803702(+) m6A 3'UTR       24981863
chr22:21804427-21804428(+) m6A 3'UTR       22608085
chr22:21804484-21804485(+) m6A 3'UTR       24284625//25456834//24981863//22608085
chr22:21804543-21804544(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22608085
chr22:21804570-21804571(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22608085
chr22:21804617-21804618(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22608085
chr22:21804726-21804727(+) m6A 3'UTR       24284625//25456834//24981863//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-30d-5p
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome HCC tissues     30542726
Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Renal cancer cells     21670082
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Cerebrospinal fluid     25420022
Exosome Blood|B lymphoblastoid cells|Breast milk|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Epithelial cells|Kidney tissue|Lymphoma tissue|Mast cells|Seminal fluid|Tongue tissue     -
Extracellular vesicle HEK-293T cells     22849433
Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Microvesicle Plasma     23077538
Microvesicle Seminal plasma     23539611
Microvesicle Follicular fluid     23666971
Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleolus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
HIC2
Chromatin K562 cells     -
Cytosol K562 cells     -
Exosome Blood     -
Insoluble cytoplasm HCC cell line (HepG2)     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells|K562 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-30d-5p
Midostaurin 9829523 Drug resistant
Herveline O 5459269 Drug sensitive
Cuspidatin C 5459164 Drug sensitive
2,7-Bis(methoxycarbonylmethyl)-10-methylphenothiazine 384444 Drug sensitive
2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant
Antimycin A3 245869 Drug sensitive
5-Hydroxy-3-phenylpyrano[3,2-c]chromen-2(5H)-one 24205741 Drug sensitive
4,5-Bis(4-methoxyphenyl)-1,5-dihydroimidazol-2-one 231112 Drug sensitive
Kinetin riboside 20345 Drug resistant
Astrazon Orange R 135747272 Drug sensitive
Cladospirone bisepoxide 10316810 Drug sensitive
(3Z,4R)-4-Hydroxy-3-[2-[(1S,3R)-3-[2-[(1S,3S,3'R,4S)-1-hydroxy-4,6,6-trimethylspiro[2,5-dioxabicyclo[2.2.2]octane-3,6'-oxane]-3'-yl]ethyl]-2,2-dimethyl-6-methylidenecyclohexyl]ethylidene]oxolan-2-one 101206903 Drug sensitive
antineoplastic-d655481 - Drug resistant
4-[4-(3-Methoxy-phenyl)-piperazin-1 -yl]-5H-pyrrolo[3,2-d]pyrimidine - Drug sensitive
4-morpholinecarbodithioic acid, antimony complex - Drug sensitive
7-n,n-dimethylamino brefeldin a hydrochloride - Drug sensitive
E)-1-(4-(quinazolin-4-ylamino)phenyl)-3-(2,4,6-trimethoxyphenyl)prop-2-en-1-one - Drug sensitive
isatin dr - Drug sensitive
tetra(isobutenyl)antimony bromide - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-30d-5p
Gemcitabine 60750 Drug interaction    RC00001621
Sunitinib 5329102 Drug interaction    RC00001626
Eloxatine 5310940 Drug interaction    RC00001625
Trichostatin A 444732 Drug interaction    RC00001624
Paroxetine 43815 Drug interaction    RC00001620
Etoposide 36462 Drug interaction    RC00001619
5-Fluorouracil 3385 Drug interaction    RC00001617
Doxorubicin 31703 Drug interaction    RC00001618
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001616
Verapamil 2520 Drug interaction    RC00001615
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00001627
Bicalutamide 2375 Drug interaction    RC00001614
Docetaxel 148124 Drug interaction    RC00001623
1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00001628
Trastuzumab - Drug interaction    RC00001629
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-30d-5p
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-30d-5p
Interactor2: HIC2

Evidence Support:


Weak-Evidence HITS-CLIP//PAR-CLIP
Support Database ViRBase

References:


PMID 22473208 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line Jijoye cells Interactor2 expression None
Description Our HITS-CLIP data yield 1185 human 3'UTRs targeted by members of the miR-17~92 cluster in Jijoye cells. Comparison to the 1664 3'UTRs targeted by EBV miRNAs reveals 740 shared genes (44% of EBV targets and 62% of miR-17~92 targets; Figure 6B and Supplementary Table 7). Thus, EBV miRNAs co-target a majority of miR-17~92 regulated mRNAs, which are assigned to a variety of pathways, most notably regulating transcription, apoptosis, and the cell cycle (Figure 6C). Similarly, other abundant immunologically relevant miRNAs, 142-3p and miR-155, co-target with EBV miRNAs a large fraction of their Ago-bound 3'UTRs, representing ~60% of the targets for each of these host miRNAs (Supplementary Figure 5).

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