Basic Information:

  VIRBase ID:  

HHID00048044

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-30d-5p:  MIMAT0000245          CBX3:  NM_016587     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-30d-5p	CBX3
miRBase Accession/Entrez ID	MIMAT0000245	11335
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	HECH//HP1-GAMMA//HP1Hs-gamma

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-30d-5p	rs1203910650 chr8:134804928    G/A rs1244539439 chr8:134804930    G/T rs1441595222 chr8:134804927    C/A rs1441595222 chr8:134804927    C/T rs374432132 chr8:134804931    G/A rs776972352 chr8:134804925    G/A rs1187386485 chr8:134804934    G/A rs1373057893 chr8:134804937    TACA/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CBX3	chr7:26247399(+) A-I      intronic chr7:26247358(+) A-I      intronic chr7:26245456(+) A-I      intronic chr7:26244474(+) A-I      intronic chr7:26244453(+) A-I      intronic chr7:26247611(+) A-I      intronic chr7:26247635(+) A-I      intronic chr7:26247621(+) A-I      intronic chr7:26247629(+) A-I      intronic chr7:26247575(+) A-I      intronic chr7:26247576(+) A-I      intronic chr7:26247644(+) A-I      intronic chr7:26244527(+) A-I      intronic chr7:26247625(+) A-I      intronic chr7:26247763(+) A-I      intronic chr7:26247208(+) A-I      intronic chr7:26244683(+) A-I      intronic chr7:26247338(+) A-I      intronic chr7:26247829(+) A-I      intronic chr7:26245530(+) A-I      intronic chr7:26247645(+) A-I      intronic chr7:26245548(+) A-I      intronic chr7:26247581(+) A-I      intronic chr7:26244510(+) A-I      intronic chr7:26245680(+) A-I      intronic chr7:26244428(+) A-I      intronic chr7:26245651(+) A-I      intronic chr7:26247630(+) A-I      intronic chr7:26244458(+) A-I      intronic chr7:26247268(+) A-I      intronic chr7:26245611(+) A-I      intronic chr7:26247318(+) A-I      intronic chr7:26245451(+) A-I      intronic chr7:26245520(+) A-I      intronic chr7:26247278(+) A-I      intronic chr7:26247736(+) A-I      intronic chr7:26247700(+) A-I      intronic chr7:26245542(+) A-I      intronic chr7:26245550(+) A-I      intronic chr7:26244689(+) A-I      intronic chr7:26245586(+) A-I      intronic chr7:26244539(+) A-I      intronic chr7:26248405(+) A-I      intronic chr7:26245598(+) A-I      intronic chr7:26247265(+) A-I      intronic chr7:26247825(+) A-I      intronic chr7:26248440(+) A-I      intronic chr7:26244551(+) A-I      intronic chr7:26244466(+) A-I      intronic chr7:26249760(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CBX3	chr7:26244458(+) A-G intron -    22484847 chr7:26244460(+) A-G intron -    22484847 chr7:26244466(+) A-G intron -    22484847 chr7:26244583(+) A-G intron -    22484847 chr7:26245450(+) A-G intron -    22484847 chr7:26247318(+) A-G intron -    22484847 chr7:26247338(+) A-G intron -    22484847 chr7:26247645(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CBX3	chr7:26240841-26240842(+) m6A 5'UTR       27773535 chr7:26240912-26240913(+) m6A 5'UTR       24981863//27773535 chr7:26241108-26241109(+) m6A 5'UTR       25456834//24981863 chr7:26241156-26241157(+) m6A 5'UTR       25456834//24981863 chr7:26241413-26241414(+) m6A 5'UTR//intron       24284625//24981863//27773535 chr7:26241554-26241555(+) m6A 5'UTR//intron       24284625//27773535 chr7:26242560-26242561(+) m6A exon//intron       24981863//27773535 chr7:26242633-26242634(+) m6A CDS//exon       24981863//27773535 chr7:26245702-26245703(+) m6A exon//intron       24981863//27773535 chr7:26245722-26245723(+) m6A exon//intron       24981863//27773535 chr7:26246004-26246005(+) m6A CDS//exon       24981863//27773535//22575960 chr7:26247831-26247832(+) m6A exon//intron       27773535 chr7:26248001-26248002(+) m6A exon//intron       24981863 chr7:26248006-26248007(+) m6A exon//intron       24981863 chr7:26248030-26248031(+) m6A CDS//exon//intron       24981863 chr7:26249672-26249673(+) m6A 3'UTR//intron       27773535 chr7:26250170-26250171(+) m6A 3'UTR//intron       24981863 chr7:26251289-26251290(+) m6A CDS//exon       24981863 chr7:26251342-26251343(+) m6A 3'UTR//CDS//exon       27773535 chr7:26251721-26251722(+) m6A 3'UTR//CDS//exon       27773535 chr7:26251788-26251789(+) m6A 3'UTR//CDS//exon       27773535 chr7:26252012-26252013(+) m6A 3'UTR//exon       27773535 chr7:26252537-26252538(+) m6A 3'UTR       27773535 chr7:26252542-26252543(+) m6A 3'UTR       27773535 chr7:26252571-26252572(+) m6A 3'UTR       27773535 chr7:26252576-26252577(+) m6A 3'UTR       27773535 chr7:26252590-26252591(+) m6A 3'UTR       27773535 chr7:26252687-26252688(+) m6A 3'UTR       27773535 chr7:26252702-26252703(+) m6A 3'UTR       27773535 chr7:26252738-26252739(+) m6A 3'UTR       27773535 chr7:26252760-26252761(+) m6A 3'UTR       27773535 chr7:26252872-26252873(+) m6A 3'UTR       27773535 chr7:26252938-26252939(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-30d-5p	Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Exosome HCC tissues     30542726 Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Exosome Breast cancer cell line (MCF-7)     20976003 Exosome Renal cancer cells     21670082 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Human mast cell line (HMC-1)     24009880 Exosome Cerebrospinal fluid     25420022 Exosome Blood|B lymphoblastoid cells|Breast milk|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Epithelial cells|Kidney tissue|Lymphoma tissue|Mast cells|Seminal fluid|Tongue tissue     - Extracellular vesicle HEK-293T cells     22849433 Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901 Microvesicle Plasma     23077538 Microvesicle Seminal plasma     23539611 Microvesicle Follicular fluid     23666971 Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     - Mitochondrion Cell line (HEK-293|HeLa)     22984580 Nucleolus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059 Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
	CBX3	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus K562 cells     - Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-miR-30d-5p	Midostaurin 9829523 Drug resistant Herveline O 5459269 Drug sensitive Cuspidatin C 5459164 Drug sensitive 2,7-Bis(methoxycarbonylmethyl)-10-methylphenothiazine 384444 Drug sensitive 2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant Antimycin A3 245869 Drug sensitive 5-Hydroxy-3-phenylpyrano[3,2-c]chromen-2(5H)-one 24205741 Drug sensitive 4,5-Bis(4-methoxyphenyl)-1,5-dihydroimidazol-2-one 231112 Drug sensitive Kinetin riboside 20345 Drug resistant Astrazon Orange R 135747272 Drug sensitive Cladospirone bisepoxide 10316810 Drug sensitive (3Z,4R)-4-Hydroxy-3-[2-[(1S,3R)-3-[2-[(1S,3S,3'R,4S)-1-hydroxy-4,6,6-trimethylspiro[2,5-dioxabicyclo[2.2.2]octane-3,6'-oxane]-3'-yl]ethyl]-2,2-dimethyl-6-methylidenecyclohexyl]ethylidene]oxolan-2-one 101206903 Drug sensitive antineoplastic-d655481 - Drug resistant 4-[4-(3-Methoxy-phenyl)-piperazin-1 -yl]-5H-pyrrolo[3,2-d]pyrimidine - Drug sensitive 4-morpholinecarbodithioic acid, antimony complex - Drug sensitive 7-n,n-dimethylamino brefeldin a hydrochloride - Drug sensitive E)-1-(4-(quinazolin-4-ylamino)phenyl)-3-(2,4,6-trimethoxyphenyl)prop-2-en-1-one - Drug sensitive isatin dr - Drug sensitive tetra(isobutenyl)antimony bromide - Drug sensitive

Resource	Symbol	Drug Name	PubChem ID	Function	Link
RNAInter	hsa-miR-30d-5p	Gemcitabine 60750 Drug interaction    RC00001621 Sunitinib 5329102 Drug interaction    RC00001626 Eloxatine 5310940 Drug interaction    RC00001625 Trichostatin A 444732 Drug interaction    RC00001624 Paroxetine 43815 Drug interaction    RC00001620 Etoposide 36462 Drug interaction    RC00001619 5-Fluorouracil 3385 Drug interaction    RC00001617 Doxorubicin 31703 Drug interaction    RC00001618 cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001616 Verapamil 2520 Drug interaction    RC00001615 N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00001627 Bicalutamide 2375 Drug interaction    RC00001614 Docetaxel 148124 Drug interaction    RC00001623 1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00001628 Trastuzumab - Drug interaction    RC00001629

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-miR-30d-5p	N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-30d-5p
Interactor2: CBX3

Evidence Support:

Weak-Evidence	HITS-CLIP
Support Database	ViRBase

References:

PMID	22473208	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	Jijoye cells	Interactor2 expression	None
Description	Our HITS-CLIP data yield 1185 human 3'UTRs targeted by members of the miR-17~92 cluster in Jijoye cells. Comparison to the 1664 3'UTRs targeted by EBV miRNAs reveals 740 shared genes (44% of EBV targets and 62% of miR-17~92 targets; Figure 6B and Supplementary Table 7). Thus, EBV miRNAs co-target a majority of miR-17~92 regulated mRNAs, which are assigned to a variety of pathways, most notably regulating transcription, apoptosis, and the cell cycle (Figure 6C). Similarly, other abundant immunologically relevant miRNAs, 142-3p and miR-155, co-target with EBV miRNAs a large fraction of their Ago-bound 3'UTRs, representing ~60% of the targets for each of these host miRNAs (Supplementary Figure 5).