Detail Information

Basic Information:


  VIRBase ID:  

HHID00048043

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-30d-5p:           DBF4:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-30d-5p DBF4
miRBase
Accession/Entrez ID		 MIMAT0000245 10926
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - ASK//CHIF//DBF4A//ZDBF1

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-30d-5p
rs1203910650 chr8:134804928    G/A
rs1244539439 chr8:134804930    G/T
rs1441595222 chr8:134804927    C/A
rs1441595222 chr8:134804927    C/T
rs374432132 chr8:134804931    G/A
rs776972352 chr8:134804925    G/A
rs1187386485 chr8:134804934    G/A
rs1373057893 chr8:134804937    TACA/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR DBF4
chr7:87535366(+) A-I      intronic
chr7:87535344(+) A-I      intronic
chr7:87527927(+) A-I      intronic
chr7:87534366(+) A-I      intronic
chr7:87533221(+) A-I      intronic
chr7:87533220(+) A-I      intronic
chr7:87533194(+) A-I      intronic
chr7:87510571(+) A-I      intronic
chr7:87510569(+) A-I      intronic
chr7:87527943(+) A-I      intronic
chr7:87527999(+) A-I      intronic
chr7:87528002(+) A-I      intronic
chr7:87518002(+) A-I      intronic
chr7:87509147(+) A-I      intronic
chr7:87528076(+) A-I      intronic
chr7:87509115(+) A-I      intronic
chr7:87508511(+) A-I      intronic
chr7:87518612(+) A-I      intronic
chr7:87518648(+) A-I      intronic
chr7:87508484(+) A-I      intronic
chr7:87522641(+) A-I      intronic
chr7:87522700(+) A-I      intronic
chr7:87522759(+) A-I      intronic
chr7:87522767(+) A-I      intronic
chr7:87522771(+) A-I      intronic
chr7:87522820(+) A-I      intronic
chr7:87508416(+) A-I      intronic
chr7:87510444(+) A-I      intronic
chr7:87508393(+) A-I      intronic
chr7:87508337(+) A-I      intronic
chr7:87518778(+) A-I      intronic
chr7:87518675(+) A-I      intronic
chr7:87509117(+) A-I      intronic
chr7:87518816(+) A-I      intronic
chr7:87519762(+) A-I      intronic
chr7:87519767(+) A-I      intronic
chr7:87523585(+) A-I      intronic
chr7:87508516(+) A-I      intronic
chr7:87509126(+) A-I      intronic
chr7:87523700(+) A-I      intronic
chr7:87519590(+) A-I      intronic
chr7:87527145(+) A-I      intronic
chr7:87523572(+) A-I      intronic
chr7:87523628(+) A-I      intronic
chr7:87513564(+) A-I      intronic
chr7:87533937(+) A-I      intronic
chr7:87533250(+) A-I      intronic
chr7:87523575(+) A-I      intronic
chr7:87523701(+) A-I      intronic
chr7:87519684(+) A-I      intronic
chr7:87534302(+) A-I      intronic
chr7:87523644(+) A-I      intronic
chr7:87509066(+) A-I      intronic
chr7:87518664(+) A-I      intronic
chr7:87527290(+) A-I      intronic
chr7:87527293(+) A-I      intronic
chr7:87518674(+) A-I      intronic
chr7:87508332(+) A-I      intronic
chr7:87527219(+) A-I      intronic
chr7:87519779(+) A-I      intronic
chr7:87523564(+) A-I      intronic
chr7:87534359(+) A-I      intronic
chr7:87527882(+) A-I      intronic
chr7:87528069(+) A-I      intronic
chr7:87527138(+) A-I      intronic
chr7:87534395(+) A-I      intronic
chr7:87534291(+) A-I      intronic
chr7:87523509(+) A-I      intronic
chr7:87519727(+) A-I      intronic
chr7:87527111(+) A-I      intronic
chr7:87527909(+) A-I      intronic
chr7:87527197(+) A-I      intronic
chr7:87535267(+) A-I      intronic
chr7:87527193(+) A-I      intronic
chr7:87533936(+) A-I      intronic
chr7:87523584(+) A-I      intronic
chr7:87509065(+) A-I      intronic
chr7:87523632(+) A-I      intronic
chr7:87519768(+) A-I      intronic
chr7:87508492(+) A-I      intronic
chr7:87527276(+) A-I      intronic
chr7:87533136(+) A-I      intronic
chr7:87527273(+) A-I      intronic
chr7:87519726(+) A-I      intronic
chr7:87510493(+) A-I      intronic
chr7:87534405(+) A-I      intronic
chr7:87527919(+) A-I      intronic
chr7:87527218(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED DBF4
chr7:87527138(+) A-I intron -    22327324
chr7:87523509(+) A-I intron -    22028664
chr7:87523521(+) A-I intron -    22028664
chr7:87523572(+) A-I intron -    22028664
chr7:87523575(+) A-I intron -    22028664
chr7:87523584(+) A-I intron -    22028664
chr7:87523585(+) A-I intron -    22028664
chr7:87523612(+) A-I intron -    22028664
chr7:87523628(+) A-I intron -    22028664
chr7:87523632(+) A-I intron -    22028664
chr7:87523644(+) A-I intron -    22028664
chr7:87523654(+) A-I intron -    22028664
chr7:87523700(+) A-I intron -    22028664
chr7:87523701(+) A-I intron -    22028664
chr7:87508332(+) A-G intron -    22484847
chr7:87508447(+) A-G intron -    22484847
chr7:87508492(+) A-G intron -    22484847
chr7:87509038(+) A-G intron -    22484847
chr7:87509041(+) T-C intron -    22484847
chr7:87509057(+) A-G intron -    22484847
chr7:87509065(+) A-G intron -    22484847
chr7:87509066(+) A-G intron -    22484847
chr7:87509126(+) A-G intron -    22484847
chr7:87518724(+) A-G intron -    22484847
chr7:87519590(+) A-G intron -    22484847
chr7:87519726(+) A-G intron -    22484847
chr7:87519727(+) A-G intron -    22484847
chr7:87519735(+) T-C intron -    22484847
chr7:87519768(+) A-G intron -    22484847
chr7:87523509(+) A-G intron -    22484847
chr7:87523584(+) A-G intron -    22484847
chr7:87523585(+) A-G intron -    22484847
chr7:87523654(+) A-G intron -    22484847
chr7:87523701(+) A-G intron -    22484847
chr7:87527138(+) A-G intron -    22484847
chr7:87527145(+) A-G intron -    22484847
chr7:87527210(+) A-G intron -    22484847
chr7:87527218(+) A-G intron -    22484847
chr7:87527230(+) T-C intron -    22484847
chr7:87527257(+) T-C intron -    22484847
chr7:87527268(+) T-C intron -    22484847
chr7:87527269(+) T-C intron -    22484847
chr7:87527276(+) A-G intron -    22484847
chr7:87527281(+) T-C intron -    22484847
chr7:87527290(+) A-G intron -    22484847
chr7:87527293(+) A-G intron -    22484847
chr7:87527345(+) A-G intron -    22484847
chr7:87527852(+) A-G intron -    22484847
chr7:87527882(+) A-G intron -    22484847
chr7:87528069(+) A-G intron -    22484847
chr7:87532420(+) T-C intron -    22484847
chr7:87533214(+) T-C intron -    22484847
chr7:87533974(+) T-C intron -    22484847
chr7:87534011(+) T-C intron -    22484847
chr7:87534291(+) A-G intron -    22484847
chr7:87534302(+) A-G intron -    22484847
chr7:87534359(+) A-G intron -    22484847
chr7:87535390(+) T-C intron -    22484847
chr7:87517988(+) A-G intron -    22484847
chr7:87517989(+) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase DBF4
chr7:87505563-87505564(+) m6A 5'UTR       25456834
chr7:87505577-87505578(+) m6A 5'UTR       25456834
chr7:87505597-87505598(+) m6A 5'UTR       25456834
chr7:87505637-87505638(+) m6A 5'UTR       25456834
chr7:87505888-87505889(+) m6A 5'UTR//exon       24981863
chr7:87517316-87517317(+) m6A 3'UTR//CDS//exon       24981863
chr7:87525534-87525535(+) m6A exon//intron       24981863
chr7:87533712-87533713(+) m6A 3'UTR//CDS//exon       24981863//27773535//22608085
chr7:87536557-87536558(+) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22608085
chr7:87536562-87536563(+) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22608085
chr7:87536656-87536657(+) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22608085
chr7:87536665-87536666(+) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22608085
chr7:87536787-87536788(+) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22575960//22608085
chr7:87536819-87536820(+) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22575960//22608085
chr7:87536823-87536824(+) m6A 3'UTR//CDS       27773535//22575960
chr7:87536850-87536851(+) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22575960//22608085
chr7:87536880-87536881(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr7:87536967-87536968(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr7:87537017-87537018(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr7:87537062-87537063(+) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22575960//22608085
chr7:87537123-87537124(+) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22575960//22608085
chr7:87537225-87537226(+) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22608085
chr7:87537250-87537251(+) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22608085
chr7:87537275-87537276(+) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22608085
chr7:87537311-87537312(+) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22608085
chr7:87537322-87537323(+) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-30d-5p
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome HCC tissues     30542726
Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Renal cancer cells     21670082
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Cerebrospinal fluid     25420022
Exosome Blood|B lymphoblastoid cells|Breast milk|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Epithelial cells|Kidney tissue|Lymphoma tissue|Mast cells|Seminal fluid|Tongue tissue     -
Extracellular vesicle HEK-293T cells     22849433
Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Microvesicle Plasma     23077538
Microvesicle Seminal plasma     23539611
Microvesicle Follicular fluid     23666971
Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleolus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
DBF4
Chromatin K562 cells     -
Exosome Blood     -
Membrane K562 cells     -
Nucleoplasm K562 cells     -
Nucleus K562 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-30d-5p
Midostaurin 9829523 Drug resistant
Herveline O 5459269 Drug sensitive
Cuspidatin C 5459164 Drug sensitive
2,7-Bis(methoxycarbonylmethyl)-10-methylphenothiazine 384444 Drug sensitive
2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant
Antimycin A3 245869 Drug sensitive
5-Hydroxy-3-phenylpyrano[3,2-c]chromen-2(5H)-one 24205741 Drug sensitive
4,5-Bis(4-methoxyphenyl)-1,5-dihydroimidazol-2-one 231112 Drug sensitive
Kinetin riboside 20345 Drug resistant
Astrazon Orange R 135747272 Drug sensitive
Cladospirone bisepoxide 10316810 Drug sensitive
(3Z,4R)-4-Hydroxy-3-[2-[(1S,3R)-3-[2-[(1S,3S,3'R,4S)-1-hydroxy-4,6,6-trimethylspiro[2,5-dioxabicyclo[2.2.2]octane-3,6'-oxane]-3'-yl]ethyl]-2,2-dimethyl-6-methylidenecyclohexyl]ethylidene]oxolan-2-one 101206903 Drug sensitive
antineoplastic-d655481 - Drug resistant
4-[4-(3-Methoxy-phenyl)-piperazin-1 -yl]-5H-pyrrolo[3,2-d]pyrimidine - Drug sensitive
4-morpholinecarbodithioic acid, antimony complex - Drug sensitive
7-n,n-dimethylamino brefeldin a hydrochloride - Drug sensitive
E)-1-(4-(quinazolin-4-ylamino)phenyl)-3-(2,4,6-trimethoxyphenyl)prop-2-en-1-one - Drug sensitive
isatin dr - Drug sensitive
tetra(isobutenyl)antimony bromide - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-30d-5p
Gemcitabine 60750 Drug interaction    RC00001621
Sunitinib 5329102 Drug interaction    RC00001626
Eloxatine 5310940 Drug interaction    RC00001625
Trichostatin A 444732 Drug interaction    RC00001624
Paroxetine 43815 Drug interaction    RC00001620
Etoposide 36462 Drug interaction    RC00001619
5-Fluorouracil 3385 Drug interaction    RC00001617
Doxorubicin 31703 Drug interaction    RC00001618
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001616
Verapamil 2520 Drug interaction    RC00001615
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00001627
Bicalutamide 2375 Drug interaction    RC00001614
Docetaxel 148124 Drug interaction    RC00001623
1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00001628
Trastuzumab - Drug interaction    RC00001629
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-30d-5p
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-30d-5p
Interactor2: DBF4

Evidence Support:


Weak-Evidence HITS-CLIP
Support Database ViRBase

References:


PMID 22473208 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line Jijoye cells Interactor2 expression None
Description Our HITS-CLIP data yield 1185 human 3'UTRs targeted by members of the miR-17~92 cluster in Jijoye cells. Comparison to the 1664 3'UTRs targeted by EBV miRNAs reveals 740 shared genes (44% of EBV targets and 62% of miR-17~92 targets; Figure 6B and Supplementary Table 7). Thus, EBV miRNAs co-target a majority of miR-17~92 regulated mRNAs, which are assigned to a variety of pathways, most notably regulating transcription, apoptosis, and the cell cycle (Figure 6C). Similarly, other abundant immunologically relevant miRNAs, 142-3p and miR-155, co-target with EBV miRNAs a large fraction of their Ago-bound 3'UTRs, representing ~60% of the targets for each of these host miRNAs (Supplementary Figure 5).

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