Detail Information

Basic Information:


  VIRBase ID:  

HHID00048010

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-30d-5p:           BECN1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-30d-5p BECN1
miRBase
Accession/Entrez ID		 MIMAT0000245 8678
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - ATG6//beclin1//VPS30

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-30d-5p
rs1203910650 chr8:134804928    G/A
rs1244539439 chr8:134804930    G/T
rs1441595222 chr8:134804927    C/A
rs1441595222 chr8:134804927    C/T
rs374432132 chr8:134804931    G/A
rs776972352 chr8:134804925    G/A
rs1187386485 chr8:134804934    G/A
rs1373057893 chr8:134804937    TACA/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR BECN1
chr17:40965497(-) A-I      intronic
chr17:40965096(-) A-I      intronic
chr17:40964950(-) A-I      intronic
chr17:40964949(-) A-I      intronic
chr17:40964938(-) A-I      intronic
chr17:40964550(-) A-I      intronic
chr17:40964488(-) A-I      intronic
chr17:40964319(-) A-I      intronic
chr17:40964302(-) A-I      intronic
chr17:40964240(-) A-I      intronic
chr17:40964237(-) A-I      intronic
chr17:40964159(-) A-I      intronic
chr17:40974109(-) A-I      intronic
chr17:40975333(-) A-I      intronic
chr17:40975325(-) A-I      intronic
chr17:40975284(-) A-I      intronic
chr17:40974836(-) A-I      intronic
chr17:40974783(-) A-I      intronic
chr17:40974097(-) A-I      intronic
chr17:40973294(-) A-I      intronic
chr17:40973180(-) A-I      intronic
chr17:40973174(-) A-I      intronic
chr17:40973163(-) A-I      intronic
chr17:40969862(-) A-I      intronic
chr17:40969848(-) A-I      intronic
chr17:40969834(-) A-I      intronic
chr17:40965129(-) A-I      intronic
chr17:40964717(-) A-I      intronic
chr17:40968905(-) A-I      intronic
chr17:40965112(-) A-I      intronic
chr17:40973328(-) A-I      intronic
chr17:40968631(-) A-I      intronic
chr17:40973980(-) A-I      intronic
chr17:40964315(-) A-I      intronic
chr17:40969639(-) A-I      intronic
chr17:40975437(-) A-I      intronic
chr17:40969291(-) A-I      intronic
chr17:40968912(-) A-I      intronic
chr17:40964198(-) A-I      intronic
chr17:40973257(-) A-I      intronic
chr17:40964290(-) A-I      intronic
chr17:40969204(-) A-I      intronic
chr17:40964358(-) A-I      intronic
chr17:40964345(-) A-I      intronic
chr17:40965510(-) A-I      intronic
chr17:40969684(-) A-I      intronic
chr17:40964254(-) A-I      intronic
chr17:40975401(-) A-I      intronic
chr17:40974206(-) A-I      intronic
chr17:40968452(-) A-I      intronic
chr17:40975421(-) A-I      intronic
chr17:40965135(-) A-I      intronic
chr17:40969800(-) A-I      intronic
chr17:40973345(-) A-I      intronic
chr17:40964158(-) A-I      intronic
chr17:40973968(-) A-I      intronic
chr17:40975544(-) A-I      intronic
chr17:40973981(-) A-I      intronic
chr17:40974139(-) A-I      intronic
chr17:40964513(-) A-I      intronic
chr17:40974876(-) A-I      intronic
chr17:40964964(-) A-I      intronic
chr17:40973261(-) A-I      intronic
chr17:40964475(-) A-I      intronic
chr17:40964677(-) A-I      intronic
chr17:40964547(-) A-I      intronic
chr17:40965302(-) A-I      intronic
chr17:40969840(-) A-I      intronic
chr17:40964191(-) A-I      intronic
chr17:40965134(-) A-I      intronic
chr17:40969664(-) A-I      intronic
chr17:40964137(-) A-I      intronic
chr17:40965548(-) A-I      intronic
chr17:40973258(-) A-I      intronic
chr17:40973990(-) A-I      intronic
chr17:40964619(-) A-I      intronic
chr17:40965442(-) A-I      intronic
chr17:40974121(-) A-I      intronic
chr17:40975452(-) A-I      intronic
chr17:40974043(-) A-I      intronic
chr17:40975051(-) A-I      intronic
chr17:40968453(-) A-I      intronic
chr17:40964487(-) A-I      intronic
chr17:40974679(-) A-I      intronic
chr17:40964682(-) A-I      intronic
chr17:40964270(-) A-I      intronic
chr17:40970662(-) A-I      NonSyn:Thr->Ala
chr17:40965227(-) A-I      intronic
chr17:40974878(-) A-I      intronic
chr17:40964206(-) A-I      intronic
chr17:40974058(-) A-I      intronic
chr17:40973192(-) A-I      intronic
chr17:40965371(-) A-I      intronic
chr17:40964199(-) A-I      intronic
chr17:40969810(-) A-I      intronic
chr17:40965001(-) A-I      intronic
chr17:40964663(-) A-I      intronic
chr17:40975455(-) A-I      intronic
chr17:40964220(-) A-I      intronic
chr17:40974055(-) A-I      intronic
chr17:40964961(-) A-I      intronic
chr17:40969839(-) A-I      intronic
chr17:40964278(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED BECN1
chr17:40964146(-) A-I intron -    15342557
chr17:40964158(-) A-I intron -    15342557
chr17:40964191(-) A-I intron -    15342557
chr17:40964198(-) A-I intron -    15342557
chr17:40964199(-) A-I intron -    15342557
chr17:40964206(-) A-I intron -    15342557
chr17:40964220(-) A-I intron -    15342557
chr17:40964270(-) A-I intron -    15342557
chr17:40964278(-) A-I intron -    15342557
chr17:40964315(-) A-I intron -    15342557
chr17:40964345(-) A-I intron -    15342557
chr17:40964358(-) A-I intron -    15342557
chr17:40964363(-) A-I intron -    15342557
chr17:40964475(-) A-I intron -    15342557
chr17:40964487(-) A-I intron -    15342557
chr17:40964513(-) A-I intron -    15342557
chr17:40964547(-) A-I intron -    15342557
chr17:40964677(-) A-I intron -    15342557
chr17:40964717(-) A-I intron -    15342557
chr17:40970662(-) A-I exon CDS    15342557
chr17:40971402(-) A-I intron -    15342557
chr17:40964137(-) A-G intron -    22484847
chr17:40964220(-) A-G intron -    22484847
chr17:40964547(-) A-G intron -    22484847
chr17:40969684(-) A-G intron -    22484847
chr17:40969810(-) A-G intron -    22484847
chr17:40969839(-) A-G intron -    22484847
chr17:40973328(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase BECN1
chr17:40962515-40962516(-) m6A 3'UTR//exon       24981863//26404942
chr17:40962543-40962544(-) m6A 3'UTR//exon       24981863//26404942
chr17:40962687-40962688(-) m6A 3'UTR//exon       27773535
chr17:40962719-40962720(-) m6A 3'UTR//exon       27773535
chr17:40962854-40962855(-) m6A 3'UTR//CDS//exon       26404942//27773535
chr17:40962881-40962882(-) m6A 3'UTR//CDS//exon       26404942//27773535
chr17:40962916-40962917(-) m6A 3'UTR//CDS//exon       27773535
chr17:40963694-40963695(-) m6A 3'UTR//CDS//exon//intron       27773535
chr17:40963735-40963736(-) m6A 3'UTR//CDS//exon//intron       27773535
chr17:40963771-40963772(-) m6A 3'UTR//CDS//exon//intron       27773535
chr17:40967692-40967693(-) m6A exon//intron       27773535
chr17:40968000-40968001(-) m6A CDS//exon//intron       -
chr17:40970258-40970259(-) m6A CDS//exon       24981863//28052920//26404942//27371828
chr17:40970310-40970311(-) m6A CDS//exon       24981863//28052920//26404942//27371828
chr17:40970387-40970388(-) m6A CDS//exon       24981863//26404942//27371828
chr17:40970567-40970568(-) m6A CDS//exon//intron       24981863//26404942//27371828
chr17:40970603-40970604(-) m6A CDS//exon//intron       27371828
chr17:40970612-40970613(-) m6A CDS//exon//intron       27371828
chr17:40970661-40970662(-) m6A CDS//exon//intron       27371828
chr17:40970687-40970688(-) m6A 3'UTR//CDS//exon//intron       27371828//27773536
chr17:40970810-40970811(-) m6A 3'UTR//CDS//exon//intron       27371828//27773536
chr17:40970823-40970824(-) m6A 3'UTR//CDS//exon//intron       27371828//27773536
chr17:40971611-40971612(-) m6A 3'UTR//CDS//exon       -
chr17:40972390-40972391(-) m6A exon//intron       -
chr17:40972805-40972806(-) m6A CDS//exon       27773535
chr17:40972820-40972821(-) m6A CDS//exon       27773535
chr17:40972830-40972831(-) m6A CDS//exon       27773535
chr17:40975755-40975756(-) m6A CDS//intron       27773535
chr17:40975772-40975773(-) m6A CDS//exon       27773535
chr17:40975791-40975792(-) m6A CDS//exon       27773535//27773536
chr17:40975812-40975813(-) m6A CDS//exon       27773535//27773536
chr17:40975817-40975818(-) m6A CDS//exon       27773535//27773536
chr17:40976200-40976201(-) m6A 5'UTR//exon//intron       24284625//24981863//27371828//27773536
chr17:40976205-40976206(-) m6A 5'UTR//exon//intron       24284625//24981863//27371828//27773536
chr17:40976273-40976274(-) m6A 5'UTR//exon//intron       24981863//27371828//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-30d-5p
Cytoplasm Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Exosome HCC tissues     30542726
Exosome Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Exosome Breast cancer cell line (MCF-7)     20976003
Exosome Renal cancer cells     21670082
Exosome Brain tissue     23382797
Exosome Plasma     23663360
Exosome Human mast cell line (HMC-1)     24009880
Exosome Cerebrospinal fluid     25420022
Exosome Blood|B lymphoblastoid cells|Breast milk|Chronic lymphocytic leukemia cells|Colon tissue|Endothelial cells|Epithelial cells|Kidney tissue|Lymphoma tissue|Mast cells|Seminal fluid|Tongue tissue     -
Extracellular vesicle HEK-293T cells     22849433
Microvesicle Hepatocellular carcinoma cell line (HepG2)|Lung epithelial carcinoma cell line (A549)     20615901
Microvesicle Plasma     23077538
Microvesicle Seminal plasma     23539611
Microvesicle Follicular fluid     23666971
Microvesicle Blood|Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells|Urine     -
Mitochondrion Cell line (HEK-293|HeLa)     22984580
Nucleolus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
Nucleus Breast adenocarcinoma cells (MCF-7)|Cervical adenocarcinoma cells (HeLa)     24918059
BECN1
Chromatin K562 cells     -
Exosome Blood     -
Membrane K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells|K562 cells     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-30d-5p
Midostaurin 9829523 Drug resistant
Herveline O 5459269 Drug sensitive
Cuspidatin C 5459164 Drug sensitive
2,7-Bis(methoxycarbonylmethyl)-10-methylphenothiazine 384444 Drug sensitive
2-Acetyl-1,2-dihydroellipticine 376328 Drug resistant
Antimycin A3 245869 Drug sensitive
5-Hydroxy-3-phenylpyrano[3,2-c]chromen-2(5H)-one 24205741 Drug sensitive
4,5-Bis(4-methoxyphenyl)-1,5-dihydroimidazol-2-one 231112 Drug sensitive
Kinetin riboside 20345 Drug resistant
Astrazon Orange R 135747272 Drug sensitive
Cladospirone bisepoxide 10316810 Drug sensitive
(3Z,4R)-4-Hydroxy-3-[2-[(1S,3R)-3-[2-[(1S,3S,3'R,4S)-1-hydroxy-4,6,6-trimethylspiro[2,5-dioxabicyclo[2.2.2]octane-3,6'-oxane]-3'-yl]ethyl]-2,2-dimethyl-6-methylidenecyclohexyl]ethylidene]oxolan-2-one 101206903 Drug sensitive
antineoplastic-d655481 - Drug resistant
4-[4-(3-Methoxy-phenyl)-piperazin-1 -yl]-5H-pyrrolo[3,2-d]pyrimidine - Drug sensitive
4-morpholinecarbodithioic acid, antimony complex - Drug sensitive
7-n,n-dimethylamino brefeldin a hydrochloride - Drug sensitive
E)-1-(4-(quinazolin-4-ylamino)phenyl)-3-(2,4,6-trimethoxyphenyl)prop-2-en-1-one - Drug sensitive
isatin dr - Drug sensitive
tetra(isobutenyl)antimony bromide - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-30d-5p
Gemcitabine 60750 Drug interaction    RC00001621
Sunitinib 5329102 Drug interaction    RC00001626
Eloxatine 5310940 Drug interaction    RC00001625
Trichostatin A 444732 Drug interaction    RC00001624
Paroxetine 43815 Drug interaction    RC00001620
Etoposide 36462 Drug interaction    RC00001619
5-Fluorouracil 3385 Drug interaction    RC00001617
Doxorubicin 31703 Drug interaction    RC00001618
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00001616
Verapamil 2520 Drug interaction    RC00001615
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00001627
Bicalutamide 2375 Drug interaction    RC00001614
Docetaxel 148124 Drug interaction    RC00001623
1,2,6-Tri-O-galloyl-beta-D-glucopyranose - Drug interaction    RC00001628
Trastuzumab - Drug interaction    RC00001629
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-30d-5p
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-30d-5p
Interactor2: BECN1

Evidence Support:


Weak-Evidence HITS-CLIP
Support Database ViRBase

References:


PMID 22473208 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line Jijoye cells Interactor2 expression None
Description Our HITS-CLIP data yield 1185 human 3'UTRs targeted by members of the miR-17~92 cluster in Jijoye cells. Comparison to the 1664 3'UTRs targeted by EBV miRNAs reveals 740 shared genes (44% of EBV targets and 62% of miR-17~92 targets; Figure 6B and Supplementary Table 7). Thus, EBV miRNAs co-target a majority of miR-17~92 regulated mRNAs, which are assigned to a variety of pathways, most notably regulating transcription, apoptosis, and the cell cycle (Figure 6C). Similarly, other abundant immunologically relevant miRNAs, 142-3p and miR-155, co-target with EBV miRNAs a large fraction of their Ago-bound 3'UTRs, representing ~60% of the targets for each of these host miRNAs (Supplementary Figure 5).

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